scopoletin
2H-1-benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI)
Identification
| Name | scopoletin |
| IUPAC | 7-hydroxy-6-methoxychromen-2-one |
| CAS Number | 92-61-5 |
| EINECS | 202-171-9 |
| FDA UNII | KLF1HS0SXJ |
| Molecular Formula | C10 H8 O4 |
| Molecular Weight | 192.17056000 |
| MDL Number | MFCD00006872 |
| Nikkaji Number | J4.658B |
| Beilstein | 0156296 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 204.00 °C. @ 760.00 mm Hg |
| Boiling Point | 413.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 342.00 °F. TCC ( 172.40 °C. ) (est) |
| logP (o/w) | 1.280 (est) |
| Soluble in | water, 8879 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-mouse LD50 350 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for scopoletin usage levels up to | not for fragrance use. |
| Recommendation for scopoletin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2H-1-
benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI)
chrysatropic acid
coumarin, 7-hydroxy-6-methoxy-
escopoletin
esculetin 6-methyl ether
gelseminic acid
7-
hydroxy-6-methoxy-2H-1-benzopyran-2-one
7-
hydroxy-6-methoxychromen-2-one
7-
hydroxy-6-methoxycoumarin
6-
methoxy-7-hydroxycoumarin
6-
methylesculetin
6-O-
methylesculetin
beta-
methylesculetin
murrayetin
scopoletine
scopoletol
PubMed:
Rapid simultaneous determination of marmelosin, umbelliferone and scopoletin from Aegle marmelos fruit by RP-HPLC.
PubMed:
Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK-SREBP pathway in diet-induced obese mice.
PubMed:
Inhibition of Orobanche crenata seed germination and radicle growth by allelochemicals identified in cereals.
PubMed:
Pentadecyl ferulate, a potent antioxidant and antiproliferative agent from the halophyte Salicornia herbacea.
PubMed:
Pre-clinical anti-inflammatory aspects of a cuisine and medicinal millennial herb: Malva sylvestris L.
PubMed:
Antioxidant markers based TLC-DPPH differentiation on four commercialized botanical sources of Shankhpushpi (A Medhya Rasayana): A preliminary assessment.
PubMed:
[Study on chemical constituents of root bark of Discocleidion rufescens].
PubMed:
Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae).
PubMed:
Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species.
PubMed:
Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris.
PubMed:
Identification of polyphenols and their metabolites in human urine after cranberry-syrup consumption.
PubMed:
Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.
PubMed:
Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation.
PubMed:
Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4 T cells.
PubMed:
A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit.
PubMed:
Changes in scopoletin concentration in cassava chips from four varieties during storage.
PubMed:
Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice.
PubMed:
Extraction and identification of three major aldose reductase inhibitors from Artemisia montana.
PubMed:
Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compounds.
PubMed:
Cassava: an appraisal of its phytochemistry and its biotechnological prospects.
PubMed:
Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice.
PubMed:
Phenolic compounds in chestnut (Castanea sativa Mill.) heartwood. Effect of toasting at cooperage.
PubMed:
Anti-proliferative and antioxidative activities of Thai noni/Yor (Morinda citrifolia Linn.) leaf extract.
PubMed:
Constituents and secondary metabolite natural products in fresh and deteriorated cassava roots.
PubMed:
Bioactive metabolites from Spilanthes acmella Murr.
PubMed:
[Studies on chemical constituents of Saussurea laniceps].
PubMed:
Involvement of limonene hydroperoxides formed after oil gland injury in the induction of defense response against Penicillium digitatum in lemon fruit.
PubMed:
Identification of TLC markers and quantification by HPLC-MS of various constituents in noni fruit powder and commercial noni-derived products.
PubMed:
New constituents from noni (Morinda citrifolia) fruit juice.
PubMed:
Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida).
PubMed:
Biological and physical approaches to improve induced resistance against green mold of stored citrus fruit.
PubMed:
Sodium carbonate treatment induces scoparone accumulation, structural changes, and alkalinization in the albedo of wounded citrus fruits.
PubMed:
Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits.
PubMed:
Characterization of cigarette tobacco by direct electrospray ionization-ion trap mass spectrometry (ESI-ITMS) analysis of the aqueous extract--a novel and simple approach.
PubMed:
Influence of distillation system, oak wood type, and aging time on composition of cider brandy in phenolic and furanic compounds.
PubMed:
Potential functional foods in the traditional Maori diet.
PubMed:
Mode of action of hot-water dip in reducing decay of lemon fruit.
PubMed:
Ultraviolet C irradiation at 0.5 kJ.m(-)(2) reduces decay without causing damage or affecting postharvest quality of star ruby grapefruit (C. paradisi Macf.).
PubMed:
A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases.
PubMed:
Metabolic and analytical interactions of grapefruit juice and 1,2-benzopyrone (coumarin) in man.
PubMed:
Coumarin compounds in cassava diets: 2 health implications of scopoletin in gari.
PubMed:
Identification of scopoletin in dried bract of the cotton plant.
PubMed:
Scopoletin as a trace constituent of compounded feeds and the lack of an association with the haemorrhagic bowel syndrome in the pig.