saccharin

3-benzisothiazolinone 1,1-dioxide

CAS: 81-07-2 C7 H5 N O3 S MW: 183.18645000

Identification

Namesaccharin
IUPAC1,1-dioxo-1,2-benzothiazol-3-one
CAS Number81-07-2
EINECS201-321-0
FDA UNIIFST467XS7D
Molecular FormulaC7 H5 N O3 S
Molecular Weight183.18645000
MDL NumberMFCD00005866
Nikkaji NumberJ3.855E
Beilstein006888
XlogP30.90 (est)

Regulatory

JECFA Food AdditiveSaccharin
GSFA CodexSaccharin (954(i))
DG SANTE Food Additivessaccharin
FDA Mainterm (SATF)81-07-2 ; SACCHARIN
FDA RegulationFDA PART 145 -- CANNED FRUITS

Physical Properties

Appearance white crystalline powder (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 228.00 °C. @ 760.00 mm Hg
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) 0.910
Soluble in water, 4000 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 17000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysweetening agent only in special dietary foods
Recommendation for saccharin usage levels up tonot for fragrance use.

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Potential Uses

oral care agents

Natural Occurrence

not found in nature

Synonyms

anhydro-o-sulfaminebenzoic acid 1,2- benzisothiazol-3(2H)-one 1,1-dioxide 1,2- benzisothiazol-3(2H)-one, 1,1-dioxide 1,2- benzisothiazolin-3-one 1,1-dioxide 1,2- benzisothiazolin-3-one, 1,1-dioxide 1,2- benzisothiazoline-3-one 1,1-dioxide 3- benzisothiazolinone 1,1-dioxide o- benzoic acid sulfimide benzoic sulfimide o- benzoic sulfimide benzoic sulphinide benzosulphimide 1,2- benzothiazol-3(2H)-on-1,1-dioxid 1,2- benzothiazol-3(2H)-one 1,1-dioxide 1,2- benzothiazol-3(2H)-one-1,1-dioxyde 2,3- dihydro-1lamda6,2-benzothiazole-1,1,3-trione 1,2- dihydro-2-ketobenzisosulfonazole 1,2- dihydro-2-ketobenzisosulphonazole 2,3- dihydro-3-oxobenzisosulfonazole 2,3- dihydro-3-oxobenzisosulphonazole 2,3- dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide 1,1- diox-1,2-benzisothiazol-3-one 1,1- dioxide-1,2-benzisothiazolin-3-one 1,1- dioxo-1,2-benzothiazol-3-one 2- hydrobenzo[d]isothiazole-1,1,3-trione 3- hydroxybenzisothiazole S,S-dioxide 3- hydroxybenzisothiazole-S,S-dioxide 2- sulfobenzoic acid imide 2- sulphobenzoic imide PubMed: Circulating Glucagon-like Peptide-1 (GLP-1) Inhibits Eating in Male Rats by Acting in the Hindbrain and Without Inducing Avoidance. PubMed: Post-oral fat stimulation of intake and conditioned flavor preference in C57BL/6J mice: A concentration-response study. PubMed: Evaluation of saccharin intake and expression of fructose-conditioned flavor preferences following opioid receptor antagonism in the medial prefrontal cortex, amygdala or lateral hypothalamus in rats. PubMed: Role of NMDA, opioid and dopamine D1 and D2 receptor signaling in the acquisition of a quinine-conditioned flavor avoidance in rats. PubMed: Persistent enhancement of ethanol drinking following a monosodium glutamate-substitution procedure in C57BL6/J and DBA/2J mice. PubMed: "Jello® shots" and cocktails as ethanol vehicles: parametric studies with high- and low-saccharin-consuming rats. PubMed: Effect of dopamine D1 and D2 receptor antagonism in the lateral hypothalamus on the expression and acquisition of fructose-conditioned flavor preference in rats. PubMed: Flavor preferences conditioned by intragastric monosodium glutamate in mice. PubMed: Contextual control of flavor neophobia. PubMed: Sensory-specific appetition: Postingestive detection of glucose rapidly promotes continued consumption of a recently encountered flavor. PubMed: Refeeding after acute food restriction: differential reduction in preference for ethanol and ethanol-paired flavors in selectively bred rats. PubMed: Post-oral glucose stimulation of intake and conditioned flavor preference in C57BL/6J mice: a concentration-response study. PubMed: Double-dissociation of D1 and opioid receptor antagonism effects on the acquisition of sucrose-conditioned flavor preferences in BALB/c and SWR mice. PubMed: Do gastrointestinal taste receptors contribute to associative learning and foraging behavior? PubMed: Saccharin pre-exposure enhances appetitive flavor learning in pre-weanling rats. PubMed: Dopamine signaling in the medial prefrontal cortex and amygdala is required for the acquisition of fructose-conditioned flavor preferences in rats. PubMed: Flavor avoidance learning based on