pivaloyl chloride

propanoyl chloride, 2,2-dimethyl-

CAS: 3282-30-2 C5 H9 Cl O MW: 120.57793000

Identification

Namepivaloyl chloride
IUPAC2,2-dimethylpropanoyl chloride
CAS Number3282-30-2
EINECS221-921-6
FDA UNIIJQ82J0O21T
Molecular FormulaC5 H9 Cl O
Molecular Weight120.57793000
MDL NumberMFCD00000709
Nikkaji NumberJ33.810I
Beilstein385668

Regulatory

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.97900 @ 25.00 °C.
Refractive Index 1.41200 @ 20.00 °C.
Boiling Point 107.00 °C. @ 760.00 mm Hg
Vapor Pressure 27.400000 mmHg @ 25.00 °C. (est)
Flash Point 48.00 °F. TCC ( 8.89 °C. )
logP (o/w) 1.680 (est)
Soluble in water, 1.735e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for pivaloyl chloride usage levels up tonot for fragrance use.
Recommendation for pivaloyl chloride flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2,2- dimethyl-propionyl chloride 2,2- dimethylpropanoyl chloride 2,2- dimethylpropionyl chloride pivalyl chloride propanoyl chloride, 2,2-dimethyl- trimethyl acetyl chloride trimethylacetyl chloride trimethylacetylchloride PubMed: Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates. PubMed: Ex situ generation of stoichiometric and substoichiometric 12CO and 13CO and its efficient incorporation in palladium catalyzed aminocarbonylations. PubMed: Stereochemistry of internucleotide bond formation by the H-phosphonate method. 5. The role of Brønsted and H-bonding base catalysis in ribonucleoside H-phosphonate condensation-chemical and stereochemical consequences. PubMed: Synthesis and structural investigation of N-acyl selenophosphoramides. PubMed: O-Pivaloyl diphenyl-seleno-phosphinate. PubMed: 6-Coordinate tungsten(VI) tris-n-isopropylanilide complexes: products of terminal oxo and nitrido transformations effected by main group electrophiles. PubMed: Boronated protohaemins: synthesis and in vivo antitumour efficacy. PubMed: Oxonitriles: a grignard addition-acylation route to enamides. PubMed: Formation of surface-bound acyl groups by reaction of acyl halides on ge(100)-2x1. PubMed: Preparation of nucleoside H-phosphonoselenoate monoesters via the phosphinate approach. PubMed: Organic nitriles from acid chlorides: an isovalent N for (O)CL exchange reaction mediated by a tungsten nitride complex. PubMed: 4'-pivaloyl substituted thymidine as a precursor for the thymyl radical: an EPR spectroscopic study. PubMed: Side reactions in the H-phosphonate approach to oligonucleotide synthesis: a kinetic investigation on bisacylphosphite formation and 5'-O-acylation. PubMed: Synthesis, intramolecular migrations and enzymic hydrolysis of partially pivaloylated methyl alpha-D-mannopyranosides. PubMed: Analysis of isomeric long-chain hydroxy fatty acids by tandem mass spectrometry: application to the diagnosis of long-chain 3-hydroxyacyl CoA dehydrogenase deficiency. PubMed: Regioselective Acylation of Hexopyranosides with Pivaloyl Chloride. PubMed: Syntheses of anomerically phosphodiester-linked oligomers of the repeating units of the Haemophilus influenzae types c and f capsular polysaccharides. PubMed: Generation of N-acylpyridinium ions from pivaloyl chloride and pyridine derivatives by means of silyl triflates PubMed: Unexpected dipivaloylation of 9-lithiated fluorene: formation of 1-(fluoren-9-ylidene)-2,2-dimethylpropyl pivalate. PubMed: Cross-linking of starch with bifunctional precursors of nitroalkenes. PubMed: Selective pivaloylation and diphenylacetylation of cyclomalto-oligosaccharides. PubMed: 5'-Hydrogenphosphonates of anti-HIV nucleoside analogues revisited: controversial mode of action. PubMed: [Synthesis of new pyrimidine 5'-H-thiophosphonates]. PubMed: A facile method for preparation of t-butyloxycarbonylamino acid p-nitroanilides. PubMed: [N-phosphonate synthesis of oligodeoxyribonucleotides with the use of a p-nitrophenylethyl blocking group]. PubMed: [Synthesis of 5'-phosphorylated oligodeoxyribonucleotides by the H-phosphonate method]. PubMed: Selective pivaloylation of 2-acetamido-2-deoxy sugars. PubMed: The preparation and application of functionalised synthetic oligonucleotides: III. Use of H-phosphonate derivatives of protected amino-hexanol and mercapto-propanol or -hexanol. PubMed: [Synthesis of oligoribonucleotides via ribonucleoside-H-phosphonates]. PubMed: A model study directed towards the preparation of nucleopeptides via H-phosphonate intermediates. PubMed: Studies on biologically active nucleosides and nucleotides. 5. Synthesis and antitumor activity of some 2,2'-anhydro-1-(3',5'-di-O-acyl-beta-D-arabinofuranosyl)cytosine salts and 2,2'-anhydro-1-(3'-O-acyl-beta-D-arabinofuranoxyl)cytosine 5'-phosphates. PubMed: Synthesis and pharmacological screening of certain N-substituted amides structurally related to some local anesthetics.