phenyl t-butylnitrone

2-propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide

CAS: 3376-24-7 C11 H15 N O MW: 177.24675000

Identification

Namephenyl t-butylnitrone
CAS Number3376-24-7
EINECS222-168-6
FDA UNII3I91332OPG
Molecular FormulaC11 H15 N O
Molecular Weight177.24675000
MDL NumberMFCD00008799
Nikkaji NumberJ4.356G
Beilstein2044028

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 4766 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants
Recommendation for phenyl t-butylnitrone usage levels up tonot for fragrance use.
Recommendation for phenyl t-butylnitrone flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

N-tert- butyl-1-phenylmethanimine oxide N-tert- butyl-a-phenylnitrone N-tert- butyl-alpha-phenyl nitrone 2- methyl-N-(phenylmethylene)-S-propanamine N-oxide 2- propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide PubMed: Natural Products Screening for the Identification of Selective Monoamine Oxidase-B Inhibitors. PubMed: Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells. PubMed: Berberine Antifungal Activity in Fluconazole-Resistant Pathogenic Yeasts: Action Mechanism Evaluated by Flow Cytometry and Biofilm Growth Inhibition in Candida spp. PubMed: Extracting the Benefit of Nexrutine(®) for Cancer Prevention. PubMed: Tolerance of Phellodendron amurense bark extract (Nexrutine®) in patients with human prostate cancer. PubMed: Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP. PubMed: STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth. PubMed: The anti-inflammatory potential of Cortex Phellodendron in vivo and in vitro: down-regulation of NO and iNOS through suppression of NF-κB and MAPK activation. PubMed: Protective effects of Zhibai Dihuang Wan on renal tubular cells affected with gentamicin-induced apoptosis. PubMed: Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. PubMed: Comparison the neuropreotective effect of Cortex Phellodendri chinensis and Cortex Phellodendri amurensis against beta-amyloid-induced neurotoxicity in PC12 cells. PubMed: Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids. PubMed: Bioguided isolation of (9Z)-octadec-9-enoic acid from Phellodendron amurense Rupr. and identification of fatty acids as PTP1B inhibitors. PubMed: Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. PubMed: Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes. PubMed: Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management. PubMed: Natural products: potential for developing Phellodendron amurense bark extract for prostate cancer management. PubMed: Extracts of bark from the traditional Chinese herb Phellodendron amurense inhibit contractility of the isolated rat prostate gland. PubMed: Quality assessment of Cortex Phellodendri by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry. PubMed: Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. PubMed: In vitro antioxidant, antimicrobial and anti-herpes simplex virus type 1 activity of Phellodendron amurense Rupr. from China. PubMed: Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. PubMed: Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study. PubMed: Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine. PubMed: Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract. PubMed: Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity. PubMed: A rapid and simple determination of protoberberine alkaloids in cortex phellodendri by 1H NMR and its application for quality control of commercial traditional Chinese medicine prescriptions. PubMed: Identification of dyes on ancient Chinese paper samples using the subtracted shifted Raman spectroscopy method. PubMed: Principle of the bark of Phellodendron amurense to suppress the cellular immune response: effect of phellodendrine on cellular and humoral immune responses. PubMed: Principle of the bark of Phellodendron amurense to suppress the cellular immune response.