meglumine
N-methyl-D-glucamine
Identification
| Name | meglumine |
| CAS Number | 6284-40-8 |
| EINECS | 228-506-9 |
| FDA UNII | 6HG8UB2MUY |
| Molecular Formula | C7 H17 N O5 |
| Molecular Weight | 195.21549000 |
| MDL Number | MFCD00004707 |
| Nikkaji Number | J8.375E |
| Beilstein | 385906 |
| XlogP3 | -2.80 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 128.50 °C. @ 760.00 mm Hg |
| Boiling Point | 490.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 485.00 °F. TCC ( 251.60 °C. ) (est) |
| logP (o/w) | -3.370 (est) |
| Soluble in | water, 5.00E+05 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for meglumine usage levels up to | not for fragrance use. |
| Recommendation for meglumine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1-
deoxy-1-(methylamino)-D-glucitol
1-
deoxy-1-methylaminosorbitol
D-
glucitol, 1-deoxy-1-(methylamino)-
glucitol, 1-deoxy-1-(methylamino)-, D- (8CI)
iosulamide
meglumin
meglumina
megluminum
methyl glucamine
N-
methyl-D-glucamine
N-
methyl-D(-)-glucamine
N-
methyl-dextro-glucamine
(2R,3R,4R,5S)-6-(
methylamino)hexane-1,2,3,4,5-pentol
methylglucamine
D-(-)-N-
methylglucamine
N-
methylglucamine
N-
methylglucamine solution
N-
methylsorbitylamine
sorbitol, 1-deoxy-1-methylamino-
PubMed:
Pain sensitivity and healing of hot-iron cattle brands.
PubMed:
Healing of surgical castration wounds: a description and an evaluation of flunixin.
PubMed:
The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine.
PubMed:
Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells.
PubMed:
Gd(3+)-DTPA-Meglumine-Anionic Linear Globular Dendrimer G1: Novel Nanosized Low Toxic Tumor Molecular MR Imaging Agent.
PubMed:
The CCKB antagonist CI988 reduces food intake in fasted rats via a dopamine mediated pathway.
PubMed:
Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey.
PubMed:
Tafamidis for transthyretin amyloidosis.
PubMed:
Roux-en-Y gastric bypass in mice--surgical technique and characterisation.
PubMed:
Taeniasis and cysticercosis due to Taenia solium in Japan.
PubMed:
Associations among behavioral and acute physiologic responses to lipopolysaccharide-induced clinical mastitis in lactating dairy cows.
PubMed:
Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice.
PubMed:
[Simultaneous analysis of 4 non-steroidal anti-inflammatory drug residues in mutton muscle using high performance liquid chromatography assisted by ultrasonic-microwave extraction].
PubMed:
Signal quality of single dose gadobenate dimeglumine pulmonary MRA examinations exceeds quality of MRA performed with double dose gadopentetate dimeglumine.
PubMed:
Incidence of immediate gadolinium contrast media reactions.
PubMed:
Biomarkers of inflammation in cattle determining the effectiveness of anti-inflammatory drugs.
PubMed:
Phosphine intoxication following oral exposure of horses to aluminum phosphide-treated feed.
PubMed:
Pain mitigation after band castration of beef calves and its effects on performance, behavior, Escherichia coli, and salivary cortisol.
PubMed:
Treatment of calf diarrhea: antimicrobial and ancillary treatments.
PubMed:
A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition.
PubMed:
Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.
PubMed:
[The Grenelle of MR contrast agents?].
PubMed:
Response to the FDA's May 23, 2007, nephrogenic systemic fibrosis update.
PubMed:
FDA issues reminder on correct use of flunixin meglumine.
PubMed:
Surveillance for selected bacterial and toxicologic contaminants in donated carcass meat fed to carnivores.
PubMed:
Pharmacokinetics of flunixin meglumine in swine after intravenous dosing.
PubMed:
A woman who excreted a tape-like substance. Diphyllobothriasis.
PubMed:
Evaluating postoperative analgesics in mice using telemetry.
PubMed:
Residue depletion study and withdrawal period for flunixin-N-methyl glucamine in bovine milk following intravenous administration.
PubMed:
Flunixin residues in milk after intravenous treatment of dairy cattle with (14)C-flunixin.
PubMed:
Transcervical catheterization and cervical patency during the oestrous cycle in domestic cats.
