sarcosine

acetic acid, (methylamino)-

CAS: 107-97-1 C3 H7 N O2 MW: 89.09419000

Identification

Namesarcosine
IUPAC2-(methylamino)acetic acid
CAS Number107-97-1
EINECS203-538-6
FDA UNIIZ711V88R5F
Molecular FormulaC3 H7 N O2
Molecular Weight89.09419000
MDL NumberMFCD00004279
Nikkaji NumberJ5.067I
Beilstein1699442

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 212.50 °C. @ 760.00 mm Hg
Soluble in water, 3.00E+05 mg/L @ 20 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic ingredient for skin conditioning
Recommendation for sarcosine usage levels up tonot for fragrance use.
Recommendation for sarcosine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

acetic acid, (methylamino)- glycine, N-methyl- methylamino)acetic acid 2-( methylamino)acetic acid methylamino)ethanoic acid N- methylaminoacetic acid methylglycine N- methylglycine sarcosin sarcosinic acid PubMed: Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions. PubMed: Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. PubMed: Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations. PubMed: Creatine is a scavenger for methylglyoxal under physiological conditions via formation of N-(4-methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr). PubMed: Possible glyphosate tolerance mechanism in pitted morningglory (Ipomoea lacunosa L.). PubMed: Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread. PubMed: Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms. PubMed: PEG-amine-initiated polymerization of sarcosine N-thiocarboxyanhydrides toward novel double-hydrophilic PEG-b-polysarcosine diblock copolymers. PubMed: 1-Sarcosine-angiotensin II infusion effects on food intake, weight loss, energy expenditure, and skeletal muscle UCP3 gene expression in a rat model. PubMed: Use of sodium lauroyl sarcosinate (sarkosyl) in viable real-time PCR for enumeration of Escherichia coli. PubMed: Metabolomic analysis of cold acclimation of Arctic Mesorhizobium sp. strain N33. PubMed: Comparative study of the use of sarcosine, proline and glycine as acrylamide inhibitors in ripe olive processing. PubMed: Thermodynamic analysis of osmolyte effect on thermal stability of ribonuclease A in terms of water activity. PubMed: Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice. PubMed: Effects of carbohydrates on the oNPG converting activity of β-galactosidases. PubMed: DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. PubMed: Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1. PubMed: Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study. PubMed: Transport of IRW, an ovotransferrin-derived antihypertensive peptide, in human intestinal epithelial Caco-2 cells. PubMed: Nutritional attributes of ash (Fraxinus spp.) outer bark and phloem and their relationships to resistance against the emerald ash borer. PubMed: Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model. PubMed: Characterization of new stable ghrelin analogs with prolonged orexigenic potency. PubMed: Pool of resistance mechanisms to glyphosate in Digitaria insularis. PubMed: Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients. PubMed: Tolerance and safety evaluation of N,N-dimethylglycine, a naturally occurring organic compound, as a feed additive in broiler diets. PubMed: Peptide absorption after massive proximal small bowel resection: mechanisms of ileal adaptation. PubMed: Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation. PubMed: GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation. PubMed: Taste contribution of (R)-strombine to dried scallop. PubMed: Oseltamivir (tamiflu) is a substrate of peptide transporter 1. PubMed: Permeabilization of baker's yeast with N-lauroyl sarcosine. PubMed: Expression and putative roles in attachment of outer membrane proteins of Escherichia coli O157 from planktonic and sessile culture. PubMed: Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. PubMed: DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes. PubMed: Treatment for mitochondrial disorders. PubMed: Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. PubMed: Homocysteine metabolism in children with Down syndrome: in vitro modulation. PubMed: Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome. PubMed: Actions of amylin on subfornical organ neurons and on drinking behavior in rats. PubMed: Comment: N,N-dimethylglycine and L-carnitine as performance enhancers in athletes. PubMed: Effect of replacement therapy with cholylsarcosine on fat malabsorption associated with severe bile acid malabsorption. Studies in dogs with ileal resection. PubMed: Bradykinin-induced dipsogenesis in captopril-treated rats. PubMed: The effects of recessive lethal Notch mutations of Drosophila melanogaster on flavoprotein enzyme activities whose inhibitions cause Notch-like phenocopies. PubMed: Abundance of dimethylamine in seafoods: possible implications in the incidence of human cancer. PubMed: Nitrosation of sarcosine, proline and 4-hydroxyproline by exposure to nitrogen oxides. PubMed: Mutagenicity of pyrolysates from guanidine, ureide, secondary amines and polyamines found by the Salmonella/mammalian-microsome test. PubMed: [On the problems with respect to the formation of N-nitroso compound precursors when using alkylating agents in the fumigation of foodstuffs. II. N-methylation of various amino acids by the action of methyl bromide (author's transl)]. PubMed: Kinetics of uptake of an amino acid and a dipeptide into hamster jejunum and ileum: the effect of semistarvation and starvation. PubMed: Determination of a non-volatile N-nitrosamine on a food matrix. PubMed: The rate of nitrosation of sarcosine in the presence of hydrophile and lipophilic antioxidants. PubMed: Identification and quantitative determination of nitrosoproline and nitrososarcosine and preliminary investigations on nitrosohydroxyproline in cured meat products. PubMed: Toxicities of methionine and other amino acids.