hypoxanthine

9H-purin-6(1H)-one

CAS: 68-94-0 C5 H4 N4 O MW: 136.11408000

Identification

Namehypoxanthine
IUPAC3,7-dihydropurin-6-one
CAS Number68-94-0
EINECS200-697-3
FDA UNII2TN51YD919
Molecular FormulaC5 H4 N4 O
Molecular Weight136.11408000
MDL NumberMFCD00005725
Nikkaji NumberJ1.934H
Beilstein0005811
XlogP3-1.10 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 150.00 °C. @ 760.00 mm Hg
Boiling Point 551.00 °C. @ 760.00 mm Hg (est)
Flash Point 549.00 °F. TCC ( 287.00 °C. ) (est)
logP (o/w) -0.910 (est)
Soluble in water, 700 mg/L @ 23C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 750 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for hypoxanthine usage levels up tonot for fragrance use.
Recommendation for hypoxanthine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

beet root celery shoot coffee bean oat plant potato plant rice plant soybean sprout tea plant

Synonyms

1,7- dihydro-6H-purin-6-one 3,7- dihydropurin-6-one 6- hydroxy-1H-purine 6- hydroxypurine hypoxanthine enol purin-6-ol 9H- purin-6-ol purin-6(1H)-one 9H- purin-6(1H)-one sarcine sarkin sarkine PubMed: The receptor for activated complement factor 5 (C5aR) conveys myocardial ischemic damage by mediating neutrophil transmigration. PubMed: In vitro evaluation of antioxidants of fruit extract of Momordica charantia L. on fibroblasts and keratinocytes. PubMed: The Fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro. PubMed: Fast simultaneous determination of 14 nucleosides and nucleobases in cultured Cordyceps using ultra-performance liquid chromatography. PubMed: Choice of endogenous control for gene expression in nonsmall cell lung cancer. PubMed: Natural and newly synthesized hydroxy-1-aryl-isochromans: a class of potential antioxidants and radical scavengers. PubMed: Effects of propolis on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells and on neutrophil elastase activity. PubMed: The mutagenic potentiator effect of chlorophyllin by the HGPRT assay. PubMed: [Production of monoclonal antibodies specific for the ABO blood group and rhesus D antigens]. PubMed: [Role of xanthine oxidase and xanthine dehydrogenase systems in thymocyte apoptosis, induced by papaverine]. PubMed: [Dietary fiber inhibits the incidence of hepatic metastasis with the anti-oxidant activity and portal scavenging functions]. PubMed: Nitric oxide inhibits tissue factor synthesis, expression and activity in human monocytes by prior formation of peroxynitrite. PubMed: Potential antitumor alpha-methylene-gamma-butyrolactone-bearing nucleic acid base. 3. Synthesis of 5'-methyl-5'-[(6-substituted-9H-purin-9-yl)methyl]-2'-oxo-3'- methylenetetrahydrofurans. PubMed: Serum hypoxanthine and xanthine concentrations in horses heterozygous for combined immunodeficiency. PubMed: High-performance liquid chromatographic assay for N2-[5-(hypoxanthin-9-yl)pentyloxycarbonyl]-L-arginine (ST 789) in plasma by cyclization with benzoin and fluorimetric detection. PubMed: Superoxide radical scavenging activity of phenolic compounds. PubMed: Effect of a new peptidyl-hypoxanthine derivative on natural killer cells and antitumor activity. PubMed: Cultivation of a nocardioform acid-fast chemoautotrophic bacterium from armadillo tissues infected with Mycobacterium leprae. PubMed: Synthetic biological response modifiers; Part 1. Synthesis and immunomodulatory properties of some N2-(omega-(hypoxanthin-9-yl)alkoxycarbonyl)-L-arginines. PubMed: [Incidence of somatic mutations of the lymphocytes in subjects working in an environment with cancer risk]. PubMed: High-performance liquid chromatographic evaluation of PCF 39, a new immunomodulator agent. PubMed: [Quantitative evaluation of the mutagenic potential of benzo(a)pyrene by in vitro and in vivo tests]. PubMed: [Creatine kinase of rat lymphocytes and its activity as affected by adenosine, cAMP, AMP and products of their transformation]. PubMed: Ovalbumin is synthesized in mouse cells transformed with the natural chicken ovalbumin gene. PubMed: [Studies on xanthin, hypoxanthin and calcium urate crystals]. PubMed: [Not available]. PubMed: THE CHEMISTRY OF THE LIVER IN ACUTE YELLOW ATROPHY.