betulin
lup-20(30)-ene-3beta,28-diol
Identification
| Name | betulin |
| CAS Number | 473-98-3 |
| EINECS | 207-475-5 |
| FDA UNII | 6W70HN7X7O |
| Molecular Formula | C30 H50 O2 |
| Molecular Weight | 442.72690000 |
| MDL Number | MFCD00016802 |
| Nikkaji Number | J5.959E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.97500 @ 25.00 °C. |
| Refractive Index | 1.50179 @ 20.00 °C. |
| Melting Point | 147.00 to 148.00 °C. @ 760.00 mm Hg |
| Boiling Point | 284.00 to 288.00 °C. @ 743.00 mm Hg, 138.00 to 140.00 °C. @ 4.00 mm Hg |
| Flash Point | 412.00 °F. TCC ( 210.90 °C. ) (est) |
| logP (o/w) | 8.607 (est) |
| Soluble in | water, 0.0001726 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for betulin usage levels up to | not for fragrance use. |
| Recommendation for betulin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
betuline
betulinic alcohol
betulinol
betulol
(3beta)-
lup-20(29)-ene-3,28-diol
3b-
lup-20(29)-ene-3,28-diol
lup-20(29)-ene-3,28-diol, (3b)-
lup-20(29)-ene-3b,28-diol
lup-20(30)-ene-3b,28-diol
lup-20(30)-ene-3beta,28-diol
messagenin
triterpenoid
trochol
PubMed:
Nutraceutical potential of Aerva lanata (L.) Juss. ex Schult ameliorates secondary complications in streptozotocin-induced diabetic rats.
PubMed:
Molecular modeling of Ruellia tuberosa L compounds as a-amylase inhibitor: an in silico comparation between human and rat enzyme model.
PubMed:
A new SPE/GC-fid method for the determination of cholesterol oxidation products. Application to subcutaneous fat from Iberian dry-cured ham.
PubMed:
Effect of betulin-containing extract from birch tree bark on α-amylase activity in vitro and on weight gain of broiler chickens in vivo.
PubMed:
Synthesis and cytotoxic activity of new betulin and betulinic acid esters with conjugated linoleic acid (CLA).
PubMed:
Caffeoyl triterpenes from pear (Pyrus pyrifolia Nakai) fruit peels and their antioxidative activities against oxidation of rat blood plasma.
PubMed:
A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana.
PubMed:
Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum.
PubMed:
Comparison of the triterpenoid content of berries and leaves of lingonberry Vaccinium vitis-idaea from Finland and Poland.
PubMed:
Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells.
PubMed:
Secondary plant substances in various extracts of the leaves, fruits, stem and bark of Caraipa densifolia Mart.
PubMed:
Antimicrobial and cytotoxic constituents from leaves of Sapium baccatum.
PubMed:
Optimization of subcritical fluid extraction of bioactive compounds using Hansen solubility parameters.
PubMed:
Optimization of ultrasonic-assisted extraction (UAE) of betulin from white birch bark using response surface methodology.
PubMed:
Triterpenic and other lipophilic components from industrial cork byproducts.
PubMed:
Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships.
PubMed:
Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.