missing calories but not on palatability reduction. PubMed: Flavor preferences conditioned by intragastric glucose but not fructose or galactose in C57BL/6J mice. PubMed: Roles of dopamine D1 and D2 receptors in the acquisition and expression of fat-conditioned flavor preferences in rats. PubMed: MK-801 induces a low intensity conditioned taste aversion. PubMed: Rapid post-oral stimulation of intake and flavor conditioning by glucose and fat in the mouse. PubMed: Strain differences in sucrose- and fructose-conditioned flavor preferences in mice. PubMed: Flavor preferences conditioned by post-oral infusion of monosodium glutamate in rats. PubMed: Dopamine and learned food preferences. PubMed: SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats. PubMed: Rats' learned preferences for flavors encountered early or late in a meal paired with the postingestive effects of glucose. PubMed: Rational development of taste masked oral liquids guided by an electronic tongue. PubMed: Opioid mediation of starch and sugar preference in the rat. PubMed: Increased liking for a solution is not necessary for the attenuation of neophobia in rats. PubMed: Latent inhibition of conditioned disgust reactions in rats. PubMed: Post-oral infusion sites that support glucose-conditioned flavor preferences in rats. PubMed: Opioid receptor antagonism in the nucleus accumbens fails to block the expression of sugar-conditioned flavor preferences in rats. PubMed: Ondansetron blocks LiCl-induced conditioned place avoidance but not conditioned taste/flavor avoidance in rats. PubMed: Role of amygdala dopamine D1 and D2 receptors in the acquisition and expression of fructose-conditioned flavor preferences in rats. PubMed: Rapid acquisition of conditioned flavor preferences in rats. PubMed: Conditioned flavor avoidance as a measure of withdrawal in rats chronically exposed to a caffeine solution. PubMed: Sucrose taste but not Polycose taste conditions flavor preferences in rats. PubMed: Impact of brief or extended extinction of a taste aversion on inhibitory associations: evidence from summation, retardation, and preference tests. PubMed: Role of systemic endocannabinoid CB-1 receptor antagonism in the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats. PubMed: Role of dopamine D1 and D2 receptors in the nucleus accumbens shell on the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats. PubMed: Potentiation of taste and extract stimuli in conditioned flavor preference learning. PubMed: The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood. PubMed: CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. PubMed: Overeating by young obesity-prone and lean rats caused by tastes associated with low energy foods. PubMed: Effect of prior exposure to a lithium- and an amphetamine-paired flavor on the acoustic startle response in rats. PubMed: NMDA receptor in conditioned flavor-taste preference learning: blockade by MK-801 and enhancement by D-cycloserine. PubMed: Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation. PubMed: Fat and sugar flavor preference and acceptance in C57BL/6J and 129 mice: experience attenuates strain differences. PubMed: Persistence of conditioned flavor preferences is not due to inadvertent food reinforcement. PubMed: Robust preference for a flavor paired with intragastric glucose acquired in a single trial. PubMed: Extinction of a saccharin-lithium association: assessment by consumption and taste reactivity. PubMed: Nutrient-conditioned flavor preference and incentive value measured by progressive ratio licking in rats. PubMed: Ethanol withdrawal and proclivity are inversely related in rats selectively bred for differential saccharin intake. PubMed: Flavor preference conditioning as a function of fat source. PubMed: Sugar and fat conditioned flavor preferences in C57BL/6J and 129 mice: oral and postoral interactions. PubMed: Flavor preferences conditioned by postingestive effects of nutrients in preweanling rats. PubMed: Flavor processing: perceptual and cognitive factors in multi-modal integration. PubMed: Stability of an Extemporaneously Compounded Propylthiouracil Suspension. PubMed: Odor of taste stimuli in conditioned "taste" aversion learning. PubMed: 'Thermal taste' predicts higher responsiveness to chemical taste and flavor. PubMed: