N,N-dimethyl ethyl amine
methanamine, N-ethyl-N-methyl-
Identification
| Name | N,N-dimethyl ethyl amine |
| IUPAC | N,N-dimethylethanamine |
| CAS Number | 598-56-1 |
| EINECS | 209-940-8 |
| FDA UNII | 9N5384XVEM |
| Molecular Formula | C4 H11 N |
| Molecular Weight | 73.13867000 |
| MDL Number | MFCD00009039 |
| Nikkaji Number | J60.917J |
| Beilstein | 1696893 |
| XlogP3 | 0.70 (est) |
Regulatory
Physical Properties
| Appearance | colorless to pale yellow clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.67500 @ 25.00 °C. |
| Refractive Index | 1.37200 @ 20.00 °C. |
| Melting Point | -140.00 °C. @ 760.00 mm Hg (est) |
| Boiling Point | 36.50 °C. @ 760.00 mm Hg |
| Vapor Pressure | 495.356995 mmHg @ 25.00 °C. (est) |
| Flash Point | -33.00 °F. TCC ( -36.11 °C. ) |
| logP (o/w) | 0.700 |
| Soluble in | water, 3.451e+005 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for N,N-dimethyl ethyl amine usage levels up to | not for fragrance use. |
| Recommendation for N,N-dimethyl ethyl amine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
amines, C13-15-alkyldimethyl
N,N-
dimethylethanamine
dimethylethylamine
N,N-
dimethylethylamine
DMEA
ethanamine, N,N-dimethyl-
ethylamine, dimethyl-
ethylamine, N,N-dimethyl-
ethyldimethylamine
N-
ethyldimethylamine
methanamine, N-ethyl-N-methyl-
PubMed:
Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor.
PubMed:
Studies on the nuances of the electrochemically induced room temperature isomerization of cis-stilbene in acetonitrile and ionic liquids.
PubMed:
Self-reinforced endocytoses of smart polypeptide nanogels for "on-demand" drug delivery.
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Human trace amine-associated receptor TAAR5 can be activated by trimethylamine.
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Cytotoxicity study of novel water-soluble chitosan derivatives applied as membrane material of alginate microcapsules.
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Use of recreational drug 1,3 Dimethylamylamine (DMAA) [corrected] associated with cerebral hemorrhage.
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Ammonia as a preferred additive in chiral and achiral applications of supercritical fluid chromatography for small, drug-like molecules.
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Synthesis and Properties of Dissymmetric Gemini Surfactants.
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Thermochemistry of Alane Complexes for Hydrogen Storage: A Theoretical and Experimental Investigation.
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Formation and properties of stabilized aluminum nanoparticles.
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Inorganic or organic azide-containing hypergolic ionic liquids.
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Photoreduction of oxoisoaporphines by amines: laser flash and steady-state photolysis, pulse radiolysis, and TD-DFT studies.
PubMed:
New universal, portable and cryogenic sampler for time weighted average monitoring of H2S, NH3, benzene, toluene, ethylbenzene, xylenes and dimethylethylamine.
PubMed:
1,2-Eliminations from (CH3)2NH+CH2CH3 and (CH3)2NH2+: guided dissociations.
PubMed:
Aluminum-coated hollow glass fibers for ArF-excimer laser light fabricated by metallorganic chemical-vapor deposition.
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Physicochemical properties of tamoxifen hemicitrate sesquihydrate.
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Physicochemical characterization of tamoxifen citrate pseudopolymorphs, methanolate and ethanolate.
PubMed:
Regenerating fuel-gas desulfurizing agents by using bipolar membrane electrodialysis (BMED): effect of molecular structure of alkanolamines on the regeneration performance.
PubMed:
Analgesic and anti-inflammatory activities evaluation of (-)-O-acetyl, (-)-O-methyl, (-)-O-dimethylethylamine cubebin and their preparation from (-)-cubebin.
PubMed:
Enzyme-mediated precipitation of parent drugs from their phosphate prodrugs.
PubMed:
[Synthesis of new N3S pseudo-peptide complexes and biodistribution in mice].
PubMed:
Oleiphilaceae fam. nov., to include Oleiphilus messinensis gen. nov., sp. nov., a novel marine bacterium that obligately utilizes hydrocarbons.
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Exposure to chemical agents in Swedish aluminum foundries and aluminum remelting plants--a comprehensive survey.
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Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions.
PubMed:
Delivery of F2-excimer laser light by aluminum hollow fibers.
PubMed:
Carboxylic acid analogues of tamoxifen: (Z)-2-[p-(1, 2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine. Estrogen receptor affinity and estrogen antagonist effects in MCF-7 cells.
PubMed:
[Steady state and disappearance of the metabolites of miproxifene phosphate in the treatment of breast cancer].
PubMed:
[Phase I study of TAT-59 (a new antiestrogen) in breast cancer. TAT-59 Study Group].
PubMed:
Effects of OK-432 (picibanil) on the estrogen receptors of MCF-7 cells and potentiation of antiproliferative effects of tamoxifen in combination with OK-432.
