trichloroethylene
ethylene trichloride
Identification
| Name | trichloroethylene |
| IUPAC | 1,1,2-trichloroethene |
| CAS Number | 79-01-6 |
| EINECS | 201-167-4 |
| FDA UNII | 290YE8AR51 |
| Molecular Formula | C2 H Cl3 |
| Molecular Weight | 131.38597000 |
| MDL Number | MFCD00000838 |
| Nikkaji Number | J4.408C |
| Beilstein | 1736782 |
| XlogP3 | 2.60 (est) |
Regulatory
| FDA Mainterm (SATF) | 79-01-6 ; TRICHLOROETHYLENE |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Appearance | colorless to pale yellow clear liquid (est) |
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.46300 @ 25.00 °C. |
| Melting Point | 87.00 to 88.00 °C. @ 760.00 mm Hg |
| Boiling Point | 87.20 °C. @ 760.00 mm Hg |
| Vapor Pressure | 69.000000 mmHg @ 25.00 °C. (est) |
| Flash Point | 54.00 °F. TCC ( 12.10 °C. ) (est) |
| logP (o/w) | 2.420 |
| Soluble in | water, 1280 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-rat LD50 4920 mg/kg |
| Dermal Toxicity | subcutaneous-dog LDLo 150 mg/kg |
| Inhalation Toxicity | inhalation-mouse LC50 8450 ppm/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ATAXIA\nSKIN AND APPENDAGES (SKIN): HAIR: OTHER\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nBEHAVIORAL: GENERAL ANESTHETIC\nBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)', 'KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI\nKIDNEY, URETER, AND BLADDER: PROTEINURIS']
Safety in Use
| Category | solvents |
| Recommendation for trichloroethylene usage levels up to | not for fragrance use. |
| Recommendation for trichloroethylene flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
1-
chloro-2,2-dichloroethylene
1,1-
dichloro-2-chloroethylene
ethene, 1,1,2-trichloro-
ethylene trichloride
trichloroethene
1,1,2-
trichloroethene
1,1,2-
trichloroethylene
1,2,2-
trichloroethylene
trilene
PubMed:
The Potential of the Ni-Resistant TCE-Degrading Pseudomonas putida W619-TCE to Reduce Phytotoxicity and Improve Phytoremediation Efficiency of Poplar Cuttings on A Ni-TCE Co-Contamination.
PubMed:
"Cutaneous adverse drug reactions" are not always drug-induced.
PubMed:
Ultra sound assisted one step rapid derivatization and dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometric determination of amino acids in complex matrices.
PubMed:
Protistan predation affects trichloroethene biodegradation in a bedrock aquifer.
PubMed:
Solvent tolerance acquired by Brevibacillus brevis during an olive-waste vermicomposting process.
PubMed:
The use of nonregular fractional factorial designs in combination toxicity studies.
PubMed:
Effect of trichloroethylene (TCE) toxicity on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in kidney and other rat tissues.
PubMed:
Risk assessment of exposure to volatile organic compounds in groundwater in Taiwan.
PubMed:
Insight into the variation in calculated human exposure to soil contaminants using seven different European models.
PubMed:
Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review.
PubMed:
Use of beer bran as an adsorbent for the removal of organic compounds from wastewater.
PubMed:
Continuous treatment of gas-phase trichloroethylene by Burkholderia cepacia G4 in a two-stage continuous stirred tank reactor/trickling biofilter system.
PubMed:
Biochemical reaction network modeling: predicting metabolism of organic chemical mixtures.
PubMed:
An ecological study of the association of environmental chemicals on breast cancer incidence in Texas.
PubMed:
[Two-dimensional electrophoresis and mass spectrometry analysis on effects of trichloroethylene on protein of L-02 liver cells].
PubMed:
Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry.
PubMed:
Liver regeneration: a critical toxicodynamic response in predictive toxicology.
PubMed:
Final report of the amended safety assessment of Dioscorea Villosa (Wild Yam) root extract.
PubMed:
A search for residual behavioral effects of trichloroethylene (TCE) in rats exposed as young adults.
PubMed:
Acrylamide and cancer risk--expert risk assessments and the public debate.
PubMed:
Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure.
PubMed:
Development and operation of a trickling biofilter system for continuous treatment of gas-phase trichloroethylene.
PubMed:
Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate.
PubMed:
Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systems.
PubMed:
The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene.
PubMed:
Potential food contaminants and associated health risks.
PubMed:
Modelling the responses to biological reactive intermediates: establishing the borderlines of risk.
PubMed:
Sorption and biodegradation of vapor-phase organic compounds with wastewater sludge and food waste compost.
PubMed:
Guar gum reduces trichloroethylene accumulation in the body by reducing TCE absorption and fat tissue mass.
PubMed:
Efficiency of rice bran for removal of organochlorine compounds and benzene from industrial wastewater.
PubMed:
Studies on defatted seed removal efficiency for organochlorine compounds.
PubMed:
[Prevention of renal carcinoma: the nutri-genetic approach].
