hypoxanthine
9H-purin-6(1H)-one
Identification
| Name | hypoxanthine |
| IUPAC | 3,7-dihydropurin-6-one |
| CAS Number | 68-94-0 |
| EINECS | 200-697-3 |
| FDA UNII | 2TN51YD919 |
| Molecular Formula | C5 H4 N4 O |
| Molecular Weight | 136.11408000 |
| MDL Number | MFCD00005725 |
| Nikkaji Number | J1.934H |
| Beilstein | 0005811 |
| XlogP3 | -1.10 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 150.00 °C. @ 760.00 mm Hg |
| Boiling Point | 551.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 549.00 °F. TCC ( 287.00 °C. ) (est) |
| logP (o/w) | -0.910 (est) |
| Soluble in | water, 700 mg/L @ 23C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 750 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for hypoxanthine usage levels up to | not for fragrance use. |
| Recommendation for hypoxanthine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,7-
dihydro-6H-purin-6-one
3,7-
dihydropurin-6-one
6-
hydroxy-1H-purine
6-
hydroxypurine
hypoxanthine enol
purin-6-ol
9H-
purin-6-ol
purin-6(1H)-one
9H-
purin-6(1H)-one
sarcine
sarkin
sarkine
PubMed:
The receptor for activated complement factor 5 (C5aR) conveys myocardial ischemic damage by mediating neutrophil transmigration.
PubMed:
In vitro evaluation of antioxidants of fruit extract of Momordica charantia L. on fibroblasts and keratinocytes.
PubMed:
The Fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro.
PubMed:
Fast simultaneous determination of 14 nucleosides and nucleobases in cultured Cordyceps using ultra-performance liquid chromatography.
PubMed:
Choice of endogenous control for gene expression in nonsmall cell lung cancer.
PubMed:
Natural and newly synthesized hydroxy-1-aryl-isochromans: a class of potential antioxidants and radical scavengers.
PubMed:
Effects of propolis on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells and on neutrophil elastase activity.
PubMed:
The mutagenic potentiator effect of chlorophyllin by the HGPRT assay.
PubMed:
[Production of monoclonal antibodies specific for the ABO blood group and rhesus D antigens].
PubMed:
[Role of xanthine oxidase and xanthine dehydrogenase systems in thymocyte apoptosis, induced by papaverine].
PubMed:
[Dietary fiber inhibits the incidence of hepatic metastasis with the anti-oxidant activity and portal scavenging functions].
PubMed:
Nitric oxide inhibits tissue factor synthesis, expression and activity in human monocytes by prior formation of peroxynitrite.
PubMed:
Potential antitumor alpha-methylene-gamma-butyrolactone-bearing nucleic acid base. 3. Synthesis of 5'-methyl-5'-[(6-substituted-9H-purin-9-yl)methyl]-2'-oxo-3'- methylenetetrahydrofurans.
PubMed:
Serum hypoxanthine and xanthine concentrations in horses heterozygous for combined immunodeficiency.
PubMed:
High-performance liquid chromatographic assay for N2-[5-(hypoxanthin-9-yl)pentyloxycarbonyl]-L-arginine (ST 789) in plasma by cyclization with benzoin and fluorimetric detection.
PubMed:
Superoxide radical scavenging activity of phenolic compounds.
PubMed:
Effect of a new peptidyl-hypoxanthine derivative on natural killer cells and antitumor activity.
PubMed:
Cultivation of a nocardioform acid-fast chemoautotrophic bacterium from armadillo tissues infected with Mycobacterium leprae.
PubMed:
Synthetic biological response modifiers; Part 1. Synthesis and immunomodulatory properties of some N2-(omega-(hypoxanthin-9-yl)alkoxycarbonyl)-L-arginines.
PubMed:
[Incidence of somatic mutations of the lymphocytes in subjects working in an environment with cancer risk].
PubMed:
High-performance liquid chromatographic evaluation of PCF 39, a new immunomodulator agent.
PubMed:
[Quantitative evaluation of the mutagenic potential of benzo(a)pyrene by in vitro and in vivo tests].
PubMed:
[Creatine kinase of rat lymphocytes and its activity as affected by adenosine, cAMP, AMP and products of their transformation].
PubMed:
Ovalbumin is synthesized in mouse cells transformed with the natural chicken ovalbumin gene.
PubMed:
[Studies on xanthin, hypoxanthin and calcium urate crystals].
PubMed:
[Not available].
PubMed:
THE CHEMISTRY OF THE LIVER IN ACUTE YELLOW ATROPHY.