Naltrexone does not prevent acquisition or expression of flavor preferences conditioned by fructose in rats. PubMed: Fructose-conditioned flavor preferences in male and female rats: effects of sweet taste and sugar concentration. PubMed: Lateral parabrachial lesions impair lithium chloride-induced aversive responses but not saccharin-induced flavor preference. PubMed: Flavor preferences conditioned in C57BL/6 mice by intragastric carbohydrate self-infusion. PubMed: Simmondsin: effects on meal patterns and choice behavior in rats. PubMed: Flavor preferences conditioned by intragastric ethanol with limited access training. PubMed: Dopamine D1 and D2 antagonists reduce the acquisition and expression of flavor-preferences conditioned by fructose in rats. PubMed: Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients. PubMed: Flavor quality and ethanol concentration affect ethanol-conditioned flavor preferences. PubMed: Naltrexone suppresses the late but not early licking response to a palatable sweet solution: opioid hedonic hypothesis reconsidered. PubMed: Low body temperature, time dilation, and long-trace conditioned flavor aversion in rats. PubMed: Conditioned inhibition of cyclophosphamide-induced taste aversion. PubMed: Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice. PubMed: Amphetamine and morphine produce a conditioned taste and place preference in the house musk shrew (Suncus murinus). PubMed: Conditioned enhancement of flavor evaluation reinforced by intragastric glucose. II. Taste reactivity analysis. PubMed: D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions. PubMed: Two procedures establishing preference for oral cocaine and lidocaine solutions which do not use an associative history with a reinforcer. PubMed: Flavor preferences conditioned by intragastric infusion of ethanol in rats. PubMed: Basolateral and central amygdaloid lesions leave aversion to dietary amino acid imbalance intact. PubMed: Naltrexone fails to block the acquisition or expression of a flavor preference conditioned by intragastric carbohydrate infusions. PubMed: Role of D(1) and D(2) dopamine receptors in the acquisition and expression of flavor-preference conditioning in sham-feeding rats. PubMed: Establishing preference for lidocaine solution to water: comparison between a fading and an abrupt-removal procedure for withdrawing a compound vehicle. PubMed: Pharmacology of flavor preference conditioning in sham-feeding rats: effects of dopamine receptor antagonists. PubMed: Motivational state regulates the content of learned flavor preferences. PubMed: Pharmacology of flavor preference conditioning in sham-feeding rats: effects of naltrexone. PubMed: Conditioned flavor avoidance, preference, and indifference produced by intragastric infusions of galactose, glucose, and fructose in rats. PubMed: Galactose consumption induces conditioned flavor avoidance in rats. PubMed: Effects of haloperidol or SCH-23390 on ethanol-induced conditioned taste aversion. PubMed: Flavor preferences conditioned by high-fat versus high-carbohydrate diets vary as a function of session length. PubMed: Differential reinforcing and satiating effects of intragastric fat and carbohydrate infusions in rats. PubMed: Palatability and foraging cost interact to control caloric intake. PubMed: Low body temperature affects associative processes in long-trace conditioned flavor aversion. PubMed: High-fat diet preference and overeating mediated by postingestive factors in rats. PubMed: Learned suppression of intake based on anticipated calories: cross-nutrient comparisons. PubMed: Effects of acute and repeated exposures to Aroclor 1254 in adult rats: motor activity and flavor aversion conditioning. PubMed: Retention of context blocking in taste-aversion learning. PubMed: Conditioned Inhibition Produced by Extinction of a Conditioned Stimulus PubMed: The composition of the maintenance diet alters flavor-preference conditioning by intragastric fat infusions in rats. PubMed: Stimulus specificity in flavor acceptance learning. PubMed: The importance of taste and palatability in carbohydrate-induced overeating in rats. PubMed: Food deprivation increases the rat's preference for a fatty flavor over a sweet taste. PubMed: Carbohydrate- and protein-conditioned flavor preferences: