etidronic acid
phosphonic acid, (1-hydroxyethylidene)bis-
Identification
| Name | etidronic acid |
| CAS Number | 2809-21-4 |
| EINECS | 220-552-8 |
| FDA UNII | M2F465ROXU |
| Molecular Formula | C2 H8 O7 P2 |
| Molecular Weight | 206.02768400 |
| MDL Number | MFCD00070585 |
| Nikkaji Number | J7.915D |
| Beilstein | 1789291 |
Regulatory
| JECFA Food Additive | 1-Hydroxyethylidene-1,1-diphosphonic acid |
| FDA Mainterm (SATF) | 2809-21-4 ; 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID |
| FDA Regulation | FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Appearance | pale yellow clear liquid (est) |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.43000 to 1.47100 @ 20.00 °C. |
| Pounds per Gallon - (est). | 11.913 to 12.254 |
| Boiling Point | 578.76 °C. @ 760.00 mm Hg (est) |
| Flash Point | 579.00 °F. TCC ( 303.80 °C. ) (est) |
| logP (o/w) | -0.746 (est) |
| Soluble in | water, 690000 mg/L @ 20 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | chelating agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-mouse LD50 1800 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | sequestrants |
| Recommendation for etidronic acid usage levels up to | not for fragrance use. |
| Recommendation for etidronic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
acetodiphosphonic acid
cublen HE-K 60
didronel IV
oxy
ethylidenediphosphonic acid
(1-
hydroxy-1-phosphono-ethyl)-phosphonic acid
(1-
hydroxy-1-phosphonoethyl)phosphonic acid
(1-
hydroxy-1,1-ethanediyl)bis(phosphonic acid)
1-
hydroxyethane-1,1-bisphosphonic acid
1-
hydroxyethane-1,1-diphosphonic acid
(1-
hydroxyethane-1,1-diyl)bis(phosphonic acid)
(1-
hydroxyethane-1,1-diyl)diphosphonic acid
1-
hydroxyethane-1,1,-diphosphonic acid
1-
hydroxyethanediphosphonic acid
(1-
hydroxyethylene)diphosphonic acid
1-
hydroxyethylidene-1,1-diphosphonic acid
1-
hydroxyethylidene-1,1-diphosphonicacid
(1-
hydroxyethylidene)bis(phosphonic acid)
(1-
hydroxyethylidene)bisphonic acid
(1-
hydroxyethylidene)bisphosphonic acid
(1-
hydroxyethylidene)diphoshonic acid
hydroxyethylidene)diphosphonic acid
(1-
hydroxyethylidene)diphosphonic acid
1-
hydroxyethylidenediphosphonic acid
phosphonic acid, (1-hydroxyethylidene)bis-
PubMed:
Biosorption of heavy metal ions onto agricultural residues buckwheat hulls functionalized with 1-hydroxylethylidenediphosphonic acid.
PubMed:
Intravenous zoledronic acid: what are the indications for male osteoporosis?
PubMed:
Effect of osteoporosis treatment on mortality: a meta-analysis.
PubMed:
Comparison of the effects of once-monthly versus once-daily risedronate in postmenopausal osteoporosis: a phase II, 6-month, multicenter, randomized, double-blind, active-controlled, dose-ranging study.
PubMed:
Risedronate dosing before breakfast compared with dosing later in the day in women with postmenopausal osteoporosis.
PubMed:
Compatibility of risedronate sodium tablets with food thickeners.
PubMed:
Paget disease of bone: therapeutic options.
PubMed:
Nonvertebral fracture risk reduction with nitrogen-containing bisphosphonates.
PubMed:
Effects of risedronate 5 mg/d on bone mineral density and bone turnover markers in late-postmenopausal women with osteopenia: a multinational, 24-month, randomized, double-blind, placebo-controlled, parallel-group, phase III trial.
PubMed:
Evaluation of 41calcium as a new approach to assess changes in bone metabolism: effect of a bisphosphonate intervention in postmenopausal women with low bone mass.
PubMed:
Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal.
PubMed:
Importance of calcium co-medication in bisphosphonate therapy of osteoporosis: an approach to improving correct intake and drug adherence.
PubMed:
Pharmaceutical care and community pharmacists' understanding of bisphosphonate dosing information.
PubMed:
Clinical trial of risedronate in Japanese volunteers: a study on the effects of timing of dosing on absorption.
PubMed:
An approach to postmenopausal osteoporosis treatment: a case study review.
PubMed:
Prevention and treatment of osteoporosis.
PubMed:
Bone density changes with once weekly risedronate in postmenopausal women.
PubMed:
Treatment of hypercalcemia of malignancy with bisphosphonates.
PubMed:
Food-drug interactions.
PubMed:
Risedronate: a new oral bisphosphonate.
PubMed:
Gender differences in osteoporosis treatment: a review of clinical research.
PubMed:
Timing of cyclical etidronate.
PubMed:
Prevention and treatment of osteoporosis.
PubMed:
The effect of dosing regimen on the pharmacokinetics of risedronate.
PubMed:
Evaluation of the effects of risedronate on hepatic microsomal drug metabolizing enzyme activities following administration to rats for 14 days: lack of an induction response.
PubMed:
Risedronate released for Paget's disease.
PubMed:
Bisphosphonates: preclinical aspects and use in osteoporosis.
PubMed:
Adverse effects of bisphosphonates. A comparative review.
PubMed:
Osteoporosis: pathophysiology, prevention, diagnosis, and treatment.
PubMed:
Etidronate for hypercalcemia of malignancy and osteoporosis.
PubMed:
Absorption of oral diphosphonate in normal subjects.