ninhydrin
1H-indene-1,3(2H)-dione, 2,2-dihydroxy-
Identification
| Name | ninhydrin |
| IUPAC | 2,2-dihydroxyindene-1,3-dione |
| CAS Number | 485-47-2 |
| EINECS | 207-618-1 |
| FDA UNII | HCL6S9K23A |
| Molecular Formula | C9 H6 O4 |
| Molecular Weight | 178.14362000 |
| MDL Number | MFCD00003791 |
| Nikkaji Number | J6.001A |
| Beilstein | 1910963 |
Regulatory
Physical Properties
| Appearance | White to light yellow crystals or powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 242.00 °C. @ 760.00 mm Hg |
| Boiling Point | 449.30 °C. @ 760.00 mm Hg (est) |
| Flash Point | 463.00 °F. TCC ( 239.70 °C. ) (est) |
| logP (o/w) | 0.670 |
| Soluble in | water, 1.506e+004 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | reducing agents |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 78 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for ninhydrin usage levels up to | not for fragrance use. |
| Recommendation for ninhydrin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2,2-
dihydroxy-1,3-indandione
2,2-
dihydroxy-1,3-indanedione
2,2-
dihydroxy-1H-indene-1,3(2H)-dione
2,2-
dihydroxy-2-hydrocyclopenta[1,2-a]benzene-1,3-dione
2,2-
dihydroxy-2H-indene-1,3-dione
2,2-
dihydroxyindane-1,3-dione
2,2-
dihydroxyindene-1,3-dione
indan-1,2,3-trione
1,3-
indandione, 2,2-dihydroxy-
1,2,3-
indantrione
1H-
indene-1,3(2H)-dione, 2,2-dihydroxy-
ninhydrine
PubMed:
Tetrahydroindeno[1',2':4,5]pyrrolo[1,2-a]imidazol-5(1H)-ones as Novel Neonicotinoid Insecticides: Reaction Selectivity and Substituent Effects on the Activity Level.
PubMed:
Purification and identification of novel antioxidant peptides from egg white protein and their antioxidant activities.
PubMed:
Isolation and identification of cyclic lipopeptides from Paenibacillus ehimensis, strain IB-X-b.
PubMed:
Actinophytocola sediminis sp. nov., an actinomycete isolated from a marine sediment.
PubMed:
Validation and application of an improved method for the rapid determination of proline in grape berries.
PubMed:
Proteolytic activities of kiwifruit actinidin (Actinidia deliciosa cv. Hayward) on different fibrous and globular proteins: a comparative study of actinidin with papain.
PubMed:
Determining the effects of routine fingermark detection techniques on the subsequent recovery and analysis of explosive residues on various substrates.
PubMed:
Quantification of taurine in energy drinks using ¹H NMR.
PubMed:
An investigation into the enhancement of fingermarks in blood on fruit and vegetables.
PubMed:
One- and two-dimensional high-performance thin-layer chromatography as an alternative analytical tool for investigating polyphenol-protein interactions.
PubMed:
A modified ninhydrin micro-assay for determination of total cyanogens in plants.
PubMed:
Preparation, characterization and antioxidant property of water-soluble ferulic acid grafted chitosan.
PubMed:
Characterization and application of a L-specific amino acid oxidase from Rhodococcus sp. AIU LAB-3.
PubMed:
Direct separation and detection of biogenic amines by ion-pair liquid chromatography with chemiluminescent nitrogen detector.
PubMed:
Separation of gamma-aminobutyric acid from fermented broth.
PubMed:
Accelerated hydrolysis method to estimate the amino acid content of wheat (Triticum durum Desf.) flour using microwave irradiation.
PubMed:
Analysis of Monosodium l-Glutamate in Food Products by High-Performance Thin Layer Chromatography.
PubMed:
[Humidity as a necessary condition for latent fingerprint detection with ninhydrin--a practice-oriented and inexpensive method using potassium citrate].
PubMed:
Melamine and Cyanuric Acid do not interfere with Bradford and Ninhydrin assays for protein determination.
PubMed:
Wheat gluten amino acid composition analysis by high-performance anion-exchange chromatography with integrated pulsed amperometric detection.
PubMed:
Various methods for determination of the degree of N-acetylation of chitin and chitosan: a review.
PubMed:
An antibacterial pyrazole derivative from Burkholderia glumae, a bacterial pathogen of rice.
PubMed:
Characterization of antimicrobial properties on the growth of S. aureus of novel renewable blends of gliadins and chitosan of interest in food packaging and coating applications.
PubMed:
Impurity profile of amino acids?
PubMed:
A review of the current literature on aetiology and measurement methods of halitosis.
PubMed:
Effect of the electrical currents generated by the intestinal smooth muscle layers on pancreatic enzyme activity: an in vitro study.
PubMed:
Rapid analysis of taurine in energy drinks using amino acid analyzer and Fourier transform infrared (FTIR) spectroscopy as basis for toxicological evaluation.
