precocene I
2H-1-benzopyran, 7-methoxy-2,2-dimethyl-
Identification
| Name | precocene I |
| CAS Number | 17598-02-6 |
| EINECS | 241-566-0 |
| FDA UNII | 25HLF91DGR |
| Molecular Formula | C12 H14 O2 |
| Molecular Weight | 190.24198000 |
| MDL Number | MFCD00006818 |
| Nikkaji Number | J4.080K |
| Beilstein | 0133917 |
| XlogP3 | 3.30 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.05200 @ 25.00 °C. |
| Refractive Index | 1.56000 @ 20.00 °C. |
| Boiling Point | 292.74 °C. @ 760.00 mm Hg (est) |
| Flash Point | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w) | 3.350 |
| Soluble in | water, 67.52 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for precocene I usage levels up to | not for fragrance use. |
| Recommendation for precocene I flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
2H-1-
benzopyran, 2,2-dimethyl-7-methoxy-
2H-1-
benzopyran, 7-methoxy-2,2-dimethyl-
demethoxyageratochromene
6-
demethoxyageratochromene
2,2-
dimethyl-2H-chromen-7-yl methyl ether
2,2-
dimethyl-7-methoxy-2H-1-benzopyran
7-
methoxy-2,2-dimethyl chromene
7-
methoxy-2,2-dimethyl-2H-1-benzopyran
7-
methoxy-2,2-dimethyl-2H-chromen
7-
methoxy-2,2-dimethyl-2H-chromene
7-
methoxy-2,2-dimethyl-3-chromene
7-
methoxy-2,2-dimethylchromene
PubMed:
Ecocatalysis for 2H-chromenes synthesis: an integrated approach for phytomanagement of polluted ecosystems.
PubMed:
Precocene-I inhibits juvenile hormone biosynthesis, ovarian activation, aggression and alters sterility signal production in bumble bee (Bombus terrestris) workers.
PubMed:
Potential of essential oils for protection of grains contaminated by aflatoxin produced by Aspergillus flavus.
PubMed:
Early manipulation of juvenile hormone has sexually dimorphic effects on mature adult behavior in Drosophila melanogaster.
PubMed:
Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.
PubMed:
Volatile oils from the plant and hairy root cultures of Ageratum conyzoides L.
PubMed:
Schistosomicidal activity of the essential oil of Ageratum conyzoides L. (Asteraceae) against adult Schistosoma mansoni worms.
PubMed:
Chemical composition and antibacterial activity of essential oils of Lantana camara, Ageratum houstonianum and Eupatorium adenophorum.
PubMed:
Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus.
PubMed:
New synthetic precocenoids as potential insect control agents.
PubMed:
Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum.
PubMed:
Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
PubMed:
Photochromic agents as tools for protein structure study: lapachenole is a photoaffinity ligand of cytochrome P450 3A4.
PubMed:
Toxicological efficacy of some indigenous dill compounds against the flesh fly, Parasarcophaga dux Thomson.
PubMed:
[Effect of plants synthesizing biologically active substances-precocenes on insects].
PubMed:
Synthesis of new heterocycles through a cation-driven tandem ring-enlargement-annulation reaction.
PubMed:
Analysis of precocenes in the essential oil of Ageratum spp. by reverse-phase high-performance liquid chromatography.
PubMed:
An ion exchange liquid chromatography/mass spectrometry method for the determination of reduced and oxidized glutathione and glutathione conjugates in hepatocytes.
PubMed:
Role of juvenile hormone in the synthesis and sequestration of vitellogenins in the red cotton stainer, Dysdercus koenigii (Heteroptera: Pyrrhocoridae).
PubMed:
[The effect of antihormones on the susceptibility of Anopheles sacharovi Favre. mosquitoes to the causative agent of malaria Plasmodium gallinaceum Brumpt].
PubMed:
Cloning of the cDNA encoding Scg-SPRP, an unusual Ser-protease-related protein from vitellogenic female desert locusts (Schistocerca gregaria).
PubMed:
Cloning of two cDNAs encoding three small serine protease inhibiting peptides from the desert locust Schistocerca gregaria and analysis of tissue-dependent and stage-dependent expression.
PubMed:
Structural requirements for the direct and cytochrome P450-dependent reaction of cyclic alpha,beta-unsaturated carbonyl compounds with glutathione: a study with coumarin and related compounds.
PubMed:
Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes.
PubMed:
Effects of precocenes on vitellogenesis in the adult female tick, Ornithodoros moubata (Acari: Argasidae).
PubMed:
Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures.
PubMed:
Effects of proallatotoxins (precocenes) on the development and reproduction of Rhodnius prolixus: some data.
PubMed:
Precocene I and Other Constituents of the Essential Oil of Platostoma africanum.
PubMed:
Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). II. Competitions with a juvenile hormone analog (Methoprene).
PubMed:
Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). I. Structure/activity relations.
PubMed:
The antiallatal effects on locusts and lethal effects on nematodes of synthetic precocene-1 derivatives differing at the carbon 7 position.
PubMed:
Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice.
PubMed:
Hepatotoxicity of precocene I in rats. Role of metabolic activation in vivo.
PubMed:
Effects of precocenes on ovarian development of the seed bug, Oxycarenus lavaterae (F.).
PubMed:
Metabolism and hepatotoxicity of the naturally occurring benzo[b]pyran precocene I.
PubMed:
The absolute configuration of precocene I dihydrodiols produced by metabolism of precocene I by corpora allata of Locusta migratoria, in vitro.
PubMed:
[Action of development inhibitors on Aedes aegypti L. mosquitoes and Rhodnius prolixus Stal. bugs. IV. The activity of precocenes].
PubMed:
Activity of precocenes on the Chagas's disease vector, Panstrongylus megistus.