meglumine

N-methyl-D-glucamine

CAS: 6284-40-8 C7 H17 N O5 MW: 195.21549000

Identification

Namemeglumine
CAS Number6284-40-8
EINECS228-506-9
FDA UNII6HG8UB2MUY
Molecular FormulaC7 H17 N O5
Molecular Weight195.21549000
MDL NumberMFCD00004707
Nikkaji NumberJ8.375E
Beilstein385906
XlogP3-2.80 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 128.50 °C. @ 760.00 mm Hg
Boiling Point 490.40 °C. @ 760.00 mm Hg (est)
Flash Point 485.00 °F. TCC ( 251.60 °C. ) (est)
logP (o/w) -3.370 (est)
Soluble in water, 5.00E+05 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Useshair conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for meglumine usage levels up tonot for fragrance use.
Recommendation for meglumine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

1- deoxy-1-(methylamino)-D-glucitol 1- deoxy-1-methylaminosorbitol D- glucitol, 1-deoxy-1-(methylamino)- glucitol, 1-deoxy-1-(methylamino)-, D- (8CI) iosulamide meglumin meglumina megluminum methyl glucamine N- methyl-D-glucamine N- methyl-D(-)-glucamine N- methyl-dextro-glucamine (2R,3R,4R,5S)-6-( methylamino)hexane-1,2,3,4,5-pentol methylglucamine D-(-)-N- methylglucamine N- methylglucamine N- methylglucamine solution N- methylsorbitylamine sorbitol, 1-deoxy-1-methylamino- PubMed: Pain sensitivity and healing of hot-iron cattle brands. PubMed: Healing of surgical castration wounds: a description and an evaluation of flunixin. PubMed: The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine. PubMed: Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells. PubMed: Gd(3+)-DTPA-Meglumine-Anionic Linear Globular Dendrimer G1: Novel Nanosized Low Toxic Tumor Molecular MR Imaging Agent. PubMed: The CCKB antagonist CI988 reduces food intake in fasted rats via a dopamine mediated pathway. PubMed: Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey. PubMed: Tafamidis for transthyretin amyloidosis. PubMed: Roux-en-Y gastric bypass in mice--surgical technique and characterisation. PubMed: Taeniasis and cysticercosis due to Taenia solium in Japan. PubMed: Associations among behavioral and acute physiologic responses to lipopolysaccharide-induced clinical mastitis in lactating dairy cows. PubMed: Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice. PubMed: [Simultaneous analysis of 4 non-steroidal anti-inflammatory drug residues in mutton muscle using high performance liquid chromatography assisted by ultrasonic-microwave extraction]. PubMed: Signal quality of single dose gadobenate dimeglumine pulmonary MRA examinations exceeds quality of MRA performed with double dose gadopentetate dimeglumine. PubMed: Incidence of immediate gadolinium contrast media reactions. PubMed: Biomarkers of inflammation in cattle determining the effectiveness of anti-inflammatory drugs. PubMed: Phosphine intoxication following oral exposure of horses to aluminum phosphide-treated feed. PubMed: Pain mitigation after band castration of beef calves and its effects on performance, behavior, Escherichia coli, and salivary cortisol. PubMed: Treatment of calf diarrhea: antimicrobial and ancillary treatments. PubMed: A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition. PubMed: Extralabel use of nonsteroidal anti-inflammatory drugs in cattle. PubMed: [The Grenelle of MR contrast agents?]. PubMed: Response to the FDA's May 23, 2007, nephrogenic systemic fibrosis update. PubMed: FDA issues reminder on correct use of flunixin meglumine. PubMed: Surveillance for selected bacterial and toxicologic contaminants in donated carcass meat fed to carnivores. PubMed: Pharmacokinetics of flunixin meglumine in swine after intravenous dosing. PubMed: A woman who excreted a tape-like substance. Diphyllobothriasis. PubMed: Evaluating postoperative analgesics in mice using telemetry. PubMed: Residue depletion study and withdrawal period for flunixin-N-methyl glucamine in bovine milk following intravenous administration. PubMed: Flunixin residues in milk after intravenous treatment of dairy cattle with (14)C-flunixin. PubMed: Transcervical catheterization and cervical patency during the oestrous cycle in domestic cats. PubMed: Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator. PubMed: A simple method for the identification and assay of iopamidol and iothalamate meglumine in pharmaceutical samples based on proton nuclear magnetic resonance