crotamiton

N-ethyl-N-(2-methylphenyl)-2-butenamide

CAS: 483-63-6 C13 H17 N O MW: 203.28469000

Identification

Namecrotamiton
CAS Number483-63-6
EINECS207-596-3
FDA UNIID6S4O4XD0H
Molecular FormulaC13 H17 N O
Molecular Weight203.28469000
MDL NumberMFCD00026989
Nikkaji NumberJ2.055I
Beilstein3275497

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.98700 @ 25.00 °C.
Refractive Index 1.54000 @ 20.00 °C.
Boiling Point 282.00 to 283.00 °C. @ 760.00 mm Hg (est), 155.00 °C. @ 13.00 mm Hg
Vapor Pressure 0.003000 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 115.47 °C. )
logP (o/w) 3.099 (est)
Soluble in water, 195.3 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 1500 mg/kg
Dermal Toxicitysubcutaneous-rat LD50 1630 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial agents
Recommendation for crotamiton usage levels up tonot for fragrance use.
Recommendation for crotamiton flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2- butenamide, N-ethyl-N-(2-methylphenyl)- 2- butenamide, N-ethyl-N-(2-methylphenyl)-, (2E)- crotamitex crotamitone o- crotonotoluidide, N-ethyl- crotonyl-N-ethyl-o-toluidine N- ethyl-N-(2-methylphenyl)-2-butenamide (2E)-N- ethyl-N-(2-methylphenyl)but-2-enamide (E)-N- ethyl-N-(2-methylphenyl)but-2-enamide N- ethyl-o-crotonotoluidide N- ethyl-ortho-crotonotoluidide eurasil eurax euraxil PubMed: Investigating sources and pathways of perfluoroalkyl acids (PFAAs) in aquifers in Tokyo using multiple tracers. PubMed: Hailey-Hailey disease diagnosed based on an exacerbation of contact dermatitis with topical crotamiton. PubMed: Comparison of oral ivermectin versus crotamiton 10% cream in the treatment of scabies. PubMed: Combined ivermectin and topical therapy significantly reduces treatment time in aged scabietic patients. PubMed: Occurrence of selected pharmaceuticals in river water in Japan and assessment of their environmental risk. PubMed: Plant uptake of pharmaceutical chemicals detected in recycled organic manure and reclaimed wastewater. PubMed: Photocatalytic decomposition of crotamiton over aqueous TiO(2) suspensions: determination of intermediates and the reaction pathway. PubMed: Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. PubMed: Treatment of rosacea. PubMed: Assessment of groundwater pollution in Tokyo using PPCPs as sewage markers. PubMed: [Ectoparasitosis of clinical importance in Chile]. PubMed: Nationwide monitoring of selected antibiotics: Distribution and sources of sulfonamides, trimethoprim, and macrolides in Japanese rivers. PubMed: [Treatment of rosacea]. PubMed: [Dapsone efficacy in lupus miliaris disseminatus faciei: two cases]. PubMed: Mass balance analysis of triclosan, diethyltoluamide, crotamiton and carbamazepine in sewage treatment plants. PubMed: Treatment of crusted scabies with albendazole: A case report. PubMed: Hydrophilic anthropogenic markers for quantification of wastewater contamination in ground- and surface waters. PubMed: Demodicosis: a clinicopathological study. PubMed: An Adolescent Patient with Scabies Mimicking Gottron Papules. PubMed: Demodex dermatitis: a retrospective analysis of clinical diagnosis and successful treatment with topical crotamiton. PubMed: [Infantile scabies]. PubMed: Occurrence and sources of perfluorinated surfactants in rivers in Japan. PubMed: Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage. PubMed: Guideline for the diagnosis and treatment of scabies in Japan (second edition). PubMed: Demodex folliculorum and Demodex brevis as a cause of chronic marginal blepharitis. PubMed: Review: topical permethrin was more effective than topical crotamiton or lindane for scabies. PubMed: Removal efficiency of 66 pharmaceuticals during wastewater treatment process in Japan. PubMed: Scabies. PubMed: Occurrence of 70 pharmaceutical and personal care products in Tone River basin in Japan. PubMed: Interventions for treating scabies. PubMed: Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant. PubMed: A human case of otoacariasis involving a histiostomatid mite (Acari: Histiostomatidae). PubMed: [Treatment for scabies]. PubMed: Scabies: a ubiquitous neglected skin disease. PubMed: Percutaneous absorption of crotamiton in man following single and multiple dosing. PubMed: Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. PubMed: [Demodicidosis in humans as a current problem in dermatology]. PubMed: Scabies presenting with bullous pemphigoid-like lesions. PubMed: Crusted scabies in an adult T-cell leukemia/lymphoma patient successfully treated with oral ivermectin. PubMed: Acaricidal activity of Melaleuca alternifolia (tea tree) oil: in vitro sensitivity of sarcoptes scabiei var hominis to terpinen-4-ol. PubMed: Allergic contact dermatitis due to crotamiton. PubMed: Concomitant allergic reaction to cetyl alcohol and crotamiton. PubMed: Triple allergic contact sensitivities due to ferbinac, crotamiton and diisopropanolamine. PubMed: Controlling scabies in institutional settings: a review of medications, treatment models, and implementation. PubMed: Oral ivermectin treatment in two cases of scabies: effective in crusted scabies induced by corticosteroid but ineffective in nail scabies. PubMed: Current treatments for scabies. PubMed: Chromatographic performance of large-pore versus small-pore columns in micellar liquid chromatography. PubMed: Scabies incognito presenting as urticaria pigmentosa in an infant. PubMed: Scabies. PubMed: The management of rosacea.