hexyl nicotinate

nicotinic acid, hexyl ester

CAS: 23597-82-2 C12 H17 N O2 MW: 207.27289000

Identification

Namehexyl nicotinate
CAS Number23597-82-2
EINECS245-767-4
FDA UNIIBN07PB44IV
Molecular FormulaC12 H17 N O2
Molecular Weight207.27289000
MDL NumberMFCD00023587
Nikkaji NumberJ135.445K
XlogP33.60 (est)

Regulatory

Physical Properties

Appearance colorless to yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.01700 to 1.02100 @ 20.00 °C.
Pounds per Gallon - (est). 8.472 to 8.506
Refractive Index 1.48800 to 1.49200 @ 20.00 °C.
Boiling Point 329.00 to 330.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000181 mmHg @ 25.00 °C. (est)
Flash Point 262.00 °F. TCC ( 127.80 °C. ) (est)
logP (o/w) 3.510
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantistatic agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for hexyl nicotinate usage levels up tonot for fragrance use.
Recommendation for hexyl nicotinate flavor usage levels up tonot for flavor use.

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Potential Uses

antistatic agents

Natural Occurrence

averrhoa bilimbi

Synonyms

hexyl 3-pyridine carboxylate hexyl 3-pyridinecarboxylate hexyl nicotinoate hexyl pyridine-3-carboxylate nicotherm nicotinic acid hexyl ester nicotinic acid N-hexyl ester nicotinic acid, hexyl ester 3- pyridine carboxylic acid hexyl ester 3- pyridinecarboxylic acid hexyl ester 3- pyridinecarboxylic acid, hexyl ester PubMed: Reactions of non-immunologic contact urticaria on scalp, face, and back. PubMed: Mapping the human face: biophysical properties. PubMed: Microneedle penetration and injection past the stratum corneum in humans. PubMed: Estimation of serum protein binding of compounds metabolized in serum using matrix inhibition. PubMed: Functional map and age-related differences in the human face: nonimmunologic contact urticaria induced by hexyl nicotinate. PubMed: Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with topical pharmacological effect. PubMed: Differences among moisturizers in affecting skin susceptibility to hexyl nicotinate, measured as time to increase skin blood flow. PubMed: Hydration vs. skin permeability to nicotinates in man. PubMed: Effect of drug lipophilicity on in vitro release rate from oil vehicles using nicotinic acid esters as model prodrug derivatives. PubMed: In vivo human skin permeability enhancement by oleic acid: a laser Doppler velocimetry study. PubMed: Opposing effects of glycerol on the protective function of the horny layer against irritants and on the penetration of hexyl nicotinate. PubMed: In vivo human skin barrier modulation by topical application of fatty acids. PubMed: An in vivo-In vitro study of the use of a human skin equivalent for irritancy screening of fatty acids. PubMed: Transdermal nicotine suppresses cutaneous inflammation. PubMed: Photo-initiated peroxidation of lipids in micelles by azaaromatics. PubMed: The occlusive effects of protective gloves on the barrier properties of the stratum corneum. PubMed: Irritant reactions on hairless micropig skin: a model for testing barrier creams? PubMed: Circadian dosing time dependency in the forearm skin penetration of methyl and hexyl nicotinate. PubMed: Barrier function parameters in various keratinization disorders: transepidermal water loss and vascular response to hexyl nicotinate. PubMed: Skin barrier function in healthy volunteers as assessed by transepidermal water loss and vascular response to hexyl nicotinate: intra- and inter-individual variability. PubMed: In vivo differences between Asian, black and white in the stratum corneum barrier function. PubMed: Quantitative evaluation of drug-induced erythema by using a tristimulus colour analyzer: experimental design and data analysis. PubMed: Mediators of increased blood flow in porcine skin. PubMed: Racial differences in pharmacodynamic response to nicotinates in vivo in human skin: black and white. PubMed: The effects of topically applied hexyl nicotinate lotion on the cutaneous blood flow in patients with Raynaud's phenomenon. PubMed: Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo. PubMed: Alterations in scalp blood flow after the epicutaneous application of 3% minoxidil and 0.1% hexyl nicotinate in alopecia. PubMed: Hexyl-nicotinate-induced vasodilation in normal human skin. PubMed: The influence of urea on percutaneous absorption. PubMed: Pharmacodynamic measurement of percutaneous penetration enhancement in vivo.