phenyl butazone

4-butyl-1,2-diphenylpyrazolidine-3,5-dione

CAS: 50-33-9 C19 H20 N2 O2 MW: 308.38080000

Identification

Namephenyl butazone
IUPAC4-butyl-1,2-diphenylpyrazolidine-3,5-dione
CAS Number50-33-9
EINECS200-029-0
FDA UNIIGN5P7K3T8S
Molecular FormulaC19 H20 N2 O2
Molecular Weight308.38080000
MDL NumberMFCD00005500
Nikkaji NumberJ792G
Beilstein0290080
XlogP33.20 (est)

Regulatory

Physical Properties

Appearance white crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 105.00 °C. @ 760.00 mm Hg
Boiling Point 424.89 °C. @ 760.00 mm Hg (est)
Vapor Pressure 6.380000 mmHg @ 25.00 °C. (est)
Flash Point 346.00 °F. TCC ( 174.30 °C. ) (est)
logP (o/w) 3.160
Soluble in water, 47.5 mg/L @ 30 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-cat LD50 100 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 230 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'KIDNEY, URETER, AND BLADDER: HEMATURIA\nKIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED\nVASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION', 'BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD\nLUNGS, THORAX, OR RESPIRATION: OTHER CHANGES\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for phenyl butazone usage levels up tonot for fragrance use.
Recommendation for phenyl butazone flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