effects of nutrient preloads. PubMed: Genetic differences in ethanol-induced conditioned taste aversion after ethanol preexposure. PubMed: Investigation of the devaluation interpretation of anticipatory negative contrast. PubMed: Limited importance of a learned aversion in the hypophagic effect of interleukin-1 beta. PubMed: Stimulation of fluid intake by maltodextrins and starch. PubMed: The intensity of a fetal taste aversion is modulated by the anesthesia used during conditioning. PubMed: Carbohydrate, fat, and protein condition similar flavor preferences in rats using an oral-delay procedure. PubMed: Morphine-induced taste avoidance is attenuated with multiple conditioning trials. PubMed: Robust conditioned flavor preferences with a sensory preconditioning procedure. PubMed: Motivational properties of ethanol in mice selectively bred for ethanol-induced locomotor differences. PubMed: Glucose- and fructose-conditioned flavor preferences in rats: taste versus postingestive conditioning. PubMed: Flavor preferences conditioned by intragastric infusions of dilute polycose solutions. PubMed: Dissociation of palatability and calorie effects in learned flavor preferences. PubMed: Stimulation of fluid intake by carbohydrates: interaction between taste and calories. PubMed: Effects of neuropeptide Y on ingestion of flavored solutions in nondeprived rats. PubMed: How herbivores track variable environments: Response to variability of phytotoxins. PubMed: The alcohol-deprivation effect in hybrid mice. PubMed: Early onset of reduced morphine analgesia by ingestion of sweet solutions. PubMed: Morphine acts in the parabrachial nucleus, a pontine viscerosensory relay, to produce discriminative stimulus effects. PubMed: Ambient temperature effects on taste aversion conditioned by ethanol: contribution of ethanol-induced hypothermia. PubMed: Conditioned taste and taste-potentiated odor aversions in the Syracuse high- and low-avoidance (SHA/Bru and SLA/Bru) strains of rats (Rattus norvegicus). PubMed: Determinants of the slow acquisition of medical and sulcal prefrontal cortex self-stimulation: an individual differences approach. PubMed: Effects of acute swim stress on LiCl-induced conditioned taste aversions. PubMed: Functional dissociation of acute and persistent cognitive deficits accompanying amygdala-kindled seizures. PubMed: Lambs form preferences for nonnutritive flavors paired with glucose. PubMed: Negative anticipatory contrast and preference conditioning: flavor cues support preference conditioning, and environmental cues support contrast. PubMed: Both conditioned taste preference and aversion induced by corticotropin-releasing factor. PubMed: Flavor preferences conditioned by sugars: rats learn to prefer glucose over fructose. PubMed: Preference of Old World monkeys for amino acids and other gustatory stimuli: the influence of monosodium glutamate. PubMed: Cholecystokinin conditions flavor preferences in rats. PubMed: Assessment of ethanol's hedonic effects in mice selectively bred for sensitivity to ethanol-induced hypothermia. PubMed: Withdrawal from chronic nicotine fails to produce a conditioned taste aversion to saccharin in rats. PubMed: Flavor preferences conditioned by intragastric polycose infusions: a detailed analysis using an electronic esophagus preparation. PubMed: Influence of the sense of taste on broiler chick feed consumption. PubMed: Effect of ingestion-contingent hypothermia on ethanol self-administration. PubMed: Flavor preferences conditioned by intragastric fat infusions in rats. PubMed: A flavor paired with lithium chloride blocks the formation of a pentobarbital-lithium chloride association. PubMed: Conditional immunomodulation following training with cyclophosphamide. PubMed: Conditioned taste aversion to injected flavor: differential effect of anesthesia on the formation of the gustatory trace and on its association with poisoning in rats. PubMed: Effects of antihistamines on centrifugal rotation-induced analgesia and conditioned flavor aversions. PubMed: Drinking saccharin increases food intake and preference--III. Sensory and associative factors. PubMed: The behavioral effects of pesticides in male mice. PubMed: Starch-based conditioned flavor preferences in rats: influence of taste, calories and CS-US delay. PubMed: Tolerance to morphine analgesia from brief exposure to a palatable solution. PubMed: Aversive conditioning properties of caffeine in rats. PubMed: Behavioral consequences of chelator administration in acute cadmium toxicity. PubMed: Conditioned flavor aversion induced by inhaled p-xylene in rats. PubMed: From contrast to reinforcement: role of response contingency in anticipatory contrast. PubMed: Non-reinforcing effects of giving 'dessert' in rats. PubMed: Conditioned flavor aversions: applications in assessing the efficacy of chelators in the treatment of heavy-metal intoxication. PubMed: Conditioned flavor preferences based on delayed caloric consequences. PubMed: Hunger enhances the expression of calorie- but not taste-mediated conditioned flavor preferences. PubMed: Effects of centrifugal rotation on analgesia and conditioned flavor aversions. PubMed: Caffeine enhancement of saccharin but not cyclamate flavor avoidance. PubMed: Flavor aversions induced by thallium sulfate: importance of route of administration. PubMed: Effects of learned flavor avoidance on grooming behavior in rats. PubMed: Olfactory responses in the gustatory area of the parabrachial pons. PubMed: Flavor avoidance expressed in grooming by pine voles (Microtus pinetorum): importance of context and hormonal factors. PubMed: Effects of preexposure flavor concentration on conditioned aversion and neophobia. PubMed: The effect of intracerebroventricularly infused satietin on conditioned taste aversion and feeding in rats fasted different lengths. PubMed: Norepinephrine-facilitated eating: reduction in saccharin preference and conditioned flavor preferences with increase in quinine aversion. PubMed: Aversive consequences of jejunoileal bypass in the rat: a conditioned taste aversion analysis. PubMed: Involvement of the anterior insular gustatory neocortex in taste-potentiated odor aversion learning. PubMed: Behavioral conditioned responses across multiple conditioning/testing trials elicited by lithium- and amphetamine-paired flavors. PubMed: Disparity between formation of conditioned flavor aversions and neophobia during grooming in rats and mice. PubMed: Potentiation of a conditioned taste aversion in preweanling and adult rats. PubMed: Developmental flavor experience affects utilization of odor, not taste in toxiphobic conditioning. PubMed: The effect of CS-preexposure on conditioned taste aversion in young and adult rats. PubMed: How sensory properties of foods affect human feeding behavior. PubMed: Long-delay associations between drug states produced in rats by injecting two drugs in sequence. PubMed: Flavor-illness aversions: potentiation of odor by taste with toxin but not shock in rats. PubMed: Pre-exposure to flavor and conditioned taste aversion: amphetamine and lithium reinforcers. PubMed: Alcohol dependence and taste-mediated learning in the rat. PubMed: Conditioned flavor aversions: a toxicity test of the anticholinesterase agent, physostigmine. PubMed: Aversion learning in 5-day-old rats: taste-toxicosis and texture-shock associations. PubMed: Vasopressin and conditioned flavor aversion in aged rats. PubMed: Flavor and location aversions produced by ethanol. PubMed: Non-specific enhancement of ethanol-induced taste aversion by naloxone. PubMed: An associative analysis of pretreatment effects in gustatory conditioning by amphetamine. PubMed: Flavor-illness aversions: potentiation of odor by taste in rats. PubMed: Long-term retention of flavor familiarization: effects of number and amount of prior exposures. PubMed: Fortification of soft drinks with protein from cottage cheese whey. PubMed: Saccharin sodium as a potential sweetener for antidotal charcoal. PubMed: Taste-aversion conditioning with expected versus unexpected drug treatment. PubMed: Evidence for withdrawal from caffeine by rats. PubMed: Conditioned flavor aversions for assessing precipitated morphine abstinence in rats. PubMed: Determinants of the enhancement of flavored-water intake by prior exposure. PubMed: [An organoleptic method for determining optimal flavor composition of foods by exchange of constituents]. PubMed: The nature of the thirst stimulus: a factor in conditioned taste-aversion behavior. PubMed: Flavor preference: effects of ingestion-contingent intravenous saline or glucose.