polysorbate 85
tween 85
Identification
| Name | polysorbate 85 |
| CAS Number | 9005-70-3 |
| FDA UNII | A7F3N56197 |
| MDL Number | MFCD01779641 |
Regulatory
| DG SANTE Food Contact Materials | polyethyleneglycol sorbitan trioleate |
| FDA Mainterm (IAUFC) | 9005-70-3 ; POLYSORBATE 85 |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.02800 @ 25.00 °C. |
| Refractive Index | 1.46800 @ 20.00 °C. |
| Flash Point | > 230.00 °F. TCC ( > 110.00 °C. ) |
| Soluble in | water, 2.718e-019 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | surfactants |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | emulsifiers, surfactants |
| Recommendation for polysorbate 85 usage levels up to | not for fragrance use. |
| Recommendation for polysorbate 85 flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
glycosperse TO-20
hetsorb TO-20
liposorb TO-20
lonzest STO-20
monebat - 85
nikkol TO-30V
poe-20 sorbitan trioleate
polyethyleneglycol sorbitan trioleate
polyoxyethylene (20) sorbitan trioleate
protasorb TO-20
rheodol TW-O320V
toximul see-340
tween 85
PubMed:
On the behaviour of nanoparticles in oil-in-water emulsions with different surfactants.
PubMed:
Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis.
PubMed:
Characterization of polysorbate 85, a nonionic surfactant, by liquid chromatography vs. ion mobility separation coupled with tandem mass spectrometry.
PubMed:
In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine.
PubMed:
The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles.
PubMed:
Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions.
PubMed:
Enhanced chemiluminescence of cerium(IV)-Tween 85 system and the analytical application.
PubMed:
Joint-action of antifouling substances in copper-free paints.
PubMed:
Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models.
PubMed:
Low-energy formation of edible nanoemulsions: factors influencing droplet size produced by emulsion phase inversion.
PubMed:
Biodegradation of a keratin waste and the concomitant production of detergent stable serine proteases from Paecilomyces lilacinus.
PubMed:
The influence of the structure and the composition of water/AOT-Tween 85/IPM microemulsion system on transdermal delivery of 5-fluorouracil.
PubMed:
Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: synthesis and in vitro characteristics.
PubMed:
[Water in oil microemulsions containing NaCl for transdermal delivery of fluorouracil].
PubMed:
A novel biocatalytic approach to acetylation of 1-β-D-arabinofuranosylcytosine by Aspergillus oryzae whole cell in organic solvents.
PubMed:
[Microemulsion-based gel of fluorouracil for transdermal delivery].
PubMed:
Formulation and physicochemical characterization of imwitor 308 based self microemulsifying drug delivery systems.
PubMed:
Characterization of potent anticholinesterase plant oil based microemulsion.
PubMed:
Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride.
PubMed:
Extraction of monoclonal antibodies (IgG1) using anionic and anionic/nonionic reverse micelles.
PubMed:
Direct and rapid determination of ultratrace heavy metals in solid plant materials by ET-AAS ultrasonic-assisted slurry sampling.
PubMed:
Optimization of mono and diacylglycerols production from enzymatic glycerolysis in solvent-free systems.
PubMed:
[Water in oil microemulsions for transdermal delivery of fluorouracil].
PubMed:
Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum.
PubMed:
Potential of nanoemulsions for intravenous delivery of rifampicin.
PubMed:
Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: structural characterization and dermal pharmacokinetics in vivo.
PubMed:
Immobilization of lipases on hydrophobilized zirconia nanoparticles: highly enantioselective and reusable biocatalysts.
PubMed:
Investigation of microemulsion system for transdermal delivery of meloxicam.
PubMed:
Influence of excipients on moisturizing effect of urea.
PubMed:
Behavior of soybean oil-in-water emulsion stabilized by nonionic surfactant.
PubMed:
[Comparison of non-protected fluid room temperature phosphorescence and micellar-stabilized room temperature phosphorescence properties of indole-3-butyric acid].
