DMDM hydantoin
hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
Identification
| Name | DMDM hydantoin |
| CAS Number | 6440-58-0 |
| EINECS | 229-222-8 |
| FDA UNII | BYR0546TOW |
| Molecular Formula | C7 H12 N2 O4 |
| Molecular Weight | 188.18344000 |
| Nikkaji Number | J207.046D |
| Beilstein | 0882348 |
Regulatory
| FDA Mainterm (IAUFC) | 6440-58-0 ; 1,3-BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOIN |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 303.71 °C. @ 760.00 mm Hg (est) |
| Flash Point | 279.00 °F. TCC ( 137.50 °C. ) (est) |
| logP (o/w) | -1.078 (est) |
| Soluble in | water, 2.612e+005 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | preservatives |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LDLo 1320 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | preservatives |
| Recommendation for DMDM hydantoin usage levels up to | not for fragrance use. |
| Recommendation for DMDM hydantoin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
dantoin-DMDMH
1,3-
di(hydroxymethyl)-5,5-dimethylhydantoin
1,3-
dihydroxymethyl-5,5-dimethylhydantoin
1,3-
dimethylol-5,5-dimethyl hydantoin
1,3-
dimethylol-5,5-dimethyl-hydantoin
1,3-
dimethylol-5,5-dimethylhydantion
dimethylol-5,5-dimethylhydantoin
1,3-
dimethylol-5,5-dimethylhydantoin
dimethyloldimethyl hydantoin
dimethyloldimethylhydantoin
DMDMH
glycoserve-DMDMH
hydantoin
hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
1,3-bis(
hydroxymethyl)-5,5-dimethyl-1,3-diazolidine-2,4-dione
1,3-bis(
hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione
1,3-bis(
hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
2,4-
imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
mackstat DM
PubMed:
Preservatives in cosmetics in the Israeli market conform well to the EU legislation.
PubMed:
Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives.
PubMed:
Frequency of positive patch test reactions to preservatives: The Australian experience.
PubMed:
Preservatives in cosmetics: reactivity of allergenic formaldehyde-releasers towards amino acids through breakdown products other than formaldehyde.
PubMed:
Lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms.
PubMed:
Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde.
PubMed:
Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics.
PubMed:
Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II.
PubMed:
Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: a retrospective analysis from the North American Contact Dermatitis Group.
PubMed:
[Contact allergy to preservatives contained in cosmetics].
PubMed:
Contact sensitivity to preservatives in Turkey.
PubMed:
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].
PubMed:
Contact allergy from DMDM hydantoin, 1994-2000.
PubMed:
Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group.
PubMed:
Patch test reactivity to DMDM hydantoin. Relationship to formaldehyde allergy.
PubMed:
Contact allergy to preservatives--II.