PubMed:
Skin absorption of the industrial catalyst dimethylethylamine in vitro in guinea pig and human skin, and of gaseous dimethylethylamine in human volunteers.
PubMed:
Antiestrogenic activity of DP-TAT-59, an active metabolite of TAT-59 against human breast cancer.
PubMed:
Acute toxicity and primary irritancy of alkylalkanolamines.
PubMed:
Effect of dietary intake of trimethylamine on human metabolism of the industrial catalyst dimethylethylamine.
PubMed:
Phosphatidylethanolamine and sarcolemmal damage during ischemia or metabolic inhibition of heart myocytes.
PubMed:
A new triphenylethylene derivative, TAT-59; hormone receptors; insulin-like growth factor 1; and growth suppression of hormone-dependent MCF-7 tumors in athymic mice.
PubMed:
Gas chromatographic determination of primary and secondary low-molecular-mass aliphatic amines in urine using derivatization with isobutyl chloroformate.
PubMed:
Interaction of tricyclic drug analogs with synaptic plasma membranes: structure-mechanism relationships in inhibition of neuronal Na+/K(+)-ATPase activity.
PubMed:
Interaction of DP-TAT-59, an active metabolite of new triphenylethylene-derivative (TAT-59), with estrogen receptors.
PubMed:
Carcinogenesis and mutagenesis by N-nitroso compounds having a basic center.
PubMed:
Liquid membrane work-up of blood plasma samples applied to gas chromatographic determination of aliphatic amines.
PubMed:
Local and systemic carcinogenic effects of alkylating carcinogens in rats treated by intravesicular administration.
PubMed:
Dimethylethylamine in mould core manufacturing: exposure, metabolism, and biological monitoring.
PubMed:
Visual disturbances in man as a result of experimental and occupational exposure to dimethylethylamine.
PubMed:
Experimental study on the metabolism of dimethylethylamine in man.
PubMed:
Effects of estrogen on cell proliferation and leukotriene formation in transformed mouse Leydig cells cultured under serum-free conditions.
PubMed:
NTP Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CAS No. 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies).
PubMed:
An industrial hygiene appraisal of triethylamine and dimethylethylamine exposure limits in the foundry industry.
PubMed:
Occupational exposure to volatile nitrosamines in foundries using the "Ashland" core-making process.
PubMed:
Simultaneous determination of tamoxifen citrate and its E isomer impurity in bulk drug and tablets by high-performance liquid chromatography.
PubMed:
Isotachophoretic determination of amines from workroom air.
PubMed:
Placental transfer of diphenhydramine in chronically instrumented pregnant sheep.
PubMed:
[Pharmacokinetics and bioavailability of diphenhydramine in man].
PubMed:
Determination of dimethylethylamine in air samples from iron foundries by isotachophoresis.
PubMed:
Respiratory disease in foundry workers.
PubMed:
Estrogenic and antiestrogenic activity of monophenolic analogues of tamoxifen, (Z)-2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N, N-dimethylethylamine.
PubMed:
[Scope and limitations of the analytical use of dansyl chloride, I: The reaction of aromatic sulfonyl chlorides with aliphatic tertiary amines: the microanalytical aspects of the Hinsberg test (author's transl)].
PubMed:
The control of pharmaceuticals. IX. The nuclear magnetic resonance spectra of substituted 2-(di-phenylmethoxy)-N-N-dimethylethylamine hydrochlorides or maleates.
PubMed:
The infrared spectra of substituted 2-(diphenylmethoxy)-N,N-dimethylethylamine hydrochlorides.
PubMed:
The influence of xyloxemine hydrochloride, 2-[2-(DI-2,6-xylylmethoxy)ethoxy]-N,N-dimethylethylamine hydrochloride, on reproduction in laboratory animals.
PubMed:
Investigation of xyloxemine hydrochloride, 2-[2-(di-2,6-xylylmethoxy)ethoxy]-N,N-dimethylethylamine hydrochloride (BS 6748).
PubMed:
Pharmacological properties of xyloxemine hydrochloride, 2-[2-(di-2,6-xylylmethoxy) ethoxy]-N,N-dimethylethylamine hydrochloride (BS 6748), a new antitussive agent.
PubMed:
Toxicological data of 2-[2-(DI-2,6-xylylmethoxy) ethoxy]-N,N-dimethylethylamine hydrochloride (BS 6748).
PubMed:
[Determination of 8-chlorotheophylline-2-(benzohydryloxy)-N-N-dimethylethylamine].
PubMed:
[Study of the use of dimenhydrinate (2-(benzylhydroxy)-N, N-dimethylethylamine 8-chlorotheophyllinate) in vomiting and nausea in pregnancy].
PubMed:
[Potentiometric determination of the hydrochlorides of 2,2'-dichloro-N-methyldiethylamine (DEMA), of 2,2', 2"-trichlorotriethylamine, and of 2-chloro-N,N-dimethylethylamine].
PubMed:
[Experience in 58 cases of bronchial asthma treated with 2-(benzohydryloxy)-N,N-dimethylethylamine 8-chlorotheophyllinate; preliminary report].