precocene II
2H-1-benzopyran, 6,7-dimethoxy-2,2-dimethyl-
Identification
| Name | precocene II |
| CAS Number | 644-06-4 |
| EINECS | 211-408-5 |
| FDA UNII | 1W2R4TRY5H |
| Molecular Formula | C13 H16 O3 |
| Molecular Weight | 220.26812000 |
| MDL Number | MFCD00006816 |
| Nikkaji Number | J5.187J |
| Beilstein | 0160683 |
| XlogP3 | 3.30 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 300.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w) | 3.380 (est) |
| Soluble in | water, 52.04 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for precocene II usage levels up to | not for fragrance use. |
| Recommendation for precocene II flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ageratochromene
2H-1-
benzopyran, 6,7-dimethoxy-2,2-dimethyl-
6,7-
dimethoxy-2,2-dimethyl-2H-benzo(b)pyran
6,7-
dimethoxy-2,2-dimethyl-2H-chromene
6,7-
dimethoxy-2,2-dimethylchromene
precocen 2
precocene 2
preconene II
pricocene II
PubMed:
Volatile composition and sensory properties of Indian herbal medicine-Pavonia odorata-used in Ayurveda.
PubMed:
Correlation of ATP citrate lyase and acetyl CoA levels with trichothecene production in Fusarium graminearum.
PubMed:
[Antijuvenile influence of the precocene on the development of adult antennae in the apple surface eating tortricid Archips podana Scop. (Lepidoptera: Tortricidae)].
PubMed:
[Analyze on chemical compositions of Dalbergia odorifera essential oils extracted by CO2-supercritical-fluid-extraction and steam distillation extraction].
PubMed:
A new chromene isolated from Ageratum conyzoides.
PubMed:
Sensitivity of last larval stadium of Chrysomya megacephala (Fabricius) to anti-allatin ageratochromene Precocene II.
PubMed:
Volatile oils from the plant and hairy root cultures of Ageratum conyzoides L.
PubMed:
Acaricidal properties of the essential oil and precocene II obtained from Calea serrata (Asteraceae) on the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).
PubMed:
Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride.
PubMed:
Composition of essential oils in subterranean organs of three species of Valeriana L.
PubMed:
Chemical composition and antibacterial activity of essential oils of Lantana camara, Ageratum houstonianum and Eupatorium adenophorum.
PubMed:
Changes in the corpora allata and epidermal proliferation along the fourth instar of the Chagas disease vector Triatoma infestans.
PubMed:
Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus.
PubMed:
New synthetic precocenoids as potential insect control agents.
PubMed:
Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum.
PubMed:
[Influence of precocene II on the sensory system of antennae and mouthparts in larvae of the fruit tree tortricid Archips podana Scop. (Lepidoptera: Tortricidae)].
PubMed:
Comparison of radioimmunoassay and liquid chromatography tandem mass spectrometry for determination of juvenile hormone titers.
PubMed:
Multigeneration effects of insect growth regulators on the springtail Folsomia candida.
PubMed:
The pupal specifier broad directs progressive morphogenesis in a direct-developing insect.
PubMed:
Volatile allelochemicals in the Ageratum conyzoides intercropped citrus orchard and their effects on mites Amblyseius newsami and Panonychus citri.
PubMed:
Effects of insect growth regulators on the nontarget soil arthropod Folsomia candida (Collembola).
PubMed:
Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
PubMed:
Effect of precocene II on fatty acid metabolism in the pea aphid, Acyrthosiphon pisum, under cold stress.
PubMed:
Effect of precocene on development of ovarian follicles in flesh fly, Sarcophaga ruficornis F.
PubMed:
[Effect of plants synthesizing biologically active substances-precocenes on insects].
PubMed:
Juvenile hormone regulates the expression of the gene encoding ceratotoxin a, an antibacterial peptide from the female reproductive accessory glands of the medfly Ceratitis capitata.
PubMed:
Sensitive periods for wing development and precocious metamorphosis after precocene treatment of the brown planthopper, Nilaparvata lugens.
PubMed:
Identification and action of juvenile hormone III from sexually mature alate females of the red imported fire ant, Solenopsis invicta.
PubMed:
Efficacy of BaySir-8514 and precocene II against the grey flesh fly Parasarcophaga dux (Thomson) (Diptera: Sarcophagidae).
PubMed:
Perturbed turnover of microtubule-based nutritive tubes in ovarioles of virgin and precocene-treated Dysdercus fasciatus.
PubMed:
Analysis of precocenes in the essential oil of Ageratum spp. by reverse-phase high-performance liquid chromatography.
PubMed:
Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential.
PubMed:
Lack of Effect of Medium Supplementation With Pyruvate and Hormones on Cytochrome P450-mediated Activity of Rat Hepatocytes in Primary Culture.
PubMed:
A Preliminary Comparison of LiverBeads⢠with a Conventional Rat Hepatocyte Culture Preparation: Some Aspects of Xenobiotic Metabolism and Related Toxicity.
PubMed:
Involvement of cytochrome P4502E1 in the toxicity of dichloropropanol to rat hepatocyte cultures.
PubMed:
Effects of culture duration, cytochrome P-450 inhibition and glutathione depletion on toxicity of diverse xenobiotics.
PubMed:
Mechanism of toxicity of precocene II in rat hepatocyte cultures.
PubMed:
Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time.
PubMed:
Maintenance of xenobiotic metabolism and toxicity in rat hepatocyte cultures after cell preservation at 4 degrees.
PubMed:
Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes.
PubMed:
Effects of precocenes on vitellogenesis in the adult female tick, Ornithodoros moubata (Acari: Argasidae).
