laevo-carnitine hydrochloride
(R)-3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, inner salt, hydrochloride (1:1)
Identification
| Name | laevo-carnitine hydrochloride |
| CAS Number | 6645-46-1 |
| EINECS | 229-663-6 |
| FDA UNII | J3Y5E6IKS3 |
| Molecular Formula | C7 H16 Cl N O3 |
| Molecular Weight | 197.66112000 |
| MDL Number | MFCD00066100 |
| Beilstein | 0773748 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | -4.518 (est) |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | humectants |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-dog LD50 2272 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 4320 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | humectants, skin conditioning |
| Recommendation for laevo-carnitine hydrochloride usage levels up to | not for fragrance use. |
| Recommendation for laevo-carnitine hydrochloride flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, chloride
(R)-3-
carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, inner salt, hydrochloride (1:1)
(R)-3-
carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
[(2R)-3-
carboxy-2-hydroxypropyl)-trimethylazanium;chloride
(±)-(3-
carboxy-2-hydroxypropyl)trimethyl-ammonium chloride
carnitine chloride
L-
carnitine hydrochloirde (bovine)
laevo-
carnitine hydrochloride from equine muscle
L-
carnitinehydrochloride
entomin
(R)-3-
hydroxy-4-(trimethylamino)butanoic acid, chloride
(R)-3-
hydroxy-4-(trimethylammonio)butanoate hydrochloride
(R)-3-
hydroxy-4-(trimethylammonio)butyrate hydrochloride
levocarnitine hydrochloride
1-
propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (R)-
1-
propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (R)- (1:1)
1-
propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, hydrochloride, (R)- (1:1)
PubMed:
[Experience with levocarnitine chloride supplementation for the treatment of fatigue in cancer patients undergoing chemotherapy].
PubMed:
L-carnitine exposure and mitochondrial function in human neuronal cells.
PubMed:
2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway.
PubMed:
Novel c.2216T > C (p.I739T) mutation in exon 13 and c.1481T > A (p.L494X) mutation in exon 8 of MUT gene in a female with methylmalonic acidemia.
PubMed:
Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases.
PubMed:
Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells.
PubMed:
[Optimum preparation of levocarnitine chloride solution in the hospital pharmacy].
PubMed:
Protective effect of L-carnitine on renal ischaemia-reperfusion injury in the rat.
PubMed:
Effects of L-carnitine-hydrochloride in the cold ischemic preservation of fatty liver grafts.
PubMed:
Effect of acetyl-L-carnitine on leukemia L1210 resistant to mitoxantrone.
PubMed:
Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption.
PubMed:
[Influence of multiple-dose administration of cefetamet pivoxil on blood and urinary concentrations of carnitine and effects of simultaneous administration of carnitine with cefetamet pivoxil].
PubMed:
A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease.
PubMed:
Propionyl-L-carnitine: labelling in the N-methyl position with carbon-11 and pharmacokinetic studies in rats.
PubMed:
[Effects of levocarnitine chloride, a new mitochondrial function reactivating agent, on fatty acid and glucose oxidation under hypoxic condition in homogenates from rat heart].
PubMed:
[Studies on the beneficial effect of levocarnitine chloride (LC-80) on organic acidemias, especially propionic acidemia and methylmalonic acidemia].
PubMed:
[Effects of levocarnitine chloride (LC-80) on the cardiovascular system].
PubMed:
[Effects of levocarnitine chloride (LC-80) on hemodynamics and myocardial metabolism in anesthetized open-chest dogs under normoxic or hypoxic conditions].
PubMed:
Metabolism and disposition of intravenously administered acetyl-L-carnitine in healthy volunteers.
PubMed:
[Induction of fetal lung-maturity. Part III: surfactant-parameters in amniotic-fluid and fetal lung].