tetramethylammonium chloride

methanaminium, N,N,N-trimethyl-, chloride (1:1)

CAS: 75-57-0 C4 H12 Cl N MW: 109.59864000

Identification

Nametetramethylammonium chloride
IUPACtetramethylazanium;chloride
CAS Number75-57-0
EINECS200-880-8
FDA UNIIDCQ9S88703
Molecular FormulaC4 H12 Cl N
Molecular Weight109.59864000
MDL NumberMFCD00011628
Beilstein3911201

Regulatory

Physical Properties

Appearance white crystalline solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 420.00 °C. @ 760.00 mm Hg
Soluble in water, 1e+006 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesviscosity controlling agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityunreported-guinea pig LDLo 20 mg/kg
Dermal Toxicitysubcutaneous-frog LDLo 2000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION\nLUNGS, THORAX, OR RESPIRATION: OTHER CHANGES']

Safety in Use

Categoryviscosity controlling agents
Recommendation for tetramethylammonium chloride usage levels up tonot for fragrance use.
Recommendation for tetramethylammonium chloride flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Charkit Chemical Corporation

The Specialty Chemical Specialists

Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.

View All Website 203-299-3220 sales@charkit.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

viscosity controlling agents

Natural Occurrence

not found in nature

Synonyms

ammonium, tetramethyl-, chloride methanaminium, N,N,N-trimethyl-, chloride methanaminium, N,N,N-trimethyl-, chloride (1:1) tetramethyl ammonium chloride tetramethylazanium;chloride tetramine chloride N,N,N- trimethylmethanaminium chloride PubMed: Epoxy resin synthesis using low molecular weight lignin separated from various lignocellulosic materials. PubMed: Low transition temperature mixtures as innovative and sustainable CO2 capture solvents. PubMed: Optimized whole-genome amplification strategy for extremely AT-biased template. PubMed: Deep eutectic solvents as novel extraction media for protein partitioning. PubMed: Long open amphotericin channels revealed in cholesterol-containing phospholipid membranes are blocked by thiazole derivative. PubMed: Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs. PubMed: External and semi-internal controls for PCR amplification of homologous sequences in mixed templates. PubMed: Formulation and stability of a soap microemulsion and the apparent pK(A) herein. PubMed: Consequences of normalizing transcriptomic and genomic libraries of plant genomes using a duplex-specific nuclease and tetramethylammonium chloride. PubMed: Effects of tetramethyl- and tetraethylammonium chloride on H2O: calorimetric and near-infrared spectroscopic study. PubMed: Independent pathway formation of guest-host in host ternary complexes made of ammonium salt, calixarene, and cyclodextrin. PubMed: Ionization, transport, separation, and detection of ions in non-electrolyte containing liquids. PubMed: Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding chlorides. PubMed: The role of the chemical burns caused by hydroxide ion in the toxicity of dermal exposure to tetramethylammonium ion in a rat model. PubMed: Dissolution kinetics and mechanisms at dolomite-water interfaces: effects of electrolyte specific ionic strength. PubMed: Salt-assisted thermal desorption of mercury from contaminated dredging sludge. PubMed: Role of calcium in the conformational dynamics of factor XIII activation examined by hydrogen-deuterium exchange coupled with MALDI-TOF MS. PubMed: Synthesis of aryl alkyl ethers by alkylation of phenols with quaternary ammonium salts. PubMed: Dissociation of the octameric enolase from S. pyogenes--one interface stabilizes another. PubMed: Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration. PubMed: Optimization of the hybridization-based method for purification of thermostable tRNAs in the presence of tetraalkylammonium salts. PubMed: SANS investigation of the microstructures in catanionic mixtures of SDS/DTAC and the effect of various added salts. PubMed: Binding of ionic species: a general approach to measuring binding constants and assessing affinities. PubMed: Protonation of carbonate in aqueous tetraalkylammonium salts at 25 degrees C. PubMed: Interaction of l-malic acid with alkaline metals and open chain polyammonium cations in aqueous solution. PubMed: Cation effects in the separation of calix[4]pyrroles by nonaqueous capillary electrophoresis with tetraalkylammonium chloride salts as background electrolytes. PubMed: