disiloxane
hexamethyldisiloxane
Identification
| Name | disiloxane |
| CAS Number | 107-46-0 |
| EINECS | 203-492-7 |
| FDA UNII | D7M4659BPU |
| Molecular Formula | C6 H18 O Si2 |
| Molecular Weight | 162.37926000 |
| MDL Number | MFCD00008265 |
| Nikkaji Number | J3.247F |
| Beilstein | 1736258 |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.76400 @ 25.00 °C. |
| Flash Point | 27.00 °F. TCC ( -2.78 °C. ) |
| Soluble in | water, 0.93 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antifoaming agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-guinea pig LDLo 50000 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 16 mL/kg |
| Inhalation Toxicity | inhalation-rat LC50 15956 ppm/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)', 'BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nPERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITH APPROPRIATE ANESTHESIA']
Safety in Use
| Category | antifoaming, emollient agents |
| Recommendation for disiloxane usage levels up to | not for fragrance use. |
| Recommendation for disiloxane flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
belsil DM 0.65
hexamethyldisiloxane
silane, oxybis(trimethyl-
trimethyl(trimethylsilyloxy)silane
bis(
trimethylsyl)oxide
PubMed:
Formation of unexpected silicon- and disiloxane-bridged multiferrocenyl derivatives bearing Si-O-CH[double bond, length as m-dash]CH2 and Si-(CH2)2C(CH3)3 substituents via cleavage of tetrahydrofuran and trapping of its ring fragments.
PubMed:
Reactivity of the Sterically Demanding Siloxanediol Mes2Si(OH)(µ-O)Si(OH)Mes2 Towards Water and Ether Molecules.
PubMed:
Neutral and cationic bismuth compounds supported by bis(amidodimethyl)disiloxane ligands.
PubMed:
Cu3(BTC)2 catalyzed dehydrogenative coupling of dimethylphenylsilane with phenol and homocoupling of dimethylphenylsilane to disiloxane.
PubMed:
Improving the Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells.
PubMed:
Catalytic Synthesis of Saturated Oxygen Heterocycles by Hydrofunctionalization of Unactivated Olefins: Unprotected and Protected Strategies.
PubMed:
Co-Catalyzed Hydroarylation of Unactivated Olefins.
PubMed:
Disiloxane Synthesis Based on Silicon-Hydrogen Bond Activation using Gold and Platinum on Carbon in Water or Heavy Water.
PubMed:
In situ generated polysiloxanes stabilizing μ3-oxo bridged Sb3 triangles.
PubMed:
Disiloxanes and Functionalized Silica Gels: One Route, Two Complementary Outcomes-Guanidinium and Pyridinium Ion-Exchangers.
PubMed:
Dimer formation upon deprotonation: synthesis and structure of a m-terphenyl substituted (R,S)-dilithium disiloxanolate disilanol.
PubMed:
Charge and Spin States in Schiff Base Metal Complexes with a Disiloxane Unit Exhibiting a Strong Noninnocent Ligand Character: Synthesis, Structure, Spectroelectrochemistry, and Theoretical Calculations.
PubMed:
SILA-421 activity in vitro against rifampicin-susceptible and rifampicin-resistant Mycobacterium tuberculosis, and in vivo in a murine tuberculosis model.
PubMed:
Silanetriols as Powerful Starting Materials for Selective Condensation to Bulky POSS Cages.
PubMed:
Easily processable highly ordered Langmuir-Blodgett films of quaterthiophene disiloxane dimer for monolayer organic field-effect transistors.
PubMed:
Catalytic hydroamination of unactivated olefins using a Co catalyst for complex molecule synthesis.
PubMed:
Enhanced hydrolytic stability of siliceous surfaces modified with pendant dipodal silanes.
PubMed:
A 3,4-trans-fused cyclic protecting group facilitates α-selective catalytic synthesis of 2-deoxyglycosides.
PubMed:
Computational study of structural properties of lithium cation complexes with carbamate-modified disiloxanes.
PubMed:
Study of carbamate-modified disiloxane in porous PVDF-HFP membranes: new electrolytes/separators for lithium-ion batteries.
PubMed:
Chain length selectivity during the polycondensation of siloxane-containing esters and alcohols by immobilized Candida antarctica lipase B.
PubMed:
Electron transport characteristics in nanosegregated columnar phases of perylene tetracarboxylic bisimide derivatives bearing oligosiloxane chains.
PubMed:
Convergent synthesis of 4-O-phosphorylated L-glycero-D-manno-heptosyl lipopolysaccharide core oligosaccharides based on regioselective cleavage of a 6,7-O-tetraisopropyldisiloxane-1,3-diyl protecting group.
