norharman

2,9-diazafluorene

CAS: 244-63-3 C11 H8 N2 MW: 168.19876000

Identification

Namenorharman
CAS Number244-63-3
EINECS205-959-0
FDA UNII94HMA1I78O
Molecular FormulaC11 H8 N2
Molecular Weight168.19876000
MDL NumberMFCD00004956
Nikkaji NumberJ10.931B
Beilstein0128414
XlogP33.20 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 199.00 °C. @ 760.00 mm Hg
Boiling Point 391.30 °C. @ 760.00 mm Hg (est)
Flash Point 360.00 °F. TCC ( 182.10 °C. ) (est)
logP (o/w) 3.170
Soluble in water, 9.553 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-mouse LD50 100 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02316']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for norharman usage levels up tonot for fragrance use.
Recommendation for norharman flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

None Found

Natural Occurrence

chicory root

Synonyms

2- azacarbazole carbazoline beta- carboline 2,9- diazafluorene nor harmane 9H- pyrido[3,4-b]indole PubMed: Effects of frying conditions on the formation of heterocyclic amines and trans fatty acids in grass carp (Ctenopharyngodon idellus). PubMed: Inhibitory effects of pomegranate seed extract on the formation of heterocyclic aromatic amines in beef and chicken meatballs after cooking by four different methods. PubMed: Inhibitory Effect of Liposomal Solutions of Grape Seed Extract on the Formation of Heterocyclic Aromatic Amines. PubMed: Effects of frying and boiling on the formation of heterocyclic amines in braised chicken. PubMed: Effect of different types of sugars in a marinating formulation on the formation of heterocyclic amines in grilled chicken. PubMed: Identification of seafood as an important dietary source of heterocyclic amines by chemometry and chromatography-mass spectrometry. PubMed: Formation of heterocyclic amines in salami and ham pizza toppings during baking of frozen pizza. PubMed: [Simultaneous determination of nine heterocyclic aromatic amines in mutton products by solid phase extraction-high performance liquid chromatography]. PubMed: Antioxidant capacity and inhibitory effect of grape seed and rosemary extract in marinades on the formation of heterocyclic amines in fried beef patties. PubMed: Formation of heterocyclic amines during cooking of duck meat. PubMed: [Determination of 10 heterocyclic aromatic amines in beef jerky by high performance liquid chromatography]. PubMed: [Simultaneous determination of 9 heterocyclic aromatic amine in poultry products by solid-phase extraction-high performance liquid chromatography]. PubMed: Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors. PubMed: Screening of non-polar heterocyclic amines in urine by microextraction in packed sorbent-fluorimetric detection and confirmation by capillary liquid chromatography. PubMed: Effects of cooking variables on formation of heterocyclic amines (HCA) in roasted pork and mackerel. PubMed: Capillary liquid chromatography with diode array and mass spectrometry detection for heterocyclic aromatic amine determination in ready-to-eat food treated with electron-beam irradiation. PubMed: Effect of cooking methods on the formation of heterocyclic aromatic amines in chicken and duck breast. PubMed: Electrospray MS-based characterization of beta-carbolines--mutagenic constituents of thermally processed meat. PubMed: Hollow fibre-supported liquid membrane extraction and LC-MS/MS detection for the analysis of heterocyclic amines in urine samples. PubMed: Analysis of heterocyclic amines and beta-carbolines by liquid chromatography-mass spectrometry in cooked meats commonly consumed in Korea. PubMed: Preparation and characterisation of fried chicken as a laboratory reference material for the analysis of heterocyclic amines. PubMed: Effect of marinades on the formation of heterocyclic amines in grilled beef steaks. PubMed: Quantification of heterocyclic amines from thermally processed meats selected from a small-scale population-based study. PubMed: Quantification of heterocyclic aromatic amines in fried meat by HPTLC/UV-FLD and HPLC/UV-FLD: a comparison of two methods. PubMed: Determination of heterocyclic aromatic amines by capillary high-performance liquid chromatography with diode array detection in ready-to-eat cooked ham treated with electron-beam irradiation. PubMed: Effect of oil marinades with garlic, onion, and lemon juice on the formation of heterocyclic aromatic amines in fried beef patties. PubMed: Identification and occurrence of beta-carboline alkaloids in raisins and inhibition of monoamine oxidase (MAO). PubMed: Degradation of heterocyclic aromatic amines in oil under storage and frying conditions and reduction of their mutagenic potential. PubMed: Validation of an ion-pair liquid chromatography-electrospray-tandem mass spectrometry method for the determination of heterocyclic aromatic amines in meat-based infant foods. PubMed: Factors influencing the norharman and harman contents in espresso coffee. PubMed: Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells. PubMed: Heterocyclic amines in griddled beef steak analysed using a single extract clean-up procedure. PubMed: Effect of red wine marinades on the formation of heterocyclic amines in fried chicken breast. PubMed: Analysis of monoamine oxidase enzymatic activity by reversed-phase high performance liquid chromatography and inhibition by beta-carboline alkaloids occurring in foods and plants. PubMed: Norharman-induced motoric impairment in mice: neurodegeneration and glial activation in substantia nigra. PubMed: Relative exposure to beta-carbolines norharman and harman from foods and tobacco smoke. PubMed: Addition of various carbohydrates to beef burgers affects the formation of heterocyclic amines during frying. PubMed: Exposure to beta-carbolines norharman and harman. PubMed: Long-term retention of neurotoxic beta-carbolines in brain neuromelanin. PubMed: Influence of antioxidants in virgin olive oil on the formation of heterocyclic amines in fried beefburgers. PubMed: Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay. PubMed: Identification and occurrence of the bioactive beta-carbolines norharman and harman in coffee brews. PubMed: Screening for heterocyclic amines in chicken cooked in various ways. PubMed: Natural variations of precursors in pig meat affect the yield of heterocyclic amines--effects of RN genotype, feeding regime, and sex. PubMed: Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline. PubMed: Degradation of tetrahydro-beta-carbolines in the presence of nitrite: HPLC-MS analysis of the reaction products. PubMed: Tetrahydro-beta-carboline-3-carboxylic acid compounds in fish and meat: possible precursors of co-mutagenic beta-carbolines norharman and harman in cooked foods. PubMed: [In vitro study of the interference of certain food components with the metabolism of aflatoxin B1]. PubMed: [In vivo studies of the inhbitory effect of various food components on aflatoxin B1 metabolism]. PubMed: Formation of heterocyclic amines in fried fish fiber during processing and storage. PubMed: Analysis of tetrahydro-beta-carboline-3-carboxylic acids in foods by solid-phase extraction and reversed-phase high-performance liquid chromatography combined with fluorescence detection. PubMed: Formation of the comutagenic beta-carboline norharman in a simple tryptophan-containing model system at low temperature (40 degrees C-80 degrees C). PubMed: Formation of heterocyclic amines in a model system during heating. PubMed: Quantification of the co-mutagenic beta-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods. PubMed: Heterocyclic amines in process flavours, process flavour ingredients, bouillon concentrates and a pan residue. PubMed: Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectrometry. PubMed: Determination of heterocyclic amines in flame-grilled fish patty by capillary electrophoresis. PubMed: Influence of frying fat on the formation of heterocyclic amines in fried beefburgers and pan residues. PubMed: [Effects of harman and norharman on aflatoxin B1 and aminopyrine metabolism by phenobarbital and 3-methylcholanthrene-induced rat liver microsomes]. PubMed: Optimization of the sensitivity of high-performance liquid chromatography in the detection of heterocyclic aromatic amine mutagens. PubMed: Determination of beta-carbolines in foodstuffs by high-performance liquid chromatography and high-performance liquid chromatography-mass spectrometry. PubMed: Simple methods for quantifying mutagenic heterocyclic aromatic amines in food products. PubMed: Mutagenicity, comutagenicity, and antimutagenicity of erythrosine (FD and C red 3), a food dye, in the Ames/Salmonella assay. PubMed: Mutagenicities of nitrosated carboline derivatives. PubMed: Food-borne amines and amides as potential precursors of endogenous carcinogens. PubMed: Alteration of mutagenic potentials by peroxidase, catalase, and superoxide dismutase. PubMed: Stability of tryptophan during food processing and storage. 2. A comparison of methods used for the measurement of tryptophan losses in processed foods. PubMed: Possible genotoxic carcinogens in foods in relation to cancer causation. PubMed: Tissue damage and nutritional factors in experimental respiratory tract (Co-)carcinogenesis. PubMed: Carcinogenic, Mutagenic, and Comutagenic Aromatic Amines in Human Foods. PubMed: Mutagenic factors in cooked foods.