chlorhexidine digluconate

1,6-bis(5-(p-chlorophenyl)biguandino)hexane digluconate

CAS: 18472-51-0 C34 H54 Cl2 N10 O14 MW: 897.76718000

Identification

Namechlorhexidine digluconate
CAS Number18472-51-0
EINECS242-354-0
FDA UNIIMOR84MUD8E
Molecular FormulaC34 H54 Cl2 N10 O14
Molecular Weight897.76718000
MDL NumberMFCD00083599
Beilstein4348068

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 699.30 °C. @ 760.00 mm Hg (est)
Flash Point 710.00 °F. TCC ( 376.70 °C. ) (est)
logP (o/w) 4.931 (est)
Soluble in water, 65.36 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-mouse LD50 12900 ug/kg
Dermal Toxicitysubcutaneous-mouse LD50 1140 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for chlorhexidine digluconate usage levels up tonot for fragrance use.
Recommendation for chlorhexidine digluconate flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

Consistent sources

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Jiangyin Healthway International Trade Co., Ltd

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We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

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OQEMA

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Qingdao Free Trade Zone United International Co Ltd

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

arlacide G betasept chloraprep chlorhexamed chlorhexidine bigluconate chlorhexidine D-digluconate chlorhexidine di-D-gluconate 4- chlorhexidine digluconate chlorhexidine gluconate N,N''-bis(4- chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di-D-gluconate 1,6-bis(5-(p- chlorophenyl)biguandino)hexane digluconate corsodyl disteryl D- gluconic acid compd. with N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1) 1,1'- hexamethylene bis(5-(p-chlorophenyl)biguanide), digluconate 1,1'- hexamethylenebis(5-(p-chlorophenyl)biguanide) di-D-gluconate 1,1'- hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconate N',N'''''- hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2) N,N''''- hexane-1,6-diylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2) N,N''''-1,6- hexanediylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2) hexidine hibident hibisol imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, compd. with D-gluconic acid (1:2) manusan maskin R orahexal (2R,3S,4R,5R)-2,3,4,5,6- pentahydroxyhexanoic acid - N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] (2:1) (2R,3S,4R,5R)-2,3,4,5,6- pentahydroxyhexansäure--N,N''''-hexan-1,6-diylbis[N'-(4-chlorphenyl)(imidodicarbonimidic diamid)](2:1) phiso-med plurexid rotersept sterilon 2,4,11,13- tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate 2,4,11,13- tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, digluconate unisept PubMed: Antibacterial paperboard packaging using microfibrillated cellulose. PubMed: Survival and susceptibility of Burkholderia cepacia complex in chlorhexidine gluconate and benzalkonium chloride. PubMed: Effect of the hand antiseptic agents benzalkonium chloride, povidone-iodine, ethanol, and chlorhexidine gluconate on atopic dermatitis in NC/Nga mice. PubMed: Comparative efficacy of alcohol-based surgical scrubs: the importance of formulation. PubMed: Prospective evaluation of 2% (w/v) alcoholic chlorhexidine gluconate as an antiseptic agent for blood donor arm preparation. PubMed: Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. PubMed: Effects of food colouring added to 2% chlorhexidine gluconate and 70% alcohol for surgical site antisepsis. PubMed: Nonsurgical management of inflammatory periimplant disease caused by food impaction: a clinical report. PubMed: Effect of subinhibitory concentrations of four commonly used biocides on the conjugative transfer of Tn916 in Bacillus subtilis. PubMed: Lethal and sub lethal effects of the biocide chlorhexidine on aquatic organisms. PubMed: Involvement of leptin in the progression of experimentally induced peritoneal fibrosis in mice. PubMed: Presence of antiseptic resistance genes in porcine methicillin-resistant Staphylococcus aureus. PubMed: Efficacy of surgical preparation solutions in lumbar spine surgery. PubMed: Neurologic complications after chlorhexidine antisepsis for spinal anesthesia. PubMed: Comparative antibacterial efficacy of endemic satureja khuzistanica jamzad essential oil, sodium hypochlorite and chlorhexidine gluconate solutions as root canal irrigations. PubMed: A meta-analysis of the published literature on the effectiveness of antimicrobial soaps. PubMed: Avagard hand antisepsis vs. traditional scrub in 3600 pediatric urologic procedures. PubMed: Clinical management of root caries. PubMed: Application of the gingival contour plaque index: six-month plaque and gingivitis study. PubMed: Comparison of the efficacy of three different mouthrinse solutions in decreasing the level of streptococcus mutans in saliva. PubMed: Effects of commonly used food preservatives on biofilm formation of Streptococcus mutans in vitro. PubMed: A review of anti-septic agents for pre-operative skin preparation. PubMed: Characterization of predominant bacteria isolates from clean rooms in a pharmaceutical production unit. PubMed: Susceptibility of Listeria monocytogenes strains isolated from dairy products and frozen vegetables to antibiotics inhibiting murein synthesis and to disinfectants. PubMed: Comparative of a new and innovative 2% chlorhexidine gluconate-impregnated cloth with 4% chlorhexidine gluconate as topical antiseptic for preparation of the skin prior to surgery. PubMed: In vivo efficacy of an alcohol-based surgical hand disinfectant containing a synergistic combination of ethylhexylglycerin and preservatives. PubMed: A unique water optional health care personnel handwash provides antimicrobial persistence and residual effects while decreasing the need for additional products. PubMed: Risk assessment of hand washing efficacy using literature and experimental data. PubMed: Diazepam submicron emulsions containing soya-bean oil and intended for oral or rectal delivery. PubMed: New drug approvals in 1998. PubMed: Different responses of planktonic and attached Bacillus subtilis and Pseudomonas fluorescens to sanitizer treatment. PubMed: Latest FDA approvals for dentistry. PubMed: Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application. PubMed: Clinical efficacy of a chlorous acid preoperative skin antiseptic. PubMed: Caries diagnosis and risk assessment. A review of preventive strategies and management. PubMed: Identification and isolation of chlorhexidine digluconate impurities. PubMed: Efficacy evaluations on five chlorhexidine teat dip formulations. PubMed: How the FDA and the ADA affect development of prescription drugs for oral care. PubMed: Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans. PubMed: Problems affecting the liquid chromatographic quantitation of chlorhexidine digluconate in ophthalmic solutions. PubMed: Importance of neutralizers in the stripping fluid in a simulated healthcare personnel handwash. PubMed: Evaluation of the skin disinfecting activity and cumulative effect of chlorhexidine and triclosan handwash preparations on hands artificially contaminated with Serratia marcescens. PubMed: Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action.