Extraction of chromium(VI) by salting-out with a homogeneous, mixed solvent of water and 2-propanol: a laboratory study. PubMed: Identification of loss of heterozygosity on circulating free DNA in peripheral blood of prostate cancer patients: potential and technical improvements. PubMed: Microfluidic purification and preconcentration of mRNA by flow-through polymeric monolith. PubMed: Voltage and ionic regulation of human serotonin transporter in Xenopus oocytes. PubMed: Nuclear magnetic resonance and small-angle neutron scattering studies of anionic surfactants with macrocounterions: tetramethylammonium dodecyl sulfate. PubMed: [Study on the modification of short chain phoshate ammonium salt of bentonites]. PubMed: Disruption of RCI2A leads to over-accumulation of Na+ and increased salt sensitivity in Arabidopsis thaliana plants. PubMed: Simple method for the assay of clindamycin in human plasma by reversed-phase high-performance liquid chromatography with UV detector. PubMed: Solvation of tetraalkylammonium chlorides in acetonitrile-water mixtures: mass spectrometry and molecular dynamics simulations. PubMed: [Study on the determination of aluminum in soil samples by air-acetylene flame atomic absorption spectrometry]. PubMed: Absorption and fluorescence spectroscopic study on complexation of Oxazine 1 Dye by calix[8]arenesulfonate. PubMed: Effect of combination of extracts of ginseng and ginkgo biloba on acetylcholine in amyloid beta-protein-treated rats determined by an improved HPLC. PubMed: Electrochemical synthesis and X-ray crystal structures of beta-D-2-phenylselenyl-1,3,4,6-tetra-O-acetylglucopyranose and alpha-D-2-phenylselenyl-1,3,4,6-tetra-O-acetylmannopyranose. PubMed: [Analysis of perfect and mismatched DNA duplexes by a generic hexanucleotide microchip]. PubMed: Intramembrane electrostatic interactions destabilize lipid vesicles. PubMed: Formation of vinyl halides via a ruthenium-catalyzed three-component coupling. PubMed: Development of a method for the determination of pyrimethamine concentrations in feeds by ion-pairing high-performance liquid chromatography. PubMed: Facile Synthesis and Structure of Heavy Alkali Metal Thiocarboxylates: Structural Comparison with the Selenium and Tellurium Isologues. PubMed: Heavy Alkali Metal Arenedithiocarboxylates: A Facile Synthesis, Dimeric Structure, and Nonbonding Interaction between the Metals and Aromatic Ring Carbons. PubMed: Differential effects of pH on the pore-forming properties of Bacillus thuringiensis insecticidal crystal toxins. PubMed: On the Temperature Dependence of Intrinsic Surface Protonation Equilibrium Constants: An Extension of the Revised MUSIC Model. PubMed: Parallel multiplex thermodynamic analysis of coaxial base stacking in DNA duplexes by oligodeoxyribonucleotide microchips. PubMed: Determination of glucosinolates in canola seeds using anion exchange membrane extraction combined with the high-pressure liquid chromatography detection. PubMed: Effects of chloride transport inhibition and chloride substitution on neuron function and on hypoxic spreading-depression-like depolarization in rat hippocampal slices. PubMed: Simultaneous determination of inulin and p-aminohippuric acid (PAH) in human plasma and urine by high-performance liquid chromatography. PubMed: Electrostatic dependence of the thrombin-thrombomodulin interaction. PubMed: A simple, rapid method of nucleic acid extraction without tissue homogenization for detecting viroids by hybridization and RT-PCR. PubMed: Binding of Polycarboxylic Acids to Cationic Mixed Micelles: Effects of Polymer Counterion Binding and Polyion Charge Distribution. PubMed: Stability-indicating analysis of isoxazolyl penicillins using dual wavelength high-performance liquid chromatography. PubMed: Effect of temperature on DNA secondary structure in the absence and presence of 0.5 M tetramethylammonium chloride. PubMed: Evaluation of DNA sequencing ambiguities using tetramethylammonium chloride hybridization conditions. PubMed: Studies on the pharmacological properties of novel arylene bis(methylketone) compounds using solid-phase extraction and high-performance liquid chromatography. PubMed: The ionic product of water in concentrated tetramethylammonium chloride solutions. PubMed: Electrogenic Li+/Li+ exchange mediated by the Na+-K+ pump in rabbit cardiac myocytes. PubMed: Electrogenic L-histidine transport in neutral and basic amino acid transporter (NBAT)-expressing Xenopus laevis oocytes. Evidence