2-propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, d-lactone

CAS: 66-97-7 C11 H6 O3 MW: 186.16642000

Identification

Namepsoralen
IUPACfuro[3,2-g]chromen-7-one
CAS Number66-97-7
EINECS200-639-7
FDA UNIIKTZ7ZCN2EX
Molecular FormulaC11 H6 O3
Molecular Weight186.16642000
MDL NumberMFCD00010520
Nikkaji NumberJ2.363I
Beilstein0152784

Regulatory

Physical Properties

Assay 94.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 163.00 to 164.00 °C. @ 760.00 mm Hg
Boiling Point 362.00 to 363.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.000019 mmHg @ 25.00 °C. (est)
Flash Point 344.00 °F. TCC ( 173.33 °C. )
logP (o/w) 1.670
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

No sensory data available

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for psoralen usage levels up tonot for fragrance use.
Recommendation for psoralen flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

carrot root carrot shoot celery leaf celery plant celery seed celery stem coriander fruit coriander seed fennel seed fig fruit fig leaf fig plant fig sap lovage fruit lovage root parsley parsley fruit parsley leaf parsley leaf oil @ 1.24% Data parsley root parsley tissue culture parsnip root psoralea corylifolia rue flower oil colombia @ 0.24% Data

Synonyms

ficusin furano[3,2-g]chromen-2-one 6,7- furanocoumarin furo(2',3',7,6)coumarin furo(3,2-g)-coumarin 7H- furo(3,2-g)(1)benzopyran-7-one furo(4',5',6,7)coumarin furo[2',3':7,6]coumarin furo[2'.3':7.6]coumarin 7H- furo[3,2-g][1]benzopyran-7-one 7H- furo[3,2-g]benzopyran-7-one furo[3,2-g]chromen-7-one 7H- furo[3,2-g]chromen-7-one furo[3,2-g]coumarin furo[4',5':6,7]coumarin furocoumarin 6- hydroxy-5-benzofuranacrylic acid beta-lactone 3-(6- hydroxy-5-benzofuranyl)-2-propenoic acid d-lactone 2- propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, d-lactone psoralen psoralene PubMed: Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines. PubMed: Probing the binding mode of psoralen to calf thymus DNA. PubMed: Bioassay guided isolation and identification of anti-inflammatory active compounds from the root of Ficus formosana. PubMed: Chemical quantification and antioxidant assay of four active components in Ficus hirta root using UPLC-PAD-MS fingerprinting combined with cluster analysis. PubMed: Plasma components: properties, differences, and uses. PubMed: Furanocoumarins in celeriac from different farming systems: a 3-year study. PubMed: Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice. PubMed: Vitiligo in adults and children. PubMed: Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents. PubMed: [High-performance liquid chromatography for determination of psoralene, bergapten and apigenin in Ficus hirta Vahl]. PubMed: Application of the concept of relative photomutagenic potencies to selected furocoumarins in V79 cells. PubMed: Ficus carica L.: Metabolic and biological screening. PubMed: Psoriasis (chronic plaque). PubMed: Growth inhibition of mammalian cells by synthetic and natural photosensitising agents. PubMed: Chemical composition and antioxidant potential of Ruta montana L. essential oil from Algeria. PubMed: Pathogen reduction: a precautionary principle paradigm. PubMed: Vitiligo. PubMed: [Use of psoralen plus UV-A therapy in the autonomous community of Valencia, Spain]. PubMed: Fluorescent DNA probes: study of mechanisms of changes in spectral properties and features of practical application. PubMed: Treatment of mycosis fungoides using a 308-nm excimer laser: two case studies. PubMed: Can dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy? PubMed: Evaluation of inactivation methods for severe acute respiratory syndrome coronavirus in noncellular blood products. PubMed: Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. PubMed: Distribution of furanocoumarins in grapefruit juice fractions. PubMed: Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin. PubMed: Advancements in the treatment of psoriasis: role of biologic agents. PubMed: Comparative tolerability of systemic treatments for plaque-type psoriasis. PubMed: Atopic dermatitis and fungi. PubMed: Effects of storage conditions on furocoumarin levels in intact, chopped, or homogenized parsnips. PubMed: Simultaneous determination of furanocoumarins in infusions and decoctions from "Carapiá" (dorstenia species) by high-performance liquid chromatography. PubMed: Prevention of transfusion-associated graft-versus-host disease by inactivation of T cells in platelet components. PubMed: Furanocoumarins in celery and parsnips: method and multiyear Canadian survey. PubMed: Anti-oxidant, pro-oxidant properties of tannic acid and its binding to DNA. PubMed: Effect of selected coumarins on spinach chloroplast photosynthesis. PubMed: Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells. PubMed: The profile of atopic dermatitis in a tertiary dermatology outpatient clinic in Singapore. PubMed: Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. PubMed: Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. PubMed: Psoralen photochemotherapy. PubMed: Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. PubMed: Isolation and identification of antimicrobial furocoumarins from parsley. PubMed: Medical UV exposures and HIV activation. PubMed: Furocoumarin-photosensitized hydroxylation of guanosine in RNA and DNA. PubMed: Treatment of psoriasis with psoralens and ultraviolet A. A double-blind comparison of 8-methoxypsoralen and 5-methoxypsoralen. PubMed: Cellular and molecular mechanisms in photochemical sensitization: studies on the mechanism of action of psoralens. PubMed: Phototoxic coumarins in limes. PubMed: Psoralen photosensitization and plasma and cutaneous beta-carotene concentrations in hairless mice. PubMed: Fate of [(14)C]xanthotoxin (8-methoxypsoralen) in laying hens and a lactating goat. PubMed: Phototoxicity testing in guinea-pigs. PubMed: Dietary intake and risk assessment of phototoxic furocoumarins in humans. PubMed: [Influence of retinoids on the bioavailability of methoxy-8-psoralen]. PubMed: Photosensitizing potential of benzanthrone. PubMed: Analysis of spontaneous and psoralen-induced Salmonella typhimurium hisG46 revertants by oligodeoxyribonucleotide colony hybridization: use of psoralens to cross-link probes to target sequences. PubMed: Natural pesticides and bioactive components in foods. PubMed: Psoralen photochemotherapy. PubMed: Phytophotodermatitis from celery among grocery store workers. PubMed: Clinical pharmacokinetics of methoxsalen and other psoralens. PubMed: Quantitative tests for psoralens in the blood: methods and uses in monitoring psoralen and longwave radiation therapy. PubMed: Clinical pharmacology of oral psoralen drugs. PubMed: Long-term risks of psoralen and UV-A therapy for psoriasis. PubMed: HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens).