sarcosine
acetic acid, (methylamino)-
Identification
| Name | sarcosine |
| IUPAC | 2-(methylamino)acetic acid |
| CAS Number | 107-97-1 |
| EINECS | 203-538-6 |
| FDA UNII | Z711V88R5F |
| Molecular Formula | C3 H7 N O2 |
| Molecular Weight | 89.09419000 |
| MDL Number | MFCD00004279 |
| Nikkaji Number | J5.067I |
| Beilstein | 1699442 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 212.50 °C. @ 760.00 mm Hg |
| Soluble in | water, 3.00E+05 mg/L @ 20 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin conditioning |
| Recommendation for sarcosine usage levels up to | not for fragrance use. |
| Recommendation for sarcosine flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Glentham Life Sciences Ltd
The Chemical, Biochemical & Research Essentials Supplier
Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.
Potential Uses
Natural Occurrence
Synonyms
acetic acid, (methylamino)-
glycine, N-methyl-
methylamino)acetic acid
2-(
methylamino)acetic acid
methylamino)ethanoic acid
N-
methylaminoacetic acid
methylglycine
N-
methylglycine
sarcosin
sarcosinic acid
PubMed:
Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions.
PubMed:
Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells.
PubMed:
Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations.
PubMed:
Creatine is a scavenger for methylglyoxal under physiological conditions via formation of N-(4-methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr).
PubMed:
Possible glyphosate tolerance mechanism in pitted morningglory (Ipomoea lacunosa L.).
PubMed:
Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread.
PubMed:
Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms.
PubMed:
PEG-amine-initiated polymerization of sarcosine N-thiocarboxyanhydrides toward novel double-hydrophilic PEG-b-polysarcosine diblock copolymers.
PubMed:
1-Sarcosine-angiotensin II infusion effects on food intake, weight loss, energy expenditure, and skeletal muscle UCP3 gene expression in a rat model.
PubMed:
Use of sodium lauroyl sarcosinate (sarkosyl) in viable real-time PCR for enumeration of Escherichia coli.
PubMed:
Metabolomic analysis of cold acclimation of Arctic Mesorhizobium sp. strain N33.
PubMed:
Comparative study of the use of sarcosine, proline and glycine as acrylamide inhibitors in ripe olive processing.
PubMed:
Thermodynamic analysis of osmolyte effect on thermal stability of ribonuclease A in terms of water activity.
PubMed:
Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice.
PubMed:
Effects of carbohydrates on the oNPG converting activity of β-galactosidases.
PubMed:
DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
PubMed:
Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1.
PubMed:
Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study.
PubMed:
Transport of IRW, an ovotransferrin-derived antihypertensive peptide, in human intestinal epithelial Caco-2 cells.
PubMed:
Nutritional attributes of ash (Fraxinus spp.) outer bark and phloem and their relationships to resistance against the emerald ash borer.
PubMed:
Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.
PubMed:
Characterization of new stable ghrelin analogs with prolonged orexigenic potency.
PubMed:
Pool of resistance mechanisms to glyphosate in Digitaria insularis.
PubMed:
Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients.
PubMed:
Tolerance and safety evaluation of N,N-dimethylglycine, a naturally occurring organic compound, as a feed additive in broiler diets.
PubMed:
Peptide absorption after massive proximal small bowel resection: mechanisms of ileal adaptation.
PubMed:
Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation.
PubMed:
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.
PubMed:
Taste contribution of (R)-strombine to dried scallop.
PubMed:
Oseltamivir (tamiflu) is a substrate of peptide transporter 1.
PubMed:
Permeabilization of baker's yeast with N-lauroyl sarcosine.
PubMed:
Expression and putative roles in attachment of outer membrane proteins of Escherichia coli O157 from planktonic and sessile culture.
PubMed:
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.
PubMed:
DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes.
PubMed:
Treatment for mitochondrial disorders.
PubMed:
Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis.
PubMed:
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
PubMed:
Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome.
PubMed:
Actions of amylin on subfornical organ neurons and on drinking behavior in rats.
PubMed:
Comment: N,N-dimethylglycine and L-carnitine as performance enhancers in athletes.
PubMed:
Effect of replacement therapy with cholylsarcosine on fat malabsorption associated with severe bile acid malabsorption. Studies in dogs with ileal resection.
PubMed:
Bradykinin-induced dipsogenesis in captopril-treated rats.
PubMed:
The effects of recessive lethal Notch mutations of Drosophila melanogaster on flavoprotein enzyme activities whose inhibitions cause Notch-like phenocopies.
PubMed:
Abundance of dimethylamine in seafoods: possible implications in the incidence of human cancer.
PubMed:
Nitrosation of sarcosine, proline and 4-hydroxyproline by exposure to nitrogen oxides.
PubMed:
Mutagenicity of pyrolysates from guanidine, ureide, secondary amines and polyamines found by the Salmonella/mammalian-microsome test.
PubMed:
[On the problems with respect to the formation of N-nitroso compound precursors when using alkylating agents in the fumigation of foodstuffs. II. N-methylation of various amino acids by the action of methyl bromide (author's transl)].
PubMed:
Kinetics of uptake of an amino acid and a dipeptide into hamster jejunum and ileum: the effect of semistarvation and starvation.
PubMed:
Determination of a non-volatile N-nitrosamine on a food matrix.
PubMed:
The rate of nitrosation of sarcosine in the presence of hydrophile and lipophilic antioxidants.
PubMed:
Identification and quantitative determination of nitrosoproline and nitrososarcosine and preliminary investigations on nitrosohydroxyproline in cured meat products.
PubMed:
Toxicities of methionine and other amino acids.