PubMed:
Synthesis of lipase-catalysed silicone-polyesters and silicone-polyamides at elevated temperatures.
PubMed:
Preparation of vinyl silyl ethers and disiloxanes via the silyl-Heck reaction of silyl ditriflates.
PubMed:
2-Acetyl-amino-1,3,4,6-tetra-O-(tri-methyl-silyl)-2-de-oxy-α-d-gluco-pyran-ose.
PubMed:
Nucleophilic addition to silyl-protected five-membered ring oxocarbenium ions governed by stereoelectronic effects.
PubMed:
Chemistry and structures of hexakis(halogenomethyl)-, hexakis(azidomethyl)-, and hexakis(nitratomethyl)disiloxanes.
PubMed:
Effects of two disiloxanes ALIS-409 and ALIS-421 on chemoprevention in model experiments.
PubMed:
Hyperconjugative interactions in permethylated siloxanes and ethers: the nature of the SiO bond.
PubMed:
Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis.
PubMed:
Disiloxanes with cyclic or non-cyclic carbamate moieties as electrolytes for lithium-ion batteries.
PubMed:
Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation.
PubMed:
Tetraisopropyldisiloxane-1,3-diyl as a versatile protecting group for pentopyranosides.
PubMed:
Chemical properties of 1,3-bis(3-methacryloxypropyl)-1,1,3,3-tetramethyldisiloxane-methyl methacrylate copolymer.
PubMed:
Assembly, growth, and catalytic activity of gold nanoparticles in hollow carbon nanofibers.
PubMed:
Tetra-carbon-yl[bis-(diphenyl-phosphan-yl)tetra-methyl-disiloxane-κP,P']chromium(0).
PubMed:
Anticancer effects of the organosilicon multidrug resistance modulator SILA 421.
PubMed:
Highly mass-sensitive thin film plate acoustic resonators (FPAR).
PubMed:
Self-assembly of linear and cyclic siloxane-containing mesogens: investigation of layered structures in bulk and thin films.
PubMed:
Dissociation of the disilatricyclic diallylic dianion [(C4Ph4SiMe)2]-2 to the silole anion [MeSiC4Ph4]- by halide ion coordination or halide ion nucleophilic substitution at the silicon atom.
PubMed:
A disiloxane-functionalized phosphonium-based ionic liquid as electrolyte for lithium-ion batteries.
PubMed:
Synthesis of octyl S-glycosides of tri- to pentasaccharide fragments related to the GPI anchor of Trypanosoma brucei.
PubMed:
Role of positive ions in determining the deposition rate and film chemistry of continuous wave hexamethyl disiloxane plasmas.
PubMed:
Brønsted acid-promoted azide-olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A.
PubMed:
Novel hard-block polyurethanes with high strength and transparency for biomedical applications.
PubMed:
Vinyldisiloxanes: their synthesis, cross coupling and applications.
PubMed:
An isolable bis-silylene oxide ("disilylenoxane") and its metal coordination.
PubMed:
Unexpected formation of complexes between protonated organic ligand and neutral salt molecule studied by electrospray ionization mass spectrometry.
PubMed:
The catalytic role of N-heterocyclic carbene in a metal-free conversion of carbon dioxide into methanol: a computational mechanism study.
PubMed:
Si-C bond activation in the reaction of first generation Grubbs' catalyst with alkynylsilanes - formation of [Cl(2){P(C(6)H(11))(3)}(2)Ru(=CHCH=CHPh)] anddisiloxanes.
PubMed:
Magnesium-mediated intramolecular reductive coupling: a stereoselective synthesis of C(2)-symmetric 3,4-bis-silyl-substituted adipic acid derivatives.
PubMed:
Formation of two- and three-dimensional hybrid mesostructures from branched siloxane molecules.
PubMed:
Tellurasiloxane cages containing Te(6)Si(4)O(12) and Te(6)Si(6)O(15) frameworks.
PubMed:
SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis (XDR-TB).
PubMed:
Bis(η-penta-methyl-cyclo-penta-dien-yl)cobalt(II).
PubMed:
Incorporation of Linear Spacer Molecules in Vapor Deposited Silicone Polymer Thin Films.
PubMed:
Silanol-based pincer Pt(II) complexes: synthesis, structure, and unusual reactivity.
PubMed:
Plasma treatments of PET meshes for fuel-water separation applications.
PubMed:
Reduction of ribonucleosides to 2'-deoxyribonucleosides.
