Identification

Namemorpholine
IUPACmorpholine
CAS Number110-91-8
EINECS203-815-1
FDA UNII8B2ZCK305O
Molecular FormulaC4 H9 N O
Molecular Weight87.12193000
MDL NumberMFCD00005972
Nikkaji NumberJ2.453H
Beilstein0102549
XlogP3-0.90 (est)

Regulatory

FDA Mainterm (SATF)110-91-8 ; MORPHOLINE
FDA RegulationFDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.00000 to 1.00400 @ 20.00 °C.
Pounds per Gallon - (est). 8.331 to 8.364
Refractive Index 1.45200 to 1.45600 @ 20.00 °C.
Boiling Point 128.00 °C. @ 760.00 mm Hg
Vapor Pressure 10.396000 mmHg @ 25.00 °C. (est)
Flash Point 96.00 °F. TCC ( 35.56 °C. )
logP (o/w) -0.860
Soluble in water, 1000000 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesbuffering agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 1450 mg/kg
Dermal Toxicityskin-rabbit LD50 500 ul/kg
Inhalation Toxicityinhalation-rat LC50 8000 ppm/8H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycertain adjuvants and production aids
Recommendation for morpholine usage levels up tonot for fragrance use.
Recommendation for morpholine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

1-oxa-4-aza cyclohexane diethylene imidoxide diethylene oximide diethyleneimide oxide diethylenimide oxide 4- oxazine; tetrahydro-p-oxazine tetrahydro-1,4-isoxazine tetrahydro-1,4-oxazine tetrahydro-2H-1,4-oxazine tetrahydro-p-oxazine tetrahydro-para-oxazine PubMed: Novel dispersive micro-solid-phase extraction combined with ultrahigh-performance liquid chromatography-high-resolution mass spectrometry to determine morpholine residues in citrus and apples. PubMed: Effect of granule organisation on the behaviour of starches in the NMMO (N-methyl morpholine N-oxide) solvent system. PubMed: Development and validation of a standardized method for the determination of morpholine residues in fruit commodities by liquid chromatography-mass spectrometry. PubMed: Evaluation of volatile metabolites as markers in Lycopersicon esculentum L. cultivars discrimination by multivariate analysis of headspace solid phase microextraction and mass spectrometry data. PubMed: Two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones as new non-purine xanthine oxidase inhibitors and anti-inflammatory agents. PubMed: 6-(Propan-2-yl)-3-methyl-morpholine-2,5-dione, a novel cyclodidepsipeptide with modulatory effect on rat thymocytes. PubMed: Stimulatory effect on rat thymocytes proliferation and antimicrobial activity of two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones. PubMed: 4-[(2'-Cyano-biphen-yl-4-yl)meth-yl]morpholin-4-ium tetra-fluoridoborate. PubMed: Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization. PubMed: Solvent effects on starch dissolution and gelatinization. PubMed: Connections between structure and performance of four cationic copolymers used as physically adsorbed coatings in capillary electrophoresis. PubMed: Selective hydrolysis of the 3,6-anhydrogalacotosidic linkage in red algal galactan: a combination of reductive acid hydrolysis and anhydrous mercaptolysis. PubMed: Risk assessment of domestic and industrial effluents unloaded into a freshwater environment. PubMed: Cytotoxic and genotoxic effects of some substituted tetrazolo[1,5-c]quinazolines. PubMed: Final report on the safety assessment of Cetethyl Morpholinium Ethosulfate. PubMed: Shellac formulations to reduce epiphytic survival of coliform bacteria on citrus fruit postharvest. PubMed: [Teratogenicity study of morpholine salts of fatty acids (oleic acid, 50% water solution) in rats by oral administration]. PubMed: Gas chromatographic-mass spectrometric method for the analysis of dimethomorph fungicide in dried hops. PubMed: In vitro inhibition studies of phytoene desaturase by bleaching ketomorpholine derivatives. PubMed: Chemopreventive effects of S-methylcysteine on rat hepatocarcinogenesis induced by concurrent administration of sodium nitrite and morpholine. PubMed: Carcinogenicity of methylurea or morpholine in combination with sodium nitrite in rat multi-organ carcinogenesis bioassay. PubMed: Potential nitrosamine formation and its prevention during biological denitrification of red beet juice. PubMed: Dietary secondary amines and liver hepatoma in Port Harcourt, Nigeria. PubMed: Comparison of the therapeutic effects of a new arotinoid, Ro 40-8757, and all-trans- and 13-cis-retinoic acids on rat breast cancer. PubMed: Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines. PubMed: Macrophages produce nitrite, nitrate and nitrosamines after addition of catalase. PubMed: The formation, disposition, and hepatic metabolism of dimethylnitrosamine in the pig. PubMed: [The effect of lysine-enriched bread on the formation of N-nitrosamines from their precursors in the stomach of dogs]. PubMed: Mutagenicity of N-nitrosomorpholine biosynthesized from morpholine in the presence of nitrate and its inhibition by ascorbic acid. PubMed: Antiarrhythmic activity of the local anaesthetic fomocaine and some of its analogues. PubMed: Effects of lysosomotropic detergents on the human malarial parasite Plasmodium falciparum in in vitro culture. PubMed: [Assessment of the degree of carcinogenicity of small doses of nitrites]. PubMed: Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice. PubMed: Determination of volatile nitrosamines in cheese and cured meat products. Model study of a temperature- and pH-dependent artefact formation phenomenon in alkaline medium. PubMed: Nitrate as a precursor of the in-vivo formation of N-nitrosomorpholine in the stomach of guinea-pigs. PubMed: Effects of phenol and 2,6-dimethoxyphenol (syringol) on in vivo formation of N-nitrosomorpholine in rats. PubMed: Analysis of the genotoxic activity of four N-nitroso compounds by the Drosophila mosaic test. PubMed: Tissue specificity of N-nitrosomorpholine metabolism in Sprague-Dawley rats. PubMed: [Mutagenicity of food additive morpholine (fatty acid salt)]. PubMed: Nitrosating properties of bis-methylthio-diiron-tetranitrosyl (Roussin's red methyl ester), a nitroso compound isolated from pickled vegetables consumed in northern China. PubMed: No volatile N-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate. PubMed: Mutagenicity of pyrolysates from guanidine, ureide, secondary amines and polyamines found by the Salmonella/mammalian-microsome test. PubMed: Inhibition by an antioxidant of the carcinogenic effect of nitrosomorpholine formed in vivo. PubMed: Discriminative stimulus properties of phencyclidine and five analogues in the squirrel monkey. PubMed: The sequential determination of nitrite, N-nitroso compounds and nitrate and its application. PubMed: Significance of in vivo formation of N-nitroso compounds. PubMed: Effect of sodium ascorbate on tumor induction in rats treated with morpholine and sodium nitrite, and with nitrosomorpholine. PubMed: Dose-response study of the carcinogenicity of dietary sodium nitrite and morpholine in rats and hamsters. PubMed: Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine. PubMed: Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite. II. Rate enhancement in frozen solution. PubMed: Induction of liver and lung tumours in rats by the simultaneous administration of sodium nitrite and morpholine. PubMed: Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite: acceleration by thiocyanate and other anions.