spectroscopy. PubMed: Review of studies establishing the aging male spontaneously hypertensive rat as a detector and quantifier of the kidney toxicity of radiocontrast media and other chemicals. PubMed: [Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration]. PubMed: [Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (2)--Combined study of effects on fertility and embryo-fetal toxicity in female rats by intravenous administration]. PubMed: [Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (1)--Fertility study in male rats by intravenous administration]. PubMed: [General toxicity study of gadobenate dimeglumine formulation (E7155) (4)--4-week repeated dose intravenous toxicity study followed by 4-week recovery period in dogs]. PubMed: [General toxicity study of gadobenate dimeglumine formulation (E7155) (2)--Single dose intravenous toxicity study in dogs]. PubMed: Clinical follow-up examination after treatment of canine leishmaniasis. PubMed: Drug disposition and dosage determination of once daily administration of gentamicin sulfate in horses after abdominal surgery. PubMed: Effects of radiocontrast, mannitol, and endothelin on blood pressure and renal damage in the aging male spontaneously hypertensive rat. PubMed: Inhibition of gastrin-stimulated cell proliferation by the CCK-B/gastrin receptor ligand CI-988. PubMed: CholecystokininB receptor antagonist increases food intake in rats. PubMed: Fatal adverse event secondary to high osmolality contrast agent. PubMed: Effects of radiocontrast and endothelin administration on systolic blood pressure and renal damage in male spontaneously hypertensive and Wistar Kyoto rats with phentolamine-induced adrenergic blockade. PubMed: Gastric effects of the CCK-B/gastrin receptor ligand CI-988 in cynomolgus monkeys. PubMed: The SHR as a small animal model for radiocontrast renal failure. Relation of nephrotoxicity to animal's age, gender, strain, and dose of radiocontrast. PubMed: Ancillary therapy of bovine respiratory disease. PubMed: Extralabel use of nonsteroidal anti-inflammatory drugs. PubMed: Failure of dietary bentonite clay, Silent Herder mineral supplement, or parenteral Banamine to alleviate locoweed toxicosis in rats. PubMed: Effect of portal venous flow augmentation on liver enhancement with CT. PubMed: Effects of a liquid meal on contrast-enhanced CT of the liver. PubMed: Cholecystokinin A receptor antagonist inhibits feed memory in Japanese quail. PubMed: Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions. PubMed: PD-135158, a CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior. PubMed: Determination of flunixin in milk by liquid chromatography with confirmation by gas chromatography/mass spectrometry and selected ion monitoring. PubMed: Approval from the Food and Drug Administration for unapproved use of an approved drug or device. PubMed: [Relationship between oral food intake and nausea caused by intravenous injection of iodinated contrast material]. PubMed: Esophageal perforation in recessive dystrophic epidermolysis bullosa. PubMed: Effects of cholecystokinin antagonists on the discriminative stimulus effects of cocaine in rats and monkeys. PubMed: Use of nonsteroidal anti-inflammatory drugs in food animal practice. PubMed: Inhibition of food intake by omeprazole in the chicken. PubMed: Treatment of diarrhea of neonatal calves. PubMed: Evaluation of the effects of PD 134308 (CI-988), a CCK-B antagonist, on the punished responding of squirrel monkeys. PubMed: The influence of anti-inflammatory therapy on bacterial clearance following intramammary Escherichia coli challenge in goats. PubMed: Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuscular and intravenous administrations. PubMed: Gadopentetate dimeglumine: observations on the clinical research process. PubMed: Opening of the blood-brain barrier by intravenous contrast media in euvolemic and dehydrated rabbits. PubMed: Castor-oil induced diarrhoea in ponies: a model for acute colitis. PubMed: Anti-inflammatory therapy in acute endotoxin-induced bovine mastitis. PubMed: Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals. PubMed: Cardiovascular responses to the intravertebral artery injection of hypertonic contrast media in the dog. PubMed: Avoidance reaction of painful stimulation of another rat: effect of methylglucamine orotate.