octamethyl cyclotetrasiloxane
cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
Identification
| Name | octamethyl cyclotetrasiloxane |
| IUPAC | 2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane |
| CAS Number | 556-67-2 |
| EINECS | 209-136-7 |
| FDA UNII | CZ227117JE |
| Molecular Formula | C8 H24 O4 Si4 |
| Molecular Weight | 296.61728000 |
| MDL Number | MFCD00003269 |
| Nikkaji Number | J428F |
| Beilstein | 1787074 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.95600 @ 25.00 °C. |
| Refractive Index | 1.39600 @ 20.00 °C. |
| Melting Point | 17.50 °C. @ 760.00 mm Hg |
| Boiling Point | 175.80 °C. @ 760.00 mm Hg |
| Vapor Pressure | 1.600000 mmHg @ 25.00 °C. (est) |
| Flash Point | 140.00 °F. TCC ( 60.00 °C. ) |
| logP (o/w) | 5.100 |
| Soluble in | water, 0.005 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 1540 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 794 uL/kg |
| Inhalation Toxicity | inhalation-rat LC50 36000 mg/m3/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for octamethyl cyclotetrasiloxane usage levels up to | not for fragrance use. |
| Recommendation for octamethyl cyclotetrasiloxane flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
cyclotetrasiloxane, octamethyl-
2,2,4,4,6,6,8,8-
octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
2,2,4,4,6,6,8,8-
octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
union carbide 7207
volasil 244
PubMed:
Trophic transfer of methyl siloxanes in the marine food web from coastal area of northern china.
PubMed:
Nanorheology by atomic force microscopy.
PubMed:
Regeneration of siloxane-exhausted activated carbon by advanced oxidation processes.
PubMed:
Occurrence of cyclic and linear siloxanes in indoor air from Albany, New York, USA, and its implications for inhalation exposure.
PubMed:
Fate of anthropogenic cyclic volatile methylsiloxanes in a wastewater treatment plant.
PubMed:
Aggregate dermal exposure to cyclic siloxanes in personal care products: implications for risk assessment.
PubMed:
Measurement of cyclic volatile methylsiloxanes in the aquatic environment using low-density polyethylene passive sampling devices using an in-field calibration study--challenges and guidance.
PubMed:
Comment on "Emergence and fate of cyclic volatile polydimethylsiloxanes (D4, D5) in municipal waste streams: release mechanisms, partitioning and persistence in air, water, soil and sediments".
PubMed:
Organophosphate flame retardants and organosiloxanes in predatory freshwater fish from locations across Canada.
PubMed:
Solvation force simulations in atomic force microscopy.
PubMed:
Determination of soil-water sorption coefficients of volatile methylsiloxanes.
PubMed:
Siloxanes removal from biogas by a lab-scale biotrickling filter inoculated with Pseudomonas aeruginosa S240.
PubMed:
Biogas upgrading: optimal activated carbon properties for siloxane removal.
PubMed:
Sensitive method for quantification of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air by thermal desorption gas chromatography mass spectrometry.
PubMed:
Allometric relationships to liver tissue concentrations of cyclic volatile methyl siloxanes in Atlantic cod.
PubMed:
Absorption of a linear (L2) and a cyclic (D4) siloxane using different oils: application to biogas treatment.
PubMed:
Relevance of an organic solvent for absorption of siloxanes.
PubMed:
Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie, Canada.
PubMed:
Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout.
PubMed:
Concentrations of cyclic volatile methylsiloxanes in European cosmetics and personal care products: prerequisite for human and environmental exposure assessment.
PubMed:
Improving the efficiency of quantitative (1)H NMR: an innovative external standard-internal reference approach.
PubMed:
Emergence and fate of cyclic volatile polydimethylsiloxanes (D4, D5) in municipal waste streams: release mechanisms, partitioning and persistence in air, water, soil and sediments.
PubMed:
Atomic force microscopy of confined liquids using the thermal bending fluctuations of the cantilever.
PubMed:
Composition and source identification of deposits forming in landfill gas (LFG) engines and effect of activated carbon treatment on deposit composition.
PubMed:
Adsorption characteristics of siloxanes in landfill gas by the adsorption equilibrium test.
PubMed:
Pharmacodynamic models: parameterizing the hill equation, Michaelis-Menten, the logistic curve, and relationships among these models.
PubMed:
Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation.
PubMed:
Calibration and application of a passive air sampler (XAD-PAS) for volatile methyl siloxanes.
PubMed:
Selected ion flow tube studies of several siloxanes.
PubMed:
Evaluating the fate and behaviour of cyclic volatile methyl siloxanes in two contrasting North American lakes using a multi-media model.
