sanguinarine chloride
(1,3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl-, chloride
Identification
| Name | sanguinarine chloride |
| CAS Number | 5578-73-4 |
| FDA UNII | B8Z8J4400H |
| Molecular Formula | C20 H14 Cl N O4 |
| Molecular Weight | 367.78738000 |
| MDL Number | MFCD00012126 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| Soluble in | water, 140.8 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-mouse LD50 15900 ug/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 102 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for sanguinarine chloride usage levels up to | not for fragrance use. |
| Recommendation for sanguinarine chloride flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(1,3)
benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl-, chloride
sanguinarine hydrochloride
sanguinarium chloride
viadent
PubMed:
Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines.
PubMed:
Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1.
PubMed:
Micronucleus formation in human lymphocytes and in the metabolically competent human hepatoma cell line Hep-G2: results with 15 naturally occurring substances.
PubMed:
SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).
PubMed:
In vitro activities of antimicrobial agents against Candida species.
PubMed:
The use of locally delivered doxycycline in the treatment of periodontitis. Clinical results.
PubMed:
Cytotoxicity of sanguinarine chloride to cultured human cells from oral tissue.
PubMed:
Sanguinarine, a phototoxic H2O2-producing alkaloid.
PubMed:
Lacking anti-plaque efficacy of 2 sanguinarine mouth rinses.
PubMed:
Clinical experiments with a mouthrinse containing sanguinarine chloride.
PubMed:
Evaluation of sanguinarine chloride in control of plaque in the dental practice.