glycofurol
ethylene oxide homopolymer 2-tetrahydrofuranylmethyl ether
Identification
| Name | glycofurol |
| FDA UNII | Search |
| Molecular Formula | C7 H14 O3 |
| Molecular Weight | 1692.00000000 |
| MDL Number | MFCD00801146 |
| Nikkaji Number | J218.084G |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.06900 @ 25.00 °C. |
| Refractive Index | 1.46200 @ 20.00 °C. |
| Boiling Point | 256.00 to 257.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.002000 mmHg @ 25.00 °C. (est) |
| Flash Point | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w) | 5.997 (est) |
| Soluble in | water, 5.436e+005 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | solvents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-mouse LD50 3500 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nCARDIAC: OTHER CHANGES', 'CARDIAC: OTHER CHANGES\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']
Safety in Use
| Category | viscosity controlling agents |
| Recommendation for glycofurol usage levels up to | not for fragrance use. |
| Recommendation for glycofurol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ethanol, 2-[(tetrahydro-2-furanyl)methoxy]-
ethylene oxide homopolymer 2-tetrahydrofuranylmethyl ether
glycofural
glycofurol 75
glycofurolum 75
glycols, polyethylene, mono(tetrahydrofurfuryl) ether
2-(oxo
lan-2-ylmethoxy)ethanol
poly(ethylene glycol) tetrahydrofurfuryl ether
polyethylene glycol tetrahydrofurfuryl ether
2-(
tetrahydro-2-furanylmethoxy)-1-ethanol
2-(
tetrahydrofuran-2-ylmethoxy)ethanol
tetrahydrofurfuryl alcohol polyethylene glycol ether
tetrahydrofurfuryl ethoxylate
2-((
tetrahydrofurfuryl)oxy)ethanol
2-[(
tetrahydrofurfuryl)oxy]ethanol
THFP
PubMed:
Pharmacokinetics of a self-microemulsifying drug delivery system of tacrolimus.
PubMed:
Optimized formulation of solid self-microemulsifying sirolimus delivery systems.
PubMed:
Oral insulin delivery in rats by nanoparticles prepared with non-toxic solvents.
PubMed:
Preparation of polymeric particles in CO(2) medium using non-toxic solvents: formulation and comparisons with a phase separation method.
PubMed:
Preparation and biocompatibility study of in situ forming polymer implants in rat brains.
PubMed:
Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide.
PubMed:
Biocompatibility study of glycofurol in rat brains.
PubMed:
Microsphere preparation using the untoxic solvent glycofurol.
PubMed:
Evaluation of glycofurol-based gel as a new vehicle for topical application of naproxen.
PubMed:
Solubility enhancement of hydrophobic compounds by cosolvents: role of solute hydrophobicity on the solubilization effect.
PubMed:
Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates.
PubMed:
Green fluorescent protein: structure, folding and chromophore maturation.
PubMed:
Bioavailability and tolerability of intranasal diazepam in healthy adult volunteers.
PubMed:
Photoregulation of ion permeation through a polyelectrolyte multilayer membrane by manipulating the chromophore orientation.
PubMed:
Development and characterization of self-microemulsifying drug delivery system of tacrolimus for intravenous administration.
PubMed:
Physicochemical studies of a newly synthesized molecule, 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione (JSH18) for topical formulations.
PubMed:
The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils.
PubMed:
Mutant screen distinguishes between residues necessary for light-signal perception and signal transfer by phytochrome B.
PubMed:
Reversible protein precipitation to ensure stability during encapsulation within PLGA microspheres.
PubMed:
Cardiovascular effects of selected water-miscible solvents for pharmaceutical injections and embolization materials: a comparative hemodynamic study using a sheep model.
PubMed:
Organic solvents as vehicles for precipitating liquid embolics: a comparative angiotoxicity study with superselective injections of swine rete mirabile.
PubMed:
The effect of commonly used vehicles on canine hematology and clinical chemistry values.
PubMed:
Enhanced permeation of diazepam through artificial membranes from supersaturated solutions.
PubMed:
Acrylic polymers as thickening agents for tetraglycol cosolvent.
PubMed:
Peripheral neuropathy: a persisting challenge in paclitaxel-based regimes.
PubMed:
A green light-absorbing phycoerythrin is present in the high-light-adapted marine cyanobacterium Prochlorococcus sp. MED4.
PubMed:
Crystal structures and mutational analysis of amFP486, a cyan fluorescent protein from Anemonia majano.
PubMed:
Preparation of PLGA microparticles by an emulsion-extraction process using glycofurol as polymer solvent.
PubMed:
Bioavailabilities of rectal and oral methadone in healthy subjects.
PubMed:
[Study on the auxochrome of the electronic spectrum of organic compounds and its effect mechanism (II)].
PubMed:
Solubilization of the lichen metabolite (+)-usnic acid for testing in tissue culture.
PubMed:
Nasal bioavailability of peptide T in rabbits: absorption enhancement by sodium glycocholate and glycofurol.
PubMed:
Solubilization and stability of bumetanide in vehicles for intranasal administration, a pilot study.
PubMed:
Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.
PubMed:
Organic solvents for pharmaceutical parenterals and embolic liquids: a review of toxicity data.
PubMed:
Intranasal administration of different liquid formulations of bumetanide to rabbits.
PubMed:
Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins.
PubMed:
Development and evaluation of microbicidal hydrogels containing monoglyceride as the active ingredient.
PubMed:
Single- and repeated-dose local toxicity in the nasal cavity of rabbits after intranasal administration of different glycols for formulations containing benzodiazepines.
PubMed:
Solubilization of various benzodiazepines for intranasal administration, a pilot study.
PubMed:
Pharmacokinetic and pharmacodynamic response after intranasal administration of diazepam to rabbits.
PubMed:
Intravenous carbamazepine: comparison of different parenteral formulations in a mouse model of convulsive status epilepticus.
PubMed:
Evaluation of local toxicity after repeated intranasal vaccination of guinea-pigs.
PubMed:
New injectable aqueous carbamazepine solution through complexing with 2-hydroxypropyl-beta-cyclodextrin: tolerability and pharmacokinetics after intravenous injection in comparison to a glycofurol-based formulation.
PubMed:
The effect of progesterone and its metabolite 5 alpha-pregnan-3 alpha-ol-20-one on focal epileptic seizures in the cat's visual cortex in vivo.
PubMed:
Selective 5-lipoxygenase inhibitor BW A4C does not influence progression of tissue injury in a canine model of regional myocardial ischaemia and reperfusion.
PubMed:
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. I. The influence of administration vehicles.
PubMed:
A new injectable carbamazepine solution--antiepileptic effects and pharmaceutical properties.
PubMed:
Advances in the use of computerized gas chromatography-mass spectrometry and high-performance liquid chromatography with rapid scanning detection for clinical diagnosis.
PubMed:
Topical application of penetration enhancers to the skin of nude mice: a histopathological study.
PubMed:
Plasma and tissue concentrations of coenzyme Q10 in the rat after intravenous administration by a microsphere delivery system or in a new type of solution.
PubMed:
Disposition of intravenous glycofurol: effect of hepatic cirrhosis.
PubMed:
[Local tolerance for co-trimoxazole i. m.. Comparison with an intramuscularly administered penicillin combination].
PubMed:
The induction of immunologic tolerance in guinea pigs infused with dimethylbenz(a)anthracene.
PubMed:
Mechanisms in the potentiation and inhibition of pharmacological actions of hexobarbital and zoxazolamine by glycofurol.
PubMed:
[A new injectable solvent (glycofurol)].