Identification

Namepolysorbate 85
CAS Number9005-70-3
FDA UNIIA7F3N56197
MDL NumberMFCD01779641

Regulatory

DG SANTE Food Contact Materialspolyethyleneglycol sorbitan trioleate
FDA Mainterm (IAUFC)9005-70-3 ; POLYSORBATE 85

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.02800 @ 25.00 °C.
Refractive Index 1.46800 @ 20.00 °C.
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
Soluble in water, 2.718e-019 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usessurfactants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryemulsifiers, surfactants
Recommendation for polysorbate 85 usage levels up tonot for fragrance use.
Recommendation for polysorbate 85 flavor usage levels up tonot for flavor use.

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Potential Uses

emulsifying agents surfactants

Natural Occurrence

not found in nature

Synonyms

glycosperse TO-20 hetsorb TO-20 liposorb TO-20 lonzest STO-20 monebat - 85 nikkol TO-30V poe-20 sorbitan trioleate polyethyleneglycol sorbitan trioleate polyoxyethylene (20) sorbitan trioleate protasorb TO-20 rheodol TW-O320V toximul see-340 tween 85 PubMed: On the behaviour of nanoparticles in oil-in-water emulsions with different surfactants. PubMed: Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis. PubMed: Characterization of polysorbate 85, a nonionic surfactant, by liquid chromatography vs. ion mobility separation coupled with tandem mass spectrometry. PubMed: In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine. PubMed: The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles. PubMed: Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions. PubMed: Enhanced chemiluminescence of cerium(IV)-Tween 85 system and the analytical application. PubMed: Joint-action of antifouling substances in copper-free paints. PubMed: Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models. PubMed: Low-energy formation of edible nanoemulsions: factors influencing droplet size produced by emulsion phase inversion. PubMed: Biodegradation of a keratin waste and the concomitant production of detergent stable serine proteases from Paecilomyces lilacinus. PubMed: The influence of the structure and the composition of water/AOT-Tween 85/IPM microemulsion system on transdermal delivery of 5-fluorouracil. PubMed: Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: synthesis and in vitro characteristics. PubMed: [Water in oil microemulsions containing NaCl for transdermal delivery of fluorouracil]. PubMed: A novel biocatalytic approach to acetylation of 1-β-D-arabinofuranosylcytosine by Aspergillus oryzae whole cell in organic solvents. PubMed: [Microemulsion-based gel of fluorouracil for transdermal delivery]. PubMed: Formulation and physicochemical characterization of imwitor 308 based self microemulsifying drug delivery systems. PubMed: Characterization of potent anticholinesterase plant oil based microemulsion. PubMed: Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride. PubMed: Extraction of monoclonal antibodies (IgG1) using anionic and anionic/nonionic reverse micelles. PubMed: Direct and rapid determination of ultratrace heavy metals in solid plant materials by ET-AAS ultrasonic-assisted slurry sampling. PubMed: Optimization of mono and diacylglycerols production from enzymatic glycerolysis in solvent-free systems. PubMed: [Water in oil microemulsions for transdermal delivery of fluorouracil]. PubMed: Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum. PubMed: Potential of nanoemulsions for intravenous delivery of rifampicin. PubMed: Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: structural characterization and dermal pharmacokinetics in vivo. PubMed: Immobilization of lipases on hydrophobilized zirconia nanoparticles: highly enantioselective and reusable biocatalysts. PubMed: Investigation of microemulsion system for transdermal delivery of meloxicam. PubMed: Influence of excipients on moisturizing effect of urea. PubMed: Behavior of soybean oil-in-water emulsion stabilized by nonionic surfactant. PubMed: [Comparison of non-protected fluid room temperature phosphorescence and micellar-stabilized room temperature phosphorescence properties of indole-3-butyric acid]. PubMed: Effect of surfactant HLB and different formulation variables on the properties of poly-D,L-lactide microspheres of naltrexone prepared by double emulsion technique. PubMed: Simultaneous conductivity and viscosity measurements as a technique to track emulsion inversion by the phase-inversion-temperature method. PubMed: Self-generation of tiered surfactant superstructures for one-pot synthesis of Co3O4 nanocubes and their close- and non-close-packed organizations. PubMed: Polymyxin B enhances ISS-mediated immune responses across multiple species. PubMed: Poly-epsilon-caprolactone nanocapsules containing octyl methoxycinnamate: preparation and characterization. PubMed: Influence of surfactant hydrophobicity on the detachment of Escherichia coli O157:H7 from lettuce. PubMed: Microemulsion formulation of clonixic acid: solubility enhancement and pain reduction. PubMed: Effect of surface active agents on the production of biopesticides using wastewater sludge as a raw material. PubMed: Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection. PubMed: Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system. PubMed: Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration. PubMed: Chiral epoxide production using mycobacterium solubilized in a water-in-oil microemulsion. PubMed: Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells. PubMed: Lipase activity from strains of Pasteurella multocida. PubMed: Long-term stability of PBCA nanoparticle suspensions. PubMed: Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats. PubMed: Gelatin-stabilised microemulsion-based organogels: rheology and application in iontophoretic transdermal drug delivery. PubMed: Protein separation using affinity-based reversed micelles PubMed: Nanoparticle technology for delivery of drugs across the blood-brain barrier. PubMed: Efficacy of oral dalargin-loaded nanoparticle delivery across the blood-brain barrier. PubMed: Protection against haemorrhagic septicaemia induced by vaccination of buffalo calves with an improved oil adjuvant vaccine. PubMed: Effect of dosing vehicle on the hepatotoxicity of CCl4 and nephrotoxicity of CHCl3 in rats. PubMed: Contribution of hydrophobicity of nonionic detergents to membrane lipid fluidity and disopyramide uptake by rat intestinal brush-border membrane vesicles. PubMed: [Catalytic properties of catalase in microemulsions of surface-active agents in octane]. PubMed: Renaturation and ligand blotting of the major subunit of the rat asialoglycoprotein receptor after denaturing polyacrylamide gel electrophoresis. PubMed: Degradation of pesticides in a continuous-flow two-phase microemulsion reactor. PubMed: Biodegradation of pesticides in nonionic water-in-oil microemulsions of tween 85: Relationship between micelle structure and activity. PubMed: High pressure EPR studies of protein mobility in reversed micelles. PubMed: Surfactant-Induced hydrogen production in cyanobacteria. PubMed: Solubilization and activity of proteins in compressible-fluid based microemulsions. PubMed: Polarographic measurement of oxygen uptake using lipoxygenase in reverse micelles. PubMed: The irritancy and allergenicity of 2-n-octyl-4-isothiazolin-3-one (Skane M-8), with recommendations for patch test concentration. PubMed: Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis. PubMed: Solubilization of bacterial cells in organic solvents via reverse micelles. PubMed: [Effect of polyoxyethylene (20) sorbitan trioleate (tween 85) on E-rosette formation (in vitro) in blastomatosis patients]. PubMed: The triggering effect of surfaces and surfactants on heat output, oxygen consumption and size reduction of a starving marine Vibrio. PubMed: [Complex effect of surface-active substances on the process of microbiological hydrocarbon oxidation]. PubMed: Hydrolytic enzymes of Moraxella bovis. PubMed: Properties of a membrane-bound triglyceride lipase of rapeseed (Brassica napus L.) cotyledons. PubMed: Studies on 2', 3'-cyclic AMP 3'-phosphohydrolase in rabbit skin. PubMed: In vivo method for monitoring polysorbate 85 effect on epidermal permeability. PubMed: Effect of polysorbate 85 on human skin.