PubMed:
Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator.
PubMed:
A simple method for the identification and assay of iopamidol and iothalamate meglumine in pharmaceutical samples based on proton nuclear magnetic resonance spectroscopy.
PubMed:
Review of studies establishing the aging male spontaneously hypertensive rat as a detector and quantifier of the kidney toxicity of radiocontrast media and other chemicals.
PubMed:
[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration].
PubMed:
[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (2)--Combined study of effects on fertility and embryo-fetal toxicity in female rats by intravenous administration].
PubMed:
[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (1)--Fertility study in male rats by intravenous administration].
PubMed:
[General toxicity study of gadobenate dimeglumine formulation (E7155) (4)--4-week repeated dose intravenous toxicity study followed by 4-week recovery period in dogs].
PubMed:
[General toxicity study of gadobenate dimeglumine formulation (E7155) (2)--Single dose intravenous toxicity study in dogs].
PubMed:
Clinical follow-up examination after treatment of canine leishmaniasis.
PubMed:
Drug disposition and dosage determination of once daily administration of gentamicin sulfate in horses after abdominal surgery.
PubMed:
Effects of radiocontrast, mannitol, and endothelin on blood pressure and renal damage in the aging male spontaneously hypertensive rat.
PubMed:
Inhibition of gastrin-stimulated cell proliferation by the CCK-B/gastrin receptor ligand CI-988.
PubMed:
CholecystokininB receptor antagonist increases food intake in rats.
PubMed:
Fatal adverse event secondary to high osmolality contrast agent.
PubMed:
Effects of radiocontrast and endothelin administration on systolic blood pressure and renal damage in male spontaneously hypertensive and Wistar Kyoto rats with phentolamine-induced adrenergic blockade.
PubMed:
Gastric effects of the CCK-B/gastrin receptor ligand CI-988 in cynomolgus monkeys.
PubMed:
The SHR as a small animal model for radiocontrast renal failure. Relation of nephrotoxicity to animal's age, gender, strain, and dose of radiocontrast.
PubMed:
Ancillary therapy of bovine respiratory disease.
PubMed:
Extralabel use of nonsteroidal anti-inflammatory drugs.
PubMed:
Failure of dietary bentonite clay, Silent Herder mineral supplement, or parenteral Banamine to alleviate locoweed toxicosis in rats.
PubMed:
Effect of portal venous flow augmentation on liver enhancement with CT.
PubMed:
Effects of a liquid meal on contrast-enhanced CT of the liver.
PubMed:
Cholecystokinin A receptor antagonist inhibits feed memory in Japanese quail.
PubMed:
Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions.
PubMed:
PD-135158, a CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior.
PubMed:
Determination of flunixin in milk by liquid chromatography with confirmation by gas chromatography/mass spectrometry and selected ion monitoring.
PubMed:
Approval from the Food and Drug Administration for unapproved use of an approved drug or device.
PubMed:
[Relationship between oral food intake and nausea caused by intravenous injection of iodinated contrast material].
PubMed:
Esophageal perforation in recessive dystrophic epidermolysis bullosa.
PubMed:
Effects of cholecystokinin antagonists on the discriminative stimulus effects of cocaine in rats and monkeys.
PubMed:
Use of nonsteroidal anti-inflammatory drugs in food animal practice.
PubMed:
Inhibition of food intake by omeprazole in the chicken.
PubMed:
Treatment of diarrhea of neonatal calves.
PubMed:
Evaluation of the effects of PD 134308 (CI-988), a CCK-B antagonist, on the punished responding of squirrel monkeys.
PubMed:
The influence of anti-inflammatory therapy on bacterial clearance following intramammary Escherichia coli challenge in goats.
PubMed:
Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuscular and intravenous administrations.
PubMed:
Gadopentetate dimeglumine: observations on the clinical research process.
PubMed:
Opening of the blood-brain barrier by intravenous contrast media in euvolemic and dehydrated rabbits.
PubMed:
Castor-oil induced diarrhoea in ponies: a model for acute colitis.
PubMed:
Anti-inflammatory therapy in acute endotoxin-induced bovine mastitis.
PubMed:
Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals.
PubMed:
Cardiovascular responses to the intravertebral artery injection of hypertonic contrast media in the dog.
PubMed:
Avoidance reaction of painful stimulation of another rat: effect of methylglucamine orotate.