crotamiton
N-ethyl-N-(2-methylphenyl)-2-butenamide
Identification
| Name | crotamiton |
| CAS Number | 483-63-6 |
| EINECS | 207-596-3 |
| FDA UNII | D6S4O4XD0H |
| Molecular Formula | C13 H17 N O |
| Molecular Weight | 203.28469000 |
| MDL Number | MFCD00026989 |
| Nikkaji Number | J2.055I |
| Beilstein | 3275497 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.98700 @ 25.00 °C. |
| Refractive Index | 1.54000 @ 20.00 °C. |
| Boiling Point | 282.00 to 283.00 °C. @ 760.00 mm Hg (est), 155.00 °C. @ 13.00 mm Hg |
| Vapor Pressure | 0.003000 mmHg @ 25.00 °C. (est) |
| Flash Point | > 230.00 °F. TCC ( > 115.47 °C. ) |
| logP (o/w) | 3.099 (est) |
| Soluble in | water, 195.3 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antimicrobial agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 1500 mg/kg |
| Dermal Toxicity | subcutaneous-rat LD50 1630 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antimicrobial agents |
| Recommendation for crotamiton usage levels up to | not for fragrance use. |
| Recommendation for crotamiton flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2-
butenamide, N-ethyl-N-(2-methylphenyl)-
2-
butenamide, N-ethyl-N-(2-methylphenyl)-, (2E)-
crotamitex
crotamitone
o-
crotonotoluidide, N-ethyl-
crotonyl-N-ethyl-o-toluidine
N-
ethyl-N-(2-methylphenyl)-2-butenamide
(2E)-N-
ethyl-N-(2-methylphenyl)but-2-enamide
(E)-N-
ethyl-N-(2-methylphenyl)but-2-enamide
N-
ethyl-o-crotonotoluidide
N-
ethyl-ortho-crotonotoluidide
eurasil
eurax
euraxil
PubMed:
Investigating sources and pathways of perfluoroalkyl acids (PFAAs) in aquifers in Tokyo using multiple tracers.
PubMed:
Hailey-Hailey disease diagnosed based on an exacerbation of contact dermatitis with topical crotamiton.
PubMed:
Comparison of oral ivermectin versus crotamiton 10% cream in the treatment of scabies.
PubMed:
Combined ivermectin and topical therapy significantly reduces treatment time in aged scabietic patients.
PubMed:
Occurrence of selected pharmaceuticals in river water in Japan and assessment of their environmental risk.
PubMed:
Plant uptake of pharmaceutical chemicals detected in recycled organic manure and reclaimed wastewater.
PubMed:
Photocatalytic decomposition of crotamiton over aqueous TiO(2) suspensions: determination of intermediates and the reaction pathway.
PubMed:
Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior.
PubMed:
Treatment of rosacea.
PubMed:
Assessment of groundwater pollution in Tokyo using PPCPs as sewage markers.
PubMed:
[Ectoparasitosis of clinical importance in Chile].
PubMed:
Nationwide monitoring of selected antibiotics: Distribution and sources of sulfonamides, trimethoprim, and macrolides in Japanese rivers.
PubMed:
[Treatment of rosacea].
PubMed:
[Dapsone efficacy in lupus miliaris disseminatus faciei: two cases].
PubMed:
Mass balance analysis of triclosan, diethyltoluamide, crotamiton and carbamazepine in sewage treatment plants.
PubMed:
Treatment of crusted scabies with albendazole: A case report.
PubMed:
Hydrophilic anthropogenic markers for quantification of wastewater contamination in ground- and surface waters.
PubMed:
Demodicosis: a clinicopathological study.
PubMed:
An Adolescent Patient with Scabies Mimicking Gottron Papules.
PubMed:
Demodex dermatitis: a retrospective analysis of clinical diagnosis and successful treatment with topical crotamiton.
PubMed:
[Infantile scabies].
PubMed:
Occurrence and sources of perfluorinated surfactants in rivers in Japan.
PubMed:
Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage.
PubMed:
Guideline for the diagnosis and treatment of scabies in Japan (second edition).
PubMed:
Demodex folliculorum and Demodex brevis as a cause of chronic marginal blepharitis.
PubMed:
Review: topical permethrin was more effective than topical crotamiton or lindane for scabies.
PubMed:
Removal efficiency of 66 pharmaceuticals during wastewater treatment process in Japan.
PubMed:
Scabies.
PubMed:
Occurrence of 70 pharmaceutical and personal care products in Tone River basin in Japan.
PubMed:
Interventions for treating scabies.
PubMed:
Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant.
PubMed:
A human case of otoacariasis involving a histiostomatid mite (Acari: Histiostomatidae).
PubMed:
[Treatment for scabies].
PubMed:
Scabies: a ubiquitous neglected skin disease.
PubMed:
Percutaneous absorption of crotamiton in man following single and multiple dosing.
PubMed:
Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment.
PubMed:
[Demodicidosis in humans as a current problem in dermatology].
PubMed:
Scabies presenting with bullous pemphigoid-like lesions.
PubMed:
Crusted scabies in an adult T-cell leukemia/lymphoma patient successfully treated with oral ivermectin.
PubMed:
Acaricidal activity of Melaleuca alternifolia (tea tree) oil: in vitro sensitivity of sarcoptes scabiei var hominis to terpinen-4-ol.
PubMed:
Allergic contact dermatitis due to crotamiton.
PubMed:
Concomitant allergic reaction to cetyl alcohol and crotamiton.
PubMed:
Triple allergic contact sensitivities due to ferbinac, crotamiton and diisopropanolamine.
PubMed:
Controlling scabies in institutional settings: a review of medications, treatment models, and implementation.
PubMed:
Oral ivermectin treatment in two cases of scabies: effective in crusted scabies induced by corticosteroid but ineffective in nail scabies.
PubMed:
Current treatments for scabies.
PubMed:
Chromatographic performance of large-pore versus small-pore columns in micellar liquid chromatography.
PubMed:
Scabies incognito presenting as urticaria pigmentosa in an infant.
PubMed:
Scabies.
PubMed:
The management of rosacea.