hydroxypropyl methyl cellulose

cellulose, 2-hydroxypropyl methyl ether

CAS: 9004-65-3 C3 H8 O2.x-C H4 O.x-unspecified

Identification

Namehydroxypropyl methyl cellulose
CAS Number9004-65-3
FDA UNII3NXW29V3WO
Molecular FormulaC3 H8 O2.x-C H4 O.x-unspecified
MDL NumberMFCD00131360

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices1973
JECFA Food AdditiveHydroxypropylmethyl cellulose
GSFA CodexHydroxypropyl methyl cellulose (464)
DG SANTE Food Additiveshydroxypropyl methyl cellulose
DG SANTE Food Contact Materialshydroxypropyl methyl cellulose
FDA Mainterm (SATF)9004-65-3 ; HYDROXYPROPYL METHYLCELLULOSE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance white to pale yello powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 1e+006 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantistatic agents

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-rat LD50 5200 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorymultipurpose additives
Recommendation for hydroxypropyl methyl cellulose usage levels up tonot for fragrance use.
Recommendation for hydroxypropyl methyl cellulose flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

Consistent sources

North American supplier for globally sourced ingredients.

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BOC Sciences

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ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

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Penta International Corporation

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At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Potential Uses

binding agents emulsion stabilisers film formers viscosity controlling agents

Natural Occurrence

not found in nature

Synonyms

cellulose hydroxypropyl methyl ether cellulose, 2-hydroxypropyl methyl ether 2- hydroxypropyl cellulose methyl ether 2- hydroxypropyl methyl cellulose hydroxypropyl methylcellulose hydroxypropylmethyl cellulose hydroxypropylmethylcellulose hydroxypropylmethylcellulosum methyl cellulose, propylene glycol ether methyl hydroxypropyl cellulose methylhydroxypropylcellulose methylhydroxypropylcellulosum PubMed: Development of novel guava puree films containing chitosan nanoparticles. PubMed: Effect of antifungal hydroxypropyl methylcellulose-lipid edible composite coatings on Penicillium decay development and postharvest quality of cold-stored "Ortanique" mandarins. PubMed: Fatty acid effect on hydroxypropyl methylcellulose-beeswax edible film properties and postharvest quality of coated 'Ortanique' mandarins. PubMed: The role of fat in flavor perception: effect of partition and viscosity in model emulsions. PubMed: Shear rheology and filament stretching behaviour of xanthan gum and carboxymethyl cellulose solution in presence of saliva. PubMed: Development of polysaccharides-based edible coatings for citrus fruits: a layer-by-layer approach. PubMed: High-viscosity dietary fibers reduce adiposity and decrease hepatic steatosis in rats fed a high-fat diet. PubMed: Near-infrared and fourier transform infrared chemometric methods for the quantification of crystalline tacrolimus from sustained-release amorphous solid dispersion. PubMed: The influence of hydroxypropyl methylcellulose (HPMC) molecular weight, concentration and effect of food on in vivo erosion behavior of HPMC matrix tablets. PubMed: Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification. PubMed: Microencapsulation of Lactobacillus acidophilus NCIMB 701748 in matrices containing soluble fibre by spray drying: Technological characterization, storage stability and survival after in vitro digestion. PubMed: Evaluating food additives as antifungal agents against Monilinia fructicola in vitro and in hydroxypropyl methylcellulose-lipid composite edible coatings for plums. PubMed: Hybrid HPMC nanocomposites containing bacterial cellulose nanocrystals and silver nanoparticles. PubMed: Assessing the efficiency of polymeric excipients by atomistic molecular dynamics simulations. PubMed: Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin. PubMed: Biopolymeric antimicrobial films: study of the influence of hydroxypropyl methylcellulose, tapioca starch and glycerol contents on physical properties. PubMed: Preparation and characterization of a gastric floating dosage form of capecitabine. PubMed: Phase behavior of concentrated hydroxypropyl methylcellulose solution in the presence of mono and divalent salt. PubMed: Antifungal activity of food additives in vitro and as ingredients of hydroxypropyl methylcellulose-lipid edible coatings against Botrytis cinerea and Alternaria alternata on cherry tomato fruit. PubMed: Developing hydroxypropyl methylcellulose/hydroxypropyl starch blends for use as capsule materials. PubMed: Physicochemical and sensory properties of soy bread made with germinated, steamed, and roasted soy flour. PubMed: Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice. PubMed: Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation. PubMed: Encapsulation and Delivery of Crystalline Hydrophobic Nutraceuticals using Nanoemulsions: Factors Affecting Polymethoxyflavone Solubility. PubMed: Effects of particle size, food, and capsule shell composition on the oral bioavailability of dabrafenib, a BRAF inhibitor, in patients with BRAF mutation-positive tumors. PubMed: Mechanistic understanding of food effects: water diffusivity in gastrointestinal tract is an important parameter for the prediction of disintegration of solid oral dosage forms. PubMed: Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats. PubMed: Competitive adsorption between sugar beet pectin (SBP) and hydroxypropyl methylcellulose (HPMC) at the oil/water interface. PubMed: Solid nanocrystalline dispersions of ziprasidone with enhanced bioavailability in the fasted state. PubMed: Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. PubMed: HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice. PubMed: Effect of HPMC on the quality of wheat-free bread made from carob germ flour-starch mixtures. PubMed: Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet. PubMed: Using white sorghum flour for gluten-free breadmaking. PubMed: Viscous dietary fiber reduces adiposity and plasma leptin and increases muscle expression of fat oxidation genes in rats. PubMed: Effect of solid content and composition of hydroxypropyl methylcellulose-lipid edible coatings on physico-chemical and nutritional quality of 'Oronules' mandarins. PubMed: Comparative evaluation of the hypolipidemic effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in high fat-fed mice. PubMed: Dietary hydroxypropyl methylcellulose increases excretion of saturated and trans fats by hamsters fed fast food diets. PubMed: Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model. PubMed: Supplementation of hydroxypropyl methylcellulose into yeast leavened all-whole grain barley bread potentiates cholesterol-lowering effect. PubMed: Preparation and characterization of shellac-coated anthocyanin pectin beads as dietary colonic delivery system. PubMed: How do xanthan and hydroxypropyl methylcellulose individually affect the physicochemical properties in a model gluten-free dough? PubMed: Effect of antifungal hydroxypropyl methylcellulose-lipid edible composite coatings on Penicillium decay development and postharvest quality of cold-stored "Ortanique" mandarins. PubMed: A possible application of magnetic resonance imaging for pharmaceutical research. PubMed: Evaluation of certain food additives and contaminants. PubMed: Physical and sensory properties of all-barley and all-oat breads with additional hydroxypropyl methylcellulose (HPMC) β-glucan. PubMed: HPMC capsules: current status and future prospects. PubMed: Assessment of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-β-cyclodextrin for use in developmental and reproductive toxicology studies. PubMed: The effect of sucrose and salts in combination on the drug release behaviour of an HPMC matrix. PubMed: Evaluation of the genotoxicity of chitosan nanoparticles for use in food packaging films. PubMed: Comprehensive investigation of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-beta-cyclodextrin for use in general toxicology studies. PubMed: Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters. PubMed: Composite edible films based on hydroxypropyl methylcellulose reinforced with microcrystalline cellulose nanoparticles. PubMed: Baking loss of bread with special emphasis on increasing water holding capacity. PubMed: Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride. PubMed: Kinetics of adsorption of whey proteins and hydroxypropyl-methyl-cellulose mixtures at the air-water interface. PubMed: Curative and preventive activity of hydroxypropyl methylcellulose-lipid edible composite coatings containing antifungal food additives to control citrus postharvest green and blue molds. PubMed: Investigation of the effects of hydroalcoholic solutions on textural and rheological properties of various controlled release grades of hypromellose. PubMed: Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals. PubMed: Scintigraphic evaluation of colon targeting pectin-HPMC tablets in healthy volunteers. PubMed: Fatty acid effect on hydroxypropyl methylcellulose-beeswax edible film properties and postharvest quality of coated 'Ortanique' mandarins. PubMed: Effect of plasticizer type and amount on hydroxypropyl methylcellulose-beeswax edible film properties and postharvest quality of coated plums (cv. Angeleno). PubMed: Properties of novel hydroxypropyl methylcellulose films containing chitosan nanoparticles. PubMed: Simultaneous characterization of bile acid, sterols, and determination of acylglycerides in feces from soluble cellulose-fed hamsters using HPLC with evaporative light-scattering detection and APCI-MS. PubMed: Safety assessment of hydroxypropyl methylcellulose as a food ingredient. PubMed: Determination of methylcellulose and hydroxypropyl methylcellulose food gums in food and food products: collaborative study. PubMed: Gluten-free sorghum bread improved by sourdough fermentation: biochemical, rheological, and microstructural background. PubMed: The role of fat in flavor perception: effect of partition and viscosity in model emulsions. PubMed: Capillary electrophoresis for monitoring dityrosine and 3-bromotyrosine synthesis. PubMed: Inhibition of Listeria monocytogenes on the surface of individually packaged hot dogs with a packaging film coating containing nisin. PubMed: Influence of hydroxypropyl methylcellulose edible coating on fresh-keeping and storability of tomato. PubMed: Oral mucosal bioadhesive tablets of pectin and HPMC: in vitro and in vivo evaluation. PubMed: A three-month repeated oral administration study of a low viscosity grade of hydroxypropyl methylcellulose in rats. PubMed: Reduced systemic availability of an antiarrhythmic drug, bidisomide, with meal co-administration: relationship with region-dependent intestinal absorption. PubMed: [Reproductive and developmental toxicity study of a new antineoplastic agent, S-1 (IV)--Perinatal and postnatal study in rats by oral administration]. PubMed: Increased intestinal contents viscosity reduces cholesterol absorption efficiency in hamsters fed hydroxypropyl methylcellulose. PubMed: In vitro/in vivo evaluation of two series of TA-5707F controlled release matrix tablets prepared with hydroxypropyl methyl cellulose derivatives with entero-soluble or gel-formation properties. PubMed: Relationships between viscosity of hydroxypropyl methylcellulose and plasma cholesterol in hamsters. PubMed: Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. PubMed: Evaluation of column flotation in the downstream processing of fermentation products: recovery of a genetically engineered alpha-amylase.