diazolidinyl urea

1-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-1,3-bis(hydroxymethyl)urea

CAS: 78491-02-8 C8 H14 N4 O7 MW: 278.22198000

Identification

Namediazolidinyl urea
CAS Number78491-02-8
EINECS278-928-2
FDA UNIIN9VX1IBW6K
Molecular FormulaC8 H14 N4 O7
Molecular Weight278.22198000
MDL NumberMFCD03547942
Nikkaji NumberJ319.774C

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -5.398 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-bird - wild LD50 > 2250 mg/kg
Dermal Toxicityskin-rabbit LD50 > 2000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nBEHAVIORAL: ATAXIA\nGASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS']

Safety in Use

Categorypreservatives
Recommendation for diazolidinyl urea usage levels up tonot for fragrance use.
Recommendation for diazolidinyl urea flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

diazolidinyl urea USP/NF diazolidinylurea germall 11 N-(1,3-bis( hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)urea 1-[1,3-bis( hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-1,3-bis(hydroxymethyl)urea N-[1,3-bis( hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)urea N-[1,3-bis( hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]-N-(hydroxymethyl)[(h ydroxymethyl)amino]carboxamide N-[1,3-bis( hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]-N-(hydroxymethyl)[(hydroxymethyl)amino]carboxamide 1-(1,3-bis( hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-1,3-bis(hydroxymethyl) urea 1-(1,3-bis( hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-1,3-bis(hydroxymethyl)urea 1-[1,3-bis( hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea N-( hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl)urea urea, diazolidinyl urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)- urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)- PubMed: The different decomposition properties of diazolidinyl urea in cosmetics and patch test materials. PubMed: Hydrogel allergic contact dermatitis and imidazolidinyl urea/diazolidinyl urea. PubMed: Allergic contact dermatitis in health care workers to diazolidinyl urea present in antimicrobial hand gel. PubMed: Allergic contact dermatitis in a girl due to several cosmetics containing diazolidinyl-urea or imidazolidinyl-urea. PubMed: Simultaneous measurement of diazolidinyl urea, urea, and allantoin in cosmetic samples by hydrophilic interaction chromatography. PubMed: Contact allergy to diazolidinyl urea (Germall II). PubMed: Experimental delayed contact sensitization to diazolidinyl urea (Germall II) in guinea pigs. PubMed: Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials. PubMed: Experimental elicitation of contact allergy from a diazolidinyl urea-preserved cream in relation to anatomical region, exposure time and concentration. PubMed: Acute allergic contact dermatitis from diazolidinyl urea (Germall II) in a hair gel. PubMed: Trends in patch-test results and allergen changes in the standard series: a Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010). PubMed: ROAT: morphology of ROAT on arm, neck and face in formaldehyde and diazolidinyl urea sensitive individuals. PubMed: Determination of diazolidinyl urea in a topical cream by high-performance liquid chromatography. PubMed: Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance. PubMed: Contact sensitivity to diazolidinyl urea (Germall II). PubMed: Antimicrobial activities of N-chloramines and diazolidinyl urea. PubMed: Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea. PubMed: Effects of the formaldehyde releasing preservatives dimethylol urea and diazolidinyl urea in several short-term genotoxicity tests. PubMed: Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches. PubMed: Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009). PubMed: [Allergy to diazolidinyl urea (Germall II) and imidazolidinyl urea (Germall 115)]. PubMed: Contact sensitization to diazolidinyl urea: report of 3 cases. PubMed: Low-level efficacy of cosmetic preservatives. PubMed: Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives. PubMed: Patch Testing with Formaldehyde 2.0% in Parallel with 1.0% by the Swedish Contact Dermatitis Research Group. PubMed: The relevance of 7-day patch test reading. PubMed: North American Contact Dermatitis Group patch test results: 2009 to 2010. PubMed: Frequency of positive patch test reactions to preservatives: The Australian experience. PubMed: North American Contact Dermatitis Group patch test results for 2007-2008. PubMed: [Contact sensitization to allergens in the Spanish standard series at Hospital Costa del Sol in Marbella, Spain: a retrospective study (2005-2010)]. PubMed: Positive patch test reactions in older individuals: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008. PubMed: Formalehyde in personal care products. PubMed: Non-fragrance allergens in specific cosmetic products. PubMed: Contact allergy to preservatives. Analysis of IVDK data 1996-2009. PubMed: Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. PubMed: Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde. PubMed: Patch testing with preservatives at St John's from 1982 to 1993. PubMed: Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. PubMed: Allergic contact dermatitis to preservatives in topical medicaments. PubMed: A method for quantification of formaldehyde in the presence of formaldehyde donors in skin-care products. PubMed: Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II. PubMed: Contact sensitivity to preservatives in Turkey. PubMed: The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance. PubMed: Microbial inhibitors for U.S. EPA drinking water methods for the determination of organic compounds. PubMed: A review of 79 cases of eyelid dermatitis. PubMed: Formaldehyde in reusable protective gloves. PubMed: Evaluation of phototoxic properties of antimicrobials used in topical preparations by a photohaemolysis test. PubMed: [Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. PubMed: Considerations necessary in gathering occurrence data for selected unstable compounds in the USEPA Unregulated Contaminant Candidate List in USEPA Method 526. PubMed: Significance-prevalence index number: a reinterpretation and enhancement of data from the North American contact dermatitis group. PubMed: Patch testing with preservatives, antimicrobials and industrial biocides. Results from a multicentre study. PubMed: Influence of formulation on the in vitro transdermal penetration of flutrimazole. PubMed: Detection of DNA-crosslinking agents with the alkaline comet assay.