DMDM hydantoin

hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-

CAS: 6440-58-0 C7 H12 N2 O4 MW: 188.18344000

Identification

NameDMDM hydantoin
CAS Number6440-58-0
EINECS229-222-8
FDA UNIIBYR0546TOW
Molecular FormulaC7 H12 N2 O4
Molecular Weight188.18344000
Nikkaji NumberJ207.046D
Beilstein0882348

Regulatory

FDA Mainterm (IAUFC)6440-58-0 ; 1,3-BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOIN

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 303.71 °C. @ 760.00 mm Hg (est)
Flash Point 279.00 °F. TCC ( 137.50 °C. ) (est)
logP (o/w) -1.078 (est)
Soluble in water, 2.612e+005 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-mouse LDLo 1320 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypreservatives
Recommendation for DMDM hydantoin usage levels up tonot for fragrance use.
Recommendation for DMDM hydantoin flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

dantoin-DMDMH 1,3- di(hydroxymethyl)-5,5-dimethylhydantoin 1,3- dihydroxymethyl-5,5-dimethylhydantoin 1,3- dimethylol-5,5-dimethyl hydantoin 1,3- dimethylol-5,5-dimethyl-hydantoin 1,3- dimethylol-5,5-dimethylhydantion dimethylol-5,5-dimethylhydantoin 1,3- dimethylol-5,5-dimethylhydantoin dimethyloldimethyl hydantoin dimethyloldimethylhydantoin DMDMH glycoserve-DMDMH hydantoin hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl- 1,3-bis( hydroxymethyl)-5,5-dimethyl-1,3-diazolidine-2,4-dione 1,3-bis( hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione 1,3-bis( hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione 2,4- imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl- mackstat DM PubMed: Preservatives in cosmetics in the Israeli market conform well to the EU legislation. PubMed: Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives. PubMed: Frequency of positive patch test reactions to preservatives: The Australian experience. PubMed: Preservatives in cosmetics: reactivity of allergenic formaldehyde-releasers towards amino acids through breakdown products other than formaldehyde. PubMed: Lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms. PubMed: Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde. PubMed: Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. PubMed: Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II. PubMed: Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: a retrospective analysis from the North American Contact Dermatitis Group. PubMed: [Contact allergy to preservatives contained in cosmetics]. PubMed: Contact sensitivity to preservatives in Turkey. PubMed: [Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. PubMed: Contact allergy from DMDM hydantoin, 1994-2000. PubMed: Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. PubMed: Patch test reactivity to DMDM hydantoin. Relationship to formaldehyde allergy. PubMed: Contact allergy to preservatives--II.