precocene II

2H-1-benzopyran, 6,7-dimethoxy-2,2-dimethyl-

CAS: 644-06-4 C13 H16 O3 MW: 220.26812000

Identification

Nameprecocene II
CAS Number644-06-4
EINECS211-408-5
FDA UNII1W2R4TRY5H
Molecular FormulaC13 H16 O3
Molecular Weight220.26812000
MDL NumberMFCD00006816
Nikkaji NumberJ5.187J
Beilstein0160683
XlogP33.30 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 300.40 °C. @ 760.00 mm Hg (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 3.380 (est)
Soluble in water, 52.04 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for precocene II usage levels up tonot for fragrance use.
Recommendation for precocene II flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

ageratochromene 2H-1- benzopyran, 6,7-dimethoxy-2,2-dimethyl- 6,7- dimethoxy-2,2-dimethyl-2H-benzo(b)pyran 6,7- dimethoxy-2,2-dimethyl-2H-chromene 6,7- dimethoxy-2,2-dimethylchromene precocen 2 precocene 2 preconene II pricocene II PubMed: Volatile composition and sensory properties of Indian herbal medicine-Pavonia odorata-used in Ayurveda. PubMed: Correlation of ATP citrate lyase and acetyl CoA levels with trichothecene production in Fusarium graminearum. PubMed: [Antijuvenile influence of the precocene on the development of adult antennae in the apple surface eating tortricid Archips podana Scop. (Lepidoptera: Tortricidae)]. PubMed: [Analyze on chemical compositions of Dalbergia odorifera essential oils extracted by CO2-supercritical-fluid-extraction and steam distillation extraction]. PubMed: A new chromene isolated from Ageratum conyzoides. PubMed: Sensitivity of last larval stadium of Chrysomya megacephala (Fabricius) to anti-allatin ageratochromene Precocene II. PubMed: Volatile oils from the plant and hairy root cultures of Ageratum conyzoides L. PubMed: Acaricidal properties of the essential oil and precocene II obtained from Calea serrata (Asteraceae) on the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). PubMed: Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. PubMed: Composition of essential oils in subterranean organs of three species of Valeriana L. PubMed: Chemical composition and antibacterial activity of essential oils of Lantana camara, Ageratum houstonianum and Eupatorium adenophorum. PubMed: Changes in the corpora allata and epidermal proliferation along the fourth instar of the Chagas disease vector Triatoma infestans. PubMed: Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus. PubMed: New synthetic precocenoids as potential insect control agents. PubMed: Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum. PubMed: [Influence of precocene II on the sensory system of antennae and mouthparts in larvae of the fruit tree tortricid Archips podana Scop. (Lepidoptera: Tortricidae)]. PubMed: Comparison of radioimmunoassay and liquid chromatography tandem mass spectrometry for determination of juvenile hormone titers. PubMed: Multigeneration effects of insect growth regulators on the springtail Folsomia candida. PubMed: The pupal specifier broad directs progressive morphogenesis in a direct-developing insect. PubMed: Volatile allelochemicals in the Ageratum conyzoides intercropped citrus orchard and their effects on mites Amblyseius newsami and Panonychus citri. PubMed: Effects of insect growth regulators on the nontarget soil arthropod Folsomia candida (Collembola). PubMed: Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety. PubMed: Effect of precocene II on fatty acid metabolism in the pea aphid, Acyrthosiphon pisum, under cold stress. PubMed: Effect of precocene on development of ovarian follicles in flesh fly, Sarcophaga ruficornis F. PubMed: [Effect of plants synthesizing biologically active substances-precocenes on insects]. PubMed: Juvenile hormone regulates the expression of the gene encoding ceratotoxin a, an antibacterial peptide from the female reproductive accessory glands of the medfly Ceratitis capitata. PubMed: Sensitive periods for wing development and precocious metamorphosis after precocene treatment of the brown planthopper, Nilaparvata lugens. PubMed: Identification and action of juvenile hormone III from sexually mature alate females of the red imported fire ant, Solenopsis invicta. PubMed: Efficacy of BaySir-8514 and precocene II against the grey flesh fly Parasarcophaga dux (Thomson) (Diptera: Sarcophagidae). PubMed: Perturbed turnover of microtubule-based nutritive tubes in ovarioles of virgin and precocene-treated Dysdercus fasciatus. PubMed: Analysis of precocenes in the essential oil of Ageratum spp. by reverse-phase high-performance liquid chromatography. PubMed: Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. PubMed: Lack of Effect of Medium Supplementation With Pyruvate and Hormones on Cytochrome P450-mediated Activity of Rat Hepatocytes in Primary Culture. PubMed: A Preliminary Comparison of LiverBeads™ with a Conventional Rat Hepatocyte Culture Preparation: Some Aspects of Xenobiotic Metabolism and Related Toxicity. PubMed: Involvement of cytochrome P4502E1 in the toxicity of dichloropropanol to rat hepatocyte cultures. PubMed: Effects of culture duration, cytochrome P-450 inhibition and glutathione depletion on toxicity of diverse xenobiotics. PubMed: Mechanism of toxicity of precocene II in rat hepatocyte cultures. PubMed: Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time. PubMed: Maintenance of xenobiotic metabolism and toxicity in rat hepatocyte cultures after cell preservation at 4 degrees. PubMed: Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes. PubMed: