cetostearyl alcohol

1-octadecanol mixed with 1-hexadecanol

CAS: 67762-27-0 C34 H72 O2 MW: 512.94624000

Identification

Namecetostearyl alcohol
CAS Number67762-27-0
EINECS267-008-6
FDA UNII2DMT128M1S
Molecular FormulaC34 H72 O2
Molecular Weight512.94624000

Regulatory

FDA Mainterm (IAUFC)67762-27-0 ; CETOSTEARYL ALCOHOL

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 334.00 to 335.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000009 mmHg @ 25.00 °C. (est)
Flash Point 282.00 °F. TCC ( 138.70 °C. ) (est)
logP (o/w) 8.314 (est)
Soluble in water, 0.1495 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesemulsion stabilisers

Organoleptic Properties

Odor Strength none
Odor Description at 100.00 %.

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for cetostearyl alcohol usage levels up tonot for fragrance use.
Recommendation for cetostearyl alcohol flavor usage levels up tonot for flavor use.

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Potential Uses

emollients emulsifying agents emulsion stabilisers opacifying agents viscosity controlling agents

Natural Occurrence

not found in nature

Synonyms

(C16-C18) alkyl alcohol (C16-C18)- alkyl alcohol alkyl alcohols C16-18 brookswax D cetax 50 cetearyl alcohol cetyl-stearyl alcohol cetyl/stearyl alcohol cosmowax cosmowax D cosmowax J crodacol CS50 crodacol CS90 crodafos CES crodafos CS20A crodex A crodex N emulsifying wax pastilles SP-210P NF hallstar NCD-20 hexadecan-1-ol; octadecan-1-ol jarcol I-167 lanette O lipocol SC lipocol SC-1618 pastilles lipomulse luxe lipowax D lipowax NI lipowax P lipowax R2 1- octadecanol mixed with 1-hexadecanol PubMed: Drug-excipient compatibility studies in binary mixtures of avobenzone. PubMed: Drug-excipient compatibility studies in binary mixtures of avobenzone. PubMed: Development and characterization of controlled release polar lipid microparticles of candesartan cilexetil by solid dispersion. PubMed: Reduced burning and stinging associated with topical application of lactic acid 10% with strontium versus ammonium lactate 12%. PubMed: Sucrose stearate-enriched lipid matrix tablets of etodolac: modulation of drug release, diffusional modeling and structure elucidation studies. PubMed: Contact dermatitis caused by fatty alcohols: may polyethoxylation of the fatty alcohols influence their sensitizing potential? PubMed: Why aqueous cream should not be used in radiotherapy-induced skin reactions. PubMed: Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide. PubMed: Suitability of Gelucire 50/13 for controlled release formulation of salbutamol sulphate. PubMed: Occupational allergic contact dermatitis from methyl aminolevulinate. PubMed: A bilateral comparison study of pimecrolimus cream 1% and a topical medical device cream in the treatment of patients with atopic dermatitis. PubMed: Formulation and in vitro evaluation of buoyant controlled release lercanidipine lipospheres. PubMed: Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance. PubMed: Development of extended release divalproex sodium tablets containing hypdrophobic and hydrophilic matrix. PubMed: Topical vehicles based on natural surfactant/fatty alcohols mixed emulsifier: The influence of two polyols on the colloidal structure and in vitro/in vivo skin performance. PubMed: Matrix embedded microspherules containing indomethacin as controlled drug delivery systems. PubMed: Stabilizing effect of cetostearyl alcohol and glyceryl monostearate as co-emulsifiers on hydrocarbon-free O/W glyceride creams. PubMed: In vitro skin permeation of sunscreen agents from O/W emulsions. PubMed: In vitro controlled drug release from loaded microspheres--dose regulation through formulation. PubMed: Empirical kinetic model of propafenone release from Hot Air Coating microparticles. PubMed: Evaluation of lotion formulations on irritation using the modified forearm-controlled application test method. PubMed: The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine. PubMed: An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: the influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. PubMed: Effect of poloxamers on nifedipine microparticles prepared by Hot Air Coating technique. PubMed: Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation. PubMed: Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000. PubMed: Evaluation of hydrophobic materials as matrices for controlled-release drug delivery. PubMed: Characterization of nifedipine microparticles prepared by hot air coating technique. PubMed: Determination of anionactive tensides using cetylpyridinium tetrachlorozincate as titrant. Analytical methods in respect to environmental and economical concern, part 20. PubMed: Final report on the amended safety assessment of diisopropyl dimer dilinoleate, dicetearyl dimer dilinoleate, diisostearyl dimer dilinoleate, dioctyl dimer dilinoleate, dioctyldodecyl dimer dilinoleate, and ditridecyl dimer dilinoleate. PubMed: Allergic contact dermatitis from cetearyl isononanoate. PubMed: The development of Cutina lipogels and gel microemulsion for topical administration of fluconazole. PubMed: Extended release lipophilic indomethacin microspheres: formulation factors and mathematical equations fitted drug release rates. PubMed: Radiolysis characterization of cetostearyl alcohol by gas chromatography-mass spectrometry. PubMed: The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance. PubMed: Allergic contact dermatitis from cetrimide and cetearyl alcohol in Burnol-plus cream. PubMed: Synchrotron X-ray investigations into the lamellar gel phase formed in pharmaceutical creams prepared with cetrimide and fatty alcohols. PubMed: An investigation into the supramolecular structure of ternary gel systems using oscillatory rheometry, microscopy, and low frequency dielectric spectroscopy. PubMed: Effects of drug concentration in inner aqueous phase and additives in oleaginous phase on release and bioavailability of isoniazid from multiple emulsion. PubMed: Contact sensitization in chronic venous insufficiency: modern wound dressings. PubMed: Contact dermatitis from cetostearyl alcohol. PubMed: Variation in cetostearyl alcohol and lecithin from different sources: evaluation by dielectric analysis. PubMed: Multiple emulsion-based systems carrying insulin: development and characterization. PubMed: High incidence of contact dermatitis in leg-ulcer patients--implications for management. PubMed: Contact dermatitis from cetostearyl alcohol in hydrocortisone butyrate lipocream, and from lanolin. PubMed: Emulsification by the phase inversion temperature method: the role of self-bodying agents and the influence of oil polarity. PubMed: Contact dermatitis to Hirudoid cream. PubMed: Water distribution in creams prepared using cetostearyl alcohol and cetrimide. PubMed: An investigation of the structural changes occurring in a cetostearyl alcohol/cetrimide/water gel after prolonged low temperature (4 degrees C) storage. PubMed: The effect of temperature on the conductivity of gels and emulsions prepared from cetrimide and cetostearyl alcohol. PubMed: Reflectance measurements on gels and emulsions containing cetrimide and cetostearyl alcohol--a preliminary investigation. PubMed: [Internal structure of oil-in-water emulsions stabilized with a cetostearyl alcohol]. PubMed: Allergy to cetylalcohol. PubMed: [Contact allergy to cetylstearylalcohol (Lanette O) as a therapeutic problem in stasis dermatitis and leg ulcer]. PubMed: Lanette-O--another test substance for lower leg series. PubMed: Proceedings: The structure of the continuous phases in creams stabilised by cetrimide and cetostearyl alcohol. PubMed: The composition of cetostearyl alcohol. PubMed: Rheology of systems containing cetrimide-cetostearyl alcohol: variation with temperature. PubMed: The self-bodying action of the mixed emulsifier cetrimide-cetostearyl alcohol.