inositol niacinate

3-pyridinecarboxylic acid, 1,2,3,4,5,6-cyclohexanehexayl ester

CAS: 6556-11-2 C42 H30 N6 O12 MW: 810.73350000

Identification

Nameinositol niacinate
IUPAC[2,3,4,5,6-pentakis(pyridine-3-carbonyloxy)cyclohexyl] pyridine-3-carboxylate
CAS Number6556-11-2
EINECS229-485-9
FDA UNIIA99MK953KZ
Molecular FormulaC42 H30 N6 O12
Molecular Weight810.73350000
MDL NumberMFCD00006387
Nikkaji NumberJ3.420G
Beilstein0077649

Regulatory

Physical Properties

Appearance white crystalline powder (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 254.00 to 255.00 °C. @ 760.00 mm Hg
Boiling Point 897.00 to 898.00 °C. @ 760.00 mm Hg (est)
Flash Point 925.00 °F. TCC ( 496.30 °C. ) (est)
logP (o/w) 3.945 (est)
Soluble in acetone
Insoluble in water

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 > 20000 mg/kg
Dermal Toxicitysubcutaneous-rat LD50 1180 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorydietary supplements
Recommendation for inositol niacinate usage levels up tonot for fragrance use.
Recommendation for inositol niacinate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

cyclohexane-1,2,3,4,5,6-hexayl hexanicotinate cyclohexane-1,2,3,4,5,6-hexayl hexapyridine-3-carboxylate hexanicotinoyl inositol inositol hexanicotinate inositol nicotinate inositol, hexanicotinate, myo- inositoli nicotinas mesonex 2,3,4,5,6- pentakis((3-pyridinylcarbonyl)oxy)cyclohexyl nicotinate [2,3,4,5,6- pentakis(pyridine-3-carbonyloxy)cyclohexyl] pyridine-3-carboxylate 3- pyridinecarboxylic acid, 1,2,3,4,5,6-cyclohexanehexayl ester PubMed: Wax-matrix extended-release niacin vs inositol hexanicotinate: a comparison of wax-matrix, extended-release niacin to inositol hexanicotinate "no-flush" niacin in persons with mild to moderate dyslipidemia. PubMed: Biotransformation and pharmacokinetics of inositol hexanicotinate in rats. PubMed: Niacin: chemical forms, bioavailability, and health effects. PubMed: A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease. PubMed: Synthesis and antihyperlipidemic activity of acetylated derivative of ulvan from Ulva pertusa. PubMed: Determination of inositol hexanicotinate in rat plasma by high performance liquid chromatography with UV detection. PubMed: Dissolution profiles of nonprescription extended-release niacin and inositol niacinate products. PubMed: Purported benefits of inositol niacinate. PubMed: Antihyperlipidemic effects of different molecular weight sulfated polysaccharides from Ulva pertusa (Chlorophyta). PubMed: Inositol hexaniacinate. PubMed: The therapeutic efficacy of inositol nicotinate (Hexopal) in intermittent claudication: a controlled trial. PubMed: Does inositol nicotinate (Hexopal) influence intermittent claudication? A controlled trial. PubMed: A double blind randomised placebo controlled trial of hexopal in primary Raynaud's disease. PubMed: Inositol nicotinate in intermittent claudication. PubMed: Treatment of intermittent claudication with inositol nicotinate. PubMed: A double-blind placebo-controlled study of Hexopal in the treatment of intermittent claudication. PubMed: [Use of derivative resolution for the spectrophotometric analysis of drug mixtures. I. Determination of inositol hexanicotinate and bamethan sulfate in tablets]. PubMed: [Experience with the medical treatment of chronic cerebrovascular insufficiency: bamethan and inositol nicotinate versus placebo]. PubMed: Quantitative thermal imaging to assess inositol nicotinate treatment for Raynaud's syndrome. PubMed: Changes in lipids and lipoproteins in patients with hyperlipidemia type IIb, IV and V treated with different lipid lowering drugs. PubMed: Lipids and lipoproteins in hyperlipidemia type IIa during treatment with different lipid lowering drugs. PubMed: Enzymatic hydrolysis of pentaerythritoltetranicotinate and meso-inositolhexanicotinate in blood and tissues. PubMed: [Comparative studies of the response of normolipemic and dyslipemic aged subjects to 2 forms of delayed-action nicotinic acid polyesters. Pentaerythrotol tetranicotinate and inositol hexanicotinate. Results of a controlled cross-over trial]. PubMed: A multiclinic double-blind trial of pyridinolcarbamate and inositol niacinate in ischemic ulcer due to chronic arterial occlusion. PubMed: [Pharmacokinetics of a combination of magnesium-chlorophenoxy-isobutyrate and meso-inositol hexanicotinate]. PubMed: [Clinical use of a thermal method for measuring peripheral blood flow according to A.M. Baptista (author's transl)]. PubMed: [Inositol hexanicotinate and its cholesteropenic effect]. PubMed: [Ulcers of the lower extremities. Treatment with inositol hexanicotinate]. PubMed: [Ocular changes experimentally induced in guinea pigs treated with an association of kallikrein and meso-inositol hexanicotinate]. PubMed: [On the fibrinolytic effect of the combination of kallikrein with meso-inositol hexanicotinate]. PubMed: The use of Hexanicotol (inositol niacinate) in peripheral vascular disease. PubMed: [Research on skin temperature and internal temperature in subjects with obliterating arteriopathy. Action of the association of kallikrein and meso-inositol hexanicotinate]. PubMed: [Clinical considerations and functional data on the use of the association of kallikrein and meso-inositol hexanicotinate in the therapy of obliterating arteriopathy]. PubMed: [The association of kallikrein and inositol hexanicotinate in the therapy of peripheral obliterating arteriopathy]. PubMed: [Effect of meso-inositol hexanicotinate on arteriosclerosis]. PubMed: [FIRST EXPERIENCES ON THE THERAPEUTIC ACTIVITY OF M-INOSITOL HEXANICOTINATE AND KALLIKREIN IN PERIPHERAL VASCULAR DISEASES AND IN CORONARY DISEASE]. PubMed: [APROPOS OF THE GASTROINTESTINAL ABSORPTION OF INOSITOL HEXANICOTINATE]. PubMed: [PHARMACOLOGICAL EXPERIMENTS WITH A COMBINATION OF KALLIKREIN AND MESO-INOSITOL HEXANICOTINATE]. PubMed: [CLINICAL TESTING OF MESO-INOSITOL-HEXANICOTINATE]. PubMed: [CLINICAL TRIAL OF A NEW NICOTINIC ACID DERIVATIVE, MESO-INOSITOL-HEXANICOTINATE, IN NEUROPSYCHIATRY]. PubMed: [INOSITOL HEXANICOTINATE IN THE THERAPY OF ULCUS CRURIS]. PubMed: [Therapy of peripheral arteriopathies with a compound with a base of inositol hexanicotinate]. PubMed: Inositol niacinate as a peripheral vasodilator. PubMed: [Apropos of the hypocholesterolemic effects of nicotinic acid. Experimental investigations of such a compound and of inositol hexanicotinate]. PubMed: Inositol hexanicotinate for improved nicotinic acid therapy. Preliminary report. PubMed: Speripheral vascular disease in general practice. Some experiences with meso-inositol-hexanicotinate.