hippuric acid
2-(phenylformamido)acetic acid
Identification
| Name | hippuric acid |
| IUPAC | 2-benzamidoacetic acid |
| CAS Number | 495-69-2 |
| EINECS | 207-806-3 |
| FDA UNII | TE0865N2ET |
| Molecular Formula | C9 H9 N O3 |
| Molecular Weight | 179.17533000 |
| MDL Number | MFCD00002692 |
| Nikkaji Number | J1.562H |
| Beilstein | 1073987 |
| XlogP3 | 0.30 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 191.50 °C. @ 760.00 mm Hg |
| Boiling Point | 464.12 °C. @ 760.00 mm Hg (est) |
| Flash Point | 454.00 °F. TCC ( 234.50 °C. ) (est) |
| logP (o/w) | 0.310 |
| Soluble in | water, 3750 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-rat LD50 1500 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for hair conditioning |
| Recommendation for hippuric acid usage levels up to | not for fragrance use. |
| Recommendation for hippuric acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
acetic acid, (benzoylamino)-
benzamidoacetic acid
2-
benzamidoacetic acid
benzoylamino-acetic acid
benzoylamino)-acetic acid
benzoylamino)acetic acid
benzoylaminoacetic acid
N-
benzoylglycine
glycine, N-benzoyl-
hippuricacid
N-(
phenylcarbonyl)glycine
2-(
phenylcarbonylamino)acetic acid
phenylcarbonylaminoacetic acid
2-(
phenylformamido)acetic acid
PubMed:
Hippuric acid in 24 h urine collections as a biomarker of fruits and vegetables intake in kidney stone formers.
PubMed:
The role of sodium in the salty taste of permeate.
PubMed:
Hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine from antibiotic-treated rats.
PubMed:
Disintegration of wheat aleurone structure has an impact on the bioavailability of phenolic compounds and other phytochemicals as evidenced by altered urinary metabolite profile of diet-induced obese mice.
PubMed:
Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry.
PubMed:
Effect of uremic serum and uremic toxins on drug metabolism in human microsomes.
PubMed:
ACE-inhibitory activity of enzymatic protein hydrolysates from lupin and other legumes.
PubMed:
Decomposition pathways and rates of human urine in soils.
PubMed:
Metabolic profiling of phenolic acids and oxidative stress markers after consumption of Lonicera caerulea L. fruit.
PubMed:
Application of ultraperformance liquid chromatography/mass spectrometry-based metabonomic techniques to analyze the joint toxic action of long-term low-level exposure to a mixture of organophosphate pesticides on rat urine profile.
PubMed:
Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2).
PubMed:
1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal.
PubMed:
Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer.
PubMed:
Metabolic influence of acute cyadox exposure on Kunming mice.
PubMed:
Blanching improves anthocyanin absorption from highbush blueberry ( Vaccinium corymbosum L.) purée in healthy human volunteers: a pilot study.
PubMed:
Rapid and simple colorimetric assay for screening angiotensin I-converting enzyme inhibitors.
PubMed:
Hippuric acid in 24-hour urine collections is a potential biomarker for fruit and vegetable consumption in healthy children and adolescents.
PubMed:
Urinary excretion and metabolism of procyanidins in pigs.
PubMed:
Authentication of beef production systems using a metabolomic-based approach.
PubMed:
Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects.
PubMed:
Dynamic metabolic response of mice to acute mequindox exposure.
PubMed:
In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations.
PubMed:
Screening assay of angiotensin-converting enzyme inhibitory activity from complex natural colourants and foods using high-throughput LC-MS/MS.
PubMed:
Differentiation of organic goat's milk based on its hippuric acid content as determined by capillary electrophoresis.
PubMed:
Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study.
PubMed:
Urinary excretion of phenolic acids in rats fed cranberry.
PubMed:
Anthocyanin absorption, metabolism, and distribution from a wild blueberry-enriched diet (Vaccinium angustifolium) is affected by diet duration in the Sprague-Dawley rat.
PubMed:
The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics.
PubMed:
Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers.
PubMed:
Colorimetric, high-throughput assay for screening Angiotensin I-converting enzyme inhibitors.
PubMed:
Bioavailability of [2-(14)C]quercetin-4'-glucoside in rats.
PubMed:
Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction.
PubMed:
Transepithelial transport and stability in blood serum of angiotensin-I-converting enzyme inhibitory dipeptides.
PubMed:
Urinary hippuric acid after ingestion of edible fruits.
PubMed:
Sorghum bran in the diet dose dependently increased the excretion of catechins and microbial-derived phenolic acids in female rats.
PubMed:
Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyric acid.
PubMed:
Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial.
PubMed:
An NMR-based metabonomic investigation on effects of milk and meat protein diets given to 8-year-old boys.
PubMed:
Influence of benzoic acid and dietary protein level on performance, nitrogen metabolism and urinary pH in growing-finishing pigs.
PubMed:
Metabonomics approach to determine metabolic differences between green tea and black tea consumption.
PubMed:
Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat.
