phenolphthalein

1(3H)-isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-

CAS: 77-09-8 C20 H14 O4 MW: 318.32838000

Identification

Namephenolphthalein
IUPAC3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
CAS Number77-09-8
EINECS201-004-7
FDA UNII6QK969R2IF
Molecular FormulaC20 H14 O4
Molecular Weight318.32838000
MDL NumberMFCD00005913
Nikkaji NumberJ4.502K
Beilstein284423
XlogP33.60 (est)

Regulatory

Physical Properties

Appearance white or yellowish-white to pale orange fine crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 262.50 °C. @ 760.00 mm Hg
Boiling Point 557.79 °C. @ 760.00 mm Hg (est)
Vapor Pressure 6.700000 mmHg (est)
Flash Point 404.00 °F. TCC ( 206.50 °C. ) (est)
logP (o/w) 2.410
Soluble in water, 400 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-man TDLo 29 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for phenolphthalein usage levels up tonot for fragrance use.
Recommendation for phenolphthalein flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

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Potential Uses

oral care agents

Natural Occurrence

not found in nature

Synonyms

agoral alophen ap-la-day 1(3H)-iso benzofuranone, 3,3-bis(4-hydroxyphenyl)- chocolax colax correctol a- di(p-hydroxyphenyl)phthalide doxan doxidan espotabs euchessina evac-q-kit evac-q-kwik evac-q-tabs evac-u-gen evac-v-lax ex-lax feen-a-mint feen-a-mint laxative mints femilax figsen 3,3-bis-(4- hydroxy-phenyl)-3H-isobenzofuran-1-one 3,3-bis(4- hydroxyphenyl)-1(3H)-isobenzofuranone 3,3-bis(4- hydroxyphenyl)-1(3H)-isobenzofurunone 3,3-bis(4- hydroxyphenyl)-2-benzofuran-1-one 3,3-bis(4- hydroxyphenyl)-2-benzofuran-1(3H)-one 3,3-bis(4- hydroxyphenyl)-3-hydroisobenzofuran-1-one a-(p- hydroxyphenyl)-a-(4-oxo-2,5-cyclohexadien-1-ylidine)-o-toluic acid 3,3-bis(4- hydroxyphenyl)isobenzofuran-1(3H)-one 3,3-bis(4- hydroxyphenyl)phthalide 3,3-bis(p- hydroxyphenyl)phthalide 3,3-bis(para- hydroxyphenyl)phthalide koprol laxatone laxcaps laxettes laxin laxogen lilo medilax modane phenolax white phenolphthalein phillips gelcaps phthalide 3,3,-bis(p-hydroxyphenyl)- phthalimetten purga purgen purgophen spulmako-lax thalinol trilax PubMed: Effects of cyclodextrins on the flavor of goat milk and its yogurt. PubMed: Identification and determination of synthetic pharmaceuticals as adulterants in eight common herbal weight loss supplements. PubMed: [Simultaneous determination of 25 illegally added drugs in diet health foods by ultra-high performance liquid chromatography]. PubMed: [Analysis and identification of illegal constituents in health food products implicitly advertizing tonic or slimming effect in the National Institute of Health Sciences in Japan]. PubMed: Screening for multiple weight loss and related drugs in dietary supplement materials by flow injection tandem mass spectrometry and their confirmation by liquid chromatography tandem mass spectrometry. PubMed: Determination of diuretics and laxatives as adulterants in herbal formulations for weight loss. PubMed: [Detection of phenolphthalein added illegally into anti-obesity and healthcare food by TLC-FTIR]. PubMed: Detection and quantitation of trace phenolphthalein (in pharmaceutical preparations and in forensic exhibits) by liquid chromatography-tandem mass spectrometry, a sensitive and accurate method. PubMed: Ovariectomized mouse uterotrophic assay of 36 chemicals. PubMed: Toxicology study of senna (CAS No. 8013-11-4) in C57BL/6NTAC Mice and toxicology and carcinogenesis study of senna in genetically modified C3B6.129F1/Tac-Trp53tm1Brd haploinsufficient mice (Feed Studies). PubMed: Qualitative screening for adulterants in weight-loss supplements by ion mobility spectrometry. PubMed: Tenside-free preparation of nanogels with high functional β-cyclodextrin content. PubMed: Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry. PubMed: