tromethamine

methylamine, 1,1,1-tris(hydroxymethyl)-

CAS: 77-86-1 C4 H11 N O3 MW: 121.13627000

Identification

Nametromethamine
IUPAC2-amino-2-(hydroxymethyl)propane-1,3-diol
CAS Number77-86-1
EINECS201-064-4
FDA UNII023C2WHX2V
Molecular FormulaC4 H11 N O3
Molecular Weight121.13627000
MDL NumberMFCD00004679
Nikkaji NumberJ4.214E
Beilstein741883

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 171.00 to 172.00 °C. @ 760.00 mm Hg
Boiling Point 357.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000001 mmHg @ 25.00 °C. (est)
Flash Point 337.00 °F. TCC ( 169.70 °C. ) (est)
logP (o/w) -2.515 (est)
Soluble in water, 550000 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesbuffering agents

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-rat LD50 5900 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorybuffering agents and neutralizing agents
Recommendation for tromethamine usage levels up tonot for fragrance use.
Recommendation for tromethamine flavor usage levels up tonot for flavor use.

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Potential Uses

buffering agents

Natural Occurrence

not found in nature

Synonyms

2- amino-2-(hydroxymethyl)-1,3-propane diol 2- amino-2-(hydroxymethyl)-1,3-propanediol 2- amino-2-(hydroxymethyl)propan-1,3-diol 2- amino-2-(hydroxymethyl)propane-1,3-diol 2- amino-2-hydroxymethyl-1,3-propanediol 2- amino-2-hydroxymethylpropane-1,3-diol 2- amino-2-methylol-1,3-propanediol aminotris(hydroxymethyl)methane tris( hydroxymethyl) aminomethane 2-( hydroxymethyl)-2-amino-1,3-propanediol 1,1,1-tris( hydroxymethyl)-methanamine tris( hydroxymethyl)aminomethane ACS 1,1,1-tris( hydroxymethyl)methanamine tris( hydroxymethyl)methanamine 1,1,1-tris( hydroxymethyl)methylamine tris( hydroxymethyl)methylamine tris( hydroxymethyly)amino methane methanamine, 1,1,1-tris(hydroxymethyl)- methylamine, 1,1,1-tris(hydroxymethyl)- 1,3- propanediol, 2-amino-2- (hydroxymethyl)- 1,3- propanediol, 2-amino-2-(hydroxymethyl)- tri(hydroxymethyl)aminomethane trimethylol aminomethane tris amino trometamol trometamole tromethamolum PubMed: High concentration of epigallocatechin-3-gallate increased the incidences of arrhythmia and diastolic dysfunction via β2-adrenoceptor. PubMed: Extraction, purification and identification of antifreeze proteins from cold acclimated malting barley (Hordeum vulgare L.). PubMed: An assay for pro-oxidant reactivity based on phenoxyl radicals generated by laccase. PubMed: Effect of pressure-induced changes in the ionization equilibria of buffers on inactivation of Escherichia coli and Staphylococcus aureus by high hydrostatic pressure. PubMed: Solvent selection and optimization of α-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Tyr-NH2 using mixture design and response surface methodology. PubMed: The effect of chilled storage and cryopreservation on the sperm DNA fragmentation dynamics of a captive population of koalas. PubMed: Intranasal ketorolac (Sprix). PubMed: Isolation of high quality RNA from cereal seeds containing high levels of starch. PubMed: Characterization of the responses of equine digital veins and arteries to calcitonin gene-related peptide. PubMed: Separation of dipeptides with two chiral centers using 2-hydroxypropyl-beta-CD-modified MEKC. PubMed: Assay of bradykinin metabolites in human body fluids by CE-LIF coupled with transient ITP preconcentration. PubMed: Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac. PubMed: [Change of glucose transporter 4 and its influence on glucose and fatty-acid metabolism in type 2 diabetic myocardium]. PubMed: Analysis of organic acids and inorganic anions in beverage drinks by capillary electrophoresis. PubMed: Process development for heme-enriched peptide by enzymatic hydrolysis of hemoglobin. PubMed: A convenient one-step extraction of cellular ATP using boiling water for the luciferin-luciferase assay of ATP. PubMed: Direct compression tablets containing a series of four beta-cyclodextrin complexes formed by neutralizing an acidic drug. PubMed: Retrospective case-control evaluation of the use of parenteral ketorolac tromethamine in patients after surgery. PubMed: The effect of food and an antacid on the bioavailability of dexketoprofen trometamol. PubMed: Response of Salmonella choleraesuis LT2 spheroplasts and permeabilized cells to the bacteriocin AS-48. PubMed: Comparative effects of ketorolac 0.5% or diclofenac 0.1% ophthalmic solutions on inflammation after cataract surgery. PubMed: Single-dose treatment of acute cystitis with fosfomycin tromethamine. PubMed: Prolonged central intravenous ketorolac continuous infusion in a cancer patient with intractable bone pain. PubMed: New therapeutic agents marketed in 1993. PubMed: New drugs from 1991-1992. PubMed: Comparison of a prostaglandin-F2alpha-based reproductive program with an estrus detection-based reproductive program on a large commercial dairy herd. PubMed: Management of low back pain by analgesics and adjuvant drugs. PubMed: Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals. PubMed: Relative bioavailability of fosfomycin and of trometamol after administration of single dose by oral route of fosfomycin trometamol in fasting conditions and after a meal. PubMed: The general utility of a glycerophosphate-Tris buffered medium. PubMed: Intra-amniotic administration of 15(S)-15-methyl-prostaglandin F2alpha for the induction of midtrimester abortion. PubMed: Release of motilin in man. PubMed: Chemicals bathing the oxyntic gland area stimulate acid secretion in dog. PubMed: New drugs and new treatments.