protoporphyrin disodium
disodium protoporphyrin
Identification
| Name | protoporphyrin disodium |
| IUPAC | disodium;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoate |
| CAS Number | 50865-01-5 |
| EINECS | 256-815-9 |
| FDA UNII | 54N4UY1C7C |
| Molecular Formula | C34 H32 N4 Na2 O4 |
| Molecular Weight | 606.63337856 |
| MDL Number | MFCD00151108 |
| Nikkaji Number | J83.641I |
| Beilstein | 5227034 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.01294 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for protoporphyrin disodium usage levels up to | not for fragrance use. |
| Recommendation for protoporphyrin disodium flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
disodium 3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionate
disodium protoporphyrin
disodium;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoate
21H,23H-
porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, disodium salt
protoporphyrin IX disodium salt
1,3,5,8-
tetramethyl-2,4-divinylporphine-6,7-dipropionate
PubMed:
Sonodynamic therapy induces apoptosis of human leukemia HL-60 cells in the presence of protoporphyrin IX.
PubMed:
Inhibition of VDAC1 prevents Ca²âº-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages.
PubMed:
Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione.
PubMed:
[Outbreak of lead poisoning associated with Ayurvedic medicine].
PubMed:
Total synthesis of hematoporphyrin and protoporphyrin; a conceptually new approach.
PubMed:
Drug-induced liver injury in hospitalized patients with notably elevated alanine aminotransferase.
PubMed:
Photomicronucleus assay of phototoxic and pseudophotoclastogenic chemicals in human keratinocyte NCTC2544 cells.
PubMed:
Sonodynamic effects of protoporphyrin IX disodium salt on Ehrlich ascetic tumor cells.
PubMed:
Determination of lead(II) in fly ash leachate using a newly developed simple spectrophotometric method.
PubMed:
Synthesis of porphyrin-incorporated polymers and their application for simultaneous detection of multimetal components by using spectrophotometry.
PubMed:
Sonodynamic antitumor effect of protoporphyrin IX disodium salt on S180 solid tumor.
PubMed:
Hemin, an inducer of heme oxygenase-1, lowers intraocular pressure in rabbits.
PubMed:
Sonodynamic effects of protoporphyrin IX disodium salt on isolated sarcoma 180 cells.
PubMed:
YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX.
PubMed:
Microbial demetallization of crude oil: nickel protoporphyrin disodium as a model organo-metallic substrate.
PubMed:
Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats.
PubMed:
Extraction of protoporphyrin disodium and its inhibitory effects on HBV-DNA.
PubMed:
Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization.
PubMed:
Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents induced hepatic and renal metallothionein in rats.
PubMed:
A vehicle for photodynamic therapy of skin cancer: influence of dimethylsulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy.
PubMed:
Mobilized plasma lead as an index of lead body burden and its relation to the heme-related indices.
PubMed:
Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits.
PubMed:
Lead intoxication epidemic caused by ingestion of contaminated ground paprika.
PubMed:
Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice.
PubMed:
Influence of methionine and zinc supplementation during chelation of lead in rats.
PubMed:
Effects of calcium disodium versenate (CaNa2EDTA) chelation in moderate childhood lead poisoning.
PubMed:
Anti-inflammatory properties of zinc protoporphyrin disodium (Zn-PP-2Na).
PubMed:
Influence of simultaneous supplementation of zinc and copper during chelation of lead in rats.
PubMed:
Need for the lead mobilization test in children with lead poisoning.
PubMed:
Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats.
PubMed:
Effects of iron deficiency on lead excretion in children with moderate lead intoxication.
PubMed:
Using unstimulated urinary lead excretion to assess the need for chelation in the treatment of lead poisoning.
PubMed:
Chelation of lead during co-exposure to ethanol.
PubMed:
Influence of methionine supplementation in chelation of lead in rats.
PubMed:
Body burdens of lead in hypertensive nephropathy.
PubMed:
The fall of zinc protoporphyrin levels in workers treated for chronic lead intoxication.
PubMed:
Adult lead poisoning.
PubMed:
Lead poisoning in a West Bank Arab Village.
PubMed:
Reversible nephrotoxic reactions to a combined 2,3-dimercapto-1-propanol and calcium disodium ethylenediaminetetraacetic acid regimen in asymptomatic children with elevated blood lead levels.
PubMed:
Diagnostic significance of edetate disodium calcium testing in children with increased lead absorption.