N-acetyl histamine

N-(2-(imidazol-4-yl)ethyl)acetamide

CAS: 673-49-4 C7 H11 N3 O MW: 153.18487000

Identification

NameN-acetyl histamine
CAS Number673-49-4
EINECS211-610-3
FDA UNIIE65S46EBQ6
Molecular FormulaC7 H11 N3 O
Molecular Weight153.18487000
MDL NumberMFCD00005209
Nikkaji NumberJ205.971A
XlogP3-0.40 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 8408 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for N-acetyl histamine usage levels up tonot for fragrance use.
Recommendation for N-acetyl histamine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

spinach leaf

Synonyms

acetamide, N-(2-(1H-imidazol-4-yl)ethyl)- (9CI) N-omega- acetyl histamine N- acetylhistamine N-(2-( imidazol-4-yl)ethyl)acetamide N-[2-(1H- imidazol-5-yl)ethyl]acetamide PubMed: Metabolomics analysis of anaphylactoid reaction reveals its mechanism in a rat model. PubMed: [Active sites of N-acetylhexosamine 1-kinase from Bifidobacterium longum]. PubMed: Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine. PubMed: Algicidal metabolites produced by Bacillus sp. strain B1 against Phaeocystis globosa. PubMed: NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. PubMed: Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum. PubMed: Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. PubMed: Effects of intracerebroventricular administration of N-acetylhistamine on body temperature in mice. PubMed: Histamine: a neurotransmitter candidate for Drosophila photoreceptors. PubMed: Histidines, histamines and imidazoles as glycosidase inhibitors. PubMed: Histamine inhibition of mixed function oxidase activity in rat and human liver microsomes and in the isolated perfused rat liver. PubMed: Monooxygenation of N-acetylhistamine mediated by L-ascorbate. PubMed: Inhibition of in vivo histamine metabolism in rats by foodborne and pharmacologic inhibitors of diamine oxidase, histamine N-methyltransferase, and monoamine oxidase. PubMed: Properties of N-acetylhistamine deacetylase in mammalian brain. PubMed: [Molecular mechanism of the interaction of histamine with hyaluronic acid]. PubMed: Histamine receptors on human peripheral blood leucocytes. PubMed: [Oscillographic polarography of the alkaloid dolicotheline and several related imidazole derivatives]. PubMed: Model studies on the coordination of copper in biological systems. The deprotonated peptide nitrogen as a potential binding site for copper(II). PubMed: Elevation of histamine levels in rat and mouse tissues by the deacetylation of administered N-acetylhistamine. PubMed: The metabolism of exogenous histamine by aortic tissues. PubMed: Chemotactic activity of guinea pig eosinophils for the ECF-A acidic tetrapeptides, histamine, histamine metabolites, and the effect of H1- and H2-receptor antagonists. PubMed: Eosinophils and mediators of anaphylaxis. Histamine and imidazole acetic acid as chemotactic agents for human eosinophil leucocytes. PubMed: Partial purification and properties of N-acetylhistamine deacetylase. PubMed: New and uncommon indole- and imidazole-alkylamines in skins of amphibians from Australia and Papua New Guinea. PubMed: Effect of pharmacologic agents on human keratinocyte mitosis in vitro. III. Inhibition by histamine and methylated analogs. PubMed: Proceedings: Enzymatic deacetylation of N-acetylhistamine in the brain of rats. PubMed: Increased urinary imidazolepropionic acid, N-acetylhistamine and other imidazole compounds in patients with intestinal disorders. PubMed: Rupture of the imidazole ring of histamine and N-acetylhistamine by human intestinal contents. PubMed: Ionization of histamine, N-acetylhistamine, and their iodinated derivatives. PubMed: Iodinated derivatives of histamine and N-acetylhistamine. PubMed: Possible in vivo de-acetylation of N-acetylhistamine in man. PubMed: Fate of histamine and N-acetylhistamine administered into the human gut. PubMed: [Determination of histamine, N-dimethylhistamine, N-acetylhistamine and acetylcholine in Spinacia oleracea]. PubMed: A method of estimating histamine in plasma.