Identification

Namepropylene oxide
IUPAC2-methyloxirane
CAS Number75-56-9
EINECS200-879-2
FDA UNIIY4Y7NYD4BK
Molecular FormulaC3 H6 O
Molecular Weight58.08002000
MDL NumberMFCD00005126
Nikkaji NumberJ1.171A
Beilstein0079763

Regulatory

JECFA Food AdditivePropylene Oxide
DG SANTE Food Contact Materialspropylene oxide
FDA Mainterm (SATF)75-56-9 ; PROPYLENE OXIDE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless clear liquid (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.82500 to 0.83500 @ 20.00 °C.
Pounds per Gallon - (est). 6.873 to 6.956
Refractive Index 1.36500 to 1.36700 @ 20.00 °C.
Boiling Point 35.00 °C. @ 760.00 mm Hg
Vapor Pressure 572.478027 mmHg @ 25.00 °C. (est)
Flash Point -35.00 °F. TCC ( -37.22 °C. )
logP (o/w) 0.030
Soluble in water, 590000 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 380 mg/kg
Dermal Toxicityskin-rabbit LD50 1500 ul/kg
Inhalation Toxicityinhalation-rat LC50 4000 ppm/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryfood starch-modified, preservative
Recommendation for propylene oxide usage levels up tonot for fragrance use.
Recommendation for propylene oxide flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

epoxypropane 1,2- epoxypropane methyl ethylene oxide methyl oxirane methyloxacyclopropane methyloxirane (±)- methyloxirane 2- methyloxirane oxirane, 2-methyl- propylene epoxide (±)- propylene oxide 1,2- propylene oxide propyleneoxide PubMed: Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity. PubMed: A novel aqueous two phase system composed of a thermo-separating polymer and an organic solvent for purification of thermo-acidic amylase enzyme from red pitaya (Hylocereus polyrhizus) peel. PubMed: Effects of acid-hydrolysis and hydroxypropylation on functional properties of sago starch. PubMed: Properties and characteristics of dual-modified rice starch based biodegradable films. PubMed: Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing "Generally Recognized As Safe" (GRAS) nanopharmaceuticals: A review. PubMed: Reaction patterns of wheat starch granules substituted with an anionic propylene oxide analog (POA) revealed by confocal microscopy and 3D anaglyph imaging. PubMed: Engineering a cyanobacterium as the catalyst for the photosynthetic conversion of CO2 to 1,2-propanediol. PubMed: Relationship of the channels of normal maize starch to the properties of its modified products. PubMed: Extractive fermentation for improved production and recovery of lipase derived from Burkholderia cepacia using a thermoseparating polymer in aqueous two-phase systems. PubMed: Preparation of lignopolyols from wheat straw soda lignin. PubMed: Effects of hydroxypropylation on the functional properties of psyllium. PubMed: Transport across the blood-brain barrier of pluronic leptin. PubMed: Hydroxypropylated tapioca starch retards the development of insulin resistance in KKAy mice, a type 2 diabetes model, fed a high-fat diet. PubMed: Hydroxypropylated starches of varying amylose contents as sustained release matrices in tablets. PubMed: An isotope dilution headspace method with gas chromatography-mass spectrometry for determination of propylene oxide in food. PubMed: High-hydroxypropylated tapioca starch improves insulin resistance in genetically diabetic KKAy mice. PubMed: Supercritical carbon dioxide interpolymer complexes improve survival of B. longum Bb-46 in simulated gastrointestinal fluids. PubMed: Dual modification of starch via partial enzymatic hydrolysis in the granular state and subsequent hydroxypropylation. PubMed: Evaluation of microwave irradiation for analysis of carbonyl sulfide, carbon disulfide, cyanogen, ethyl formate, methyl bromide, sulfuryl fluoride, propylene oxide, and phosphine in hay. PubMed: Monte Carlo simulations assessing the risk of salmonellosis from consumption of almonds. PubMed: Survival of Salmonella enteritidis PT 30 on inoculated almonds after commercial fumigation with propylene oxide. PubMed: Toxicity of propylene oxide at low pressure against life stages of four species of stored product insects. PubMed: Solubilization of Hydrophilic Compounds in Copolymer Aggregates. PubMed: Reactions of epoxide monomers in food simulants used to test plastics for migration. PubMed: A novel type of pyridine nucleotide-disulfide oxidoreductase is essential for NAD+- and NADPH-dependent degradation of epoxyalkanes by Xanthobacter strain Py2. PubMed: Neurophysiological and neuropathological evaluation of primates exposed to ethylene oxide and propylene oxide. PubMed: Effects of propylene oxide on nasal epithelial cell proliferation in F344 rats. PubMed: Complementation of Xanthobacter Py2 mutants defective in epoxyalkane degradation, and expression and nucleotide sequence of the complementing DNA fragment. PubMed: Effect of surface sterilization, fumigation and gamma irradiation on the microflora and germination of barley seeds. PubMed: Inhalation developmental toxicity study of propylene oxide in Fischer 344 rats. PubMed: Gas chromatographic determination with electron capture detection of residual ethylene oxide in intraocular lenses. PubMed: Chronic inhalation toxicity and carcinogenicity study of propylene oxide in Wistar rats. PubMed: Biomonitoring of exposure to potential mutagens and carcinogens in industrial populations. PubMed: Mutagenicity of ethylene oxide and propylene oxide and of the glycols and halohydrins formed from them during the fumigation of foodstuffs. PubMed: Mutagenic activity of propylene oxide in bacterial and mammalian systems. PubMed: Sterilization of dehydrated potato granules with propylene oxide. PubMed: Propylene oxide. PubMed: Direct addition of liquid propylene oxide to dried materials for destruction of Salmonellae. PubMed: Effect of propylene oxide treatment on the microflora of pecans. PubMed: Gaseous sterilization: methyl bromide, propylene oxide and ozone. PubMed: Effect of relative humidity on the bactericidal activity of propylene oxide vapor.