PubMed:
Fathead minnow (Pimephales promelas) embryo to adult exposure to decamethylcyclopentasiloxane (D5).
PubMed:
Mechanism of diffusion slowdown in confined liquids.
PubMed:
Determination of cyclic volatile methylsiloxanes in water, sediment, soil, biota, and biosolid using large-volume injection-gas chromatography-mass spectrometry.
PubMed:
Review of recent advances in research on the toxicity, detection, occurrence and fate of cyclic volatile methyl siloxanes in the environment.
PubMed:
Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs).
PubMed:
Determination of the dietary biomagnification of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane with the rainbow trout (Oncorhynchus mykiss).
PubMed:
Occurrence and seasonality of cyclic volatile methyl siloxanes in Arctic air.
PubMed:
Occurrence and fate of volatile siloxanes in a municipal wastewater treatment plant of Beijing, China.
PubMed:
Cyclic volatile methylsiloxanes in fish from the Baltic Sea.
PubMed:
Junge relationships in measurement data for cyclic siloxanes in air.
PubMed:
Concentrations of cyclic volatile methylsiloxanes in biosolid amended soil, influent, effluent, receiving water, and sediment of wastewater treatment plants in Canada.
PubMed:
Comprehensive mass flow analysis of Swedish sludge contaminants.
PubMed:
High refractive index polysiloxane as injectable, in situ curable accommodating intraocular lens.
PubMed:
Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants.
PubMed:
Food web accumulation of cyclic siloxanes in Lake Mjøsa, Norway.
PubMed:
Method for simultaneous determination of partition coefficients for cyclic volatile methylsiloxanes and dimethylsilanediol.
PubMed:
A surprise from 1954: siloxane equilibration is a simple, robust, and obvious polymer self-healing mechanism.
PubMed:
Quantitative force and dissipation measurements in liquids using piezo-excited atomic force microscopy: a unifying theory.
PubMed:
Prioritizing organic chemicals for long-term air monitoring by using empirical monitoring data--application to data from the Swedish screening program.
PubMed:
Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humber Estuary.
PubMed:
Confinement-dependent damping in a layered liquid.
PubMed:
Unraveling the properties of octamethylcyclotetrasiloxane under nanoscale confinement: atomistic view of the liquidlike state from molecular dynamics simulation.
PubMed:
Survey of cyclic and linear siloxanes in sediment from the Songhua River and in sewage sludge from wastewater treatment plants, Northeastern China.
PubMed:
Determination of cyclic volatile methylsiloxanes in biota with a purge and trap method.
PubMed:
Nonlinear rheology of a nanoconfined simple fluid.
PubMed:
Volatile siloxanes in the European arctic: assessment of sources and spatial distribution.
PubMed:
High-resolution friction force microscopy under electrochemical control.
PubMed:
Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures.
PubMed:
Do epitaxy and temperature affect oscillatory solvation forces?
PubMed:
Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses.
PubMed:
Dissipation and oscillatory solvation forces in confined liquids studied by small-amplitude atomic force spectroscopy.
PubMed:
Quantitative analysis of volatile methylsiloxanes in waste-to-energy landfill biogases using direct APCI-MS/MS.
PubMed:
Siloxane treatment by adsorption into porous materials.
PubMed:
Direct analysis of volatile methylsiloxanes in gaseous matrixes using atmospheric pressure chemical ionization-tandem mass spectrometry.
PubMed:
Effect of ozone and relative humidity on the heterogeneous uptake of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane on model mineral dust aerosol components.
PubMed:
Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.
PubMed:
Temperature dependence of solvation forces as measured in atomic force microscopy.
PubMed:
Drainage of a nanoconfined simple fluid: rate effects on squeeze-out dynamics.
PubMed:
Biological removal of siloxanes from landfill and digester gases: opportunities and challenges.
PubMed:
A mechanistic study of cyclic siloxane pyrolyses at low pressures.
PubMed:
Flow injection potentiometric determination of paraquat in formulations and biological samples.
PubMed:
[Analysis of the volatile oils chemical constituents of roots of Actinidia deliciosa].
PubMed:
Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans.
PubMed:
Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?
PubMed:
Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products.
PubMed:
Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies.
PubMed:
Effect of tip size on force measurement in atomic force microscopy.
PubMed:
In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5).
PubMed:
Physiologically based pharmacokinetic modeling of the disposition of octamethylcyclotetrasiloxane (D4) migration from implants in humans.
PubMed:
Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).
PubMed:
Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague-Dawley rats.
PubMed:
Surface melting of octamethylcyclotetrasiloxane confined in controlled pore glasses: curvature effects observed by 1H NMR.
PubMed:
An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens.
PubMed:
A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation.
