etidronic acid

phosphonic acid, (1-hydroxyethylidene)bis-

CAS: 2809-21-4 C2 H8 O7 P2 MW: 206.02768400

Identification

Nameetidronic acid
CAS Number2809-21-4
EINECS220-552-8
FDA UNIIM2F465ROXU
Molecular FormulaC2 H8 O7 P2
Molecular Weight206.02768400
MDL NumberMFCD00070585
Nikkaji NumberJ7.915D
Beilstein1789291

Regulatory

JECFA Food Additive1-Hydroxyethylidene-1,1-diphosphonic acid
FDA Mainterm (SATF)2809-21-4 ; 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID
FDA RegulationFDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance pale yellow clear liquid (est)
Food Chemicals Codex Listed No
Specific Gravity 1.43000 to 1.47100 @ 20.00 °C.
Pounds per Gallon - (est). 11.913 to 12.254
Boiling Point 578.76 °C. @ 760.00 mm Hg (est)
Flash Point 579.00 °F. TCC ( 303.80 °C. ) (est)
logP (o/w) -0.746 (est)
Soluble in water, 690000 mg/L @ 20 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Useschelating agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 1800 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysequestrants
Recommendation for etidronic acid usage levels up tonot for fragrance use.
Recommendation for etidronic acid flavor usage levels up tonot for flavor use.

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Potential Uses

chelating agents

Natural Occurrence

not found in nature

Synonyms

acetodiphosphonic acid cublen HE-K 60 didronel IV oxy ethylidenediphosphonic acid (1- hydroxy-1-phosphono-ethyl)-phosphonic acid (1- hydroxy-1-phosphonoethyl)phosphonic acid (1- hydroxy-1,1-ethanediyl)bis(phosphonic acid) 1- hydroxyethane-1,1-bisphosphonic acid 1- hydroxyethane-1,1-diphosphonic acid (1- hydroxyethane-1,1-diyl)bis(phosphonic acid) (1- hydroxyethane-1,1-diyl)diphosphonic acid 1- hydroxyethane-1,1,-diphosphonic acid 1- hydroxyethanediphosphonic acid (1- hydroxyethylene)diphosphonic acid 1- hydroxyethylidene-1,1-diphosphonic acid 1- hydroxyethylidene-1,1-diphosphonicacid (1- hydroxyethylidene)bis(phosphonic acid) (1- hydroxyethylidene)bisphonic acid (1- hydroxyethylidene)bisphosphonic acid (1- hydroxyethylidene)diphoshonic acid hydroxyethylidene)diphosphonic acid (1- hydroxyethylidene)diphosphonic acid 1- hydroxyethylidenediphosphonic acid phosphonic acid, (1-hydroxyethylidene)bis- PubMed: Biosorption of heavy metal ions onto agricultural residues buckwheat hulls functionalized with 1-hydroxylethylidenediphosphonic acid. PubMed: Intravenous zoledronic acid: what are the indications for male osteoporosis? PubMed: Effect of osteoporosis treatment on mortality: a meta-analysis. PubMed: Comparison of the effects of once-monthly versus once-daily risedronate in postmenopausal osteoporosis: a phase II, 6-month, multicenter, randomized, double-blind, active-controlled, dose-ranging study. PubMed: Risedronate dosing before breakfast compared with dosing later in the day in women with postmenopausal osteoporosis. PubMed: Compatibility of risedronate sodium tablets with food thickeners. PubMed: Paget disease of bone: therapeutic options. PubMed: Nonvertebral fracture risk reduction with nitrogen-containing bisphosphonates. PubMed: Effects of risedronate 5 mg/d on bone mineral density and bone turnover markers in late-postmenopausal women with osteopenia: a multinational, 24-month, randomized, double-blind, placebo-controlled, parallel-group, phase III trial. PubMed: Evaluation of 41calcium as a new approach to assess changes in bone metabolism: effect of a bisphosphonate intervention in postmenopausal women with low bone mass. PubMed: Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal. PubMed: Importance of calcium co-medication in bisphosphonate therapy of osteoporosis: an approach to improving correct intake and drug adherence. PubMed: Pharmaceutical care and community pharmacists' understanding of bisphosphonate dosing information. PubMed: Clinical trial of risedronate in Japanese volunteers: a study on the effects of timing of dosing on absorption. PubMed: An approach to postmenopausal osteoporosis treatment: a case study review. PubMed: Prevention and treatment of osteoporosis. PubMed: Bone density changes with once weekly risedronate in postmenopausal women. PubMed: Treatment of hypercalcemia of malignancy with bisphosphonates. PubMed: Food-drug interactions. PubMed: Risedronate: a new oral bisphosphonate. PubMed: Gender differences in osteoporosis treatment: a review of clinical research. PubMed: Timing of cyclical etidronate. PubMed: Prevention and treatment of osteoporosis. PubMed: The effect of dosing regimen on the pharmacokinetics of risedronate. PubMed: Evaluation of the effects of risedronate on hepatic microsomal drug metabolizing enzyme activities following administration to rats for 14 days: lack of an induction response. PubMed: Risedronate released for Paget's disease. PubMed: Bisphosphonates: preclinical aspects and use in osteoporosis. PubMed: Adverse effects of bisphosphonates. A comparative review. PubMed: Osteoporosis: pathophysiology, prevention, diagnosis, and treatment. PubMed: Etidronate for hypercalcemia of malignancy and osteoporosis. PubMed: Absorption of oral diphosphonate in normal subjects.