hexyl nicotinate
nicotinic acid, hexyl ester
Identification
| Name | hexyl nicotinate |
| CAS Number | 23597-82-2 |
| EINECS | 245-767-4 |
| FDA UNII | BN07PB44IV |
| Molecular Formula | C12 H17 N O2 |
| Molecular Weight | 207.27289000 |
| MDL Number | MFCD00023587 |
| Nikkaji Number | J135.445K |
| XlogP3 | 3.60 (est) |
Regulatory
Physical Properties
| Appearance | colorless to yellow clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.01700 to 1.02100 @ 20.00 °C. |
| Pounds per Gallon - (est). | 8.472 to 8.506 |
| Refractive Index | 1.48800 to 1.49200 @ 20.00 °C. |
| Boiling Point | 329.00 to 330.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000181 mmHg @ 25.00 °C. (est) |
| Flash Point | 262.00 °F. TCC ( 127.80 °C. ) (est) |
| logP (o/w) | 3.510 |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antistatic agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for hexyl nicotinate usage levels up to | not for fragrance use. |
| Recommendation for hexyl nicotinate flavor usage levels up to | not for flavor use. |
Beijing Lys Chemicals Co, LTD.
From Grams to Tons
Fine chemical high-tech company which contains R&D, production, and sales.
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
WholeChem, LLC
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Custom manufacturer and distributor of specialty ingredients. We make global local.
Potential Uses
Natural Occurrence
Synonyms
hexyl 3-pyridine carboxylate
hexyl 3-pyridinecarboxylate
hexyl nicotinoate
hexyl pyridine-3-carboxylate
nicotherm
nicotinic acid hexyl ester
nicotinic acid N-hexyl ester
nicotinic acid, hexyl ester
3-
pyridine carboxylic acid hexyl ester
3-
pyridinecarboxylic acid hexyl ester
3-
pyridinecarboxylic acid, hexyl ester
PubMed:
Reactions of non-immunologic contact urticaria on scalp, face, and back.
PubMed:
Mapping the human face: biophysical properties.
PubMed:
Microneedle penetration and injection past the stratum corneum in humans.
PubMed:
Estimation of serum protein binding of compounds metabolized in serum using matrix inhibition.
PubMed:
Functional map and age-related differences in the human face: nonimmunologic contact urticaria induced by hexyl nicotinate.
PubMed:
Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with topical pharmacological effect.
PubMed:
Differences among moisturizers in affecting skin susceptibility to hexyl nicotinate, measured as time to increase skin blood flow.
PubMed:
Hydration vs. skin permeability to nicotinates in man.
PubMed:
Effect of drug lipophilicity on in vitro release rate from oil vehicles using nicotinic acid esters as model prodrug derivatives.
PubMed:
In vivo human skin permeability enhancement by oleic acid: a laser Doppler velocimetry study.
PubMed:
Opposing effects of glycerol on the protective function of the horny layer against irritants and on the penetration of hexyl nicotinate.
PubMed:
In vivo human skin barrier modulation by topical application of fatty acids.
PubMed:
An in vivo-In vitro study of the use of a human skin equivalent for irritancy screening of fatty acids.
PubMed:
Transdermal nicotine suppresses cutaneous inflammation.
PubMed:
Photo-initiated peroxidation of lipids in micelles by azaaromatics.
PubMed:
The occlusive effects of protective gloves on the barrier properties of the stratum corneum.
PubMed:
Irritant reactions on hairless micropig skin: a model for testing barrier creams?
PubMed:
Circadian dosing time dependency in the forearm skin penetration of methyl and hexyl nicotinate.
PubMed:
Barrier function parameters in various keratinization disorders: transepidermal water loss and vascular response to hexyl nicotinate.
PubMed:
Skin barrier function in healthy volunteers as assessed by transepidermal water loss and vascular response to hexyl nicotinate: intra- and inter-individual variability.
PubMed:
In vivo differences between Asian, black and white in the stratum corneum barrier function.
PubMed:
Quantitative evaluation of drug-induced erythema by using a tristimulus colour analyzer: experimental design and data analysis.
PubMed:
Mediators of increased blood flow in porcine skin.
PubMed:
Racial differences in pharmacodynamic response to nicotinates in vivo in human skin: black and white.
PubMed:
The effects of topically applied hexyl nicotinate lotion on the cutaneous blood flow in patients with Raynaud's phenomenon.
PubMed:
Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo.
PubMed:
Alterations in scalp blood flow after the epicutaneous application of 3% minoxidil and 0.1% hexyl nicotinate in alopecia.
PubMed:
Hexyl-nicotinate-induced vasodilation in normal human skin.
PubMed:
The influence of urea on percutaneous absorption.
PubMed:
Pharmacodynamic measurement of percutaneous penetration enhancement in vivo.