glycine, N-(2-(bis(carboxymethyl)amino)ethyl)-N-(2-hydroxyethyl)-

CAS: 150-39-0 C10 H18 N2 O7 MW: 278.26186000

Identification

NameHEDTA
IUPAC2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid
CAS Number150-39-0
EINECS205-759-3
FDA UNIIR79J91U341
Molecular FormulaC10 H18 N2 O7
Molecular Weight278.26186000
MDL NumberMFCD00004294
Nikkaji NumberJ23.203C
Beilstein1804795

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 4.31e+005 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesabsorbents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 259 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for HEDTA usage levels up tonot for fragrance use.
Recommendation for HEDTA flavor usage levels up tonot for flavor use.

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Potential Uses

chelating agents

Natural Occurrence

not found in nature

Synonyms

N-( carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenediglycine 2-[2-[bis( carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid CHEL DM acid detarol glycine, N-(2-(bis(carboxymethyl)amino)ethyl)-N-(2-hydroxyethyl)- glycine, N-(carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenedi- N-(2- hydroxyethyl) ethylene diamine triacetic acid hydroxyethyl)ethylenediaminetriacetic acid (2- hydroxyethyl)ethylenediaminetriacetic acid N-( hydroxyethyl)ethylenediaminetriacetic acid N-(2- hydroxyethyl)ethylenediaminetriacetic acid 2- hydroxyethylenediamine triacetate N-(beta- hydroxyethylethylenediamine)-n,n',n'-triacetic acid (N- hydroxyethylethylenedinitrilo)triacetic acid PubMed: Synthesis of silver nanoparticles in aqueous aminopolycarboxylic acid solutions via γ-irradiation and hydrogen reduction. PubMed: The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway. PubMed: Synthesis and Crystal Structure of the Bioinorganic Complex [Sb(Hedta)]·2H2O. PubMed: In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium. PubMed: trans-[Ru(NO)Cl(cyclam)](PF6)2 and [Ru(NO)(Hedta)] incorporated in PLGA nanoparticles for the delivery of nitric oxide to B16-F10 cells: cytotoxicity and phototoxicity. PubMed: Calculated and measured [Ca(2+)] in buffers used to calibrate Ca(2+) macroelectrodes. PubMed: High performance ion chromatography of transition metal chelate complexes and aminopolycarboxylate ligands. PubMed: Synthesis and structural characterization of heterometallic thorium aluminum polynuclear molecular clusters. PubMed: Synthesis, spectroscopic analysis and photolabilization of water-soluble ruthenium(III)-nitrosyl complexes. PubMed: Combined effect of HEDTA and selenium against aluminum induced oxidative stress in rat brain. PubMed: Simultaneous extraction of Cr(VI) and Cu(II) from humic acid with new synthesized EDTA derivatives. PubMed: Combined treatment of HEDTA and propolis prevents aluminum induced toxicity in rats. PubMed: New coordination modes in potassium edta salts: K2[H2edta]2H2O, K3[Hedta]2H2O and K4[edta]·3.92H2O. PubMed: Chelator-buffered nutrient solution is ineffective in extracting Ni from seeds of Alyssum. PubMed: Identification of Fe-polycarboxylic complexes by electrospray ionization mass spectrometry and reduction of interferences by ion chromatography/inductively coupled plasma mass spectrometry with an octopole reaction system. PubMed: Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes. PubMed: Study of solid-phase extraction for the determination of sequestering agents in river water by high-performance liquid chromatography. PubMed: Speciation of Zn-aminopolycarboxylic complexes by electrospray ionization mass spectrometry and ion chromatography with inductively coupled plasma mass spectrometry. PubMed: Separation of yttrium from heavy lanthanide by CA-100 using the complexing agent. PubMed: Leaching and efficiency of six organic zinc fertilizers applied to navy bean crop grown in a weakly acidic soil of Spain. PubMed: Solubility and accumulation of metals in Chinese brake fern, vetiver and rostrate sesbania using chelating agents. PubMed: Poly[μ-aqua-diaqua-(μ(3)-N'-carboxy-methyl-ethylenediamine-N,N,N'-tri-acetato)oxidopotassium(I)vanadium(IV)]. PubMed: Kosmotropes enhance the yield of antibody purified by affinity chromatography using immobilized bacterial immunoglobulin binding proteins. PubMed: Determination of sequestering agents in cosmetics and synthetic detergents by high-performance liquid chromatography with ultraviolet detection. PubMed: Confirmation of lead aminocarboxylic complex formation using electrospray ionization mass spectrometry and speciation by anion-exchange