PubMed:
Recent progress in the determination of solid surface tensions from contact angles.
PubMed:
In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes.
PubMed:
NMR cryoporometry with octamethylcyclotetrasiloxane as a probe liquid. Accessing large pores.
PubMed:
Effect of octamethylcyclotetrasiloxane on methylation of bismuth by Methanosarcina barkeri.
PubMed:
Density functional theory calculation of (29)Si NMR chemical shifts of organosiloxanes.
PubMed:
Diagnosing inborn errors of lipid metabolism with proton nuclear magnetic resonance spectroscopy.
PubMed:
Oscillatory dissipation of a simple confined liquid.
PubMed:
Discrete solvation layering in confined binary liquids.
PubMed:
Interpretation of contact angle measurements on two different fluoropolymers for the determination of solid surface tension.
PubMed:
How confined lubricants diffuse during shear.
PubMed:
Contact angle measurements with liquids consisting of bulky molecules.
PubMed:
Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.
PubMed:
The measurement of conformational stability of proteins adsorbed on siloxanes.
PubMed:
Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise.
PubMed:
PBPK modeling advances understanding of D4 pharmacokinetics.
PubMed:
Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants.
PubMed:
Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models.
PubMed:
Further comments on the bioavailability of D4.
PubMed:
Bioavailability of D4 after inhalation and implantation exposure to silicones.
PubMed:
Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model.
PubMed:
Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane.
PubMed:
The effect of cyclic swelling (octamethylcyclotetrasiloxane) on the physical properties of silicone breast implant shells.
PubMed:
Effect of interfacial liquid structuring on the coherence length in nanolubrication.
PubMed:
Inhalation toxicology of octamethylcyclotetrasiloxane (D4) following a 3-month nose-only exposure in Fischer 344 rats.
PubMed:
Study of the advancing and receding contact angles: liquid sorption as a cause of contact angle hysteresis.
PubMed:
Bioavailability of octamethylcyclotetrasiloxane (D(4)) after exposure to silicones by inhalation and implantation.
PubMed:
The transport of octamethylcyclotetrasiloxane (D4) and polydimethylsiloxane (PDMS) in lightly cross-linked silicone rubber.
PubMed:
Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay.
PubMed:
Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.
PubMed:
Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.
PubMed:
Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.
PubMed:
Permeation of substituted silanes and siloxanes through selected gloves and protective clothing.
PubMed:
Genetic toxicity evaluation of octamethylcyclotetrasiloxane.
PubMed:
Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes.
PubMed:
Disposition of radioactivity in fischer 344 rats after single and multiple inhalation exposure to [(14)C]Octamethylcyclotetrasiloxane ([(14)C]D(4)).
PubMed:
Toxicology and humoral immunity assessment of octamethylcyclotetrasiloxane (D4) following a 28-day whole body vapor inhalation exposure in Fischer 344 rats.
PubMed:
Identification of metabolites of octamethylcyclotetrasiloxane (D(4)) in rat urine.
PubMed:
Microbial degradation of octamethylcyclotetrasiloxane.
PubMed:
Cyclosiloxanes produce fatal liver and lung damage in mice.
PubMed:
Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects.
PubMed:
Quantitative exposure of humans to an octamethylcyclotetrasiloxane (D4) vapor.
PubMed:
Protein denaturation induced by cyclic silicone.
PubMed:
Drug microencapsulation by PLA/PLGA coacervation in the light of thermodynamics. 2. Parameters determining microsphere formation.
PubMed:
Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study.
PubMed:
Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice.
PubMed:
Extraction of octamethylcyclotetrasiloxane and its metabolites from biological matrices.
PubMed:
Force-distance curves by AFM. A powerful technique for studying surface interactions.
PubMed:
Silicone gel and octamethylcyclotetrasiloxane (D4) enhances antibody production to bovine serum albumin in mice.
PubMed:
Cytotoxicity and membrane damage in vitro by inclusion complexes between gamma-cyclodextrin and siloxanes.
PubMed:
Silicone gel and octamethylcyclotetrasiloxane potentiate antibody production to bovine serum albumin in mice.
PubMed:
The adjuvancy of silicones: dependency on compartmentalization.
PubMed:
Induction of type II collagen arthritis in the DA rat using silicone gels and oils as adjuvant.
PubMed:
The effect of molecular weight and gel preparation on humoral adjuvancy of silicone oils and silicone gels.
PubMed:
Octamethylcyclotetrasiloxane in aquatic sediments: toxicity and risk assessment.
PubMed:
Ocular toxicity of low-molecular-weight components of silicone and fluorosilicone oils.
PubMed:
Use of plasma polymerization for preparing silicone-coated membranes for possible use in blood oxygenators.