PubMed:
Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures.
PubMed:
[Variations induced by juvenile hormone and precocene II in the metabolic rate of 3 species of insects].
PubMed:
The use of hepatocytes cultured from inducer-treated rats in the detection of cytochrome P-450-mediated cytotoxicity.
PubMed:
Effects of proallatotoxins (precocenes) on the development and reproduction of Rhodnius prolixus: some data.
PubMed:
Role of corpus allatum on the modulation of feeding rhythm in the semilooper caterpillar, Achaea janata (L).
PubMed:
[Effects of juvenile hormone and precocene II on the metabolic rate of the digestive system, fat body and ovaries of the insect Oncopeltus fasciatus].
PubMed:
Distribution and pharmacokinetics of precocene-II in the tick Ornithodoros parkeri (Acari: Argasidae).
PubMed:
Genotoxicity of the anti-juvenile hormone agent precocene II as revealed by the Drosophila wing spot test.
PubMed:
Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). II. Competitions with a juvenile hormone analog (Methoprene).
PubMed:
Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). I. Structure/activity relations.
PubMed:
Purification and characterization of a soybean flour-induced cytochrome P-450 from Streptomyces griseus.
PubMed:
Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels.
PubMed:
Xenobiotic oxidation by cytochrome P-450-enriched extracts of Streptomyces griseus.
PubMed:
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
PubMed:
Microbial transformation of precocene II: oxidative reactions by Streptomyces griseus.
PubMed:
Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice.
PubMed:
Secretory activity and endocrine regulation of male accessory glands in the blood-sucking bug Panstrongylus megistus (Hemiptera: Reduviidae).
PubMed:
Effects of precocene and azadirachtin in Rhodnius prolixus: some data on development and reproduction.
PubMed:
Effects of precocenes on ovarian development of the seed bug, Oxycarenus lavaterae (F.).
PubMed:
The effects of precocene treatment on egg wax production in Gené's organ and egg viability in the cattle tick Boophilus microplus (Acarina Ixodidae): an ultrastructural study.
PubMed:
[Biomorphogenetic changes caused by the application of precocene II in nymphs of Triatoma infestans (Klug, 1834) (Hemiptera, Reduviidae, Triatominae)].
PubMed:
The effect of precocene II and 20-OH-ecdysone on Litomosoides carinii and Dipetalonema viteae in vivo.
PubMed:
Effects of the juvenile hormone antagonist precocene II and the moulting hormone 20-OH-ecdysone on Litomosoides carinii and Dipetalonema viteae in vitro.
PubMed:
Induction of DNA damage and repair synthesis in freshly isolated rat hepatocytes by the proallatocidin precocene II.
PubMed:
Effects of juvenile hormone analogue on ecdysis prevention induced by precocene in Rhodnius prolixus (Hemiptera:Reduviidae).
PubMed:
[Morphogenetic effects of precocene II on nymphs of Rhodnius prolixus (Stal, 1859) (Hemiptera-Triatominae)].
PubMed:
High-performance liquid chromatographic methods designed for metabolic studies of the proallatocidin precocene II.
PubMed:
Toxicity of precocene-2 for the American dog tick, Dermacentor variabilis (acari: Ixodidae).
PubMed:
[Morphological changes induced by the use of precocene II in Panstrongylus megistus (Burmeister, 1835), (Hemiptera, Reduviidae, Triatominae)].
PubMed:
Toxicological significance of dihydrodiol metabolites.
PubMed:
Precocene II nephrotoxicity in the rat.
PubMed:
The effects of precocene II on reproduction and development of triatomine bugs (Reduviidae: Triatominae).
PubMed:
Metabolic fate of the hepatotoxic anti-juvenile hormone precocene II in the rat.
PubMed:
Competition between juvenile hormone antagonist precocene II and juvenile hormone analog: methoprene in the nematode Caenorhabditis elegans.
PubMed:
Precocene-induced effects and possible role of juvenile hormone during embryogenesis of the milkweed bug Oncopeltus fasciatus.
PubMed:
Immediate and latent effects induced by the antiallatotropin precocene 2(P2) on embryonic Dermacentor variabilis (Say) (Acari: Ixodidae).
PubMed:
Hepatotoxicity of the anti-juvenile hormone precocene II and the generation of dihydrodiol metabolites.
PubMed:
Effects of ecdysone on the metamorphosis and ecdysis prevention induced by precocene II in Rhodnius prolixus.
PubMed:
[Action of development inhibitors on Aedes aegypti L. mosquitoes and Rhodnius prolixus Stal. bugs. IV. The activity of precocenes].
PubMed:
Active vitellogenesis in precocene-treated Locusta migratoria.
PubMed:
Insecticidal effect of precocene II on the human body louse, Pediculus humanus.
PubMed:
Activity of precocenes on the Chagas's disease vector, Panstrongylus megistus.
PubMed:
Precocene-induced necrosis and haemocyte-mediated breakdown of corpora allata in nymps of the locust Locusta migratoria.
PubMed:
Distribution and metabolism of precocene II in the brown cockroach (Periplaneta brunnea Burmeister).
PubMed:
Effect of precocene II on the endocrine regulation of development and reproduction in the bug, Oncopeltus fasciatus.
PubMed:
Morphogenetic effects of precocene II on the immature stages of Rhodnius prolixus.
PubMed:
Radiosynthesis and metabolism of the insect antijuvenile hormone, precocene II.
PubMed:
Precocene II inhibits juvenile hormone biosynthesis by cockroach corpora allata in vitro.