PubMed:
Effect of surfactant HLB and different formulation variables on the properties of poly-D,L-lactide microspheres of naltrexone prepared by double emulsion technique.
PubMed:
Simultaneous conductivity and viscosity measurements as a technique to track emulsion inversion by the phase-inversion-temperature method.
PubMed:
Self-generation of tiered surfactant superstructures for one-pot synthesis of Co3O4 nanocubes and their close- and non-close-packed organizations.
PubMed:
Polymyxin B enhances ISS-mediated immune responses across multiple species.
PubMed:
Poly-epsilon-caprolactone nanocapsules containing octyl methoxycinnamate: preparation and characterization.
PubMed:
Influence of surfactant hydrophobicity on the detachment of Escherichia coli O157:H7 from lettuce.
PubMed:
Microemulsion formulation of clonixic acid: solubility enhancement and pain reduction.
PubMed:
Effect of surface active agents on the production of biopesticides using wastewater sludge as a raw material.
PubMed:
Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection.
PubMed:
Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system.
PubMed:
Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration.
PubMed:
Chiral epoxide production using mycobacterium solubilized in a water-in-oil microemulsion.
PubMed:
Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells.
PubMed:
Lipase activity from strains of Pasteurella multocida.
PubMed:
Long-term stability of PBCA nanoparticle suspensions.
PubMed:
Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats.
PubMed:
Gelatin-stabilised microemulsion-based organogels: rheology and application in iontophoretic transdermal drug delivery.
PubMed:
Protein separation using affinity-based reversed micelles
PubMed:
Nanoparticle technology for delivery of drugs across the blood-brain barrier.
PubMed:
Efficacy of oral dalargin-loaded nanoparticle delivery across the blood-brain barrier.
PubMed:
Protection against haemorrhagic septicaemia induced by vaccination of buffalo calves with an improved oil adjuvant vaccine.
PubMed:
Effect of dosing vehicle on the hepatotoxicity of CCl4 and nephrotoxicity of CHCl3 in rats.
PubMed:
Contribution of hydrophobicity of nonionic detergents to membrane lipid fluidity and disopyramide uptake by rat intestinal brush-border membrane vesicles.
PubMed:
[Catalytic properties of catalase in microemulsions of surface-active agents in octane].
PubMed:
Renaturation and ligand blotting of the major subunit of the rat asialoglycoprotein receptor after denaturing polyacrylamide gel electrophoresis.
PubMed:
Degradation of pesticides in a continuous-flow two-phase microemulsion reactor.
PubMed:
Biodegradation of pesticides in nonionic water-in-oil microemulsions of tween 85: Relationship between micelle structure and activity.
PubMed:
High pressure EPR studies of protein mobility in reversed micelles.
PubMed:
Surfactant-Induced hydrogen production in cyanobacteria.
PubMed:
Solubilization and activity of proteins in compressible-fluid based microemulsions.
PubMed:
Polarographic measurement of oxygen uptake using lipoxygenase in reverse micelles.
PubMed:
The irritancy and allergenicity of 2-n-octyl-4-isothiazolin-3-one (Skane M-8), with recommendations for patch test concentration.
PubMed:
Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis.
PubMed:
Solubilization of bacterial cells in organic solvents via reverse micelles.
PubMed:
[Effect of polyoxyethylene (20) sorbitan trioleate (tween 85) on E-rosette formation (in vitro) in blastomatosis patients].
PubMed:
The triggering effect of surfaces and surfactants on heat output, oxygen consumption and size reduction of a starving marine Vibrio.
PubMed:
[Complex effect of surface-active substances on the process of microbiological hydrocarbon oxidation].
PubMed:
Hydrolytic enzymes of Moraxella bovis.
PubMed:
Properties of a membrane-bound triglyceride lipase of rapeseed (Brassica napus L.) cotyledons.
PubMed:
Studies on 2', 3'-cyclic AMP 3'-phosphohydrolase in rabbit skin.
PubMed:
In vivo method for monitoring polysorbate 85 effect on epidermal permeability.
PubMed:
Effect of polysorbate 85 on human skin.