hydroxyethylpiperazine ethane sulfonic acid
1-piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-
Identification
| Name | hydroxyethylpiperazine ethane sulfonic acid |
| IUPAC | 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid |
| CAS Number | 7365-45-9 |
| EINECS | 230-907-9 |
| FDA UNII | RWW266YE9I |
| Molecular Formula | C8 H18 N2 O4 S |
| Molecular Weight | 238.30726000 |
| MDL Number | MFCD00006158 |
| Nikkaji Number | J29.038F |
| Beilstein | 0883043 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 234.00 °C. @ 760.00 mm Hg |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | -2.670 (est) |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | buffering agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-quail LD50 > 316 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | buffering agents |
| Recommendation for hydroxyethylpiperazine ethane sulfonic acid usage levels up to | not for fragrance use. |
| Recommendation for hydroxyethylpiperazine ethane sulfonic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
HEPES
4-(2-
hydroxyethyl) piperazin-1-ylethane sulfonic acid
4-(2-
hydroxyethyl)-1-piperazineethane sulfonic acid
4-(2-
hydroxyethyl)-1-piperazineethanesulfonic acid
2-[4-(2-
hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
4-(2-
hydroxyethyl)piperazin-1-ylethanesulphonic acid
N-2-
hydroxyethylpiperazine N',2'-ethanesulfonic acid
N-2-
hydroxyethylpiperazine-N-ethane sulfonic acid
N-2-
hydroxyethylpiperazine-N'-ethanesulfonic acid
1-
piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-
PubMed:
Potassium conductance causing hyperpolarization of CA1 hippocampal neurons during hypoxia.
PubMed:
Effects of CO2-HCO3- on catecholamine efflux from cat carotid body.
PubMed:
Effects of in-vivo administration of taurine and HEPES on the inflammatory response in rats.
PubMed:
Characterization of Na(+)-H+ exchange in segments of rat mesenteric artery.
PubMed:
Cation transport in vascular endothelial cells and aging.
PubMed:
Contrasting effects of HEPES vs HCO3(-)-buffered media on whole-cell currents in cultured chemoreceptors of the rat carotid body.
PubMed:
Acid-base regulation of ion transport in rabbit ileum in vitro.
PubMed:
Mitochondrial carbonic anhydrase is involved in rat renal glucose synthesis.
PubMed:
Regulation of ion transport in porcine gallbladder: effects of VIP and norepinephrine.
PubMed:
Serosal bicarbonate protects against acid injury to rabbit esophagus.
PubMed:
Catalase protection of neuronal survival in vitro is not directed to the accumulation of peroxides in the culture medium.
PubMed:
Influence of cell isolation and incubation procedures on Ca2+ dependence of glucose transport in isolated cardiac myocytes.
PubMed:
Effects of inhibitors of Cl conductance on Cl self-exchange in rabbit cortical collecting tubule.
PubMed:
Influence of surface pH on intracellular pH regulation in cardiac and skeletal muscle.
PubMed:
Effect of hydroxyethylpiperazine N-2 ethane sulphonic acid (HEPES) on the thrombin clotting time and fibrin polymerisation.
PubMed:
HEPES buffered media may induce prostaglandin release from macrophages in tissue culture.
PubMed:
Effects of divalent cations on dynein cross bridging and ciliary microtubule sliding.
PubMed:
The effect of different buffers on terminal deoxynucleotidyl transferase activity.
PubMed:
Optimal conditions for protein synthesis in incubated slices of rat brain.
PubMed:
Effect of pH on the immunogenicity of Mycoplasma pneumoniae.