Effects of cyclodextrins on the flavor of goat milk and its yogurt. PubMed: Study on detection of drugs in slimming health foods using GC-MS/MS. PubMed: Detection of hazardous weight-loss substances in adulterated slimming formulations using ultra-high-pressure liquid chromatography with diode-array detection. PubMed: Interaction of microbial β-glucuronidase with vegetable pectins. PubMed: Use of a pharmaceutically adulterated dietary supplement, Pai You Guo, among Brazilian-born women in the United States. PubMed: [Methodological study on magnetic affinity immunoassay for detecting chloramphenicol]. PubMed: Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1H-NMR. PubMed: Phenolphthalein treatment in pregnant women and congenital abnormalities in their offspring: A population-based case-control study. PubMed: The toxicology and carcinogenesis study of phenolphthalein (CAS No. 77-09-8) in genetically modified haploinsufficient p16(Ink4a)/p19(Arf) mice (feed study). PubMed: Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. PubMed: Granule enzyme exocytosis assay for cytotoxic T lymphocyte activation. PubMed: [Establishment of chemiluminescence immunoassay for detecting Staphylococcal enterotoxin B and C1]. PubMed: An accurate and reproducible method for the quantitative analysis of isoflavones and their metabolites in rat plasma using liquid chromatography/mass spectrometry combined with photodiode array detection. PubMed: Sequential injection titration with spectrophotometric detection for the assay of acidity in fruit juices. PubMed: Skin breakdown and blisters from senna-containing laxatives in young children. PubMed: Chemical method for determination of carbon dioxide content in egg yolk and egg albumen. PubMed: Evaluation of the TOPKAT system for predicting the carcinogenicity of chemicals. PubMed: Selective medium for primary isolation of members of the tribe Proteeae. PubMed: Determination of carbon dioxide evolution rates using a novel noninstrumental microrespirometer. PubMed: Laxative drug products for over-the-counter human use. Food and Drug Administration, HHS. Final rule. PubMed: Effect of gum arabic in an oral rehydration solution on recovery from diarrhea in rats. PubMed: Poly(acrylic acid) microspheres containing beta-cyclodextrin: loading and in vitro release of two dyes. PubMed: Modified starch enhances absorption and accelerates recovery in experimental diarrhea in rats. PubMed: An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. I. Evidence for a confounding nonresponder phenotype. PubMed: A laxative ingredient is linked to CA. PubMed: Chemical test for mammalian feces in ground black pepper: collaborative study. PubMed: Renal failure associated with laxative abuse. PubMed: Diagnosis of magnesium-induced diarrhea. PubMed: Effects of short-term and long-term administration of amiodarone on hepatobiliary function in male rats. PubMed: Chemical test for mammalian feces in grain products: collaborative study. PubMed: Effect of endrin and endrin derivatives on hepatobiliary function and carbon tetrachloride-induced hepatotoxicity in male and female rats. PubMed: Colorimetric determination of alkaline phosphatase as indicator of mammalian feces in corn meal: collaborative study. PubMed: Glucuronidation in the reindeer: dietary modification in the UDP-glucuronosyltransferase activity with 4-nitrophenol, 1-naphthol and phenolphthalein as acceptors. PubMed: Spectrophotometric determination of the protonation constants of o-cresolphthalexone and the formation constants of its alkaline-earth-metal comple. PubMed: Chemical test for mammalian feces: collaborative study. PubMed: A note on the development of a polymyxin-mannitol-phenolphthalein diphosphate agar for the selective enumeration of coagulase positive staphylococci in foods.