protoporphyrin disodium

disodium protoporphyrin

CAS: 50865-01-5 C34 H32 N4 Na2 O4 MW: 606.63337856

Identification

Nameprotoporphyrin disodium
IUPACdisodium;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoate
CAS Number50865-01-5
EINECS256-815-9
FDA UNII54N4UY1C7C
Molecular FormulaC34 H32 N4 Na2 O4
Molecular Weight606.63337856
MDL NumberMFCD00151108
Nikkaji NumberJ83.641I
Beilstein5227034

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 0.01294 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for protoporphyrin disodium usage levels up tonot for fragrance use.
Recommendation for protoporphyrin disodium flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

disodium 3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionate disodium protoporphyrin disodium;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoate 21H,23H- porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, disodium salt protoporphyrin IX disodium salt 1,3,5,8- tetramethyl-2,4-divinylporphine-6,7-dipropionate PubMed: Sonodynamic therapy induces apoptosis of human leukemia HL-60 cells in the presence of protoporphyrin IX. PubMed: Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. PubMed: Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione. PubMed: [Outbreak of lead poisoning associated with Ayurvedic medicine]. PubMed: Total synthesis of hematoporphyrin and protoporphyrin; a conceptually new approach. PubMed: Drug-induced liver injury in hospitalized patients with notably elevated alanine aminotransferase. PubMed: Photomicronucleus assay of phototoxic and pseudophotoclastogenic chemicals in human keratinocyte NCTC2544 cells. PubMed: Sonodynamic effects of protoporphyrin IX disodium salt on Ehrlich ascetic tumor cells. PubMed: Determination of lead(II) in fly ash leachate using a newly developed simple spectrophotometric method. PubMed: Synthesis of porphyrin-incorporated polymers and their application for simultaneous detection of multimetal components by using spectrophotometry. PubMed: Sonodynamic antitumor effect of protoporphyrin IX disodium salt on S180 solid tumor. PubMed: Hemin, an inducer of heme oxygenase-1, lowers intraocular pressure in rabbits. PubMed: Sonodynamic effects of protoporphyrin IX disodium salt on isolated sarcoma 180 cells. PubMed: YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX. PubMed: Microbial demetallization of crude oil: nickel protoporphyrin disodium as a model organo-metallic substrate. PubMed: Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. PubMed: Extraction of protoporphyrin disodium and its inhibitory effects on HBV-DNA. PubMed: Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization. PubMed: Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents induced hepatic and renal metallothionein in rats. PubMed: A vehicle for photodynamic therapy of skin cancer: influence of dimethylsulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy. PubMed: Mobilized plasma lead as an index of lead body burden and its relation to the heme-related indices. PubMed: Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. PubMed: Lead intoxication epidemic caused by ingestion of contaminated ground paprika. PubMed: Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice. PubMed: Influence of methionine and zinc supplementation during chelation of lead in rats. PubMed: Effects of calcium disodium versenate (CaNa2EDTA) chelation in moderate childhood lead poisoning. PubMed: Anti-inflammatory properties of zinc protoporphyrin disodium (Zn-PP-2Na). PubMed: Influence of simultaneous supplementation of zinc and copper during chelation of lead in rats. PubMed: Need for the lead mobilization test in children with lead poisoning. PubMed: Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats. PubMed: Effects of iron deficiency on lead excretion in children with moderate lead intoxication. PubMed: Using unstimulated urinary lead excretion to assess the need for chelation in the treatment of lead poisoning. PubMed: Chelation of lead during co-exposure to ethanol. PubMed: Influence of methionine supplementation in chelation of lead in rats. PubMed: Body burdens of lead in hypertensive nephropathy. PubMed: The fall of zinc protoporphyrin levels in workers treated for chronic lead intoxication. PubMed: Adult lead poisoning. PubMed: Lead poisoning in a West Bank Arab Village. PubMed: Reversible nephrotoxic reactions to a combined 2,3-dimercapto-1-propanol and calcium disodium ethylenediaminetetraacetic acid regimen in asymptomatic children with elevated blood lead levels. PubMed: Diagnostic significance of edetate disodium calcium testing in children with increased lead absorption.