PubMed:
Basic study of a new soft resin applied with bisfunctional siloxane oligomer.
PubMed:
Elimination of plasmids by SILA compounds that inhibit efflux pumps of bacteria and cancer cells.
PubMed:
Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells.
PubMed:
From a stable silylene to a mixed-valent disiloxane and an isolable silaformamide-borane complex with considerable silicon-oxygen double-bond character.
PubMed:
Shell-cross-linked cylindrical Polyisoprene-b-polyferrocenylsilane (PI-b-PFS) block copolymer micelles: one-dimensional (1D) organometallic nanocylinders.
PubMed:
Computational Requirements for Simulating the Structures and Proton Activity of Silicaceous Materials.
PubMed:
1-Hydr-oxy-1,1,3,3,3-penta-phenyl-disiloxane, [Si(2)O(OH)(Ph)(5)], at 150 K.
PubMed:
1-Hydr-oxy-1,1,3,3,3-penta-phenyl-disiloxane, [Si(2)O(OH)(Ph)(5)], at 100 K.
PubMed:
An ab initio and DFT study of structure and vibrational spectra of disiloxane H3SiOSiH3 conformers. Comparison to experimental data.
PubMed:
Si-O bonded interactions in silicate crystals and molecules: a comparison.
PubMed:
Naphthalene-1,8-diylbis(diphenylmethylium) as an organic two-electron oxidant: benzidine synthesis via oxidative self-coupling of N,N-dialkylanilines.
PubMed:
Hydrolysis of fluorosilanes: a theoretical study.
PubMed:
Synthesis of epothilones via a silicon-tethered RCM reaction.
PubMed:
Fluoride-promoted cross-coupling reactions of alkenylsilanols. Elucidation of the mechanism through spectroscopic and kinetic analysis.
PubMed:
Stereoselective dialkylation of the proximal hydroxy groups of calix- and thiacalix[4]arenes.
PubMed:
Endgroup-assisted siloxane bond cleavage in the gas phase.
PubMed:
Intramolecular syn and anti hydrosilylation and silicon-assisted cross-coupling: highly regio- and stereoselective synthesis of trisubstituted allylic alcohols.
PubMed:
The influence of plasma proteins and platelets on oxygen radical production and F-actin distribution in neutrophils adhering to polymer surfaces.
PubMed:
Palladium-catalyzed asymmetric diene cyclization/hydrosilylation employing functionalized silanes and disiloxanes.
PubMed:
Tautomeric equilibrium between penta- and hexacoordinate silicon chelates. A chloride bridge between two pentacoordinate silicons.
PubMed:
Syntheses and reactions of the fluorinated cyclic thionylphosphazene NSO(Ar)[NPF(2)]2(Ar = 4-t-BuC(6)H(4)-) with difunctional reagents.
PubMed:
Permeation of substituted silanes and siloxanes through selected gloves and protective clothing.
PubMed:
Synthesis of alpha-galactosylated fragments related to the core-structure of the GPI anchor of Trypanosoma brucei.
PubMed:
Disiloxane-protected 2-deoxyribonolactone as an efficient precursor to 1,2-dideoxy-1-beta-aryl-D-ribofuranoses.
PubMed:
NaY zeolite as host for the selective heterogeneous oxidation of silanes and olefins with hydrogen peroxide catalyzed by methyltrioxorhenium
PubMed:
Surface modification using a commercial triple quadrupole mass spectrometer.
PubMed:
Study of Bond Angles and Bond Lengths in Disiloxane and Related Molecules in Terms of the Topology of the Electron Density and Its Laplacian.
PubMed:
Estimation of monomer content in polymethyl methacrylate contact lens materials by Raman spectroscopy.
PubMed:
Synthesis of octyl O- and S-glycosides related to the GPI anchor of Trypanosoma brucei and their in vitro galactosylation by trypanosomal alpha-galactosyltransferases.
PubMed:
The chemiluminescence response of neutrophils on polymer surfaces made by glow discharge plasma polymerization.
PubMed:
RF-plasma-modified polystyrene surfaces for studying complement activation.
PubMed:
Studies on contact lens materials.
PubMed:
A theoretical study of the Si-O bond in disiloxane and related molecules.
PubMed:
The siloxane bond in contact lens materials: the siloxanyl alkyl methacrylate copolymers.
PubMed:
Gas-to-liquid permeation in silicon-containing, crosslinked, glassy copolymers of methyl methacrylate.
PubMed:
Shear-induced hemolysis with commercial and glow discharge silicones.