Identification

Nametrichloroethylene
IUPAC1,1,2-trichloroethene
CAS Number79-01-6
EINECS201-167-4
FDA UNII290YE8AR51
Molecular FormulaC2 H Cl3
Molecular Weight131.38597000
MDL NumberMFCD00000838
Nikkaji NumberJ4.408C
Beilstein1736782
XlogP32.60 (est)

Regulatory

FDA Mainterm (SATF)79-01-6 ; TRICHLOROETHYLENE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.46300 @ 25.00 °C.
Melting Point 87.00 to 88.00 °C. @ 760.00 mm Hg
Boiling Point 87.20 °C. @ 760.00 mm Hg
Vapor Pressure 69.000000 mmHg @ 25.00 °C. (est)
Flash Point 54.00 °F. TCC ( 12.10 °C. ) (est)
logP (o/w) 2.420
Soluble in water, 1280 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-rat LD50 4920 mg/kg
Dermal Toxicitysubcutaneous-dog LDLo 150 mg/kg
Inhalation Toxicityinhalation-mouse LC50 8450 ppm/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ATAXIA\nSKIN AND APPENDAGES (SKIN): HAIR: OTHER\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nBEHAVIORAL: GENERAL ANESTHETIC\nBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)', 'KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI\nKIDNEY, URETER, AND BLADDER: PROTEINURIS']

Safety in Use

Categorysolvents
Recommendation for trichloroethylene usage levels up tonot for fragrance use.
Recommendation for trichloroethylene flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

1- chloro-2,2-dichloroethylene 1,1- dichloro-2-chloroethylene ethene, 1,1,2-trichloro- ethylene trichloride trichloroethene 1,1,2- trichloroethene 1,1,2- trichloroethylene 1,2,2- trichloroethylene trilene PubMed: The Potential of the Ni-Resistant TCE-Degrading Pseudomonas putida W619-TCE to Reduce Phytotoxicity and Improve Phytoremediation Efficiency of Poplar Cuttings on A Ni-TCE Co-Contamination. PubMed: "Cutaneous adverse drug reactions" are not always drug-induced. PubMed: Ultra sound assisted one step rapid derivatization and dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometric determination of amino acids in complex matrices. PubMed: Protistan predation affects trichloroethene biodegradation in a bedrock aquifer. PubMed: Solvent tolerance acquired by Brevibacillus brevis during an olive-waste vermicomposting process. PubMed: The use of nonregular fractional factorial designs in combination toxicity studies. PubMed: Effect of trichloroethylene (TCE) toxicity on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in kidney and other rat tissues. PubMed: Risk assessment of exposure to volatile organic compounds in groundwater in Taiwan. PubMed: Insight into the variation in calculated human exposure to soil contaminants using seven different European models. PubMed: Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review. PubMed: Use of beer bran as an adsorbent for the removal of organic compounds from wastewater. PubMed: Continuous treatment of gas-phase trichloroethylene by Burkholderia cepacia G4 in a two-stage continuous stirred tank reactor/trickling biofilter system. PubMed: Biochemical reaction network modeling: predicting metabolism of organic chemical mixtures. PubMed: An ecological study of the association of environmental chemicals on breast cancer incidence in Texas. 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PubMed: Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats. PubMed: Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the HazDat database. PubMed: Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action. PubMed: Economical designs for detecting and characterizing departure from additivity in mixtures of many chemicals. PubMed: Characterization of presystemic elimination of trichloroethylene and its nonlinear kinetics in rats. PubMed: Continuous degradation of trichloroethylene by Xanthobacter sp. strain Py2 during growth on propene. PubMed: Population-based exposure measurements in EPA region 5: a phase I field study in support of the National Human Exposure Assessment Survey. PubMed: An epidemic in Cuba of optic neuropathy, sensorineural deafness, peripheral sensory neuropathy and dorsolateral myeloneuropathy. PubMed: Should chloral hydrate be banned? PubMed: Assessment of exposure to trichloroethylene and tetrachloroethylene in the population of Zagreb, Croatia. PubMed: Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics. PubMed: Uptake by foods of tetrachloroethylene, trichloroethylene, toluene, and benzene from air. PubMed: Health assessment of hazardous air pollutants The Netherlands. PubMed: NTP Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). PubMed: Rapid gas-chromatographic determination of trichloroethylene and/or tetrachloroethylene in lettuce by direct head-space analysis. PubMed: [Trichloroethylene poisoning. Presentation of 3 cases and review of the literature]. PubMed: Determination of fumigants in cereals and cereal products by capillary gas chromatography. PubMed: Rapid determination of fumigant and industrial chemical residues in food. PubMed: Residues of volatile halocarbons in margarines. PubMed: Issues and current applications of interspecies extrapolation of carcinogenic potency as a component of risk assessment. PubMed: Determining multifumigants in whole grains and legumes, milled and low-fat grain products, spices, citrus fruit, and beverages. PubMed: The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: studies in the CD-1 mouse. PubMed: Purge and trap method for determination of volatile halocarbons and carbon disulfide in table-ready foods. PubMed: Unpredictability: an essay in toxicology. PubMed: [Effects of one-day food restriction on the metabolism and toxicity of organic solvents in rats]. PubMed: Human exposure to volatile halogenated hydrocarbons from the general environment. 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PubMed: Separation of permitted and non-permitted solvents for use in foodstuffs by gas chromatography and the use of a solid sampler for the estimation of residual solvents in oils and oleoresins. PubMed: Trichloroethylene effects on animal behavior. The effects of trichloroethylene vapors on a food motivated conditioned climbing reaction of rats.