methyl pyruvate

methyl 2-oxopropanoate methyl 2-oxopropionate methyl glyoxylic acid methyl ester methylglyoxylic acid methyl ester 2-oxo propanoic acid methyl ester 2-oxo- propanoic acid methyl ester propanoic acid, 2-oxo-, methyl ester 2-oxo- propionic acid methyl ester pyruvic acid methyl ester pyruvic acid, methyl ester PubMed: l-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2. PubMed: Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation. PubMed: Acuticoccus yangtzensis gen. nov., sp. nov., a novel member in the family Rhodobacteraceae, isolated from the surface water of the Yangtze Estuary. PubMed: Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis. PubMed: T-type Ca2+ channel blocker, KYS05090 induces autophagy and apoptosis in A549 cells through inhibiting glucose uptake. PubMed: Oxidative damage to mitochondria at the nodes of Ranvier precedes axon degeneration in ex vivo transected axons. PubMed: Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells. PubMed: Kinetic characterization of recombinant Bacillus coagulans FDP-activated l-lactate dehydrogenase expressed in Escherichia coli and its substrate specificity. PubMed: Products and mechanism of the reactions of OH radicals and Cl atoms with methyl methacrylate (CH2═C(CH3)C(O)OCH3) in the presence of NOx. PubMed: 3-Methyl pyruvate enhances radiosensitivity through increasing mitochondria-derived reactive oxygen species in tumor cell lines. PubMed: Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca2+ influx and subsequent Ca2+ oscillations. PubMed: Stereospecific synthesis of a twinned alanine ester. PubMed: Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. PubMed: Detection and characterization of impurities in commercial products with Fourier transform microwave spectroscopy. PubMed: Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. PubMed: Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models. PubMed: Supplementation of pyruvate prevents palmitate-induced impairment of glucose uptake in C2 myotubes. PubMed: Atmospheric chemistry of two biodiesel model compounds: methyl propionate and ethyl acetate. PubMed: Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes. PubMed: Troglitazone regulates anaplerosis via a pull/push affect on glutamate dehydrogenase mediated glutamate deamination in kidney-derived epithelial cells; implications for the Warburg effect. PubMed: A general approach to anionic acid-labile surfactants with tunable properties. PubMed: Glycolytic flux occurs in Drosophila melanogaster recovering from camptothecin treatment. PubMed: Kinetics and products of gas-phase reactions of ozone with methyl methacrylate, methyl acrylate, and ethyl acrylate. PubMed: AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. PubMed: Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells. PubMed: Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets. PubMed: Starvation in the midst of plenty: making sense of ceramide-induced autophagy by analysing nutrient transporter expression. PubMed: Ceramide starves cells to death by downregulating nutrient transporter proteins. PubMed: C1-symmetric oxazolinyl sulfoximines as ligands in copper-catalyzed asymmetric mukaiyama aldol reactions. PubMed: Keto-enol driven assembly of methyl pyruvate on Pt(111). PubMed: Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells. PubMed: Rhythm of the beta-cell oscillator is not governed by a single regulator: multiple systems contribute to oscillatory behavior. PubMed: (E)-Methyl 2-[(4-nitro-phen-yl)-hydrazono]-propanoate. PubMed: Evidence for C-H...O=C bonding in coadsorbed aromatic-carbonyl systems on Pt(111). PubMed: Dioxiranes generated in situ from pyruvates and oxone as environmentally friendly oxidizing agents for disinfection. PubMed: Substrate effects on oscillations in metabolism, calcium and secretion in single mouse islets of Langerhans. PubMed: The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. PubMed: Regioselectively nucleus and/or side-chain fluorinated 2-(Phenanthryl)propionic acids by an effective combination of radical and organometallic chemistry. PubMed: P2Y purinergic potentiation of glucose-induced insulin secretion and pancreatic beta-cell metabolism. PubMed: Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2. PubMed: Taurine increases glucose sensitivity of UCP2-overexpressing beta-cells by ameliorating mitochondrial metabolism. PubMed: Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response. PubMed: Stereoselective generation of vicinal stereogenic quaternary centers by photocycloaddition of 5-methoxy oxazoles to alpha-keto esters: synthesis of erythro beta-hydroxy dimethyl aspartates. PubMed: Adsorption states and modifier-substrate interactions on Pt(111) relevant to the enantioselective hydrogenation of alkyl pyruvates in the Orito reaction. PubMed: Utility of historical vehicle-control data in the interpretation of the local lymph node assay. PubMed: Monitoring carbonyl-amine reaction between pyruvic acid and alpha-amino alcohols by FTIR spectroscopy--a possible route to Amadori products. PubMed: Dacrymenone and VM 3298-2--new antibiotics with antibacterial and antifungal activity. PubMed: Observation of high enantioselectivity for the gas phase hydrogenation of methyl pyruvate using supported Pt catalysts pre-modified with cinchonidine. PubMed: Studies with GIP/Ins cells indicate secretion by gut K cells is KATP channel independent. PubMed: Aspects of enantioselective heterogeneous catalysis: structure and reactivity of (S)-(-)-1-(1-naphthyl)ethylamine on Pt[111]. PubMed: Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate. PubMed: Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo. PubMed: Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model. PubMed: New methyl pyruvate thiosemicarbazones and their copper and zinc complexes: synthesis, characterization, X-ray structures and biological activity. PubMed: Selective C-C bond activation of methyl pyruvate on Ni(111) to yield surface methoxycarbonyl. PubMed: Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats. PubMed: Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP. PubMed: Differential regulation of [Ca2+]i oscillations in mouse pancreatic islets by glucose, alpha-ketoisocaproic acid, glyceraldehyde and glycolytic intermediates. PubMed: Energetic requirement of carbachol-induced Ca2+ signaling in single mouse beta-cells. PubMed: Insulin secretion, inositol phosphate levels, and phospholipase C isozymes in rodent pancreatic islets. PubMed: Use of a soluble tetrazolium compound to assay metabolic activation of intact beta cells. PubMed: Epoxidation reactions of unsaturated fatty esters with potassium peroxomonosulfate. PubMed: Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. PubMed: Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell. PubMed: Insulinotropic action of methyl pyruvate: enzymatic and metabolic aspects. PubMed: Insulinotropic action of methyl pyruvate: secretory, cationic, and biosynthetic aspects. PubMed: Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets. PubMed: Activation of stimulus-secretion coupling in pancreatic beta-cells by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis. PubMed: In vitro and in vivo insulinotropic action of methyl pyruvate. PubMed: Synthesis of 5-aminopentyl 4,6-O-[(R)-1-carboxyethylidene]-beta-D-galactopyranoside and its use as a ligand for the affinity chromatography of human serum amyloid P . protein. PubMed: Structural studies of the capsular polysaccharide of Klebsiella type 33. PubMed: Polarographic determination of methyl methacrylate.