N-acetyl-laevo-phenyl alanine

L-phenylalanine, N-acetyl-

CAS: 2018-61-3 C11 H13 N O3 MW: 207.22921000

Identification

NameN-acetyl-laevo-phenyl alanine
CAS Number2018-61-3
EINECS217-959-8
FDA UNIINP5BT39467
Molecular FormulaC11 H13 N O3
Molecular Weight207.22921000
MDL NumberMFCD00063158
Nikkaji NumberJ27.562J
XlogP30.60 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 6450 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for N-acetyl-laevo-phenyl alanine usage levels up tonot for fragrance use.
Recommendation for N-acetyl-laevo-phenyl alanine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

(2S)-2- acetamido-3-phenylpropanoic acid N- acetyl-L-phenylalanine L-N- acetylphenylalanine alanine, N-acetyl-3-phenyl-, L- (8CI) L- phenylalanine, N-acetyl- PubMed: Nuclease-aided target recycling signal amplification strategy for ochratoxin A monitoring. PubMed: Plasma metabonomics study on toxicity biomarker in rats treated with Euphorbia fischeriana based on LC-MS. PubMed: An HPLC evaluation of cytochalasin D biosynthesis by Xylaria arbuscula cultivated in different media. PubMed: Structural study, NCA, FT-IR, FT-Raman spectral investigations, NBO analysis, thermodynamic functions of N-acetyl-l-phenylalanine. PubMed: The early diagnosis and monitoring of squamous cell carcinoma via saliva metabolomics. PubMed: A simple and sensitive approach for ochratoxin A detection using a label-free fluorescent aptasensor. PubMed: Metabolite profiling and pathway analysis of acute hepatitis rats by UPLC-ESI MS combined with pattern recognition methods. PubMed: Pentynyl dextran as a support matrix for immobilization of serine protease subtilisin Carlsberg and its use for transesterification of N-acetyl-L-phenylalanine ethyl ester in organic media. PubMed: Single-walled carbon nanotubes based quenching of free FAM-aptamer for selective determination of ochratoxin A. PubMed: Protease activation in glycerol-based deep eutectic solvents. PubMed: Immobilization of enzymes on fumed silica nanoparticles for applications in nonaqueous media. PubMed: Exploring carbohydrate-peptide interactions in the gas phase: structure and selectivity in complexes of pyranosides with N-acetylphenylalanine methylamide. PubMed: PVP-coated graphene oxide for selective determination of ochratoxin A via quenching fluorescence of free aptamer. PubMed: High transesterification activities of immobilized proteases in new ether-functionalized ionic liquids. PubMed: Soluble, folded and active subtilisin in a protic ionic liquid. PubMed: Purification and characterization of organic solvent stable protease from Bacillus licheniformis RSP-09-37. PubMed: Pseudopolymorphism of N-acetyl-L-phenylalanine methyl ester. PubMed: Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose. PubMed: Microwave-assisted esterification of N-acetyl-L-phenylalanine using modified Mukaiyama's reagents: A new approach involving ionic liquids. PubMed: Methanolysis of ethyl esters of N-acetyl amino acids catalyzed by cyclosophoraoses isolated from Rhizobium meliloti. PubMed: Protease-catalyzed esterification of amino acid in water-miscible ionic liquid. PubMed: Molecular recognition in cyclodextrin complexes of amino acid derivatives: the effects of kinetic energy on the molecular recognition of a pseudopeptide in a nonconstraining host environment as revealed by a temperature-dependent crystallographic study. PubMed: N-Acetyl-L-phenylalanine. PubMed: Affinity chromatography of porcine pepsin and pepsinogen using immobilized ligands derived from the specific substrate for this enzyme. PubMed: Comparison of theoretical and experimental data to evaluate substrate diffusional limitations for crown ether- and methyl-beta-cyclodextrin-activated serine protease subtilisin Carlsberg in tetrahydrofuran. PubMed: Temperature dependence of the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry. PubMed: Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry. PubMed: Aromatic amino acids and their derivatives as ligands for the isolation of aspartic proteinases. PubMed: Chiral discrimination in cyclodextrin complexes of amino acid derivatives: beta-cyclodextrin/N-acetyl-L-phenylalanine and N-acetyl-D-phenylalanine complexes. PubMed: Molecular recognition in cyclodextrin complexes of amino acid derivatives. 2. A new perturbation: the room-temperature crystallographic structure determination for the N-acetyl-p-methoxy-L-phenylalanine methyl ester/beta-cyclodextrin complex. PubMed: Molecular recognition in cyclodextrin complexes of amino acid derivatives. 