piperonyl butoxide

1,3-benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-

CAS: 51-03-6 C19 H30 O5 MW: 338.44410000

Identification

Namepiperonyl butoxide
CAS Number51-03-6
EINECS200-076-7
FDA UNIILWK91TU9AH
Molecular FormulaC19 H30 O5
Molecular Weight338.44410000
MDL NumberMFCD00005842
Nikkaji NumberJ25.378B
Beilstein0288063

Regulatory

FDA Mainterm (IAUFC)51-03-6 ; PIPERONYL BUTOXIDE

Physical Properties

Appearance pale yellow to light brown liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.05900 @ 25.00 °C.
Refractive Index 1.49800 @ 20.00 °C.
Boiling Point 396.17 °C. @ 760.00 mm Hg (est)
Vapor Pressure 5.200000 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 4.750
Soluble in water, 14.3 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin protecting agents

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-dog LD50 7500 uL/kg
Dermal Toxicityskin-rabbit LD50 200 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for piperonyl butoxide usage levels up tonot for fragrance use.
Recommendation for piperonyl butoxide flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl- 1,3- benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl- 1,3- benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl- butacide butoxide, piperonyl 2-(2- butoxyethoxy) ethyl 6-propyl piperonyl ether 2-(2- butoxyethoxy)-1-[(6-propyl(2H-benzo[d]1,3-dioxolen-5-yl))methoxy]ethane 5-((2-(2- butoxyethoxy)ethoxy)methyl)-6-propyl-1,3-benzodioxole 5-((2-(2- butoxyethoxy)ethoxy)methyl)-6-propylbenzo[d][1,3]dioxole 5-[[2-(2- butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole 5-{[2-(2- butoxyethoxy)ethoxy]methyl}-6-propyl-1,3-benzodioxol 5-{[2-(2- butoxyethoxy)ethoxy]methyl}-6-propyl-1,3-benzodioxole 5-(2-(2- butoxyethoxy)ethoxymethyl)-6-propyl-1,3-benzodioxole 5-[2-(2- butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole 2-(2- butoxyethoxy)ethyl (6-propylpiperonyl) ether 2-(2- butoxyethoxy)ethyl 6-propylpiperonyl ether butyl carbitol 6-propylpiperonyl ether butylcarbityl (6-propylpiperonyl) ether butylcarbityl)(6-propylpiperonyl)ether 5-{[(2-{[2-( butyloxy)ethyl]oxy}ethyl)oxy]methyl}-6-propyl-1,3-benzodioxole heliotropin butoxide heliotropyl butoxide 4,5- methylenedioxy-2-propylbenzyldiethyleneglycol butyl ether 3,4- methylenedioxy-6-propylbenzyl N-butyl diethylene glycol ether 3,4- methylenedioxy-6-propylbenzyl N-butyl diethyleneglycol ether 3,4- methylenedioxy-6-propylbenzyl N-butyldiethyleneglycol ether [3,4-( methylenedioxy)-6-propylbenzyl] butyl diethyleneglycol ether piperonal butoxide 5- propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxole 6- propylpiperonyl butyl diethylene glycol ether 6-( propylpiperonyl)-butyl carbityl ether 6-( propylpiperonyl)butylcarbityl ether PubMed: QuEChERS approach for the determination of biopesticides in organic and nonorganic vegetables and fruits by ultra-performance liquid chromatography/tandem mass spectrometry. PubMed: Determination of multi-class pesticide residue in dietary supplements from grape seed extracts by ultra-high-performance liquid chromatography coupled to triple quadrupole mass spectrometry. PubMed: Effects of prior oral exposure to combinations of environmental immunosuppressive agents on ovalbumin allergen-induced allergic airway inflammation in Balb/c mice. PubMed: Effects of pyperonyl butoxide on the female reproductive tract in rats. PubMed: Effects of short-term oral combined exposure to environmental immunotoxic chemicals in mice. PubMed: The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. PubMed: Behavior of pesticides in coffee beans during the roasting process. PubMed: The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. PubMed: Antifeedant activity of Jatropha gossypifolia and Melia azedarach senescent leaf extracts on Spodoptera frugiperda (Lepidoptera: Noctuidae) and their potential use as synergists. PubMed: Distribution and mechanism of α-amanitin tolerance in mycophagous Drosophila (Diptera: Drosophilidae). PubMed: Lipid peroxidation, oxidative stress and acetylcholinesterase in rat brain exposed to organophosphate and pyrethroid insecticides. PubMed: Metabolism of a fungicide mepanipyrim by soil fungus Cunninghamella elegans ATCC36112. PubMed: Laboratory evaluation of verbutin as a synergist of acaricides against larvae of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). PubMed: Insecticide resistance of Culex pipiens (L.) populations (Diptera: Culicidae) from Riyadh city, Saudi Arabia: Status and overcome. PubMed: HPLC assay for characterizing alpha-cyano-3-phenoxybenzyl pyrethroids hydrolytic metabolism by Helicoverpa armigera (Hubner) based on the quantitative analysis of 3-phenoxybenzoic acid. PubMed: Metabolism of methoxychlor by Cunninghamella elegans ATCC36112. PubMed: Human exposure to insecticide products containing pyrethrins and piperonyl butoxide (2001-2003). PubMed: Transfer of fat-soluble pesticides from contaminated feed to poultry tissues and eggs. PubMed: Aldrin epoxidation and dihydroisodrin hydroxylation as probes of in vivo and in vitro oxidative metabolic capability of some caterpillars. PubMed: Inhibition of carbamate-insensitive acetylcholinesterase by piperonyl butoxide in Helicoverpa armigera. PubMed: Dietary transfer of fluoranthene from an