PubMed:
Performance of two commonly used angiotensin-converting enzyme inhibition assays using FA-PGG and HHL as substrates.
PubMed:
Nuclear magnetic resonance spectroscopic based studies of the metabolism of black tea polyphenols in humans.
PubMed:
Direct spectrophotometric measurement of angiotensin I-converting enzyme inhibitory activity for screening bioactive peptides.
PubMed:
A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion.
PubMed:
Consumption of both black tea and green tea results in an increase in the excretion of hippuric acid into urine.
PubMed:
Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice.
PubMed:
Molecular and ultrastructural characterization of porcine hippurate-negative Brachyspira pilosicoli.
PubMed:
Peptides with angiotensin I-converting enzyme (ACE) inhibitory activity from defibrinated, hydrolyzed bovine plasma.
PubMed:
Improved method for direct high-performance liquid chromatography assay of angiotensin-converting enzyme-catalyzed reactions.
PubMed:
Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans.
PubMed:
Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate.
PubMed:
Evaluation of commercial immunoassays for cross-reactivity to clenbuterol stereoisomers and bovine metabolites.
PubMed:
Analysis of neurotoxin 3-N-oxalyl-L-2,3-diaminopropionic acid and its alpha-isomer in Lathyrus sativus by high-performance liquid chromatography with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatization.
PubMed:
Hippuric acid as a major excretion product associated with black tea consumption.
PubMed:
Metabolism of n-butyl benzyl phthalate in the female Wistar rat. Identification of new metabolites.
PubMed:
Evaluation of potential disinfectants for preslaughter broiler crop decontamination.
PubMed:
Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.
PubMed:
A surgical model for determination of true absorption and biliary excretion of manganese in conscious swine fed commercial diets.
PubMed:
Excretion of benzoic acid derivatives in urine of sheep given intraruminal infusions of 3-phenylpropionic and cyclohexanecarboxylic acids.
PubMed:
Cutaneous xenobiotic metabolism: glycine conjugation in human and rat keratinocytes.
PubMed:
Use of in vitro skin penetration data and a physiologically based model to predict in vivo blood levels of benzoic acid.
PubMed:
Factors affecting the metabolism of cinnamyl anthranilate in the rat and mouse.
PubMed:
Metabolites of N-ethylbenzamide, N,N-diethylbenzamide and related compounds detected in rat urine by NMR spectroscopy.
PubMed:
Use of nuclear magnetic resonance spectroscopy and selective C-labeling for pharmacokinetic research in man: detection of benzoic acid conversion to hippuric acid.
PubMed:
Short-term inhalation toxicity of methanol, gasoline, and methanol/gasoline in the rat.
PubMed:
Effects of gavage versus dosed feed administration on the toxicokinetics of benzyl acetate in rats and mice.
PubMed:
Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose.
PubMed:
Studies on trans-cinnamaldehyde. 1. The influence of dose size and sex on its disposition in the rat and mouse.
PubMed:
Dietary sources and background levels of hippuric acid in urine: comparison of Philippine and Japanese levels.
PubMed:
Liver blood flow and metabolic clearance rate of progesterone in sheep.
PubMed:
Tissue distribution and excretion of 14C-labelled cinnamic aldehyde following single and multiple oral administration in male Fischer 344 rats.
PubMed:
Toxicokinetics of cinnamaldehyde in F344 rats.
PubMed:
The influence of insulin and amino acid supply on amino acid uptake by the lactating bovine mammary gland.
PubMed:
In vitro skin absorption and metabolism of benzoic acid, p-aminobenzoic acid, and benzocaine in the hairless guinea pig.
PubMed:
Bioavailability, metabolism, and renal excretion of benzoic acid in the channel catfish (Ictalurus punctatus).
PubMed:
Liver function in protein-energy malnutrition measured by cinnamic acid tolerance and benzoic acid tolerance: effect of carnitine supplementation.
PubMed:
Studies on benzyl acetate. III. The percutaneous absorption and disposition of [methylene-14C]benzyl acetate in the rat.
PubMed:
Studies on benzyl acetate. I. Effect of dose size and vehicle on the plasma pharmacokinetics and metabolism of [methylene-14C]benzyl acetate in the rat.
PubMed:
[Mediator concepts and modulation of renal compensatory adaptation].
PubMed:
Influence of dose and sex on the disposition and hepatic effects of cinnamyl anthranilate in the B6C3F1 mouse.
PubMed:
Evaluation of the dose response and in utero exposure to saccharin in the rat.
PubMed:
The effects of high dietary levels of sodium saccharin on mineral and water balance and related parameters in rats.
PubMed:
Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.
PubMed:
Urinary excretion of hippuric acid and o-cresol after laboratory exposure of humans to toluene.
PubMed:
Exposure to toluene: uptake, distribution and elimination in man.
PubMed:
[Physiopathological effects of feeding heated oils to rats].
PubMed:
[Urinary excretion of glucuronic and hippuric acids in rats ingesting heated linseed oil].
PubMed:
The effects of solid food and of alcoholic beverages, especially wine, on the excretion of hippuric acid.