1. Crystallographic studies of beta-cyclodextrin complexes with N-acetyl-L-phenylalanine methyl ester and N-acetyl-L-phenylalanine amide pseudopeptides. PubMed: Alpha-chymotrypsin catalysis in imidazolium-based ionic liquids. PubMed: Sol-gel immobilization of serine proteases for application in organic solvents. PubMed: Effect of crown ethers on structure, stability, activity, and enantioselectivity of subtilisin Carlsberg in organic solvents. PubMed: Screening, overexpression and characterization of an N-acylamino acid racemase from Amycolatopsis orientalis subsp. lurida. PubMed: Blood-brain barrier transport of L-tyrosine Conjugates: a model study for the brain targeting using large neutral amino acid transport system. PubMed: Surfactant-protease complex as a novel biocatalyst for peptide synthesis in hydrophilic organic solvents* PubMed: Catalytic activity and conformation of chemically modified subtilisin Carlsberg in organic media. PubMed: Large acceleration of alpha-chymotrypsin-catalyzed dipeptide formation by 18-crown-6 in organic solvents PubMed: Transesterification catalyzed by polystyrene-supported chymotrypsin in toluene: the effect of neutralization of basic or acidic groups attaching to polystyrene resins. PubMed: Effects of subzero temperatures on the kinetics of protease catalyzed dipeptide synthesis in organic media. PubMed: Effects of sorbitol addition on the action of free and immobilized hydrolytic enzymes in organic media. PubMed: Photoregulation of alpha-chymotrypsin activity in organic media: effects of bioimprinting. PubMed: Detection of proteins and phenol in DNA samples with second-derivative absorption spectroscopy. PubMed: On the importance of the support material for enzymatic synthesis in organic media. Support effects at controlled water activity. PubMed: Production of "internal surface reversed-phase" supports: the hydrolysis of selected substrates from silica using chymotrypsin. PubMed: 13C NMR study of the stereospecificity of the thiohemiacetals formed on inhibition of papain by specific enantiomeric aldehydes. PubMed: Selective inhibition of the insulin-stimulated phosphorylation of the 95,000 dalton subunit of the insulin receptor by TAME or BAEE. PubMed: Analysis of proteases involved in phagocytic activity of macrophages through the use of various amino acid esters. PubMed: Bacterial conversion of phenylalanine and aromatic carboxylic acids into dihydrodiols. PubMed: Stereochemical control of ribosomal peptidyltransferase reaction. Role of amino acid side-chain orientation of acceptor substrate. PubMed: [Degradation and biosynthesis of L-phenylalanine by chloridazon-degrading bacteria]. PubMed: Purification, characterization and localization of serine protease of Morris hepatoma 8999. PubMed: [Kinetics of alpha-chymotrypsin catalyzed hydrolysis in equilibrium. II. Comparison of ester and amide substrates]. PubMed: Protease I from Escherichia coli. Some physicochemical properties and substrate specificity. PubMed: Cryoenzymology of chymotrypsin: the detection of intermediates in the catalysis of a specific anilide substrate. PubMed: Acylation of subtilisin Carlsberg by phenyl esters. PubMed: [pH-dependence of the mechanism of pepsin action]. PubMed: Identification of neutral proteases in human neutrophil granules that degrade articular cartilage proteoglycan. PubMed: Conformational change associated with the acylation of alpha-chymotrypsin by N-acetyl-L-phenylalanine methyl ester. PubMed: Specificity-determining site of alpha-chymotrypsin. 3. Inactivation of alpha-chymotrypsin by p-diazo-N-acetyl-L-phenylalanine methyl ester. PubMed: Comparative studies of the specificities of -chymotrypsin and subtilisin BPN'. Studies with flexible substrates. PubMed: Enzymic synthesis of N-acetyl-L-phenylalanine in Escherichia coli K12. PubMed: The pathway of pepsin-catalysed transpeptidation. Evidence for the reactive species being the anion of the acceptor molecule. PubMed: The inhibition of pepsin-catalysed reactions by structural and stereochemical product analogues. PubMed: The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate. PubMed: The inhibition of pepsin-catalysed reactions by products and product analogues. Kinetic evidence for ordered release of products. PubMed: Studies on phenylketonuria. II. The excretion of N-acetyl-L-phenylalanine in phenylketonuria. PubMed: Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence PubMed: Improved Protease-Targeting and Biopharmaceutical Properties of Novel Prodrugs of Ganciclovir PubMed: Metabolite dynamics and phytochemistry of a soy whey-based beverage bio-transformed by water kefir consortium PubMed: Response of Soybean Root to Phosphorus Deficiency under Sucrose Feeding: Insight from Morphological and Metabolome Characterizations PubMed: Preparation of zinc phthalocyanine-loaded amphiphilic phosphonium chitosan nanomicelles for enhancement of photodynamic therapy efficacy