for two functionally distinct transport mechanisms induced by NBAT expression. PubMed: The tetramethylammonium chloride (TMAC) method for screening cDNA libraries with highly degenerate oligonucleotide probes obtained by reverse translation of amino acid sequences. PubMed: Purification of insulin-like growth factor-I and related proteins using underivatized silica. PubMed: Inhibition by P1075 and pinacidil of a calcium-independent chloride conductance in conditionally-immortal renal glomerular mesangial cells. PubMed: Reaction of the C30A mutant of trimethylamine dehydrogenase with diethylmethylamine. PubMed: Liquid chromatographic assay of tylosin in animal feeds. PubMed: NH4Cl-induced hypertrophy is mediated by weak base effects and is independent of cell cycle processes. PubMed: High-performance liquid chromatographic method for guanylhydrazone compounds. PubMed: High-performance liquid chromatographic analysis of biological and chemical heme polymerization. PubMed: Low concentrations of tetramethylammonium chloride increase yield and specificity of PCR. PubMed: Determination of ephedrine compounds in nutritional supplements by cyclodextrin-modified capillary electrophoresis. PubMed: Multilocus genomic mapping with intracisternal A-particle proviral oligonucleotide probes hybridized to mouse DNA in dried agarose gels. PubMed: Determination of ticarcillin in human plasma and in urine by reversed-phase LC. PubMed: PCR primers and probes for the 16S rRNA gene of most species of pathogenic bacteria, including bacteria found in cerebrospinal fluid. PubMed: Choline chloride activates time-dependent and time-independent K+ currents in dog atrial myocytes. PubMed: A study of oligonucleotide reassociation using large arrays of oligonucleotides synthesised on a glass support. PubMed: Determination of pentamidine isethionate in air. PubMed: The tetramethylammonium chloride method for screening of cDNA libraries using highly degenerate oligonucleotides obtained by backtranslation of amino-acid sequences. PubMed: Structural organization of the human isovaleryl-CoA dehydrogenase gene. PubMed: Isoelectric focusing subtypes of HLA-A can be defined by oligonucleotide typing. PubMed: Efficient 12-mutation testing in the CFTR gene: a general model for complex mutation analysis. PubMed: One-step molecular HLA-DR prescreening employing a set of 14 sequence specific oligonucleotides in a non-radioactive tetramethylammonium chloride hybridization protocol. PubMed: Effect of buffer constituents on the determination of therapeutic proteins by capillary electrophoresis. PubMed: Development and clinical evaluation of a polymerase chain reaction test for detection of Chlamydia trachomatis. PubMed: Detection of human DNA mutations with nonradioactive, allele-specific oligonucleotide probes. PubMed: Detection of enteroviruses in cell cultures by using in situ transcription. PubMed: Separation in a single step by affinity chromatography of cholinesterases differing in subunit number. PubMed: Oxidation-reduction properties of trimethylamine dehydrogenase: effect of inhibitor binding. PubMed: Laser flash photolysis study of intermolecular and intramolecular electron transfer in trimethylamine dehydrogenase. PubMed: Nonradioactive HLA class II typing using polymerase chain reaction and digoxigenin-11-2'-3'-dideoxy-uridinetriphosphate-labeled oligonucleotide probes. PubMed: Effects of extracellular sodium on cytosolic calcium, PGE2 and cAMP in papillary collecting tubule cells. PubMed: Detection of single base mismatches of thymine and cytosine residues by potassium permanganate and hydroxylamine in the presence of tetralkylammonium salts. PubMed: Continuous determination of extracellular space and changes of K+, Na+, Ca2+, and H+ during global ischaemia in isolated rat hearts. PubMed: Calcium binding to the H+,K(+)-ATPase. Evidence for a divalent cation site that is occupied during the catalytic cycle. PubMed: Interaction of monovalent cations with tetrodotoxin and saxitoxin binding at sodium channels of frog myelinated nerve. PubMed: Regulation of tonoplast k channels by voltage in the range of physiological electric potentials. PubMed: Organic cations substituted for sodium are toxic to cultured rat glioma cells. PubMed: Does noradrenaline influence the extracellular accumulation of potassium, sodium, calcium, and hydrogen ions ([K+]e, [Na+]e, [Ca2+]e, [H+]e) during global ischemia in isolated rat hearts? PubMed: The measurement of Ca2+ inflow across the liver cell plasma membrane by using quin2 and studies of the roles of Na+ and extracellular Ca2+ in the mechanism of Ca2+ inflow. PubMed: Inhibition kinetics of acetylcholinesterase with fluoromethyl ketones. PubMed: High-performance liquid chromatographic method for the quantification of several diamidine compounds with potential chemotherapeutic value. PubMed: High-performance liquid chromatographic determination of mitoxantrone in plasma utilizing non-bonded silica gel for solid-phase isolation to reduce adsorptive losses on glass during sample preparation. PubMed: Determination of clindamycin in plasma or serum by high-performance liquid chromatography with ultraviolet detection. PubMed: Liquid chromatographic determination of sulfamethazine in feeds. PubMed: Diagnostic positive and negative ion fast atom bombardment mass spectrometry of low-molecular-weight ammonium compounds of marine origin. PubMed: Southern analysis of genomic DNA with unique and degenerate oligonucleotide probes: a method for reducing probe degeneracy. PubMed: Inhibition by quinine of endothelium-dependent relaxation of rabbit aortic strips. PubMed: High-performance liquid chromatography of underivatized gangliosides. PubMed: Detection of a Na+-H+ antiporter in cultured rat renal papillary collecting duct cells. PubMed: Determination of clomipramine and its hydroxylated and demethylated metabolites in plasma and urine by liquid chromatography with electrochemical detection. PubMed: Hybridization of genomic DNA to oligonucleotide probes in the presence of tetramethylammonium chloride. PubMed: Application of modified normal pulse polarography and its differential mode to alkaline-earth metal ions in acid solutions. PubMed: A potentiometric study of lithium complexation with catecholamines. PubMed: Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries. PubMed: Detection of a bulk water structure related conformational change in horse heart cytochrome c in Cl- -H2O solutions utilizing spectrofluoroelectrochemical techniques. PubMed: Histone H1: ultracentrifugation studies of the effects of ionic strength and denaturants on the solution conformation. PubMed: Dimethonium, a divalent cation that exerts only a screening effect on the electrostatic potential adjacent to negatively charged phospholipid bilayer membranes. PubMed: Mechanistic studies on the dehydrogenases of methylotrophic bacteria. 1. The influence of substrate binding to reduced trimethylamine dehydrogenase on the intramolecular electron transfer between its prosthetic groups. PubMed: Belladonna alkaloids and phenobarbital combination pharmaceuticals analysis II: High-performance liquid chromatographic determination of phenobarbital. PubMed: Effect of reduction of culture medium sodium, using different sodium chloride substitutes, on the proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts. PubMed: Determination of nicotinamide and metabolic products in urine by high-performance liquid chromatography. PubMed: Active ion transport in dog tongue: a possible role in taste. PubMed: Proton gradients in renal cortex brush-border membrane vesicles. Demonstration of a rheogenic proton flux with acridine orange. PubMed: Effect of tetramethylammonium ion on the helix-to-coil transition of poly(deoxyadenylylthymidine): a nuclear magnetic resonance and calorimetric investigation. PubMed: Utilization of amines by yeasts. PubMed: Adsorption of monovalent cations to bilayer membranes containing negative phospholipids. PubMed: Aliphatic ketones are acetylcholinesterase inhibitors but not transition state analogs. PubMed: Fluid transport and the dimensions of cells and interspaces of living Necturus gallbladder. PubMed: Cardiovascular effects of carbachol and other cholinomimetics administered into the cerebral ventricles of conscious cats. PubMed: Effect of symmetrical tetraalkylammonium salts on cloud point on nonionic surfactants. PubMed: Two levels of resting potential in canine cardiac Purkinje fibers exposed to sodium-free solutions. PubMed: Calcium transport in intact human erthrocytes. PubMed: Purification and properties of the trimethylamine dehydrogenase of bacterium 4B6. PubMed: Microbial oxidation of amines. Partial purification of a trimethylamine mono-oxygenase from Pseudomonas aminovorans and its role in growth on trimethylamine. PubMed: Alteration of the relative stability of dA-dT and dG-dC base pairs in DNA. PubMed: Current separations in Myxicola giant axons.