propylene oxide
1,2-epoxypropane
Identification
| Name | propylene oxide |
| IUPAC | 2-methyloxirane |
| CAS Number | 75-56-9 |
| EINECS | 200-879-2 |
| FDA UNII | Y4Y7NYD4BK |
| Molecular Formula | C3 H6 O |
| Molecular Weight | 58.08002000 |
| MDL Number | MFCD00005126 |
| Nikkaji Number | J1.171A |
| Beilstein | 0079763 |
Regulatory
| JECFA Food Additive | Propylene Oxide |
| DG SANTE Food Contact Materials | propylene oxide |
| FDA Mainterm (SATF) | 75-56-9 ; PROPYLENE OXIDE |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 99.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.82500 to 0.83500 @ 20.00 °C. |
| Pounds per Gallon - (est). | 6.873 to 6.956 |
| Refractive Index | 1.36500 to 1.36700 @ 20.00 °C. |
| Boiling Point | 35.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 572.478027 mmHg @ 25.00 °C. (est) |
| Flash Point | -35.00 °F. TCC ( -37.22 °C. ) |
| logP (o/w) | 0.030 |
| Soluble in | water, 590000 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
Organoleptic Properties
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 380 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 1500 ul/kg |
| Inhalation Toxicity | inhalation-rat LC50 4000 ppm/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | food starch-modified, preservative |
| Recommendation for propylene oxide usage levels up to | not for fragrance use. |
| Recommendation for propylene oxide flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
epoxypropane
1,2-
epoxypropane
methyl ethylene oxide
methyl oxirane
methyloxacyclopropane
methyloxirane
(±)-
methyloxirane
2-
methyloxirane
oxirane, 2-methyl-
propylene epoxide
(±)-
propylene oxide
1,2-
propylene oxide
propyleneoxide
PubMed:
Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.
PubMed:
A novel aqueous two phase system composed of a thermo-separating polymer and an organic solvent for purification of thermo-acidic amylase enzyme from red pitaya (Hylocereus polyrhizus) peel.
PubMed:
Effects of acid-hydrolysis and hydroxypropylation on functional properties of sago starch.
PubMed:
Properties and characteristics of dual-modified rice starch based biodegradable films.
PubMed:
Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing "Generally Recognized As Safe" (GRAS) nanopharmaceuticals: A review.
PubMed:
Reaction patterns of wheat starch granules substituted with an anionic propylene oxide analog (POA) revealed by confocal microscopy and 3D anaglyph imaging.
PubMed:
Engineering a cyanobacterium as the catalyst for the photosynthetic conversion of CO2 to 1,2-propanediol.
PubMed:
Relationship of the channels of normal maize starch to the properties of its modified products.
PubMed:
Extractive fermentation for improved production and recovery of lipase derived from Burkholderia cepacia using a thermoseparating polymer in aqueous two-phase systems.
PubMed:
Preparation of lignopolyols from wheat straw soda lignin.
PubMed:
Effects of hydroxypropylation on the functional properties of psyllium.
PubMed:
Transport across the blood-brain barrier of pluronic leptin.
PubMed:
Hydroxypropylated tapioca starch retards the development of insulin resistance in KKAy mice, a type 2 diabetes model, fed a high-fat diet.
PubMed:
Hydroxypropylated starches of varying amylose contents as sustained release matrices in tablets.
PubMed:
An isotope dilution headspace method with gas chromatography-mass spectrometry for determination of propylene oxide in food.
PubMed:
High-hydroxypropylated tapioca starch improves insulin resistance in genetically diabetic KKAy mice.
PubMed:
Supercritical carbon dioxide interpolymer complexes improve survival of B. longum Bb-46 in simulated gastrointestinal fluids.
PubMed:
Dual modification of starch via partial enzymatic hydrolysis in the granular state and subsequent hydroxypropylation.
PubMed:
Evaluation of microwave irradiation for analysis of carbonyl sulfide, carbon disulfide, cyanogen, ethyl formate, methyl bromide, sulfuryl fluoride, propylene oxide, and phosphine in hay.
PubMed:
Monte Carlo simulations assessing the risk of salmonellosis from consumption of almonds.
PubMed:
Survival of Salmonella enteritidis PT 30 on inoculated almonds after commercial fumigation with propylene oxide.
PubMed:
Toxicity of propylene oxide at low pressure against life stages of four species of stored product insects.
PubMed:
Solubilization of Hydrophilic Compounds in Copolymer Aggregates.
PubMed:
Reactions of epoxide monomers in food simulants used to test plastics for migration.
PubMed:
A novel type of pyridine nucleotide-disulfide oxidoreductase is essential for NAD+- and NADPH-dependent degradation of epoxyalkanes by Xanthobacter strain Py2.
PubMed:
Neurophysiological and neuropathological evaluation of primates exposed to ethylene oxide and propylene oxide.
PubMed:
Effects of propylene oxide on nasal epithelial cell proliferation in F344 rats.
PubMed:
Complementation of Xanthobacter Py2 mutants defective in epoxyalkane degradation, and expression and nucleotide sequence of the complementing DNA fragment.
PubMed:
Effect of surface sterilization, fumigation and gamma irradiation on the microflora and germination of barley seeds.
PubMed:
Inhalation developmental toxicity study of propylene oxide in Fischer 344 rats.
PubMed:
Gas chromatographic determination with electron capture detection of residual ethylene oxide in intraocular lenses.
PubMed:
Chronic inhalation toxicity and carcinogenicity study of propylene oxide in Wistar rats.
PubMed:
Biomonitoring of exposure to potential mutagens and carcinogens in industrial populations.
PubMed:
Mutagenicity of ethylene oxide and propylene oxide and of the glycols and halohydrins formed from them during the fumigation of foodstuffs.
PubMed:
Mutagenic activity of propylene oxide in bacterial and mammalian systems.
PubMed:
Sterilization of dehydrated potato granules with propylene oxide.
PubMed:
Propylene oxide.
PubMed:
Direct addition of liquid propylene oxide to dried materials for destruction of Salmonellae.
PubMed:
Effect of propylene oxide treatment on the microflora of pecans.
PubMed:
Gaseous sterilization: methyl bromide, propylene oxide and ozone.
PubMed:
Effect of relative humidity on the bactericidal activity of propylene oxide vapor.