trimethyl orthoformate

orthoformic acid, trimethyl ester

CAS: 149-73-5 C4 H10 O3 MW: 106.12130000

Identification

Nametrimethyl orthoformate
IUPACtrimethoxymethane
CAS Number149-73-5
EINECS205-745-7
FDA UNIIXAM28819YJ
Molecular FormulaC4 H10 O3
Molecular Weight106.12130000
MDL NumberMFCD00008483
Nikkaji NumberJ8.664I
Beilstein0969215
XlogP30.20 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.97000 @ 25.00 °C.
Melting Point 15.00 °C. @ 760.00 mm Hg
Boiling Point 104.00 °C. @ 760.00 mm Hg
Vapor Pressure 36.487000 mmHg @ 25.00 °C. (est)
Flash Point 60.00 °F. TCC ( 15.56 °C. )
logP (o/w) 0.250
Soluble in water, 6.851e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for trimethyl orthoformate usage levels up tonot for fragrance use.
Recommendation for trimethyl orthoformate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

ortho formic acid trimethyl ester ortho formic acid, trimethyl ester methane, trimethoxy- trimethoxy-methane trimethoxymethane trimethyl ortho formate US Patents: 8,188,023 - 4-alkyl cyclohexanepropanal compounds and their use in perfume compositions PubMed: Triflic acid promoted direct α-alkylation of unactivated ketones using benzylic alcohols via in situ formed acetals. US Patents: 4-alkyl 1-(3-methoxy-2-propen-1-yl) benzene compounds and their use in perfume compositions PubMed: Highly efficient four-component synthesis of 4(3H)-quinazolinones: palladium-catalyzed carbonylative coupling reactions. PubMed: Synthesis of indenoporphyrins, highly modified porphyrins with reduced diatropic characteristics. PubMed: Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. PubMed: Novel synthesis of the ortho ester derivative of 4,5-epoxymorphinan. PubMed: Ni(II) Tol-BINAP-catalyzed enantioselective orthoester alkylations of N-acylthiazolidinethiones. PubMed: Microwave-assisted synthesis of imidazoles: reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines. PubMed: Preparation of resin-bound N-(alpha-methoxyalkyl)amides: an advantageous use of solid-phase chemistry for the handling of unstable precursors of the versatile N-acyliminium ions. PubMed: Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dithiolan-2-yl]nucleosides as Potential Inhibitors of HIV(1). PubMed: Synthesis of [4,5-Bis(hydroxymethyl)-1,3-oxathiolan-2-yl]nucleosides as Potential Inhibitors of HIV via Stereospecific Base-Induced Rearrangement of a 2,3-Epoxy Thioacetate(1). PubMed: 3-Fluoro-1-hydroxypropan-2-one (fluorohydroxyacetone) and some esters. Syntheses and effects in BDF mice.