isatin
1H-benzo[d]azoline-2,3-dione
Identification
| Name | isatin |
| IUPAC | 1H-indole-2,3-dione |
| CAS Number | 91-56-5 |
| EINECS | 202-077-8 |
| FDA UNII | 82X95S7M06 |
| Molecular Formula | C8 H5 N O2 |
| Molecular Weight | 147.13325000 |
| MDL Number | MFCD00005718 |
| Nikkaji Number | J4.342G |
| Beilstein | 0383659 |
| XlogP3 | 0.80 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 203.00 °C. @ 760.00 mm Hg |
| Boiling Point | 360.30 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000001 mmHg @ 25.00 °C. (est) |
| Flash Point | 341.00 °F. TCC ( 171.70 °C. ) (est) |
| logP (o/w) | 0.830 |
| Soluble in | water, 1.527e+004 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair dyeing agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 330 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for isatin usage levels up to | not for fragrance use. |
| Recommendation for isatin flavor usage levels up to | not for flavor use. |
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Penta International Corporation
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Potential Uses
Natural Occurrence
Synonyms
1H-
benzo[d]azoline-2,3-dione
2,3-
diketoindoline
2,3-
dioxo-2,3-dihydroindole
2,3-
dioxoindoline
3-
hydroxy-2-oxoindole
indole-2,3-dione
1H-
indole-2,3-dione
indolequinone
indoline-2,3-dione
2,3-
indolinedione
PubMed:
Mediators involved in the hyperthermic action of neuromedin U in rats.
PubMed:
5-(2-carboxyethenyl) isatin derivative induces Gâ/M cell cycle arrest and apoptosis in human leukemia K562 cells.
PubMed:
Synthesis and in vitro antioxidant activity of new 3-substituted-2-oxindole derivatives.
PubMed:
Rapid method for proline determination in grape juice and wine.
PubMed:
Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives.
PubMed:
Organophosphorus derivatives containing isatin-3-hydrazones as chemotherapeutants against fungal pathogens of sugarcane.
PubMed:
Stress-induced increase in urinary isatin excretion in rats: reversal by both dexamethasone and alpha-methyl-P-tyrosine.
PubMed:
Isatin inhibits food intake in mice.
PubMed:
On the functions of monoamine oxidase, the emotions, and adaptation to stress.
PubMed:
The response of some intravascular and intracellular lipid parameters of the rat after treatment with isatin.