estuarine oligochaete (Monopylephorus rubroniveus) to grass shrimp (Palaemonetes pugio): Influence of piperonyl butoxide. PubMed: Quantitative determination of pyrethroids, pyrethrins, and piperonyl butoxide in surface water by high-resolution gas chromatography/high-resolution mass spectrometry. PubMed: Liquid chromatographic determination of N-methyl carbamate pesticide residues at low parts-per-billion levels in eggs. PubMed: Monocyclic carotenoid biosynthetic pathway in the yeast Phaffia rhodozyma (Xanthophyllomyces dendrorhous). PubMed: Benzodioxole derivatives as negative effectors of plant proteases. PubMed: Effects of single and repeated exposure to biocidal active substances on the barrier function of the skin in vitro. PubMed: Residues and half-life times of pyrethrins on peaches after field treatments. PubMed: Multiresidue method for N-methyl carbamates and metabolite pesticide residues at the parts-per-billion level in selected representative commodities of fruit and vegetable crop groups. PubMed: Residues and half-lives of pyrethrins on field-grown pepper and tomato. PubMed: Detection and characterization of amitraz resistance in the southern cattle tick, Boophilus microplus (Acari: Ixodidae). PubMed: Phenylpyrazole insecticide photochemistry, metabolism, and GABAergic action: ethiprole compared with fipronil. PubMed: Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens. PubMed: Reproductive and neurobehavioural effects of piperonyl butoxide administered to mice in the diet. PubMed: Characterization of resistance to clofentezine in populations of European red mite from orchards in Ontario. PubMed: Efficacy of ethiprole applied alone and in combination with conventional insecticides for protection of stored wheat and stored corn. PubMed: Impact of an insecticide resistance strategy for house fly (Diptera: Muscidae) control in intensive animal units in the United Kingdom. PubMed: Fenbendazole pharmacokinetics, metabolism, and potentiation in horses. PubMed: Selective insect antifeedant and toxic action of ryanoid diterpenes. PubMed: Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione. PubMed: Aspects of extraction, spiking and distribution in the determination of incurred residues of chloramphenicol in animal tissues. PubMed: Morphometric and immunohistochemical studies on atrophic changes in lympho-hematopoietic organs of rats treated with piperonyl butoxide or subjected to dietary restriction. PubMed: Adult specific expression and induction of cytochrome P450lpr in house flies. PubMed: Piperonyl butoxide mutagenicity in human RSa cells. PubMed: Styrene-induced hepatotoxicity in mice depleted of glutathione. PubMed: p-Dichlorobenzene-induced hepatotoxicity in mice depleted of glutathione by treatment with buthionine sulfoximine. PubMed: Human in vivo percutaneous absorption of pyrethrin and piperonyl butoxide. PubMed: Cleavage of 3-phenoxybenzoic acid by chicken microsomal preparations. PubMed: Acute renal toxicity of thiabendazole (TBZ) in ICR mice. PubMed: Reproductive and neurobehavioural effects in three-generation toxicity study of piperonyl butoxide administered to mice. PubMed: Effects of ultra-low volume and thermal fog malathion, Scourge and naled applied against caged adult Culicoides furens and Culex quinquefasciatus in open and vegetated terrain. PubMed: Nephrotoxicity of thiazoles structurally related to thiabendazole in mice depleted of glutathione by treatment with buthionine sulfoximine. PubMed: Effects of piperonyl butoxide on F1 generation mice. PubMed: Effects of reserpine and L-cysteine and glutathione depletion on 2-bromoethylamine hydrobromide-induced tubular necrosis in Swiss ICR mice. PubMed: Interactions of carbaryl with susceptible and multiresistant house flies (Diptera: Muscidae). PubMed: Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. PubMed: Defense of parsnip webworm against phototoxic furanocoumarins: Role of antioxidant enzymes. PubMed: Nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with DL-buthionine sulphoximine. PubMed: Effects of bioactivation inhibitors on covalent binding of 2-AAF to rat liver DNA in vivo and on hepatocytes cultures. PubMed: Effects of drug metabolism modifiers on pulegone-induced hepatotoxicity in mice. PubMed: Insecticide residues in cattle treated with a cypermethrin, chlorpyrifos, piperonyl butoxide-impregnated ear tag. PubMed: Lack of evidence of carcinogenicity of technical-grade piperonyl butoxide in F344 rats: selective induction of ileocaecal ulcers. PubMed: Teratogenic evaluation of piperonyl butoxide in the rat. PubMed: The Environmental fate of three carcinogens: benzo-(alpha)-pyrene, benzidine, and vinyl chloride evaluated in laboratory model ecosystems. PubMed: Carbaryl penetration into and metabolism by alfalfa leafcutting bees, Megachile pacifica. PubMed: In vitro metabolism of (14C)photodieldrin by microsomal mixed-function oxidase of mouse, rat, and house flies. PubMed: Selective toxicity of N-substituted biscarbamoyl sulfides. PubMed: Selective toxicity of N-sulfenylated derivatives of insecticidal methylcarbamate esters. PubMed: Structure-activity correlations in dDT analogs. PubMed: A chromatographic-colorimetric method for determining low residues of piperonyl butoxide in flour.