laevo-erythritol
L-threitol
Identification
| Name | laevo-erythritol |
| CAS Number | 2319-57-5 |
| FDA UNII | Search |
| Molecular Formula | C4 H10 O4 |
| Molecular Weight | 122.12050000 |
| MDL Number | MFCD00064294 |
| Nikkaji Number | J232.139D |
| Beilstein | 1719754 |
| XlogP3 | -2.30 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for laevo-erythritol usage levels up to | not for fragrance use. |
| Recommendation for laevo-erythritol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(2S,3S)-
butane-1,2,3,4-tetrol
laevo-
butane-1,2,3,4-tetrol
L-1,2,3,4-
butanetetraol
(2S,3S)-1,2,3,4-
butanetetrol
(S-(R*,R*))-1,2,3,4-
butanetetrol
laevo-1,2,3,4-
butanetetrol
1,2,3,4-
butanetetrol, (2S,3S)-
L-
erythritol
L-
threitol
laevo-
threitol
PubMed:
Recent developments and future prospects on bio-based polyesters derived from renewable resources: A review.
PubMed:
Development and Validation of a High Pressure Liquid Chromatography-UV Method for the Determination of Treosulfan and Its Epoxy Metabolites in Human Plasma and Its Application in Pharmacokinetic Studies.
PubMed:
Controlled co-delivery nanocarriers based on mixed micelles formed from cyclodextrin-conjugated and cross-linked copolymers.
PubMed:
Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing.
PubMed:
Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase.
PubMed:
The 1,3-dipolar cycloaddition reaction of chiral carbohydrate-derived nitrone and olefin: towards long-chain sugars.
PubMed:
2-methyl-L-erythritol glycosides from Gardenia jasminoides.
PubMed:
Treosulfan-based conditioning before hematopoietic SCT: more than a BU look-alike.
PubMed:
Alternating oligo[(2,3-O-isopropylidene-L-threitol)]-co-[(E,E)-1,4-bis(styryl)benzene]s: the linear chirality transmission additivity relationship in nematic liquid crystals.
PubMed:
Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging.
PubMed:
Treatment of active secondary progressive multiple sclerosis with treosulfan.
PubMed:
Synthesis of a salacinol analogue and its alpha-glucosidase inhibitory activity.
PubMed:
Generation of an antibody specific to erythritol, a non-immunogenic food additive.
PubMed:
Enthalpy of sublimation in the study of the solid state of organic compounds. Application to erythritol and threitol.
PubMed:
Attempted synthesis of 2-acetamido and 2-amino derivatives of salacinol. Ring opening reactions.
PubMed:
Determination of the enthalpy of solute-solvent interaction from the enthalpy of solution: aqueous solutions of erythritol and L-threitol.
PubMed:
Towards carbohydrate derivatives of the ReI(CO)3 fragment.
PubMed:
Synthesis of D-lyxitol and D-ribitol analogues of the naturally occurring glycosidase inhibitor salacinol.
PubMed:
Conformational study of erythritol and threitol in the gas state by density functional theory calculations.
PubMed:
Inhibition of the Escherichia coli RecA protein: zinc(II), copper(II) and mercury(II) trap RecA as inactive aggregates.
PubMed:
Addition of treosulfan to a nonmyeloablative conditioning regimen results in enhanced chimerism and immunologic tolerance in an experimental allogeneic bone marrow transplant model.
PubMed:
Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes.
PubMed:
Aromatic compound glucosides, alkyl glucoside and glucide from the fruit of anise.
PubMed:
Antileukaemic activity of treosulfan in xenografted human acute lymphoblastic leukaemias (ALL).
PubMed:
Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds: comparison with singlet oxygen-induced DNA damage.
PubMed:
Saccharide Libraries as Potential Templates for Regio- and Chiroselective Introduction of Two Functional Groups into [60]Fullerene.
PubMed:
Synthesis of 2-C-methyl-D-erythritol and 2-C-methyl-L-threitol; determination of the absolute configuration of 2-C-methyl-1,2,3,4-butanetetrol isolated.
PubMed:
Purification and characterization of a NAD+-dependent sorbitol dehydrogenase from Japanese pear fruit.
PubMed:
Investigation of bioavailability and pharmacokinetics of treosulfan capsules in patients with relapsed ovarian cancer.
PubMed:
Asymmetric synthesis of axially chiral biaryls via desymmetrization of 2,2',6,6'-tetrahydroxybiphenyl using 1,4-Di-O-benzyl-L-threitol as a chiral template
PubMed:
DNA alkylation and interstrand cross-linking by treosulfan.
PubMed:
The alkylator treosulfan shows activity towards human renal-cell carcinoma in vivo and in vitro.
PubMed:
Clinical pharmacokinetics of intravenous treosulfan in patients with advanced solid tumors.
PubMed:
Stimulation of biosynthetic activity by novel succinate esters in rat pancreatic islets.
PubMed:
Reversible inhibition of sheep liver sorbitol dehydrogenase by thiol compounds.
PubMed:
Studies on L-threose as substrate for aldose reductase: a possible role in preventing protein glycation.
PubMed:
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin.
PubMed:
Antitumor activity of treosulfan in human lung carcinomas.
PubMed:
Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels.
PubMed:
Ascorbic acid glycation: the reactions of L-threose in lens tissue.
PubMed:
The crystal structure of D-threitol at 119 K and 198 K.
PubMed:
Antitumor activity of treosulfan against human breast carcinomas.
PubMed:
Inhibition of the alpha-L-arabinofuranosidase III of Monilinia fructigena by 1,4-dideoxy-1,4-imino-L-threitol and 1,4-dideoxy-1,4-imino-L-arabinitol.
PubMed:
Purification and characterization of human liver sorbitol dehydrogenase.
PubMed:
Contraction of guinea-pig lung parenchymal strips by substance P and related peptides.
PubMed:
Biosynthesis of novel acidic phospholipid analogs in Escherichia coli.
PubMed:
The effect of substance P and related peptides on the guinea-pig lung strip.
PubMed:
New type bifunctional nitrosoureido derivatives with cytostatic activity.
PubMed:
Detection and characterization of sorbitol dehydrogenase from apple callus tissue.
PubMed:
Induction of chromosomal aberrations and mutations with isomeric forms of L-threitol-I,4-bismethanesulfonate in plant materials.
PubMed:
Compounds derived from L-threitol 1,4-bismethanesulfonate.
PubMed:
IDENTIFICATION OF ALTRO-HEPTULOSE AND L-THREITOL AS PRODUCTS OF MESO-ERYTHRITOL OXIDATION BY ACETOBACTER SUBOXYDANS.
PubMed:
[ANALYSIS OF THE EFFECTS OF L-THREITOL-1,4-BISMETHANESULFONATE ON THE CHROMOSOMES OF VICIA FABA L].
PubMed:
L-Threitol dimethanesulfonate.
PubMed:
Biochemistry of the wood-rotting fungi: 5. The production of d-threitol (l-erythritol) by Armillaria mellea (Vahl) Quélet.