PubMed:
Determination of trace hydroxyl radicals by flow injection spectrofluorometry and its analytical application.
PubMed:
Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry.
PubMed:
Specificity of a Vibrio vulnificus aminopeptidase toward kinins and other peptidyl substrates.
PubMed:
A modified ninhydrin reagent using ascorbic acid instead of potassium cyanide.
PubMed:
Model studies on the influence of high hydrostatic pressure on the formation of glycated arginine modifications at elevated temperatures.
PubMed:
Dietary S-methylmethionine, a component of foods, has choline-sparing activity in chickens.
PubMed:
Influence of starter culture ratios and warm room treatment on free fatty acid and amino acid in Swiss cheese.
PubMed:
Chromogenic derivatives of AHTN (6-acetyl-1,1,2,4,4,7-hexamethyltetralin) react with amino acids and protein in vitro. Spectral characteristics of the colour products.
PubMed:
Applications of the ninhydrin reaction for analysis of amino acids, peptides, and proteins to agricultural and biomedical sciences.
PubMed:
Characterization and comparison of commercially available German and American cockroach allergen extracts.
PubMed:
Effect of exogenous histidine and Garcinia cambogia on histamine formation in skipjack (Katsuwonus pelamis) homogenates.
PubMed:
Proteolysis in Manchego-type cheese salted by brine vacuum impregnation.
PubMed:
Diversity of the polar lipids of the food-borne pathogen Listeria monocytogenes.
PubMed:
A comparison of methods for determining total body protein.
PubMed:
Metabolic activities of pseudomonads in batch cultures in extract of minced lamb.
PubMed:
Flow injection spectrophotometric determination of aspartame in dietary products.
PubMed:
Tumour-promoting activity of ninhydrin on mouse skin.
PubMed:
Heat treatment of infant formula: effect on postprandial serum alpha-amino-nitrogen concentrations in very-low-birth-weight infants.
PubMed:
Identification of alpha-carboxamidated and carboxy-terminal glycine forms of peptides in bovine hypothalamus, bovine pituitary and porcine heart extracts.
PubMed:
Detection and identification of the cross-linking amino acids N tau- and N pi-(2'-amino-2'-carboxy-ethyl)-L-histidine ("histidinoalanine", HAL) in heated milk products.
PubMed:
Monitoring tripeptidase activity using capillary electrophoresis. Comparison with the ninhydrin assay.
PubMed:
High sugar content of extracts interferes with colorimetric determination of amino acids and free proline.
PubMed:
Quantitative analysis of protein deposits on hydrophilic soft contact lenses: I. Comparison to visual methods of analysis. II. Deposit variation among FDA lens material groups.
PubMed:
A potent thromboxane formation inhibitor in green tea leaves.
PubMed:
Determination of taurine in infant formulas using ultrafiltration and cation-exchange chromatography.
PubMed:
A procedure for total protein determination with special application to allergenic extract standardization.
PubMed:
Some chemical properties of maitotoxin, a putative calcium channel agonist isolated from a marine dinoflagellate.
PubMed:
Identification of ninhydrin-positive caprolactam metabolites in the rat.
PubMed:
Studies on LHRH and physiological fluid amino acids in human colostrum and milk.
PubMed:
Isolation and liquid chromatographic determination of the cyclic peptide mycotoxin cyclosporin A from rice.
PubMed:
Determination of biogenic amines in cheese and some other food products by high-performance liquid chromatography in combination with thermo-sensitized reaction detection.
PubMed:
First evidence for the occurrence of N delta-acetyl-L-ornithine and quantification of the free amino acids in the cultivated mushroom, Pleurotus ostreatus.
PubMed:
Investigations on the origin of two radiation-induced compounds in irradiated meat.
PubMed:
Diet and medications giving positive ninhydrin reactions on TLC in a newborn urinary screening program.
PubMed:
Evaluation of lysinoalanine determinations in food proteins.
PubMed:
Comparison of thin-layer chromatographic detection methods for histamine from food extracts.
PubMed:
Design assembly of an inexpensive, automated microbore amino acid analyzer: separation and quantitation of amino acids in physiological fluids.
PubMed:
[Influence of various thermal processes and microwaves on the amino acid composition of food products: implications on their nutritional value].
PubMed:
A screening method for protein characterization and differentiation.
PubMed:
Rapid determination of tryptophan in beans (Phaseolus vulgaris) by the acid ninhydrin method.
PubMed:
Direct estimation of lysine in corn meals by the ninhydrin color reaction.
PubMed:
Characterization of growth stimulants in corn steep for lactic streptococci.
PubMed:
Growth of lactic acid bacteria in waste waters of vegetable-processing plants.
PubMed:
EVALUATION OF THE EXTRACT-RELEASE VOLUME PHENOMENON AS A RAPID TEST FOR DETECTING SPOILAGE IN BEEF.