maleic acid

cis-1,2-ethylenedicarboxylic acid

CAS: 110-16-7 C4 H4 O4 MW: 116.07268000

Identification

Namemaleic acid
CAS Number110-16-7
EINECS203-742-5
FDA UNII91XW058U2C
Molecular FormulaC4 H4 O4
Molecular Weight116.07268000
MDL NumberMFCD00063177
Nikkaji NumberJ2.446E
Beilstein0605762
XlogP3-0.30 (est)

Regulatory

DG SANTE Food Contact Materialsmaleic acid
FDA Mainterm (IAUFC)110-16-7 ; MALEIC ACID

Physical Properties

Appearance white crystalline solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.59000 @ 25.00 °C.
Melting Point 130.00 to 131.00 °C. @ 760.00 mm Hg
Boiling Point 355.00 to 356.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000005 mmHg @ 25.00 °C. (est)
Flash Point 361.00 °F. TCC ( 183.00 °C. ) (est)
logP (o/w) -0.480
Soluble in water, 4.41E+05 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesbuffering agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 708 mg/kg
Dermal Toxicityskin-rabbit LD50 1560 mg/kg
Inhalation Toxicityinhalation-rat LC50 > 720 mg/m3/1H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for maleic acid usage levels up tonot for fragrance use.
Recommendation for maleic acid flavor usage levels up tonot for flavor use.

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Potential Uses

buffering agents

Natural Occurrence

cacao plant cherry sour cherry fruit corn plant lovage root roselle flower

Synonyms

(2Z)- but-2-enedioic acid (Z)- but-2-enedioic acid cis- but-2-enedioic acid (2Z)-2- butene dioic acid (Z)- butene dioic acid (Z)-2- butene dioic acid cis- butene dioic acid (2Z)-2- butenedioic acid (Z)- butenedioic acid (Z)-2- butenedioic acid cis-2- butenedioic acid 2- butenedioic acid (2Z)- 2- butenedioic acid (Z)- 2- butenedioic acid, (2Z)- 2- butenedioic acid, (Z)- (Z)-1,2- ethylene dicarboxylic acid cis-1,2- ethylene dicarboxylic acid cis-1,2- ethylenedicarboxylic acid 1,2- ethylenedicarboxylic acid, (Z) maleicacid maleinic acid malenic acid toxilic acid (Z)- tumaric acid PubMed: Effects of acid extrusion on the degradability of maize distillers dried grain with solubles in pigs. PubMed: An in silico toxicogenomics approach for inferring potential diseases associated with maleic acid. PubMed: Impurity profiling of carbocisteine by HPLC-CAD, qNMR and UV/vis spectroscopy. PubMed: Quantitative proton nuclear magnetic resonance for the structural and quantitative analysis of atropine sulfate. PubMed: Ca2+ ion responsive pickering emulsions stabilized by PSSMA nanoaggregates. PubMed: Metabolic profiling of Chinese tobacco leaf of different geographical origins by GC-MS. PubMed: CO₂ and O₂ respiration kinetics in hydrocarbon contaminated soils amended with organic carbon sources used to determine catabolic diversity. PubMed: Self-assembly and emulsification of poly{[styrene-alt-maleic acid]-co-[styrene-alt-(N-3,4-dihydroxyphenylethyl-maleamic acid)]}. PubMed: Dual-responsive poly(styrene-alt-maleic acid)-graft-poly(N-isopropyl acrylamide) micelles as switchable emulsifiers. PubMed: Integrated separation process for isolation and purification of biosuccinic acid. PubMed: Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. PubMed: Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT). PubMed: A convenient route to the synthesis of isotopomeric dihydro-2(3H)furanones. PubMed: Comparative analysis of influence of promoters and inhibitors on in vitro available iron using two methods. PubMed: Interactions of hydrophobically modified polyelectrolytes with nonionic surfactants. PubMed: NMR regulatory analysis: determination and characterization of Chinese-herb aristolochic acids. PubMed: Aqueous photolysis of niclosamide. PubMed: Development of NMR and raman spectroscopic methods for the determination of the degree of substitution of maleate in modified starches. PubMed: Modeling solid-to-solid biocatalysis: integration of six consecutive steps. PubMed: Modulation of allergen-specific immune responses to the major shrimp allergen, tropomyosin, by specific targeting to scavenger receptors on macrophages. PubMed: Inhibition of renal uptake of indium-111-DTPA-octreotide in vivo. PubMed: [The kinetics of the excretion of a choline-containing polymer from the body of rats and its effect on the activity of intestinal enzymes]. PubMed: Thermodynamics of the maleate and citraconate hydration reactions catalysed by malease from Pseudomonas pseudoalcaligenes. PubMed: Analytical method development and preformulation stability studies of L-665,871 (a beta-agonist) in swine feed. PubMed: Screening for microorganisms producing D-malate from maleate. PubMed: Maleic acid dimethylester: evaluation of dermal toxicity and genotoxicity. PubMed: [Analysis of organic residues in the extracts from the food retortable pouch by HPLC]. PubMed: [The effect of maleic acid hydrazide (MH) on the hexose content of potato tubers].