indocyanine green
anhydro-3,3,3',3'-tetramethyl-1,1'-bis(4-sulfobutyl)-4,5,4',5'-dibenzoindotricarbocyanine hydroxide inner salt sodium salt
Identification
| Name | indocyanine green |
| IUPAC | sodium;4-[(2Z)-2-[(2E,4E,6E)-7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulf |
| CAS Number | 3599-32-4 |
| FDA UNII | IX6J1063HV |
| Molecular Formula | C43 H47 N2 Na O6 S2 |
| Molecular Weight | 774.97655928 |
| MDL Number | MFCD00013078 |
| Beilstein | 4115884 |
Regulatory
Physical Properties
| Appearance | dark green powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | -0.290 |
| Soluble in | water, 0.01494 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | uv absorbers |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-mouse LD50 60 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic UV absorber |
| Recommendation for indocyanine green usage levels up to | not for fragrance use. |
| Recommendation for indocyanine green flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
anhydro-3,3,3',3'-tetramethyl-1,1'-bis(4-sulfobutyl)-4,5,4',5'-dibenzoindotricarbocyanine hydroxide inner salt sodium salt
cardio-green
2-(7-(1,3-
dihydro-1,1-dimethyl-3-(4-sulfobutyl)benz(e)indolin-2-ylidene)-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indoliumhydroxide inner sodium salt
fox green
HWD indocyanine green
natrium 4-(2-(7-(2,3-Dihydro-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indol-2-yliden)-1,3,5-heptatrienyl)-1,1-dimethyl-1H-benz(e)indol-3-ol)butan-1-sulfonat
ujoviridin
wofaverdin
PubMed:
Fully integrated high-speed intravascular optical coherence tomography/near-infrared fluorescence structural/molecular imaging in vivo using a clinically available near-infrared fluorescence-emitting indocyanine green to detect inflamed lipid-rich atheromata in coronary-sized vessels.
PubMed:
The advancing clinical impact of molecular imaging in CVD.
PubMed:
First in-human intraoperative imaging of HCC using the fluorescence goggle system and transarterial delivery of near-infrared fluorescent imaging agent: a pilot study.
PubMed:
The effect of mannosylation of liposome-encapsulated indocyanine green on imaging of sentinel lymph node.
PubMed:
In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green.
PubMed:
A comparison of free autologous breast reconstruction with and without the use of laser-assisted indocyanine green angiography: a cost-effectiveness analysis.
PubMed:
Intraoperative near-infrared imaging of surgical wounds after tumor resections can detect residual disease.
PubMed:
Gadolinium-doped silica nanoparticles encapsulating indocyanine green for near infrared and magnetic resonance imaging.
PubMed:
Descending aortic blood flow during aortic cross-clamp indicates postoperative splanchnic perfusion and gastrointestinal function in patients undergoing aortic reconstruction.
PubMed:
Nerve mapping for prostatectomies: novel technologies under development.
PubMed:
Relationship between indocyanine green clearance test and feed intake and impaired hepatic function in dairy cows.
PubMed:
Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques.
PubMed:
Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery.
PubMed:
Near infrared fluorescence-guided real-time endoscopic detection of peritoneal ovarian cancer nodules using intravenously injected indocyanine green.
PubMed:
Endoscopic tattooing.
PubMed:
Effect of recombinant porcine somatotropin (rpST) on drug disposition in swine.
PubMed:
Toxicity of organic fluorophores used in molecular imaging: literature review.
PubMed:
Real-time assessment of cardiac perfusion, coronary angiography, and acute intravascular thrombi using dual-channel near-infrared fluorescence imaging.
PubMed:
In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green.
PubMed:
Intestinal, hepatic, splanchnic and hindquarter amino acid and metabolite partitioning during an established Trichostrongylus colubriformis infection in the small intestine of lambs fed fresh Sulla (Hedysarum coronarium).
PubMed:
Molecular contrast optical coherence tomography: A pump-probe scheme using indocyanine green as a contrast agent.
PubMed:
Effect of varying chromophores used in light-activated protein solders on tensile strength and thermal damage profile of repairs.
PubMed:
Absorption properties of alternative chromophores for use in laser tissue soldering applications.
PubMed:
Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green.
PubMed:
Ocular toxocariasis: a rare presentation of a posterior pole granuloma with an associated choroidal neovascular membrane.
PubMed:
Role of bradykinin in postprandial hypotension in humans.
PubMed:
Sucrose acetate isobutyrate (SAIB): historical aspects of its use in beverages and a review of toxicity studies prior to 1988.
PubMed:
Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator.
PubMed:
Insulin pretreatment protects the liver from ischemic damage during Pringle's maneuver.
PubMed:
Assessment of changes in liver blood flow after food intake--comparison of ICG clearance and echo-Doppler.
PubMed:
Effects of changing liver blood flow by exercise and food on kinetics and dynamics of saruplase.
PubMed:
Hepatic blood flow measurements and indocyanine green kinetics in a chronic dog model.
PubMed:
Effect of route of nutrition on recovery of hepatic organic anion clearance after fasting.
PubMed:
Chronic physical activity alters hepatobiliary excretory function in rats.
PubMed:
[Measurement of small bowel transit time in dogs with acetaminophen and indocyanine green].
PubMed:
Pharmacokinetic and metabolic aspects of the moclobemide-food interaction.
PubMed:
Food and nicotine metabolism.
PubMed:
Lipid malnutrition of patients with liver cirrhosis: effect of low intake of dietary lipid on plasma fatty acid composition.
PubMed:
Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: simulation of the food effect.
PubMed:
Indocyanine green plasma clearance as a measure of changes in hepatic blood flow.
PubMed:
Parenteral nutrition: short term effects on hepatic clearance of sodium taurocholate and indocyanine green.
PubMed:
Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis.
PubMed:
Effects of hydralazine, nitroglycerin, and food on estimated hepatic blood flow.
PubMed:
Effect of food on blood hydralazine levels and response in hypertension.
PubMed:
Effect of food on hepatic blood flow: implications in the "food effect" phenomenon.
PubMed:
Effects of feeding on the systemic clearance of indocyanine green and propranolol blood concentrations and plasma binding.
PubMed:
By-passing the sphincter of Oddi does not affect gallbladder emptying in the pig.
PubMed:
Effects of a meal on plasma clearance of [14C]glycocholic acid and indocyanine green in man.
PubMed:
Effect of paraquat (methyl viologen) on liver function in mice.
PubMed:
Biochemical effects of sucrose acetate isobutyrate (SAIB) on the liver.
PubMed:
Estimation of nutrient liver blood flow in mice by atraumatic densitometry.