4- butyl-1,2 -diphenyl-3,5-dioxo pyrazolidine 4- butyl-1,2-diphenyl-1,2-diazolidine-3,5-dione 4- butyl-1,2-diphenyl-3,5-dioxopyrazolidine 4- butyl-1,2-diphenyl-3,5-pyrazolidinedione 4-N- butyl-1,2-diphenyl-3,5-pyrazolidinedione 4- butyl-1,2-diphenyl-pyrazolidine-3,5-dione 4- butyl-1,2-diphenylpyrazolidine-3,5-dione 3,5- dioxo-1,2-diphenyl-4-N-butylpyrazolidine 3,5- dioxo-4-butyl-1-diphenyl-pyrazolidine 1,2- diphenyl-2,3-dioxo-4-N-butylpyrazoline 1,2- diphenyl-3,5-dioxo-4-butylpyrazolidine 1,2- diphenyl-3,5-dioxo-4-N-butylpyrazoline 1,2- diphenyl-4-butyl-3,5-dioxopyrazolidine 1,2- diphenyl-4-butyl-3,5-pyrazolidinedione mepha-butazon phenbutazone phenylbutazone phenylbutazonum phenyzene pyrasanone pyrazinobutazone 3,5- pyrazolidinedione, 4-butyl-1,2-diphenyl- ranoroc shigrodin tencodyne tetnor tevcodyne therazone ticinil todalgil zolidinum Info: Phenylbutazone PubMed: Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea. PubMed: Investigation into sources of contamination of cattle with phenylbutazone. PubMed: Pharmacokinetics, pharmacodynamics, metabolism, toxicology and residues of phenylbutazone in humans and horses. PubMed: Bute residues of low concern for consumers, say EFSA and EMA. PubMed: EC seeks advice on risks from phenylbutazone in horsemeat. PubMed: "Bute" in horse meat presents very low risk to health, says England's chief medical officer. PubMed: Development and validation of two multiresidue liquid chromatography tandem mass spectrometry methods based on a versatile extraction procedure for isolating non-steroidal anti-inflammatory drugs from bovine milk and muscle tissue. PubMed: Food and Chemical Toxicology, 2010, Association of phenylbutazone usage in horses bought for slaughter: a public health risk. PubMed: Development and validation of a confirmatory method for the determination of 12 non steroidal anti-inflammatory drugs in milk using liquid chromatography-tandem mass spectrometry. PubMed: Quantification of anthelmintic drug residues in milk and muscle tissues by liquid chromatography coupled to Orbitrap and liquid chromatography coupled to tandem mass spectrometry. PubMed: Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry. PubMed: Surveillance study of novobiocin and phenylbutazone residues in raw bovine milk using liquid chromatography-tandem mass spectrometry. PubMed: Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. PubMed: Association of phenylbutazone usage with horses bought for slaughter: a public health risk. PubMed: A survey on two years of medication regulation in horse races in Iran. PubMed: Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses. PubMed: Interaction of polyphenolic metabolites with human serum albumin: a circular dichroism study. PubMed: Determination of ibuprofen, ketoprofen, diclofenac and phenylbutazone in bovine milk by gas chromatography-tandem mass spectrometry. PubMed: An update on nonsteroidal anti-inflammatory drugs (NSAIDs) in small animals. PubMed: Extralabel use of nonsteroidal anti-inflammatory drugs in cattle. PubMed: Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry. PubMed: Surveillance for selected bacterial and toxicologic contaminants in donated carcass meat fed to carnivores. PubMed: Use of accelerating solvent extraction for detecting non-steroidal anti-inflammatory drugs in horse feces. PubMed: Left otitis media/interna and right maxillary sinusitis in a Percheron mare. PubMed: Comparison of the effect of Sporobolus virginicus and Rhodes (Chloris gayana) hay diets on the absorption pattern of phenylbutazone in the camel (Camelus dromedarius). PubMed: Multi-residue liquid chromatography/tandem mass spectrometry method for the detection of non-steroidal anti-inflammatory drugs in bovine muscle: optimisation of ion trap parameters. PubMed: Ornithine transcarbamylase deficiency: a urea cycle defect. PubMed: Preliminary studies of offspring exposure to phenylbutazone and ivermectin during the perinatal period in a Holstein cow-calf model. PubMed: Pharmacokinetics of phenylbutazone in beef steers. PubMed: Late diagnosis of ornithine transcarbamylase defect in three related female patients: polymorphic presentations. PubMed: Determination of non-protein bound phenylbutazone in bovine plasma using ultrafiltration and liquid chromatography with ultraviolet detection. PubMed: Pharmacokinetics of phenylbutazone in plasma and milk of lactating dairy cows. PubMed: Ancillary therapy of bovine respiratory disease. PubMed: Extralabel use of nonsteroidal anti-inflammatory drugs. PubMed: Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. PubMed: Determination of phenylbutazone residues in bovine milk by liquid chromatography with UV detection. PubMed: [The concentration changes of different phenylbutazone formulations in horse plasma]. PubMed: Interactions of warfarin with drugs and food. PubMed: Norplant: a welcome new contraceptive. PubMed: Subdermal contraceptive implants in nurse-midwifery practice. PubMed: Use of nonsteroidal anti-inflammatory drugs in food animal practice. PubMed: Contact sensitivity to pyrazinobutazone (Carudol) with positive oral provocation test. PubMed: Chemicals and drugs as triggers of food-associated disorder. PubMed: Experimental renal papillary necrosis in the Syrian hamster. PubMed: Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals. PubMed: [The pathogenetic significance of prostaglandins in food poisoning and therapy questions]. PubMed: Effects of anti-inflammatory analgesic drugs and muscarinic receptor blocking agents on appetite in the pig. PubMed: Metabolism, excretion, pharmacokinetics and tissue residues of phenylbutazone in the horse. PubMed: Risks and indications of phenylbutazone: another look. PubMed: Lack of effect of non-steroid antiinflammatory drugs on lithium clearance and on delivery of tubular fluid to the loop of Henle in rats. PubMed: Absorption and pharmacokinetics of phenylbutazone in Welsh Mountain ponies. PubMed: Genetic and histological aspects of stomach lesions induced by systemic injection of phenylbutazone in the rat. PubMed: Interactions of analgesics with other drugs. PubMed: The effect of food on the absorption of phenylbutazone from a commercial 100 mg enteric-coated tablet. PubMed: Effect of Tomanol on the pharmacokinetics and tissue distribution of penicillin G in dairy cows. PubMed: Chemically induced leukemia in humans. PubMed: Therapeutic implications of drug interactions with acetaminophen and aspirin. PubMed: Evidence for in vitro and in vivo interaction between ochratoxin A and three acidic drugs. PubMed: Research review. Interactions between environmental chemicals and drug biotransformation in man. PubMed: [Induction of cleft palate in ball mice: the comparative effect of 5-fluorouracil, phenylbutazone and water and food deprivation (author's transl)]. PubMed: Discriminative stimulus properties of analgesic drugs: narcotic versus non-narcotic analgesics. PubMed: Further studies on self-administration of antipyretic analgesics and combination of antipyretic analgesics with codeine in rhesus monkeys. PubMed: Effects of benzoquinolizine homologues on proliferative and exudative inflammation. PubMed: Indomethacin-induced intestinal lesions in the rat. PubMed: Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. II. Toxicological and general pharmacological properties. PubMed: More about isonicotinic acid hydrazide toxicity. PubMed: The biopharmaceutical properties of solid dosage forms. I. An evaluation of 23 brands of phenylbutazone tablets.