pyrazinamide

2-(aminocarbonyl)pyrazine

CAS: 98-96-4 C5 H5 N3 O MW: 123.11505000

Identification

Namepyrazinamide
IUPACpyrazine-2-carboxamide
CAS Number98-96-4
EINECS202-717-6
FDA UNII2KNI5N06TI
Molecular FormulaC5 H5 N3 O
Molecular Weight123.11505000
MDL NumberMFCD00006132
Nikkaji NumberJ3.990J
Beilstein0112306
XlogP3-0.60 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 192.00 °C. @ 760.00 mm Hg
Boiling Point 357.00 to 358.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000027 mmHg @ 25.00 °C. (est)
Flash Point 338.00 °F. TCC ( 169.90 °C. ) (est)
logP (o/w) -0.600
Soluble in alcohol

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 1680 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 2973 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for pyrazinamide usage levels up tonot for fragrance use.
Recommendation for pyrazinamide flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Synerzine, Inc.

Innovation. Customization. Aroma Ingredients.

Synerzine is a leading supplier of flavor and fragrance ingredients.

View All Website (404) 524-6744 info@synerzine.com

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2-( aminocarbonyl)pyrazine 2- carbamyl pyrazine 2- carbamylpyrazine a- pyrazinamide pyrazine carboxylamide pyrazine-2-carboxamide 2- pyrazinecarboxamide pyrazinecarboxylic acid amide pyrazinoic acid amide PubMed: Multiple drug-susceptibility screening in Mycobacterium bovis: new nucleotide polymorphisms in the embB gene among ethambutol susceptible strains. PubMed: Impact of food intake on the pharmacokinetics of first-line antituberculosis drugs in Taiwanese tuberculosis patients. PubMed: A review of tuberculosis: Focus on bedaquiline. PubMed: Provisional CDC guidelines for the use and safety monitoring of bedaquiline fumarate (Sirturo) for the treatment of multidrug-resistant tuberculosis. PubMed: Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the simultaneous determination of five first-line antituberculosis drugs in plasma. PubMed: Impact of a shortage of first-line antituberculosis medication on tuberculosis control - United States, 2012-2013. PubMed: Pharmacokinetics of first-line tuberculosis drugs in Tanzanian patients. PubMed: Optimization of a reversed-phase-high-performance thin-layer chromatography method for the separation of isoniazid, ethambutol, rifampicin and pyrazinamide in fixed-dose combination antituberculosis tablets. PubMed: [Pulmonary paragonimiasis]. PubMed: Tuberculosis (HIV-negative people). PubMed: Impact of food and antacids on the pharmacokinetics of anti-tuberculosis drugs: systematic review and meta-analysis. PubMed: Tuberculosis (HIV-negative people). PubMed: Molecular detection of drug-resistant Mycobacterium tuberculosis with a scanning-frame oligonucleotide microarray. PubMed: Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series. PubMed: Differential effects of pyrazinamide and clofibrate on gene expression of rat hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme of the tryptophan-NAD pathway. PubMed: Molecular typing and virulence markers of Yersinia enterocolitica strains from human, animal and food origins isolated between 1968 and 2000 in Brazil. PubMed: Human Mycobacterium bovis infection in the United Kingdom: Incidence, risks, control measures and review of the zoonotic aspects of bovine tuberculosis. PubMed: [Pellagra]. PubMed: A cholesterol-rich diet accelerates bacteriologic sterilization in pulmonary tuberculosis. PubMed: Antioxidant action of Moringa oleifera Lam. (drumstick) against antitubercular drugs induced lipid peroxidation in rats. PubMed: Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. PubMed: Treatment of tuberculous infection and disease in children: the North American perspective. PubMed: Evaluation of the teratogenic potential of pyrazinamide in Wistar rats. PubMed: Detection of substandard fixed-dose combination tuberculosis drugs using thin-layer chromatography. PubMed: Rifapentine: its role in the treatment of tuberculosis. PubMed: Pharmacokinetics of isoniazid under fasting conditions, with food, and with antacids. PubMed: Pharmacokinetics of rifampin under fasting conditions, with food, and with antacids. PubMed: Pharmacokinetics of pyrazinamide under fasting conditions, with food, and with antacids. PubMed: Probenecid, sulfinpyrazone and pyrazinamide do not inhibit urinary excretion of the beta 2-adrenoceptor agonist clenbuterol in cattle. PubMed: [Characteristics of Yersinia strains from clinical material and from other sources. I. Selected biochemical properties]. PubMed: Three-in-one TB drug approved. PubMed: Study of the effect of concomitant food on the bioavailability of rifampicin, isoniazid and pyrazinamide. PubMed: Molecular characterization of Yersinia enterocolitica by pulsed-field gel electrophoresis and hybridization of DNA fragments to ail and pYV probes. PubMed: From the Food and Drug Administration. PubMed: Molecular characterization of Yersinia strains isolated from human and environmental sources. PubMed: Clinical pharmacokinetic considerations in the treatment of patients with leprosy. PubMed: Package inserts for antituberculosis drugs and tuberculins. PubMed: Toxicity of morphazinamide compared with pyrazinamide. PubMed: [Liver damage after administration of pyrazinamide in animal experiments. 3. Biochemical changes in liver tissue and blood serum]. PubMed: Invitation to the gout. A consideration of the role of various predisposing and provocative factors in the genesis of acute gouty arthritis.