indocyanine green

anhydro-3,3,3',3'-tetramethyl-1,1'-bis(4-sulfobutyl)-4,5,4',5'-dibenzoindotricarbocyanine hydroxide inner salt sodium salt

CAS: 3599-32-4 C43 H47 N2 Na O6 S2 MW: 774.97655928

Identification

Nameindocyanine green
IUPACsodium;4-[(2Z)-2-[(2E,4E,6E)-7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulf
CAS Number3599-32-4
FDA UNIIIX6J1063HV
Molecular FormulaC43 H47 N2 Na O6 S2
Molecular Weight774.97655928
MDL NumberMFCD00013078
Beilstein4115884

Regulatory

Physical Properties

Appearance dark green powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -0.290
Soluble in water, 0.01494 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesuv absorbers

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-mouse LD50 60 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic UV absorber
Recommendation for indocyanine green usage levels up tonot for fragrance use.
Recommendation for indocyanine green flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

anhydro-3,3,3',3'-tetramethyl-1,1'-bis(4-sulfobutyl)-4,5,4',5'-dibenzoindotricarbocyanine hydroxide inner salt sodium salt cardio-green 2-(7-(1,3- dihydro-1,1-dimethyl-3-(4-sulfobutyl)benz(e)indolin-2-ylidene)-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indoliumhydroxide inner sodium salt fox green HWD indocyanine green natrium 4-(2-(7-(2,3-Dihydro-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indol-2-yliden)-1,3,5-heptatrienyl)-1,1-dimethyl-1H-benz(e)indol-3-ol)butan-1-sulfonat ujoviridin wofaverdin PubMed: Fully integrated high-speed intravascular optical coherence tomography/near-infrared fluorescence structural/molecular imaging in vivo using a clinically available near-infrared fluorescence-emitting indocyanine green to detect inflamed lipid-rich atheromata in coronary-sized vessels. PubMed: The advancing clinical impact of molecular imaging in CVD. PubMed: First in-human intraoperative imaging of HCC using the fluorescence goggle system and transarterial delivery of near-infrared fluorescent imaging agent: a pilot study. PubMed: The effect of mannosylation of liposome-encapsulated indocyanine green on imaging of sentinel lymph node. PubMed: In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green. PubMed: A comparison of free autologous breast reconstruction with and without the use of laser-assisted indocyanine green angiography: a cost-effectiveness analysis. PubMed: Intraoperative near-infrared imaging of surgical wounds after tumor resections can detect residual disease. PubMed: Gadolinium-doped silica nanoparticles encapsulating indocyanine green for near infrared and magnetic resonance imaging. PubMed: Descending aortic blood flow during aortic cross-clamp indicates postoperative splanchnic perfusion and gastrointestinal function in patients undergoing aortic reconstruction. PubMed: Nerve mapping for prostatectomies: novel technologies under development. PubMed: Relationship between indocyanine green clearance test and feed intake and impaired hepatic function in dairy cows. PubMed: Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques. PubMed: Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery. PubMed: Near infrared fluorescence-guided real-time endoscopic detection of peritoneal ovarian cancer nodules using intravenously injected indocyanine green. PubMed: Endoscopic tattooing. PubMed: Effect of recombinant porcine somatotropin (rpST) on drug disposition in swine. PubMed: Toxicity of organic fluorophores used in molecular imaging: literature review. PubMed: Real-time assessment of cardiac perfusion, coronary angiography, and acute intravascular thrombi using dual-channel near-infrared fluorescence imaging. PubMed: In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green. PubMed: Intestinal, hepatic, splanchnic and hindquarter amino acid and metabolite partitioning during an established Trichostrongylus colubriformis infection in the small intestine of lambs fed fresh Sulla (Hedysarum coronarium). PubMed: Molecular contrast optical coherence tomography: A pump-probe scheme using indocyanine green as a contrast agent. PubMed: Effect of varying chromophores used in light-activated protein solders on tensile strength and thermal damage profile of repairs. PubMed: Absorption properties of alternative chromophores for use in laser tissue soldering applications. PubMed: Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green. PubMed: Ocular toxocariasis: a rare presentation of a posterior pole granuloma with an associated choroidal neovascular membrane. PubMed: Role of bradykinin in postprandial hypotension in humans. PubMed: Sucrose acetate isobutyrate (SAIB): historical aspects of its use in beverages and a review of toxicity studies prior to 1988. PubMed: Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator. PubMed: Insulin pretreatment protects the liver from ischemic damage during Pringle's maneuver. PubMed: Assessment of changes in liver blood flow after food intake--comparison of ICG clearance and echo-Doppler. PubMed: Effects of changing liver blood flow by exercise and food on kinetics and dynamics of saruplase. PubMed: Hepatic blood flow measurements and indocyanine green kinetics in a chronic dog model. PubMed: Effect of route of nutrition on recovery of hepatic organic anion clearance after fasting. PubMed: Chronic physical activity alters hepatobiliary excretory function in rats. PubMed: [Measurement of small bowel transit time in dogs with acetaminophen and indocyanine green]. PubMed: Pharmacokinetic and metabolic aspects of the moclobemide-food interaction. PubMed: Food and nicotine metabolism. PubMed: Lipid malnutrition of patients with liver cirrhosis: effect of low intake of dietary lipid on plasma fatty acid composition. PubMed: Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: simulation of the food effect. PubMed: Indocyanine green plasma clearance as a measure of changes in hepatic blood flow. PubMed: Parenteral nutrition: short term effects on hepatic clearance of sodium taurocholate and indocyanine green. PubMed: Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis. PubMed: Effects of hydralazine, nitroglycerin, and food on estimated hepatic blood flow. PubMed: Effect of food on blood hydralazine levels and response in hypertension. PubMed: Effect of food on hepatic blood flow: implications in the "food effect" phenomenon. PubMed: Effects of feeding on the systemic clearance of indocyanine green and propranolol blood concentrations and plasma binding. PubMed: By-passing the sphincter of Oddi does not affect gallbladder emptying in the pig. PubMed: Effects of a meal on plasma clearance of [14C]glycocholic acid and indocyanine green in man. PubMed: Effect of paraquat (methyl viologen) on liver function in mice. PubMed: Biochemical effects of sucrose acetate isobutyrate (SAIB) on the liver. PubMed: Estimation of nutrient liver blood flow in mice by atraumatic densitometry.