Effects of precocenes on vitellogenesis in the adult female tick, Ornithodoros moubata (Acari: Argasidae). PubMed: Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures. PubMed: [Variations induced by juvenile hormone and precocene II in the metabolic rate of 3 species of insects]. PubMed: The use of hepatocytes cultured from inducer-treated rats in the detection of cytochrome P-450-mediated cytotoxicity. PubMed: Effects of proallatotoxins (precocenes) on the development and reproduction of Rhodnius prolixus: some data. PubMed: Role of corpus allatum on the modulation of feeding rhythm in the semilooper caterpillar, Achaea janata (L). PubMed: [Effects of juvenile hormone and precocene II on the metabolic rate of the digestive system, fat body and ovaries of the insect Oncopeltus fasciatus]. PubMed: Distribution and pharmacokinetics of precocene-II in the tick Ornithodoros parkeri (Acari: Argasidae). PubMed: Genotoxicity of the anti-juvenile hormone agent precocene II as revealed by the Drosophila wing spot test. PubMed: Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). II. Competitions with a juvenile hormone analog (Methoprene). PubMed: Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). I. Structure/activity relations. PubMed: Purification and characterization of a soybean flour-induced cytochrome P-450 from Streptomyces griseus. PubMed: Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels. PubMed: Xenobiotic oxidation by cytochrome P-450-enriched extracts of Streptomyces griseus. PubMed: Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity. PubMed: Microbial transformation of precocene II: oxidative reactions by Streptomyces griseus. PubMed: Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice. PubMed: Secretory activity and endocrine regulation of male accessory glands in the blood-sucking bug Panstrongylus megistus (Hemiptera: Reduviidae). PubMed: Effects of precocene and azadirachtin in Rhodnius prolixus: some data on development and reproduction. PubMed: Effects of precocenes on ovarian development of the seed bug, Oxycarenus lavaterae (F.). PubMed: The effects of precocene treatment on egg wax production in Gené's organ and egg viability in the cattle tick Boophilus microplus (Acarina Ixodidae): an ultrastructural study. PubMed: [Biomorphogenetic changes caused by the application of precocene II in nymphs of Triatoma infestans (Klug, 1834) (Hemiptera, Reduviidae, Triatominae)]. PubMed: The effect of precocene II and 20-OH-ecdysone on Litomosoides carinii and Dipetalonema viteae in vivo. PubMed: Effects of the juvenile hormone antagonist precocene II and the moulting hormone 20-OH-ecdysone on Litomosoides carinii and Dipetalonema viteae in vitro. PubMed: Induction of DNA damage and repair synthesis in freshly isolated rat hepatocytes by the proallatocidin precocene II. PubMed: Effects of juvenile hormone analogue on ecdysis prevention induced by precocene in Rhodnius prolixus (Hemiptera:Reduviidae). PubMed: [Morphogenetic effects of precocene II on nymphs of Rhodnius prolixus (Stal, 1859) (Hemiptera-Triatominae)]. PubMed: High-performance liquid chromatographic methods designed for metabolic studies of the proallatocidin precocene II. PubMed: Toxicity of precocene-2 for the American dog tick, Dermacentor variabilis (acari: Ixodidae). PubMed: [Morphological changes induced by the use of precocene II in Panstrongylus megistus (Burmeister, 1835), (Hemiptera, Reduviidae, Triatominae)]. PubMed: Toxicological significance of dihydrodiol metabolites. PubMed: Precocene II nephrotoxicity in the rat. PubMed: The effects of precocene II on reproduction and development of triatomine bugs (Reduviidae: Triatominae). PubMed: Metabolic fate of the hepatotoxic anti-juvenile hormone precocene II in the rat. PubMed: Competition between juvenile hormone antagonist precocene II and juvenile hormone analog: methoprene in the nematode Caenorhabditis elegans. PubMed: Precocene-induced effects and possible role of juvenile hormone during embryogenesis of the milkweed bug Oncopeltus fasciatus. PubMed: Immediate and latent effects induced by the antiallatotropin precocene 2(P2) on embryonic Dermacentor variabilis (Say) (Acari: Ixodidae). PubMed: Hepatotoxicity of the anti-juvenile hormone precocene II and the generation of dihydrodiol metabolites. PubMed: Effects of ecdysone on the metamorphosis and ecdysis prevention induced by precocene II in Rhodnius prolixus. PubMed: [Action of development inhibitors on Aedes aegypti L. mosquitoes and Rhodnius prolixus Stal. bugs. IV. The activity of precocenes]. PubMed: Active vitellogenesis in precocene-treated Locusta migratoria. PubMed: Insecticidal effect of precocene II on the human body louse, Pediculus humanus. PubMed: Activity of precocenes on the Chagas's disease vector, Panstrongylus megistus. PubMed: Precocene-induced necrosis and haemocyte-mediated breakdown of corpora allata in nymps of the locust Locusta migratoria. PubMed: Distribution and metabolism of precocene II in the brown cockroach (Periplaneta brunnea Burmeister). PubMed: Effect of precocene II on the endocrine regulation of development and reproduction in the bug, Oncopeltus fasciatus. PubMed: Morphogenetic effects of precocene II on the immature stages of Rhodnius prolixus. PubMed: Radiosynthesis and metabolism of the insect antijuvenile hormone, precocene II. PubMed: Precocene II inhibits juvenile hormone biosynthesis by cockroach corpora allata in vitro.