PubMed:
Cytotoxicity of MEIC Chemicals Nos. 11-30 in 3T3 Mouse Fibroblasts with and without Microsomal Activation.
PubMed:
Behavioral components of tolerance to repeated inhalation of trichloroethylene (TCE) in rats.
PubMed:
Cubé resin insecticide: identification and biological activity of 29 rotenoid constituents.
PubMed:
National Human Exposure Assessment Survey (NHEXAS): distributions and associations of lead, arsenic and volatile organic compounds in EPA region 5.
PubMed:
Effects of sodium alginate and fish oil to reduce trichloroethylene accumulation in rats.
PubMed:
Estimation of toxicity of chemical mixtures through modeling of chemical interactions.
PubMed:
Shoddy practices shut down oxygen supplier.
PubMed:
Trichloroethene and tetrachloroethene in ground waters of Zagreb, Croatia.
PubMed:
Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats.
PubMed:
Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the HazDat database.
PubMed:
Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action.
PubMed:
Economical designs for detecting and characterizing departure from additivity in mixtures of many chemicals.
PubMed:
Characterization of presystemic elimination of trichloroethylene and its nonlinear kinetics in rats.
PubMed:
Continuous degradation of trichloroethylene by Xanthobacter sp. strain Py2 during growth on propene.
PubMed:
Population-based exposure measurements in EPA region 5: a phase I field study in support of the National Human Exposure Assessment Survey.
PubMed:
An epidemic in Cuba of optic neuropathy, sensorineural deafness, peripheral sensory neuropathy and dorsolateral myeloneuropathy.
PubMed:
Should chloral hydrate be banned?
PubMed:
Assessment of exposure to trichloroethylene and tetrachloroethylene in the population of Zagreb, Croatia.
PubMed:
Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics.
PubMed:
Uptake by foods of tetrachloroethylene, trichloroethylene, toluene, and benzene from air.
PubMed:
Health assessment of hazardous air pollutants The Netherlands.
PubMed:
NTP Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed:
Rapid gas-chromatographic determination of trichloroethylene and/or tetrachloroethylene in lettuce by direct head-space analysis.
PubMed:
[Trichloroethylene poisoning. Presentation of 3 cases and review of the literature].
PubMed:
Determination of fumigants in cereals and cereal products by capillary gas chromatography.
PubMed:
Rapid determination of fumigant and industrial chemical residues in food.
PubMed:
Residues of volatile halocarbons in margarines.
PubMed:
Issues and current applications of interspecies extrapolation of carcinogenic potency as a component of risk assessment.
PubMed:
Determining multifumigants in whole grains and legumes, milled and low-fat grain products, spices, citrus fruit, and beverages.
PubMed:
The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: studies in the CD-1 mouse.
PubMed:
Purge and trap method for determination of volatile halocarbons and carbon disulfide in table-ready foods.
PubMed:
Unpredictability: an essay in toxicology.
PubMed:
[Effects of one-day food restriction on the metabolism and toxicity of organic solvents in rats].
PubMed:
Human exposure to volatile halogenated hydrocarbons from the general environment.
PubMed:
Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study.
PubMed:
Neurophysiological and psychological disorders and occupational exposure to organic solvents.
PubMed:
Personal exposure to volatile organic compounds. I. Direct measurements in breathing-zone air, drinking water, food, and exhaled breath.
PubMed:
Human exposure to potentially carcinogenic compounds.
PubMed:
Chlorinated aliphatic hydrocarbons used in the foods industry: the comparative pharmacokinetics of methylene chloride, 1,2 dichloroethane, chloroform and trichloroethylene after I.V. administration in the rat.
PubMed:
Modification of the AOAC method for determination of fumigants in wheat.
PubMed:
[Comparison of 4 methods of determination of fat in cooked meals].
PubMed:
Trichloroethylene: hepatic effects, metabolism and elimination.
PubMed:
Electrical self-stimulation of the brain: a model for the behavioral evaluation of toxic agents.
PubMed:
Gas chromatographic determination of residual methylene chloride and trichloroethylene in decaffeinated instant and ground coffee with electrolytic conductivity and electron capture detection.
PubMed:
Trichloroethylene. I. An overview.
PubMed:
Determination of hexachloro-1,3-butadiene in spinach, eggs, fish, and milk by electron capture gas-liquid chromatography.
PubMed:
Carcinogenesis bioassay of trichloroethylene.
PubMed:
Behavioral toxicology in the evaluation of food safety.
PubMed:
Determination of methylene chloride, ethylene dichloride, and trichloroethylene as solvent residues in spice oleoresins, using vacuum distillation and electron capture gas chromatography.
PubMed:
The temperature effect on fumigant descrption from cereal grain.
PubMed:
Separation of permitted and non-permitted solvents for use in foodstuffs by gas chromatography and the use of a solid sampler for the estimation of residual solvents in oils and oleoresins.
PubMed:
Trichloroethylene effects on animal behavior. The effects of trichloroethylene vapors on a food motivated conditioned climbing reaction of rats.