chromatography coupled with ICP-MS. PubMed: Separation of chelating agents as copper complexes by capillary zone electrophoresis using quaternary ammonium bromides as additives in N-methylformamide. PubMed: Behavior of zinc from six organic fertilizers applied to a navy bean crop grown in a calcareous soil. PubMed: Influence of soil type on the mobility and bioavailability of chelated zinc. PubMed: Confirmation of vanadium complex formation using electrospray mass spectrometry and determination of vanadium speciation by sample stacking capillary electrophoresis. PubMed: Determination of alternative and conventional chelating agents as copper(II) complexes by capillary zone electrophoresis--the first use of didecyldimethylammonium bromide as a flow reversal reagent. PubMed: Iron acquisition by phytosiderophores contributes to cadmium tolerance. PubMed: Effect of the methionine ligand on the reorganization energy of the type-1 copper site of nitrite reductase. PubMed: Determination of synthetic ferric chelates used as fertilizers by liquid chromatography-electrospray/mass spectrometry in agricultural matrices. PubMed: Effects of lead and chelators on growth, photosynthetic activity and Pb uptake in Sesbania drummondii grown in soil. PubMed: Improving sensitivity in simultaneous determination of copper carboxylates by nonaqueous capillary electrophoresis. PubMed: Equilibrium, kinetic and solvent effect studies on the reactions of [RuIII(Hedta)(H2O)] with thiols. PubMed: Inhibition of the Fenton reaction by nitrogen monoxide. PubMed: Macrocyclic lanthanide complexes as artificial nucleases and ribonucleases: effects of pH, metal ionic radii, number of coordinated water molecules, charge, and concentrations of the metal complexes. PubMed: Antioxidant defense in a lead accumulating plant, Sesbania drummondii. PubMed: Potential of Hemidesmus indicus for phytoextraction of lead from industrially contaminated soils. PubMed: The [Ru(Hedta)NO](0.1-) system: structure, chemical reactivity and biological assays. PubMed: Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material. PubMed: Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages. PubMed: Biogeochemistry of fluoride in a plant-solution system. PubMed: Functional and structural study on chelator-induced suppression of S2/S1 FTIR spectrum in photosynthetic oxygen-evolving complex. PubMed: Immobilization of Fe chelators on sepharose gel and its effect on their chemical properties. PubMed: Effect of N-hydroxyethyl-ethylenediamine-triacetic acid (HEDTA) on Cr(VI) reduction by Fe(II). PubMed: Isothermal titration calorimetric procedure to determine protein-metal ion binding parameters in the presence of excess metal ion or chelator. PubMed: Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA. PubMed: Lead phytoextraction from contaminated soil with high-biomass plant species. PubMed: Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. PubMed: On-column complexation and simultaneous separation of vanadium(IV) and vanadium(V) by capillary electrophoresis with direct UV detection. PubMed: Ruthenium(III) readily abstracts NO from L-arginine, the physiological precursor to NO, in the presence of H2O2. A remarkably simple model system for NO synthases. PubMed: Direct modulation of volume-regulated anion channels by Ca(2+) chelating agents. PubMed: Beneficial effects of humic acid on micronutrient availability to wheat. PubMed: Determination of strong binding chelators and their metal complexes by anion-exchange chromatography and inductively coupled plasma mass spectrometry. PubMed: Phytosiderophores influence on cadmium mobilization and uptake by wheat and barley plants. PubMed: 15N NMR and Electrochemical Studies of [Ru(II)(hedta)](-) Complexes of NO, NO(+), NO(2)(-), and NO(-). PubMed: A Proton-Induced N-1 to eta(2) Migration of the Fluxional Pyrazine in the [Ru(II)(hedta)(pz)](-) Complex. PubMed: EDTA and HEDTA effects on Cd, Cr, and Ni uptake by Helianthus annuus. PubMed: High-pressure pulse-radiolysis study of the formation and decomposition of complexes with iron-carbon sigma bonds: mechanistic comparison for different metal centers. PubMed: Biodegradability of ethylenediamine-based complexing agents and related compounds. PubMed: Biodegradability of ethylenediamine-based complexing agents. PubMed: Characterization of Fe(III)-deferoxamine and Mn(II)-pectin as magnetic resonance imaging contrast agents. PubMed: Fully automated measurement of total iron-binding capacity in serum. PubMed: Wanderlust kinetics and variable Ca(2+)-sensitivity of dSlo [correction of Drosophila], a large conductance CA(2+)-activated K+ channel, expressed in oocytes. PubMed: Wanderlust kinetics and variable Ca(2+)-sensitivity of Drosophila, a large conductance Ca(2+)-activated K+ channel, expressed in oocytes. PubMed: Volume Profile for Substitution in Labile Chromium(III) Complexes: Reactions of Aqueous [Cr(Hedta)OH(2)] and [Cr(edta)](-) with Thiocyanate Ion. PubMed: Labeling a hydrazino nicotinamide-modified cyclic IIb/IIIa receptor antagonist with 99mTc using aminocarboxylates as coligands. PubMed: Spectrophotometric determination of tin in copper-based alloys using pyrocatechol violet. PubMed: Reactions of low valent transition metal complexes with hydrogen peroxide. Are they "Fenton-like" or not? 4. The case of Fe(II)L, L = edta; hedta and tcma. PubMed: Relative efficacy of chelating agents on excretion and tissue distribution of manganese in mice. PubMed: In vitro and in vivo comparative studies on chelation of aluminum by some polyaminocarboxylic acids. PubMed: Mobilization and distribution of beryllium over the course of chelation therapy with some polyaminocarboxylic acids in the rat. PubMed: Iron assimilation in Cryptococcus neoformans. PubMed: Separation of yttrium and neodymium from samarium and the heavier lanthanides by cation-exchange chromatography with hydroxyethylenediaminetriacetate in monochloroacetate buffer. PubMed: Determination of lead by selective chelatometric titration with HEDTA after separation as its sulphate by an improved method of precipitation. PubMed: Na+-Ca2+ exchange in squid optic nerve membrane vesicles is activated by internal calcium. PubMed: Alleviation of nickel-induced biochemical alterations by chelating agents. PubMed: Correlation between calpain-mediated cytoskeletal degradation and expression of platelet procoagulant activity. A role for the platelet membrane-skeleton in the regulation of membrane lipid asymmetry? PubMed: The reaction between ferrous polyaminocarboxylate complexes and hydrogen peroxide: an investigation of the reaction intermediates by stopped flow spectrophotometry. PubMed: Samarium-153 chelate localization in malignant melanoma. PubMed: Calcium-dependent chloride currents in isolated cells from rat lacrimal glands. PubMed: Evaluation of LD50 of some polyaminocarboxylic acids used as chelating drugs in metal intoxication. PubMed: Screening of chelating agents for chemolysis. PubMed: Ascorbate autoxidation in the presence of iron and copper chelates. PubMed: Chelatometric titration of tin in non-ferrous alloys with hedta. PubMed: Chelatometric titration of bismuth with hedta. PubMed: Rapid and selective chelatometric titration of aluminium in non-ferrous alloys. PubMed: Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria. PubMed: 157Dy-HEDTA for skeletal imaging. By G. Subramanian, J.G. McAfee, R.J. Blair, R.E. O'Mara, M.W. Greene and E. Lebowitz. 1971. PubMed: The effect of EDTA and related chelating agents on the oxidation of methanol by the methylotrophic bacterium, Methylophilus methylotrophus. PubMed: Rapid and selective chelatometric titration of zinc in non-ferrous alloys. PubMed: The kinetics of the reaction of superoxide radical with Fe(III) complexes of EDTA, DETAPAC and HEDTA. PubMed: A survey of readily available chelators for buffering calcium ion concentrations in physiological solutions. PubMed: The effects of thiosalicylic and hydroxyethylethylenediaminetriacetic acids on the absorption and excretion of 54Mn and 65Zn in the duodenally dosed sheep. PubMed: Chelation in metal intoxication X: Influence of different polyaminocarboxylic acids and thiol chelators in the excretion and tissue distribution of 54Mn in rat. PubMed: Effect of chelating agents on the stability of injectable isoniazid solutions. PubMed: The effects of Ca2+ and Sr2+ on Ca2+-sensitive biochemical changes in human erythrocytes and their membranes. PubMed: Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range. PubMed: Chelation in metal intoxication. IX. Influence of amino and thiol chelators on excretion of manganese in poisoned rabbits. PubMed: Stability of injection solutions of vitamin B1 Part 1: Influence of chelating agents. PubMed: Studies on the stability of injectable solutions of some phenothiazines. Part 2: Effect of chelating agents and antioxidants. PubMed: Evaluation of 167Tm HEDTA as a bone scanning agent in humans and its comparison with 18F. PubMed: 157 Dy-HEDTA for skeletal imaging. PubMed: THE MACROMOLECULAR NATURE OF THE FIRST COMPONENT OF HUMAN COMPLEMENT.